Visual symptoms in Parkinson's disease and Parkinson's disease dementia
Identifieur interne : 000B46 ( Main/Corpus ); précédent : 000B45; suivant : 000B47Visual symptoms in Parkinson's disease and Parkinson's disease dementia
Auteurs : Neil K. Archibald ; Mike P. Clarke ; Urs P. Mosimann ; David J. BurnSource :
- Movement Disorders [ 0885-3185 ] ; 2011-11.
English descriptors
- KwdEn :
Abstract
Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty‐four subjects with PD, 26 with PD dementia, and 32 age‐matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23891
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ISTEX:148FC0A3A8EAF6B5B722AA70A0BC42F1F5597F08Le document en format XML
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Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty‐four subjects with PD, 26 with PD dementia, and 32 age‐matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Neil K. Archibald</name><affiliations><json:string>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>Mike P. Clarke</name><affiliations><json:string>Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>Urs P. Mosimann</name><affiliations><json:string>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</json:string><json:string>Department of Psychiatry, Bern University, Bern, Switzerland</json:string></affiliations></json:item><json:item><name>David J. 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Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. 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We acknowledge support from the UK NIHR Biomedical Research Center for Aging and Age‐Related Disease award to the Newcastle upon Tyne Hospitals NHS Foundation Trust.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Visual symptoms in Parkinson's disease and Parkinson's disease dementia</title><author><persName><forename type="first">Neil K.</forename><surname>Archibald</surname></persName><note type="correspondence"><p>Correspondence: Clinical Aging Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK NE4 5PL</p></note><affiliation>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</affiliation></author><author><persName><forename type="first">Mike P.</forename><surname>Clarke</surname></persName><affiliation>Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom</affiliation></author><author><persName><forename type="first">Urs P.</forename><surname>Mosimann</surname></persName><affiliation>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</affiliation><affiliation>Department of Psychiatry, Bern University, Bern, Switzerland</affiliation></author><author><persName><forename type="first">David J.</forename><surname>Burn</surname></persName><affiliation>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-11"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2387">2387</biblScope><biblScope unit="page" to="2395">2395</biblScope></imprint></monogr><idno type="istex">148FC0A3A8EAF6B5B722AA70A0BC42F1F5597F08</idno><idno type="DOI">10.1002/mds.23891</idno><idno type="ArticleID">MDS23891</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty‐four subjects with PD, 26 with PD dementia, and 32 age‐matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>Parkinson's disease dementia</term></item><item><term>complex visual hallucinations</term></item><item><term>visual acuity</term></item><item><term>contrast sensitivity</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-03-28">Received</change><change when="2011-07-01">Registration</change><change when="2011-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/148FC0A3A8EAF6B5B722AA70A0BC42F1F5597F08/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty‐four subjects with PD, 26 with PD dementia, and 32 age‐matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; <i>P</i> = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Funding agencies:</b> N.K.A. was funded by Parkinson's UK for this work. We acknowledge support from the UK NIHR Biomedical Research Center for Aging and Age‐Related Disease award to the Newcastle upon Tyne Hospitals NHS Foundation Trust.</p></note><note xml:id="fn2"><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p></note><note xml:id="fn3"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Visual symptoms in Parkinson's disease and Parkinson's disease dementia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Vision in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Visual symptoms in Parkinson's disease and Parkinson's disease dementia</title></titleInfo><name type="personal"><namePart type="given">Neil K.</namePart><namePart type="family">Archibald</namePart><affiliation>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</affiliation><description>Correspondence: Clinical Aging Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK NE4 5PL</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mike P.</namePart><namePart type="family">Clarke</namePart><affiliation>Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Urs P.</namePart><namePart type="family">Mosimann</namePart><affiliation>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</affiliation><affiliation>Department of Psychiatry, Bern University, Bern, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David J.</namePart><namePart type="family">Burn</namePart><affiliation>Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-11</dateIssued><dateCaptured encoding="w3cdtf">2011-03-28</dateCaptured><dateValid encoding="w3cdtf">2011-07-01</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent><extent unit="references">48</extent><extent unit="words">8383</extent></physicalDescription><abstract lang="en">Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains poorly understood. Our aim was to characterize the spectrum of visual symptomatology in PD and examine clinical predictors for their occurrence. Sixty‐four subjects with PD, 26 with PD dementia, and 32 age‐matched controls were assessed for visual symptoms, cognitive impairment, and ocular pathology. Complex visual hallucinations were common in PD (17%) and PD dementia (89%). Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). Visual acuity and contrast sensitivity was impaired in parkinsonian subjects, with disease severity and age emerging as the key predictors. Regression analysis identified a variety of factors independently predictive of complex visual hallucinations (e.g., dementia, visual acuity, and depression), illusions (e.g., excessive daytime somnolence and disease severity), and presence (e.g., rapid eye movement sleep behavior disorder and excessive daytime somnolence). Our results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms. If confirmed, such a finding will have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: N.K.A. was funded by Parkinson's UK for this work. We acknowledge support from the UK NIHR Biomedical Research Center for Aging and Age‐Related Disease award to the Newcastle upon Tyne Hospitals NHS Foundation Trust.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Nothing to report.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Parkinson's disease dementia</topic><topic>complex visual hallucinations</topic><topic>visual acuity</topic><topic>contrast sensitivity</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>13</number></detail><extent unit="pages"><start>2387</start><end>2395</end><total>9</total></extent></part></relatedItem><identifier type="istex">148FC0A3A8EAF6B5B722AA70A0BC42F1F5597F08</identifier><identifier type="DOI">10.1002/mds.23891</identifier><identifier type="ArticleID">MDS23891</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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