Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain‐to‐pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophy
Identifieur interne : 000A59 ( Main/Corpus ); précédent : 000A58; suivant : 000A60Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain‐to‐pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophy
Auteurs : Anna Hussl ; Philipp Mahlknecht ; Christoph Scherfler ; Regina Esterhammer ; Michael Schocke ; Werner Poewe ; Klaus SeppiSource :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
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Abstract
Using magnetic resonance (MR) planimetry, both the midbrain‐to‐pontine area ratio (m/p‐ratio) and the MR parkinsonism index (MRPI) have been shown to assist in the differential diagnosis of progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and the Parkinson variant of multiple system atrophy (MSA‐P). The aim of this study was to determine the diagnostic accuracy of the MRPI compared with the m/p‐ratio in a large cohort of 123 patients with neurodegenerative parkinsonism including patients with PSP, PD, and MSA‐P. Patients with PSP had significant higher MRPI values and significant smaller m/p‐ratios compared with the other groups with overlapping individual values. Overall predictive accuracy was similar for the m/p‐ratio (87.0%) and the MRPI (80.5%) with a predictive accuracy for PSP from MSA‐P being significantly better for the MRPI (87.5%) compared with the m/p‐ratio (75%) as well as a predictive accuracy for PSP from PD being significantly better for the m/p‐ratio (87.6%) compared with the MRPI (77.3%). Both the m/p‐ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23351
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ISTEX:336C4BDFE8B9BEA00B92FA23BB5EF553445A8389Le document en format XML
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Innsbruck, Austria</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2444">2444</biblScope><biblScope unit="page" to="2449">2449</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">336C4BDFE8B9BEA00B92FA23BB5EF553445A8389</idno><idno type="DOI">10.1002/mds.23351</idno><idno type="ArticleID">MDS23351</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MR parkinsonism index</term><term>MR planimetry</term><term>Parkinson's disease</term><term>midbrain‐to‐pontine area ratio</term><term>multiple system atrophy</term><term>parkinsonism</term><term>progressive supranuclear palsy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Using magnetic resonance (MR) planimetry, both the midbrain‐to‐pontine area ratio (m/p‐ratio) and the MR parkinsonism index (MRPI) have been shown to assist in the differential diagnosis of progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and the Parkinson variant of multiple system atrophy (MSA‐P). The aim of this study was to determine the diagnostic accuracy of the MRPI compared with the m/p‐ratio in a large cohort of 123 patients with neurodegenerative parkinsonism including patients with PSP, PD, and MSA‐P. Patients with PSP had significant higher MRPI values and significant smaller m/p‐ratios compared with the other groups with overlapping individual values. Overall predictive accuracy was similar for the m/p‐ratio (87.0%) and the MRPI (80.5%) with a predictive accuracy for PSP from MSA‐P being significantly better for the MRPI (87.5%) compared with the m/p‐ratio (75%) as well as a predictive accuracy for PSP from PD being significantly better for the m/p‐ratio (87.6%) compared with the MRPI (77.3%). Both the m/p‐ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Anna Hussl MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Philipp Mahlknecht MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Christoph Scherfler MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Regina Esterhammer MD</name><affiliations><json:string>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Michael Schocke MD</name><affiliations><json:string>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Werner Poewe MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Klaus Seppi MD</name><affiliations><json:string>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>MR planimetry</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MR parkinsonism index</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>midbrain‐to‐pontine area ratio</value></json:item></subject><articleId><json:string>MDS23351</json:string></articleId><language><json:string>eng</json:string></language><abstract>Using magnetic resonance (MR) planimetry, both the midbrain‐to‐pontine area ratio (m/p‐ratio) and the MR parkinsonism index (MRPI) have been shown to assist in the differential diagnosis of progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and the Parkinson variant of multiple system atrophy (MSA‐P). The aim of this study was to determine the diagnostic accuracy of the MRPI compared with the m/p‐ratio in a large cohort of 123 patients with neurodegenerative parkinsonism including patients with PSP, PD, and MSA‐P. Patients with PSP had significant higher MRPI values and significant smaller m/p‐ratios compared with the other groups with overlapping individual values. Overall predictive accuracy was similar for the m/p‐ratio (87.0%) and the MRPI (80.5%) with a predictive accuracy for PSP from MSA‐P being significantly better for the MRPI (87.5%) compared with the m/p‐ratio (75%) as well as a predictive accuracy for PSP from PD being significantly better for the m/p‐ratio (87.6%) compared with the MRPI (77.3%). Both the m/p‐ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.1</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1186</abstractCharCount><pdfWordCount>15305</pdfWordCount><pdfCharCount>101571</pdfCharCount><pdfPageCount>27</pdfPageCount><abstractWordCount>175</abstractWordCount></qualityIndicators><title>Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain‐to‐pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophy</title><genre><json:string>brief 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Austria</affiliation></author><author><persName><forename type="first">Philipp</forename><surname>Mahlknecht</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Christoph</forename><surname>Scherfler</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Regina</forename><surname>Esterhammer</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Schocke</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Werner</forename><surname>Poewe</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Klaus</forename><surname>Seppi</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A‐6020 Innsbruck, Austria</p></note><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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The aim of this study was to determine the diagnostic accuracy of the MRPI compared with the m/p‐ratio in a large cohort of 123 patients with neurodegenerative parkinsonism including patients with PSP, PD, and MSA‐P. Patients with PSP had significant higher MRPI values and significant smaller m/p‐ratios compared with the other groups with overlapping individual values. Overall predictive accuracy was similar for the m/p‐ratio (87.0%) and the MRPI (80.5%) with a predictive accuracy for PSP from MSA‐P being significantly better for the MRPI (87.5%) compared with the m/p‐ratio (75%) as well as a predictive accuracy for PSP from PD being significantly better for the m/p‐ratio (87.6%) compared with the MRPI (77.3%). Both the m/p‐ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>MR planimetry</term></item><item><term>progressive supranuclear palsy</term></item><item><term>multiple system atrophy</term></item><item><term>Parkinson's disease</term></item><item><term>parkinsonism</term></item><item><term>MR parkinsonism index</term></item><item><term>midbrain‐to‐pontine area ratio</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-04-23">Received</change><change when="2010-06-23">Registration</change><change when="2010-10-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/336C4BDFE8B9BEA00B92FA23BB5EF553445A8389/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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corresponding="yes"><personName><givenNames>Klaus</givenNames><familyName>Seppi</familyName><degrees>MD</degrees></personName><contactDetails><email>klaus.seppi@uki.at</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="AT" type="organization"><unparsedAffiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="AT" type="organization"><unparsedAffiliation>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">MR planimetry</keyword><keyword xml:id="kwd2">progressive supranuclear palsy</keyword><keyword xml:id="kwd3">multiple system atrophy</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword><keyword xml:id="kwd5">parkinsonism</keyword><keyword xml:id="kwd6">MR parkinsonism index</keyword><keyword xml:id="kwd7">midbrain‐to‐pontine area ratio</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Using magnetic resonance (MR) planimetry, both the midbrain‐to‐pontine area ratio (m/p‐ratio) and the MR parkinsonism index (MRPI) have been shown to assist in the differential diagnosis of progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and the Parkinson variant of multiple system atrophy (MSA‐P). The aim of this study was to determine the diagnostic accuracy of the MRPI compared with the m/p‐ratio in a large cohort of 123 patients with neurodegenerative parkinsonism including patients with PSP, PD, and MSA‐P. Patients with PSP had significant higher MRPI values and significant smaller m/p‐ratios compared with the other groups with overlapping individual values. Overall predictive accuracy was similar for the m/p‐ratio (87.0%) and the MRPI (80.5%) with a predictive accuracy for PSP from MSA‐P being significantly better for the MRPI (87.5%) compared with the m/p‐ratio (75%) as well as a predictive accuracy for PSP from PD being significantly better for the m/p‐ratio (87.6%) compared with the MRPI (77.3%). Both the m/p‐ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain‐to‐pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Diagnostic Accuracy of the MRPI and the m/p‐Ratio</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain‐to‐pontine area ratio to differentiate progressive supranuclear palsy from Parkinson's disease and the Parkinson variant of multiple system atrophy</title></titleInfo><name type="personal"><namePart type="given">Anna</namePart><namePart type="family">Hussl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philipp</namePart><namePart type="family">Mahlknecht</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Scherfler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Regina</namePart><namePart type="family">Esterhammer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Schocke</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology I, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Werner</namePart><namePart type="family">Poewe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Klaus</namePart><namePart type="family">Seppi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Innsbruck Medical University, Innsbruck, Austria</affiliation><description>Correspondence: Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A‐6020 Innsbruck, Austria</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief communication" displayLabel="shortCommunication"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-10-30</dateIssued><dateCaptured encoding="w3cdtf">2010-04-23</dateCaptured><dateValid encoding="w3cdtf">2010-06-23</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">13</extent><extent unit="words">3349</extent></physicalDescription><abstract lang="en">Using magnetic resonance (MR) planimetry, both the midbrain‐to‐pontine area ratio (m/p‐ratio) and the MR parkinsonism index (MRPI) have been shown to assist in the differential diagnosis of progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and the Parkinson variant of multiple system atrophy (MSA‐P). The aim of this study was to determine the diagnostic accuracy of the MRPI compared with the m/p‐ratio in a large cohort of 123 patients with neurodegenerative parkinsonism including patients with PSP, PD, and MSA‐P. Patients with PSP had significant higher MRPI values and significant smaller m/p‐ratios compared with the other groups with overlapping individual values. Overall predictive accuracy was similar for the m/p‐ratio (87.0%) and the MRPI (80.5%) with a predictive accuracy for PSP from MSA‐P being significantly better for the MRPI (87.5%) compared with the m/p‐ratio (75%) as well as a predictive accuracy for PSP from PD being significantly better for the m/p‐ratio (87.6%) compared with the MRPI (77.3%). Both the m/p‐ratio and the MRPI may assist the clinical differential diagnosis in neurodegenerative parkinsonism. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>MR planimetry</topic><topic>progressive supranuclear palsy</topic><topic>multiple system atrophy</topic><topic>Parkinson's disease</topic><topic>parkinsonism</topic><topic>MR parkinsonism index</topic><topic>midbrain‐to‐pontine area ratio</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2444</start><end>2449</end><total>6</total></extent></part></relatedItem><identifier type="istex">336C4BDFE8B9BEA00B92FA23BB5EF553445A8389</identifier><identifier type="DOI">10.1002/mds.23351</identifier><identifier type="ArticleID">MDS23351</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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