Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease
Identifieur interne : 000A86 ( Main/Corpus ); précédent : 000A85; suivant : 000A87Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease
Auteurs : Samay Jain ; Greg J. Siegle ; Chen Gu ; Charity G. Moore ; Larry S. Ivanco ; Stephanie Studenski ; J. Timothy Greenamyre ; Stuart R. SteinhauerSource :
- Movement Disorders [ 0885-3185 ] ; 2011-06.
English descriptors
Abstract
Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23628
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Siegle</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Gu, Chen" sort="Gu, Chen" uniqKey="Gu C" first="Chen" last="Gu">Chen Gu</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Moore, Charity G" sort="Moore, Charity G" uniqKey="Moore C" first="Charity G." last="Moore">Charity G. Moore</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Ivanco, Larry S" sort="Ivanco, Larry S" uniqKey="Ivanco L" first="Larry S." last="Ivanco">Larry S. Ivanco</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Studenski, Stephanie" sort="Studenski, Stephanie" uniqKey="Studenski S" first="Stephanie" last="Studenski">Stephanie Studenski</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. 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Steinhauer</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5AA9951AA8E86A465C49FD0B71D64B73B874131E</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23628</idno><idno type="url">https://api.istex.fr/document/5AA9951AA8E86A465C49FD0B71D64B73B874131E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease</title><author><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Siegle, Greg J" sort="Siegle, Greg J" uniqKey="Siegle G" first="Greg J." last="Siegle">Greg J. Siegle</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Gu, Chen" sort="Gu, Chen" uniqKey="Gu C" first="Chen" last="Gu">Chen Gu</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Moore, Charity G" sort="Moore, Charity G" uniqKey="Moore C" first="Charity G." last="Moore">Charity G. Moore</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Ivanco, Larry S" sort="Ivanco, Larry S" uniqKey="Ivanco L" first="Larry S." last="Ivanco">Larry S. Ivanco</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Studenski, Stephanie" sort="Studenski, Stephanie" uniqKey="Studenski S" first="Stephanie" last="Studenski">Stephanie Studenski</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Greenamyre, J Timothy" sort="Greenamyre, J Timothy" uniqKey="Greenamyre J" first="J. Timothy" last="Greenamyre">J. Timothy Greenamyre</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Steinhauer, Stuart R" sort="Steinhauer, Stuart R" uniqKey="Steinhauer S" first="Stuart R." last="Steinhauer">Stuart R. Steinhauer</name><affiliation><mods:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1344">1344</biblScope><biblScope unit="page" to="1347">1347</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5AA9951AA8E86A465C49FD0B71D64B73B874131E</idno><idno type="DOI">10.1002/mds.23628</idno><idno type="ArticleID">MDS23628</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>autonomic dysfunction</term><term>nonmotor features</term><term>pupil</term><term>sleep disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Samay Jain MD, MS</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string><json:string>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Greg J. Siegle PhD</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Chen Gu MS</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Charity G. Moore PhD</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Larry S. Ivanco MSW</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Stephanie Studenski MD, MPH</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>J. Timothy Greenamyre MD, PhD</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string><json:string>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</json:string><json:string>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Stuart R. Steinhauer PhD</name><affiliations><json:string>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</json:string><json:string>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>nonmotor features</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pupil</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sleep disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic dysfunction</value></json:item></subject><articleId><json:string>MDS23628</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.412</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1533</abstractCharCount><pdfWordCount>9473</pdfWordCount><pdfCharCount>61784</pdfCharCount><pdfPageCount>16</pdfPageCount><abstractWordCount>201</abstractWordCount></qualityIndicators><title>Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>4</total><last>1347</last><first>1344</first></pages><issn><json:string>0885-3185</json:string></issn><issue>7</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23628</json:string></doi><id>5AA9951AA8E86A465C49FD0B71D64B73B874131E</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/5AA9951AA8E86A465C49FD0B71D64B73B874131E/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/5AA9951AA8E86A465C49FD0B71D64B73B874131E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/5AA9951AA8E86A465C49FD0B71D64B73B874131E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Funding agencies: This study was funded by NIH grants KL2 RR024154, KMH082998, MH55762, UL1 RR024153, and P30 AG‐024827, the Department of Veterans Affairs, and the American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh. Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease</title><author><persName><forename type="first">Samay</forename><surname>Jain</surname></persName><roleName type="degree">MD, MS</roleName><note type="correspondence"><p>Correspondence: Assistant Professor of Neurology, Clinical Director, Movement Disorders Division, Department of Neurology, University of Pittsburgh Medical Center, 3471 Fifth Ave., Suite 811, Kaufmann Medical Building, Pittsburgh, PA 15213‐3232, USA</p></note><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Greg J.</forename><surname>Siegle</surname></persName><roleName type="degree">PhD</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Chen</forename><surname>Gu</surname></persName><roleName type="degree">MS</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Charity G.</forename><surname>Moore</surname></persName><roleName type="degree">PhD</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Larry S.</forename><surname>Ivanco</surname></persName><roleName type="degree">MSW</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Stephanie</forename><surname>Studenski</surname></persName><roleName type="degree">MD, MPH</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">J. Timothy</forename><surname>Greenamyre</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Stuart R.</forename><surname>Steinhauer</surname></persName><roleName type="degree">PhD</roleName><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1344">1344</biblScope><biblScope unit="page" to="1347">1347</biblScope></imprint></monogr><idno type="istex">5AA9951AA8E86A465C49FD0B71D64B73B874131E</idno><idno type="DOI">10.1002/mds.23628</idno><idno type="ArticleID">MDS23628</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>nonmotor features</term></item><item><term>Parkinson's disease</term></item><item><term>pupil</term></item><item><term>sleep disorders</term></item><item><term>autonomic dysfunction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-07-19">Received</change><change when="2010-12-14">Registration</change><change when="2011-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/5AA9951AA8E86A465C49FD0B71D64B73B874131E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi origin="wiley" registered="yes">10.1002/mds.v26.7</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2011-06">June 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="280" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23628</doi><idGroup><id type="unit" value="MDS23628"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-07-19"></event><event type="manuscriptRevised" date="2010-12-04"></event><event type="manuscriptAccepted" date="2010-12-14"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2011-12-15"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-04-19"></event><event type="publishedOnlineFinalForm" date="2011-06-20"></event><event type="firstOnline" date="2011-04-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1344</numbering><numbering type="pageLast">1347</numbering></numberingGroup><correspondenceTo>Assistant Professor of Neurology, Clinical Director, Movement Disorders Division, Department of Neurology, University of Pittsburgh Medical Center, 3471 Fifth Ave., Suite 811, Kaufmann Medical Building, Pittsburgh, PA 15213‐3232, USA</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23628.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="10"></count><count type="wordTotal" number="2696"></count></countGroup><titleGroup><title type="main" xml:lang="en">Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease<link href="#fn2"></link></title><title type="short" xml:lang="en">Brief Reports</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Samay</givenNames><familyName>Jain</familyName><degrees>MD, MS</degrees></personName><contactDetails><email>jains@upmc.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Greg J.</givenNames><familyName>Siegle</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Chen</givenNames><familyName>Gu</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Charity G.</givenNames><familyName>Moore</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Larry S.</givenNames><familyName>Ivanco</familyName><degrees>MSW</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Stephanie</givenNames><familyName>Studenski</familyName><degrees>MD, MPH</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>J. Timothy</givenNames><familyName>Greenamyre</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Stuart R.</givenNames><familyName>Steinhauer</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">nonmotor features</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">pupil</keyword><keyword xml:id="kwd4">sleep disorders</keyword><keyword xml:id="kwd5">autonomic dysfunction</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and <i>t</i> tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p><b>Funding agencies:</b> This study was funded by NIH grants KL2 RR024154, KMH082998, MH55762, UL1 RR024153, and P30 AG‐024827, the Department of Veterans Affairs, and the American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh. <b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Brief Reports</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Pupillary unrest correlates with arousal symptoms and motor signs in Parkinson disease</title></titleInfo><name type="personal"><namePart type="given">Samay</namePart><namePart type="family">Jain</namePart><namePart type="termsOfAddress">MD, MS</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</affiliation><description>Correspondence: Assistant Professor of Neurology, Clinical Director, Movement Disorders Division, Department of Neurology, University of Pittsburgh Medical Center, 3471 Fifth Ave., Suite 811, Kaufmann Medical Building, Pittsburgh, PA 15213‐3232, USA</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Greg J.</namePart><namePart type="family">Siegle</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chen</namePart><namePart type="family">Gu</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charity G.</namePart><namePart type="family">Moore</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Larry S.</namePart><namePart type="family">Ivanco</namePart><namePart type="termsOfAddress">MSW</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephanie</namePart><namePart type="family">Studenski</namePart><namePart type="termsOfAddress">MD, MPH</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. Timothy</namePart><namePart type="family">Greenamyre</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>Pittsburgh Institute for Neurodegenerative Diseases, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stuart R.</namePart><namePart type="family">Steinhauer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</affiliation><affiliation>VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-06</dateIssued><dateCaptured encoding="w3cdtf">2010-07-19</dateCaptured><dateValid encoding="w3cdtf">2010-12-14</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">10</extent><extent unit="words">2696</extent></physicalDescription><abstract lang="en">Background:: Arousal symptoms (e.g., sleepiness) are common in Parkinson's disease, and pupillary unrest (spontaneous changes in pupil diameter) is positively associated with sleepiness. We explored pupillary unrest in Parkinson's disease. Methods:: Arousal symptoms (Epworth sleepiness scale and sleep/fatigue domain of the nonmotor symptoms scale for Parkinson's disease) and pupillary unrest were assessed in 31 participants (14 patients with Parkinson's disease, 17 controls). Effect sizes and t tests compared patients with Parkinson's disease with control participants. Correlation coefficients were calculated among arousal symptoms, pupillary unrest, and Unified Parkinson Disease Rating Scale Part III. Linear regression was performed with arousal symptoms or pupillary unrest as outcome. Results:: Participants with Parkinson's disease reported more arousal symptoms than controls. Pupillary unrest, arousal symptoms, and Unified Parkinson Disease Rating Scale Part III were positively correlated. The association between nonmotor symptoms scale–sleep score and pupillary unrest was higher in participants with Parkinson's disease than controls and higher in those with more Parkinsonian motor signs. Unified Parkinson Disease Rating Scale Part III was positively associated with pupillary unrest. Conclusions:: Pupillary unrest correlates with motor and nonmotor features associated with Lewy‐related pathology, suggesting it may be a nonmotor marker of progression in Parkinson's disease. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: This study was funded by NIH grants KL2 RR024154, KMH082998, MH55762, UL1 RR024153, and P30 AG‐024827, the Department of Veterans Affairs, and the American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh. Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>nonmotor features</topic><topic>Parkinson's disease</topic><topic>pupil</topic><topic>sleep disorders</topic><topic>autonomic dysfunction</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1344</start><end>1347</end><total>4</total></extent></part></relatedItem><identifier type="istex">5AA9951AA8E86A465C49FD0B71D64B73B874131E</identifier><identifier type="DOI">10.1002/mds.23628</identifier><identifier type="ArticleID">MDS23628</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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