PARKINSON'S DISEASE
Identifieur interne : 000A64 ( Main/Corpus ); précédent : 000A63; suivant : 000A65PARKINSON'S DISEASE
Auteurs : Anne E. Taylor ; J. A. Saint-Cyr ; A. E. LangSource :
- Brain [ 0006-8950 ] ; 1987-02.
Abstract
Four groups of patients with Parkinson's disease matched for age, education and IQ were categorized by response to treatment and compared with a normal control group. The patient groups were (1) No Treatment (de novo); (2) Good Response (including minor fluctuations in symptoms); (3) Fluctuations (significant, including ‘on-off’ phenomena) and/or marked Abnormal Involuntary Movements (dyskinesias); and (4) Poor Response (‘secondary treatment failure’ characterized by significant deterioration over time in all major symptoms). As a previous investigation had established that neuropsychological tests thought to be sensitive to the functional integrity of the frontal lobes are selectively impaired in Parkinson's disease, the first phase of this study compared the five groups on five such tests and two tests of psychomotor ability. While all patient groups displayed deficits on the psychomotor tests and on several tests associated with frontal lobe function compared with normals, only the Poor Response group was impaired on all tasks. In a second phase, comprehensive testing of additional cognitive processes such as attention, mnemonic, and visuospatial functions, the latter two traditionally thought to depend primarily on posterior cortical regions, revealed no significant cognitive deficits in any patient group. Results are discussed with respect to the involvement of the nigrostriatal and mesocortical dopaminergic systems.
Url:
DOI: 10.1093/brain/110.1.35
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Saint-Cyr</name><affiliation><mods:affiliation>From the Playfair Neuroscience Unit, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Anatomy, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Psychology, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Institute of Medical Science, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Psychology, University of Toronto</mods:affiliation></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. 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Taylor</name><affiliation><mods:affiliation>From the Playfair Neuroscience Unit, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Institute of Medical Science, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Psychology, University of Toronto</mods:affiliation></affiliation></author><author><name sortKey="Saint Cyr, J A" sort="Saint Cyr, J A" uniqKey="Saint Cyr J" first="J. A." last="Saint-Cyr">J. A. Saint-Cyr</name><affiliation><mods:affiliation>From the Playfair Neuroscience Unit, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Anatomy, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Psychology, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Institute of Medical Science, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Psychology, University of Toronto</mods:affiliation></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation><mods:affiliation>From the Playfair Neuroscience Unit, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Medicine, University of Toronto</mods:affiliation></affiliation><affiliation><mods:affiliation>From the Department of Medicine, Division of Neurology, Toronto Western Hospital</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1987-02">1987-02</date><biblScope unit="volume">110</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="35">35</biblScope><biblScope unit="page" to="51">51</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">DA269DA6BD476573FFF4CC45B7780E2A4AC01BF0</idno><idno type="DOI">10.1093/brain/110.1.35</idno><idno type="ArticleID">110.1.35</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Four groups of patients with Parkinson's disease matched for age, education and IQ were categorized by response to treatment and compared with a normal control group. The patient groups were (1) No Treatment (de novo); (2) Good Response (including minor fluctuations in symptoms); (3) Fluctuations (significant, including ‘on-off’ phenomena) and/or marked Abnormal Involuntary Movements (dyskinesias); and (4) Poor Response (‘secondary treatment failure’ characterized by significant deterioration over time in all major symptoms). As a previous investigation had established that neuropsychological tests thought to be sensitive to the functional integrity of the frontal lobes are selectively impaired in Parkinson's disease, the first phase of this study compared the five groups on five such tests and two tests of psychomotor ability. While all patient groups displayed deficits on the psychomotor tests and on several tests associated with frontal lobe function compared with normals, only the Poor Response group was impaired on all tasks. In a second phase, comprehensive testing of additional cognitive processes such as attention, mnemonic, and visuospatial functions, the latter two traditionally thought to depend primarily on posterior cortical regions, revealed no significant cognitive deficits in any patient group. Results are discussed with respect to the involvement of the nigrostriatal and mesocortical dopaminergic systems.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>ANNE E. TAYLOR</name><affiliations><json:string>From the Playfair Neuroscience Unit, University of Toronto</json:string><json:string>From the Institute of Medical Science, University of Toronto</json:string><json:string>From the Department of Psychology, University of Toronto</json:string></affiliations></json:item><json:item><name>J. A. SAINT-CYR</name><affiliations><json:string>From the Playfair Neuroscience Unit, University of Toronto</json:string><json:string>From the Department of Anatomy, University of Toronto</json:string><json:string>From the Department of Psychology, University of Toronto</json:string><json:string>From the Institute of Medical Science, University of Toronto</json:string><json:string>From the Department of Psychology, University of Toronto</json:string><json:string>Correspondence to: Dr J. A. Saint-Cyr, Playfair Neuroscience Unit, Toronto Western Hospital, 399 Bathurst Street, Toronto, Canada M5T 2S8.</json:string></affiliations></json:item><json:item><name>A. E. LANG</name><affiliations><json:string>From the Playfair Neuroscience Unit, University of Toronto</json:string><json:string>From the Department of Medicine, University of Toronto</json:string><json:string>From the Department of Medicine, Division of Neurology, Toronto Western Hospital</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Articles</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Four groups of patients with Parkinson's disease matched for age, education and IQ were categorized by response to treatment and compared with a normal control group. 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In a second phase, comprehensive testing of additional cognitive processes such as attention, mnemonic, and visuospatial functions, the latter two traditionally thought to depend primarily on posterior cortical regions, revealed no significant cognitive deficits in any patient group. 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A. Saint-Cyr, Playfair Neuroscience Unit, Toronto Western Hospital, 399 Bathurst Street, Toronto, Canada M5T 2S8.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">PARKINSON'S DISEASE</title><title level="a" type="sub">COGNITIVE CHANGES IN RELATION TO TREATMENT RESPONSE</title><author><persName><forename type="first">ANNE E.</forename><surname>TAYLOR</surname></persName><affiliation>From the Playfair Neuroscience Unit, University of Toronto</affiliation><affiliation>From the Institute of Medical Science, University of Toronto</affiliation><affiliation>From the Department of Psychology, University of Toronto</affiliation></author><author><persName><forename type="first">J. A.</forename><surname>SAINT-CYR</surname></persName><affiliation>From the Playfair Neuroscience Unit, University of Toronto</affiliation><affiliation>From the Department of Anatomy, University of Toronto</affiliation><affiliation>From the Department of Psychology, University of Toronto</affiliation><affiliation>From the Institute of Medical Science, University of Toronto</affiliation><affiliation>From the Department of Psychology, University of Toronto</affiliation></author><author><persName><forename type="first">A. E.</forename><surname>LANG</surname></persName><affiliation>From the Playfair Neuroscience Unit, University of Toronto</affiliation><affiliation>From the Department of Medicine, University of Toronto</affiliation><affiliation>From the Department of Medicine, Division of Neurology, Toronto Western Hospital</affiliation></author></analytic><monogr><title level="j">Brain</title><idno type="pISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1987-02"></date><biblScope unit="volume">110</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="35">35</biblScope><biblScope unit="page" to="51">51</biblScope></imprint></monogr><idno type="istex">DA269DA6BD476573FFF4CC45B7780E2A4AC01BF0</idno><idno type="DOI">10.1093/brain/110.1.35</idno><idno type="ArticleID">110.1.35</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1987</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Four groups of patients with Parkinson's disease matched for age, education and IQ were categorized by response to treatment and compared with a normal control group. 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In a second phase, comprehensive testing of additional cognitive processes such as attention, mnemonic, and visuospatial functions, the latter two traditionally thought to depend primarily on posterior cortical regions, revealed no significant cognitive deficits in any patient group. Results are discussed with respect to the involvement of the nigrostriatal and mesocortical dopaminergic systems.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>Articles</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1987-02">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/DA269DA6BD476573FFF4CC45B7780E2A4AC01BF0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">brain</journal-id><journal-id journal-id-type="publisher-id">brainj</journal-id><journal-id journal-id-type="pmc">brain</journal-id><journal-title>Brain</journal-title><issn pub-type="epub">1460-2156</issn><issn pub-type="ppub">0006-8950</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">110.1.35</article-id><article-id pub-id-type="doi">10.1093/brain/110.1.35</article-id><article-categories><subj-group><subject>Articles</subject></subj-group></article-categories><title-group><article-title>PARKINSON'S DISEASE</article-title><subtitle>COGNITIVE CHANGES IN RELATION TO TREATMENT RESPONSE</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>TAYLOR</surname><given-names>ANNE E.</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref><xref ref-type="aff" rid="au4"><sup>4</sup></xref><xref ref-type="aff" rid="au6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>SAINT-CYR</surname><given-names>J. A.</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref><xref ref-type="aff" rid="au2"><sup>2</sup></xref><xref ref-type="aff" rid="au3"><sup>3</sup></xref><xref ref-type="aff" rid="au4"><sup>4</sup></xref><xref ref-type="aff" rid="au6"><sup>6</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>LANG</surname><given-names>A. E.</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref><xref ref-type="aff" rid="au5"><sup>5</sup></xref><xref ref-type="aff" rid="au7"><sup>7</sup></xref></contrib><aff id="au1"><sup>1</sup>From the <institution>Playfair Neuroscience Unit, University of Toronto</institution></aff><aff id="au2"><sup>2</sup>From the <institution>Department of Anatomy, University of Toronto</institution></aff><aff id="au3"><sup>3</sup>From the <institution>Department of Psychology, University of Toronto</institution></aff><aff id="au4"><sup>4</sup>From the <institution>Institute of Medical Science, University of Toronto</institution></aff><aff id="au5"><sup>5</sup>From the <institution>Department of Medicine, University of Toronto</institution></aff><aff id="au6"><sup>6</sup>From the <institution>Department of Psychology, University of Toronto</institution></aff><aff id="au7"><sup>7</sup>From the <institution>Department of Medicine, Division of Neurology, Toronto Western Hospital</institution></aff></contrib-group><author-notes><corresp id="cor1">Correspondence to: Dr J. A. Saint-Cyr, Playfair Neuroscience Unit, Toronto Western Hospital, 399 Bathurst Street, Toronto, Canada M5T 2S8.</corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>1987</year></pub-date><volume>110</volume><issue>1</issue><fpage>35</fpage><lpage>51</lpage><history><date date-type="received"><day>03</day><month>12</month><year>1985</year></date><date date-type="rev-recd"><day>11</day><month>3</month><year>1986</year></date><date date-type="accepted"><day>27</day><month>3</month><year>1986</year></date></history><copyright-statement>© Oxford University Press</copyright-statement><copyright-year>1987</copyright-year><abstract><p>Four groups of patients with Parkinson's disease matched for age, education and IQ were categorized by response to treatment and compared with a normal control group. The patient groups were (1) No Treatment (de novo); (2) Good Response (including minor fluctuations in symptoms); (3) Fluctuations (significant, including ‘on-off’ phenomena) and/or marked Abnormal Involuntary Movements (dyskinesias); and (4) Poor Response (‘secondary treatment failure’ characterized by significant deterioration over time in all major symptoms). As a previous investigation had established that neuropsychological tests thought to be sensitive to the functional integrity of the frontal lobes are selectively impaired in Parkinson's disease, the first phase of this study compared the five groups on five such tests and two tests of psychomotor ability. While all patient groups displayed deficits on the psychomotor tests and on several tests associated with frontal lobe function compared with normals, only the Poor Response group was impaired on all tasks. In a second phase, comprehensive testing of additional cognitive processes such as attention, mnemonic, and visuospatial functions, the latter two traditionally thought to depend primarily on posterior cortical regions, revealed no significant cognitive deficits in any patient group. 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A.</namePart><namePart type="family">SAINT-CYR</namePart><affiliation>From the Playfair Neuroscience Unit, University of Toronto</affiliation><affiliation>From the Department of Anatomy, University of Toronto</affiliation><affiliation>From the Department of Psychology, University of Toronto</affiliation><affiliation>From the Institute of Medical Science, University of Toronto</affiliation><affiliation>From the Department of Psychology, University of Toronto</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. 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The patient groups were (1) No Treatment (de novo); (2) Good Response (including minor fluctuations in symptoms); (3) Fluctuations (significant, including ‘on-off’ phenomena) and/or marked Abnormal Involuntary Movements (dyskinesias); and (4) Poor Response (‘secondary treatment failure’ characterized by significant deterioration over time in all major symptoms). As a previous investigation had established that neuropsychological tests thought to be sensitive to the functional integrity of the frontal lobes are selectively impaired in Parkinson's disease, the first phase of this study compared the five groups on five such tests and two tests of psychomotor ability. While all patient groups displayed deficits on the psychomotor tests and on several tests associated with frontal lobe function compared with normals, only the Poor Response group was impaired on all tasks. 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