Aerodynamic measurements of patients with parkinson's disease
Identifieur interne : 000B17 ( Main/Corpus ); précédent : 000B16; suivant : 000B18Aerodynamic measurements of patients with parkinson's disease
Auteurs : Jack Jiang ; Timothy O'Mara ; Hui-Jun Chen ; Jennifer I. Stern ; Demetra Vlagos ; David HansonSource :
- Journal of Voice [ 0892-1997 ] ; 1998.
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- KwdEn :
Abstract
Patients with Parkinson's disease commonly complain of voice dysfunction. Most of these complaints can be attributed to the known muscular control disorders that occur with Parkinson's disease. However, the manifestations of Parkinson's disease muscular dysfunction on parameters of phonation such as airflow, laryngeal resistance, and subglottal pressure necessary to sustain phonation have not been reported. The purpose of this study was to examine the aerodynamic characteristics of flow, laryngeal resistance, and phonation pressure threshold in a heterogeneous population of patients with Parkinson's disease who had varying voice complaints and to compare the data to similar studies for human subjects who have no voice complaints. The studies used a noninvasive method of detecting flow and acoustic signal from the lips, oral cavity and nose during phonation and used an external flow interruption technique to estimate subglottal pressure and phonation threshold pressure. About one third of the patients could not produce phonation at regular and loud intensities that were comfortable for normal subjects. The mean subglottal pressure (SGP) of patients with Parkinson disease who could produce 3 levels of intensity comparable to normal subjects was significantly higher than the mean SG-Ps for normal subjects for the same intensities of vocal production. The mean flow rates measured from patients with Parkinson's disease at the same 3 intensities of phonation was not significantly greater than in normal subjects. This indicated that the mean laryngeal resistance calculated for patients with Parkinson's disease was notably and significantly greater than mean laryngeal resistance calculated for normal subjects at the same intensity levels. The mean vocal efficiency (VE) for normal subjects was not significantly different than the mean VE for patients with Parkinson's disease, because greater pressure was used to generate similar flow and acoustic energy. These findings correlate with the perception of patients with Parkinson's disease that they are working harder to produce phonation. The observation of notably greater laryngeal resistance and phonation threshold pressure in patients with Parkinson's disease suggests that further studies of the glottic aperture in patients with Parkinson' disease may be useful for understanding how this common motor disorder disturbs phonation.
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DOI: 10.1016/S0892-1997(99)80012-5
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aerodynamic measurements of patients with parkinson's disease</title><author><name sortKey="Jiang, Jack" sort="Jiang, Jack" uniqKey="Jiang J" first="Jack" last="Jiang">Jack Jiang</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Address correspondence and reprint requests, to Dr. Jack Jiang, Department of Otolaryngology—Head and Neck Surgery, Northwestern University, Searle Building 12-561, 303 East Chicago Avenue, Chicago, IL 60611 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jjiang@nwu.edu</mods:affiliation></affiliation></author><author><name sortKey="O Mara, Timothy" sort="O Mara, Timothy" uniqKey="O Mara T" first="Timothy" last="O'Mara">Timothy O'Mara</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Chen, Hui Jun" sort="Chen, Hui Jun" uniqKey="Chen H" first="Hui-Jun" last="Chen">Hui-Jun Chen</name><affiliation><mods:affiliation>Eye and Ear Nose Throat Hospital, Shanghai Medical University, Shanghai, P.R. China</mods:affiliation></affiliation></author><author><name sortKey="Stern, Jennifer I" sort="Stern, Jennifer I" uniqKey="Stern J" first="Jennifer I." last="Stern">Jennifer I. Stern</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Vlagos, Demetra" sort="Vlagos, Demetra" uniqKey="Vlagos D" first="Demetra" last="Vlagos">Demetra Vlagos</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Hanson, David" sort="Hanson, David" uniqKey="Hanson D" first="David" last="Hanson">David Hanson</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4009891B9BE0A93A2BAB6634263CE69D2E98C082</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0892-1997(99)80012-5</idno><idno type="url">https://api.istex.fr/document/4009891B9BE0A93A2BAB6634263CE69D2E98C082/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000B17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Aerodynamic measurements of patients with parkinson's disease</title><author><name sortKey="Jiang, Jack" sort="Jiang, Jack" uniqKey="Jiang J" first="Jack" last="Jiang">Jack Jiang</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Address correspondence and reprint requests, to Dr. Jack Jiang, Department of Otolaryngology—Head and Neck Surgery, Northwestern University, Searle Building 12-561, 303 East Chicago Avenue, Chicago, IL 60611 U.S.A.</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jjiang@nwu.edu</mods:affiliation></affiliation></author><author><name sortKey="O Mara, Timothy" sort="O Mara, Timothy" uniqKey="O Mara T" first="Timothy" last="O'Mara">Timothy O'Mara</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Chen, Hui Jun" sort="Chen, Hui Jun" uniqKey="Chen H" first="Hui-Jun" last="Chen">Hui-Jun Chen</name><affiliation><mods:affiliation>Eye and Ear Nose Throat Hospital, Shanghai Medical University, Shanghai, P.R. China</mods:affiliation></affiliation></author><author><name sortKey="Stern, Jennifer I" sort="Stern, Jennifer I" uniqKey="Stern J" first="Jennifer I." last="Stern">Jennifer I. Stern</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Vlagos, Demetra" sort="Vlagos, Demetra" uniqKey="Vlagos D" first="Demetra" last="Vlagos">Demetra Vlagos</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author><author><name sortKey="Hanson, David" sort="Hanson, David" uniqKey="Hanson D" first="David" last="Hanson">David Hanson</name><affiliation><mods:affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Voice</title><title level="j" type="abbrev">YMVJ</title><idno type="ISSN">0892-1997</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="583">583</biblScope><biblScope unit="page" to="591">591</biblScope></imprint><idno type="ISSN">0892-1997</idno></series><idno type="istex">4009891B9BE0A93A2BAB6634263CE69D2E98C082</idno><idno type="DOI">10.1016/S0892-1997(99)80012-5</idno><idno type="PII">S0892-1997(99)80012-5</idno><idno type="ArticleID">99800125</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0892-1997</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Airflow interruption</term><term>Dysphonia</term><term>Laryngeal resistance</term><term>Parkinson's disease</term><term>Subglottic pressure, Vocal efficiency</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson's disease commonly complain of voice dysfunction. Most of these complaints can be attributed to the known muscular control disorders that occur with Parkinson's disease. However, the manifestations of Parkinson's disease muscular dysfunction on parameters of phonation such as airflow, laryngeal resistance, and subglottal pressure necessary to sustain phonation have not been reported. The purpose of this study was to examine the aerodynamic characteristics of flow, laryngeal resistance, and phonation pressure threshold in a heterogeneous population of patients with Parkinson's disease who had varying voice complaints and to compare the data to similar studies for human subjects who have no voice complaints. The studies used a noninvasive method of detecting flow and acoustic signal from the lips, oral cavity and nose during phonation and used an external flow interruption technique to estimate subglottal pressure and phonation threshold pressure. About one third of the patients could not produce phonation at regular and loud intensities that were comfortable for normal subjects. The mean subglottal pressure (SGP) of patients with Parkinson disease who could produce 3 levels of intensity comparable to normal subjects was significantly higher than the mean SG-Ps for normal subjects for the same intensities of vocal production. The mean flow rates measured from patients with Parkinson's disease at the same 3 intensities of phonation was not significantly greater than in normal subjects. This indicated that the mean laryngeal resistance calculated for patients with Parkinson's disease was notably and significantly greater than mean laryngeal resistance calculated for normal subjects at the same intensity levels. The mean vocal efficiency (VE) for normal subjects was not significantly different than the mean VE for patients with Parkinson's disease, because greater pressure was used to generate similar flow and acoustic energy. These findings correlate with the perception of patients with Parkinson's disease that they are working harder to produce phonation. The observation of notably greater laryngeal resistance and phonation threshold pressure in patients with Parkinson's disease suggests that further studies of the glottic aperture in patients with Parkinson' disease may be useful for understanding how this common motor disorder disturbs phonation.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Jack Jiang</name><affiliations><json:string>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</json:string><json:string>Address correspondence and reprint requests, to Dr. Jack Jiang, Department of Otolaryngology—Head and Neck Surgery, Northwestern University, Searle Building 12-561, 303 East Chicago Avenue, Chicago, IL 60611 U.S.A.</json:string><json:string>E-mail: jjiang@nwu.edu</json:string></affiliations></json:item><json:item><name>Timothy O'Mara</name><affiliations><json:string>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Hui-Jun Chen</name><affiliations><json:string>Eye and Ear Nose Throat Hospital, Shanghai Medical University, Shanghai, P.R. China</json:string></affiliations></json:item><json:item><name>Jennifer I. Stern</name><affiliations><json:string>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Demetra Vlagos</name><affiliations><json:string>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>David Hanson</name><affiliations><json:string>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Dysphonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Subglottic pressure, Vocal efficiency</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Airflow interruption</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Laryngeal resistance</value></json:item></subject><articleId><json:string>99800125</json:string></articleId><language><json:string>eng</json:string></language><abstract>Patients with Parkinson's disease commonly complain of voice dysfunction. Most of these complaints can be attributed to the known muscular control disorders that occur with Parkinson's disease. However, the manifestations of Parkinson's disease muscular dysfunction on parameters of phonation such as airflow, laryngeal resistance, and subglottal pressure necessary to sustain phonation have not been reported. The purpose of this study was to examine the aerodynamic characteristics of flow, laryngeal resistance, and phonation pressure threshold in a heterogeneous population of patients with Parkinson's disease who had varying voice complaints and to compare the data to similar studies for human subjects who have no voice complaints. The studies used a noninvasive method of detecting flow and acoustic signal from the lips, oral cavity and nose during phonation and used an external flow interruption technique to estimate subglottal pressure and phonation threshold pressure. About one third of the patients could not produce phonation at regular and loud intensities that were comfortable for normal subjects. The mean subglottal pressure (SGP) of patients with Parkinson disease who could produce 3 levels of intensity comparable to normal subjects was significantly higher than the mean SG-Ps for normal subjects for the same intensities of vocal production. The mean flow rates measured from patients with Parkinson's disease at the same 3 intensities of phonation was not significantly greater than in normal subjects. This indicated that the mean laryngeal resistance calculated for patients with Parkinson's disease was notably and significantly greater than mean laryngeal resistance calculated for normal subjects at the same intensity levels. The mean vocal efficiency (VE) for normal subjects was not significantly different than the mean VE for patients with Parkinson's disease, because greater pressure was used to generate similar flow and acoustic energy. These findings correlate with the perception of patients with Parkinson's disease that they are working harder to produce phonation. The observation of notably greater laryngeal resistance and phonation threshold pressure in patients with Parkinson's disease suggests that further studies of the glottic aperture in patients with Parkinson' disease may be useful for understanding how this common motor disorder disturbs phonation.</abstract><qualityIndicators><score>6.904</score><pdfVersion>1.3</pdfVersion><pdfPageSize>648 x 828 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>2411</abstractCharCount><pdfWordCount>3904</pdfWordCount><pdfCharCount>23574</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>348</abstractWordCount></qualityIndicators><title>Aerodynamic measurements of patients with parkinson's disease</title><pii><json:string>S0892-1997(99)80012-5</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>13</volume><pii><json:string>S0892-1997(99)X8001-5</json:string></pii><pages><last>591</last><first>583</first></pages><issn><json:string>0892-1997</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Journal of Voice</title><publicationDate>1999</publicationDate></host><categories><wos><json:string>OTORHINOLARYNGOLOGY</json:string></wos></categories><publicationDate>1998</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0892-1997(99)80012-5</json:string></doi><id>4009891B9BE0A93A2BAB6634263CE69D2E98C082</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/4009891B9BE0A93A2BAB6634263CE69D2E98C082/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/4009891B9BE0A93A2BAB6634263CE69D2E98C082/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/4009891B9BE0A93A2BAB6634263CE69D2E98C082/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4009891B9BE0A93A2BAB6634263CE69D2E98C082/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Aerodynamic measurements of patients with parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1999</date></publicationStmt><notesStmt><note>This paper was presented at the Voice Foundation's 27th Annual Symposium Care of the Professional Voice; June 2, 1998; Philadelphia, Pennsylvania.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Aerodynamic measurements of patients with parkinson's disease</title><author><persName><forename type="first">Jack</forename><surname>Jiang</surname></persName><email>jjiang@nwu.edu</email><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation><affiliation>Address correspondence and reprint requests, to Dr. Jack Jiang, Department of Otolaryngology—Head and Neck Surgery, Northwestern University, Searle Building 12-561, 303 East Chicago Avenue, Chicago, IL 60611 U.S.A.</affiliation></author><author><persName><forename type="first">Timothy</forename><surname>O'Mara</surname></persName><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation></author><author><persName><forename type="first">Hui-Jun</forename><surname>Chen</surname></persName><affiliation>Eye and Ear Nose Throat Hospital, Shanghai Medical University, Shanghai, P.R. China</affiliation></author><author><persName><forename type="first">Jennifer I.</forename><surname>Stern</surname></persName><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation></author><author><persName><forename type="first">Demetra</forename><surname>Vlagos</surname></persName><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation></author><author><persName><forename type="first">David</forename><surname>Hanson</surname></persName><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation></author></analytic><monogr><title level="j">Journal of Voice</title><title level="j" type="abbrev">YMVJ</title><idno type="pISSN">0892-1997</idno><idno type="PII">S0892-1997(99)X8001-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998"></date><biblScope unit="volume">13</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="583">583</biblScope><biblScope unit="page" to="591">591</biblScope></imprint></monogr><idno type="istex">4009891B9BE0A93A2BAB6634263CE69D2E98C082</idno><idno type="DOI">10.1016/S0892-1997(99)80012-5</idno><idno type="PII">S0892-1997(99)80012-5</idno><idno type="ArticleID">99800125</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Patients with Parkinson's disease commonly complain of voice dysfunction. Most of these complaints can be attributed to the known muscular control disorders that occur with Parkinson's disease. However, the manifestations of Parkinson's disease muscular dysfunction on parameters of phonation such as airflow, laryngeal resistance, and subglottal pressure necessary to sustain phonation have not been reported. The purpose of this study was to examine the aerodynamic characteristics of flow, laryngeal resistance, and phonation pressure threshold in a heterogeneous population of patients with Parkinson's disease who had varying voice complaints and to compare the data to similar studies for human subjects who have no voice complaints. The studies used a noninvasive method of detecting flow and acoustic signal from the lips, oral cavity and nose during phonation and used an external flow interruption technique to estimate subglottal pressure and phonation threshold pressure. About one third of the patients could not produce phonation at regular and loud intensities that were comfortable for normal subjects. The mean subglottal pressure (SGP) of patients with Parkinson disease who could produce 3 levels of intensity comparable to normal subjects was significantly higher than the mean SG-Ps for normal subjects for the same intensities of vocal production. The mean flow rates measured from patients with Parkinson's disease at the same 3 intensities of phonation was not significantly greater than in normal subjects. This indicated that the mean laryngeal resistance calculated for patients with Parkinson's disease was notably and significantly greater than mean laryngeal resistance calculated for normal subjects at the same intensity levels. The mean vocal efficiency (VE) for normal subjects was not significantly different than the mean VE for patients with Parkinson's disease, because greater pressure was used to generate similar flow and acoustic energy. These findings correlate with the perception of patients with Parkinson's disease that they are working harder to produce phonation. The observation of notably greater laryngeal resistance and phonation threshold pressure in patients with Parkinson's disease suggests that further studies of the glottic aperture in patients with Parkinson' disease may be useful for understanding how this common motor disorder disturbs phonation.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key Words</head><item><term>Parkinson's disease</term></item><item><term>Dysphonia</term></item><item><term>Subglottic pressure, Vocal efficiency</term></item><item><term>Airflow interruption</term></item><item><term>Laryngeal resistance</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998-12-12">Registration</change><change when="1998">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>YMVJ</jid><aid>99800125</aid><ce:pii>S0892-1997(99)80012-5</ce:pii><ce:doi>10.1016/S0892-1997(99)80012-5</ce:doi><ce:copyright type="unknown" year="1999">Singular Publishing Group, Inc.</ce:copyright></item-info><head><ce:article-footnote><ce:label>*</ce:label><ce:note-para>This paper was presented at the Voice Foundation's 27th Annual Symposium Care of the Professional Voice; June 2, 1998; Philadelphia, Pennsylvania.</ce:note-para></ce:article-footnote><ce:title>Aerodynamic measurements of patients with parkinson's disease</ce:title><ce:author-group><ce:author><ce:given-name>Jack</ce:given-name><ce:surname>Jiang</ce:surname><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref><ce:e-address type="email">jjiang@nwu.edu</ce:e-address></ce:author><ce:author><ce:given-name>Timothy</ce:given-name><ce:surname>O'Mara</ce:surname><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Hui-Jun</ce:given-name><ce:surname>Chen</ce:surname><ce:cross-ref refid="aff2">†</ce:cross-ref></ce:author><ce:author><ce:given-name>Jennifer I.</ce:given-name><ce:surname>Stern</ce:surname><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Demetra</ce:given-name><ce:surname>Vlagos</ce:surname><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>David</ce:given-name><ce:surname>Hanson</ce:surname><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>*</ce:label><ce:textfn>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>†</ce:label><ce:textfn>Eye and Ear Nose Throat Hospital, Shanghai Medical University, Shanghai, P.R. China</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text>Address correspondence and reprint requests, to Dr. Jack Jiang, Department of Otolaryngology—Head and Neck Surgery, Northwestern University, Searle Building 12-561, 303 East Chicago Avenue, Chicago, IL 60611 U.S.A.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="12" month="12" year="1998"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para>Patients with Parkinson's disease commonly complain of voice dysfunction. Most of these complaints can be attributed to the known muscular control disorders that occur with Parkinson's disease. However, the manifestations of Parkinson's disease muscular dysfunction on parameters of phonation such as airflow, laryngeal resistance, and subglottal pressure necessary to sustain phonation have not been reported. The purpose of this study was to examine the aerodynamic characteristics of flow, laryngeal resistance, and phonation pressure threshold in a heterogeneous population of patients with Parkinson's disease who had varying voice complaints and to compare the data to similar studies for human subjects who have no voice complaints. The studies used a noninvasive method of detecting flow and acoustic signal from the lips, oral cavity and nose during phonation and used an external flow interruption technique to estimate subglottal pressure and phonation threshold pressure. About one third of the patients could not produce phonation at regular and loud intensities that were comfortable for normal subjects. The mean subglottal pressure (SGP) of patients with Parkinson disease who could produce 3 levels of intensity comparable to normal subjects was significantly higher than the mean SG-Ps for normal subjects for the same intensities of vocal production. The mean flow rates measured from patients with Parkinson's disease at the same 3 intensities of phonation was not significantly greater than in normal subjects. This indicated that the mean laryngeal resistance calculated for patients with Parkinson's disease was notably and significantly greater than mean laryngeal resistance calculated for normal subjects at the same intensity levels. The mean vocal efficiency (VE) for normal subjects was not significantly different than the mean VE for patients with Parkinson's disease, because greater pressure was used to generate similar flow and acoustic energy. These findings correlate with the perception of patients with Parkinson's disease that they are working harder to produce phonation. The observation of notably greater laryngeal resistance and phonation threshold pressure in patients with Parkinson's disease suggests that further studies of the glottic aperture in patients with Parkinson' disease may be useful for understanding how this common motor disorder disturbs phonation.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key Words</ce:section-title><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Dysphonia</ce:text></ce:keyword><ce:keyword><ce:text>Subglottic pressure, Vocal efficiency</ce:text></ce:keyword><ce:keyword><ce:text>Airflow interruption</ce:text></ce:keyword><ce:keyword><ce:text>Laryngeal resistance</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution 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disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Aerodynamic measurements of patients with parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Jack</namePart><namePart type="family">Jiang</namePart><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation><affiliation>Address correspondence and reprint requests, to Dr. Jack Jiang, Department of Otolaryngology—Head and Neck Surgery, Northwestern University, Searle Building 12-561, 303 East Chicago Avenue, Chicago, IL 60611 U.S.A.</affiliation><affiliation>E-mail: jjiang@nwu.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy</namePart><namePart type="family">O'Mara</namePart><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hui-Jun</namePart><namePart type="family">Chen</namePart><affiliation>Eye and Ear Nose Throat Hospital, Shanghai Medical University, Shanghai, P.R. China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jennifer I.</namePart><namePart type="family">Stern</namePart><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Demetra</namePart><namePart type="family">Vlagos</namePart><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Hanson</namePart><affiliation>Department of Otolaryngology—Head and Neck Surgery, Northwestern University Medical School, Chicago, Illinois, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1998</dateIssued><dateValid encoding="w3cdtf">1998-12-12</dateValid><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Patients with Parkinson's disease commonly complain of voice dysfunction. Most of these complaints can be attributed to the known muscular control disorders that occur with Parkinson's disease. However, the manifestations of Parkinson's disease muscular dysfunction on parameters of phonation such as airflow, laryngeal resistance, and subglottal pressure necessary to sustain phonation have not been reported. The purpose of this study was to examine the aerodynamic characteristics of flow, laryngeal resistance, and phonation pressure threshold in a heterogeneous population of patients with Parkinson's disease who had varying voice complaints and to compare the data to similar studies for human subjects who have no voice complaints. The studies used a noninvasive method of detecting flow and acoustic signal from the lips, oral cavity and nose during phonation and used an external flow interruption technique to estimate subglottal pressure and phonation threshold pressure. About one third of the patients could not produce phonation at regular and loud intensities that were comfortable for normal subjects. The mean subglottal pressure (SGP) of patients with Parkinson disease who could produce 3 levels of intensity comparable to normal subjects was significantly higher than the mean SG-Ps for normal subjects for the same intensities of vocal production. The mean flow rates measured from patients with Parkinson's disease at the same 3 intensities of phonation was not significantly greater than in normal subjects. This indicated that the mean laryngeal resistance calculated for patients with Parkinson's disease was notably and significantly greater than mean laryngeal resistance calculated for normal subjects at the same intensity levels. The mean vocal efficiency (VE) for normal subjects was not significantly different than the mean VE for patients with Parkinson's disease, because greater pressure was used to generate similar flow and acoustic energy. These findings correlate with the perception of patients with Parkinson's disease that they are working harder to produce phonation. The observation of notably greater laryngeal resistance and phonation threshold pressure in patients with Parkinson's disease suggests that further studies of the glottic aperture in patients with Parkinson' disease may be useful for understanding how this common motor disorder disturbs phonation.</abstract><note>This paper was presented at the Voice Foundation's 27th Annual Symposium Care of the Professional Voice; June 2, 1998; Philadelphia, Pennsylvania.</note><subject lang="en"><genre>Key Words</genre><topic>Parkinson's disease</topic><topic>Dysphonia</topic><topic>Subglottic pressure, Vocal efficiency</topic><topic>Airflow interruption</topic><topic>Laryngeal resistance</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Voice</title></titleInfo><titleInfo type="abbreviated"><title>YMVJ</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199912</dateIssued></originInfo><identifier type="ISSN">0892-1997</identifier><identifier type="PII">S0892-1997(99)X8001-5</identifier><part><detail type="volume"><number>13</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>465</start><end>622</end></extent><extent unit="pages"><start>583</start><end>591</end></extent></part></relatedItem><identifier type="istex">4009891B9BE0A93A2BAB6634263CE69D2E98C082</identifier><identifier type="DOI">10.1016/S0892-1997(99)80012-5</identifier><identifier type="PII">S0892-1997(99)80012-5</identifier><identifier type="ArticleID">99800125</identifier><accessCondition type="use and reproduction" contentType="">© 1999Singular Publishing Group, Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Singular Publishing Group, Inc., ©1999</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/4009891B9BE0A93A2BAB6634263CE69D2E98C082/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">OTORHINOLARYNGOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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