Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease
Identifieur interne : 000A55 ( Main/Corpus ); précédent : 000A54; suivant : 000A56Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease
Auteurs : B. Weder ; N. P. Azari ; U. Knorr ; R. J. Seitz ; A. Keel ; M. Nienhusmeier ; R. P. Maguire ; K. L. Leenders ; H. LudinSource :
- Human Brain Mapping [ 1065-9471 ] ; 2000-11.
English descriptors
- KwdEn :
Abstract
Somatosensory discrimination of cuboid objects was studied in a group of healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained with positron emission tomography (PET) and 15O labeled water [H215O]. A 6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET scan demonstrated that the patients may be grouped into those with normal and those with abnormally low FDOPA uptake in the caudate nucleus. The categorical group comparisons revealed that task‐induced rCBF increases were deficient in bilateral motor and sensory cortical areas in the Parkinson patients. Moreover, deficient rCBF increases were evident in the mesial and right dorsolateral prefrontal cortex for patients in a more advanced disease state, who showed low FDOPA uptake in the caudate nucleus. A principal component analysis (PCA), performed on the rCBF data, identified three patterns (principal components, PCs) that differentiated patients from normals. The first PC represented a right‐hemisphere dominant, bilateral group of brain areas known to be involved in tactile exploration. A second PC reflected a cortical‐subcortical pattern of functional interactions, comprising cortical areas important for working memory processes. The third group‐differentiating PC revealed a pattern of functional interactions involving bilateral temporo‐parieto‐occipital association cortices, which was consistent with a hypothesized supramodal network necessary for object discrimination. In an additional subgroup analysis, greater expression of the third PC pattern predicted greater caudate FDOPA uptake in patients. Our neuroimaging data revealed a disturbance of distinct patterns of brain functional interactions related to the sensorimotor deficit in Parkinson's disease and to deficits of cognitive information processing deficits in the more advanced stage of Parkinson's disease. Hum. Brain Mapping 11:131–145, 2000. © 2000 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/1097-0193(200011)11:3<131::AID-HBM10>3.0.CO;2-M
Links to Exploration step
ISTEX:D7EED47BCE65FB85B857F750D4D6161B80A12437Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title><author><name sortKey="Weder, B" sort="Weder, B" uniqKey="Weder B" first="B." last="Weder">B. Weder</name><affiliation><mods:affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Azari, N P" sort="Azari, N P" uniqKey="Azari N" first="N. P." last="Azari">N. P. Azari</name><affiliation><mods:affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Knorr, U" sort="Knorr, U" uniqKey="Knorr U" first="U." last="Knorr">U. Knorr</name><affiliation><mods:affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Seitz, R J" sort="Seitz, R J" uniqKey="Seitz R" first="R. J." last="Seitz">R. J. Seitz</name><affiliation><mods:affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Keel, A" sort="Keel, A" uniqKey="Keel A" first="A." last="Keel">A. Keel</name><affiliation><mods:affiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Nienhusmeier, M" sort="Nienhusmeier, M" uniqKey="Nienhusmeier M" first="M." last="Nienhusmeier">M. Nienhusmeier</name><affiliation><mods:affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Maguire, R P" sort="Maguire, R P" uniqKey="Maguire R" first="R. P." last="Maguire">R. P. Maguire</name><affiliation><mods:affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Leenders, K L" sort="Leenders, K L" uniqKey="Leenders K" first="K. L." last="Leenders">K. L. Leenders</name><affiliation><mods:affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Ludin, H" sort="Ludin, H" uniqKey="Ludin H" first="H." last="Ludin">H. Ludin</name><affiliation><mods:affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D7EED47BCE65FB85B857F750D4D6161B80A12437</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1002/1097-0193(200011)11:3<131::AID-HBM10>3.0.CO;2-M</idno><idno type="url">https://api.istex.fr/document/D7EED47BCE65FB85B857F750D4D6161B80A12437/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title><author><name sortKey="Weder, B" sort="Weder, B" uniqKey="Weder B" first="B." last="Weder">B. Weder</name><affiliation><mods:affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Azari, N P" sort="Azari, N P" uniqKey="Azari N" first="N. P." last="Azari">N. P. Azari</name><affiliation><mods:affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Knorr, U" sort="Knorr, U" uniqKey="Knorr U" first="U." last="Knorr">U. Knorr</name><affiliation><mods:affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Seitz, R J" sort="Seitz, R J" uniqKey="Seitz R" first="R. J." last="Seitz">R. J. Seitz</name><affiliation><mods:affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Keel, A" sort="Keel, A" uniqKey="Keel A" first="A." last="Keel">A. Keel</name><affiliation><mods:affiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Nienhusmeier, M" sort="Nienhusmeier, M" uniqKey="Nienhusmeier M" first="M." last="Nienhusmeier">M. Nienhusmeier</name><affiliation><mods:affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Maguire, R P" sort="Maguire, R P" uniqKey="Maguire R" first="R. P." last="Maguire">R. P. Maguire</name><affiliation><mods:affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Leenders, K L" sort="Leenders, K L" uniqKey="Leenders K" first="K. L." last="Leenders">K. L. Leenders</name><affiliation><mods:affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Ludin, H" sort="Ludin, H" uniqKey="Ludin H" first="H." last="Ludin">H. Ludin</name><affiliation><mods:affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Brain Mapping</title><title level="j" type="abbrev">Hum. Brain Mapp.</title><idno type="ISSN">1065-9471</idno><idno type="eISSN">1097-0193</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11">2000-11</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="145">145</biblScope></imprint><idno type="ISSN">1065-9471</idno></series><idno type="istex">D7EED47BCE65FB85B857F750D4D6161B80A12437</idno><idno type="DOI">10.1002/1097-0193(200011)11:3<131::AID-HBM10>3.0.CO;2-M</idno><idno type="ArticleID">HBM10</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1065-9471</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET</term><term>categorical comparisons</term><term>principal component analysis</term><term>rCBF positron emission tomography (PET)</term><term>somatosensory discrimination</term><term>supramodal information transfer</term><term>tactile exploration</term><term>working memory</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Somatosensory discrimination of cuboid objects was studied in a group of healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained with positron emission tomography (PET) and 15O labeled water [H215O]. A 6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET scan demonstrated that the patients may be grouped into those with normal and those with abnormally low FDOPA uptake in the caudate nucleus. The categorical group comparisons revealed that task‐induced rCBF increases were deficient in bilateral motor and sensory cortical areas in the Parkinson patients. Moreover, deficient rCBF increases were evident in the mesial and right dorsolateral prefrontal cortex for patients in a more advanced disease state, who showed low FDOPA uptake in the caudate nucleus. A principal component analysis (PCA), performed on the rCBF data, identified three patterns (principal components, PCs) that differentiated patients from normals. The first PC represented a right‐hemisphere dominant, bilateral group of brain areas known to be involved in tactile exploration. A second PC reflected a cortical‐subcortical pattern of functional interactions, comprising cortical areas important for working memory processes. The third group‐differentiating PC revealed a pattern of functional interactions involving bilateral temporo‐parieto‐occipital association cortices, which was consistent with a hypothesized supramodal network necessary for object discrimination. In an additional subgroup analysis, greater expression of the third PC pattern predicted greater caudate FDOPA uptake in patients. Our neuroimaging data revealed a disturbance of distinct patterns of brain functional interactions related to the sensorimotor deficit in Parkinson's disease and to deficits of cognitive information processing deficits in the more advanced stage of Parkinson's disease. Hum. Brain Mapping 11:131–145, 2000. © 2000 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>B. Weder</name><affiliations><json:string>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</json:string></affiliations></json:item><json:item><name>N. P. Azari</name><affiliations><json:string>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>U. Knorr</name><affiliations><json:string>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>R. J. Seitz</name><affiliations><json:string>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>A. Keel</name><affiliations><json:string>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</json:string></affiliations></json:item><json:item><name>M. Nienhusmeier</name><affiliations><json:string>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</json:string></affiliations></json:item><json:item><name>R. P. Maguire</name><affiliations><json:string>Paul Scherrer Institute (PSI), Villigen, Switzerland</json:string></affiliations></json:item><json:item><name>K. L. Leenders</name><affiliations><json:string>Paul Scherrer Institute (PSI), Villigen, Switzerland</json:string></affiliations></json:item><json:item><name>H.‐P. Ludin</name><affiliations><json:string>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>somatosensory discrimination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rCBF positron emission tomography (PET)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>categorical comparisons</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>principal component analysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tactile exploration</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>working memory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>supramodal information transfer</value></json:item></subject><articleId><json:string>HBM10</json:string></articleId><language><json:string>eng</json:string></language><abstract>Somatosensory discrimination of cuboid objects was studied in a group of healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained with positron emission tomography (PET) and 15O labeled water [H215O]. A 6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET scan demonstrated that the patients may be grouped into those with normal and those with abnormally low FDOPA uptake in the caudate nucleus. The categorical group comparisons revealed that task‐induced rCBF increases were deficient in bilateral motor and sensory cortical areas in the Parkinson patients. Moreover, deficient rCBF increases were evident in the mesial and right dorsolateral prefrontal cortex for patients in a more advanced disease state, who showed low FDOPA uptake in the caudate nucleus. A principal component analysis (PCA), performed on the rCBF data, identified three patterns (principal components, PCs) that differentiated patients from normals. The first PC represented a right‐hemisphere dominant, bilateral group of brain areas known to be involved in tactile exploration. A second PC reflected a cortical‐subcortical pattern of functional interactions, comprising cortical areas important for working memory processes. The third group‐differentiating PC revealed a pattern of functional interactions involving bilateral temporo‐parieto‐occipital association cortices, which was consistent with a hypothesized supramodal network necessary for object discrimination. In an additional subgroup analysis, greater expression of the third PC pattern predicted greater caudate FDOPA uptake in patients. Our neuroimaging data revealed a disturbance of distinct patterns of brain functional interactions related to the sensorimotor deficit in Parkinson's disease and to deficits of cognitive information processing deficits in the more advanced stage of Parkinson's disease. Hum. Brain Mapping 11:131–145, 2000. © 2000 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>8</score><pdfVersion>1.2</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>8</keywordCount><abstractCharCount>1955</abstractCharCount><pdfWordCount>8848</pdfWordCount><pdfCharCount>58041</pdfCharCount><pdfPageCount>15</pdfPageCount><abstractWordCount>266</abstractWordCount></qualityIndicators><title>Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>11</volume><publisherId><json:string>HBM</json:string></publisherId><pages><total>15</total><last>145</last><first>131</first></pages><issn><json:string>1065-9471</json:string></issn><issue>3</issue><subject><json:item><value>Original Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1097-0193</json:string></eissn><title>Human Brain Mapping</title><doi><json:string>10.1002/(ISSN)1097-0193</json:string></doi></host><publicationDate>2000</publicationDate><copyrightDate>2000</copyrightDate><doi><json:string>10.1002/1097-0193(200011)11:3>131::AID-HBM10>3.0.CO;2-M</json:string></doi><id>D7EED47BCE65FB85B857F750D4D6161B80A12437</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/D7EED47BCE65FB85B857F750D4D6161B80A12437/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/D7EED47BCE65FB85B857F750D4D6161B80A12437/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/D7EED47BCE65FB85B857F750D4D6161B80A12437/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><availability><p>WILEY</p></availability><date>2000</date></publicationStmt><notesStmt><note>Swiss National Foundation (Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung) - No. 32‐37400.93;</note><note>Alexander von Humboldt Foundation</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title><author><persName><forename type="first">B.</forename><surname>Weder</surname></persName><note type="correspondence"><p>Correspondence: Klinik für Neurologie, Kantonsspital St. Gallen, CH‐9007 St. Gallen, Switzerland</p></note><affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation></author><author><persName><forename type="first">N. P.</forename><surname>Azari</surname></persName><affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation></author><author><persName><forename type="first">U.</forename><surname>Knorr</surname></persName><affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation></author><author><persName><forename type="first">R. J.</forename><surname>Seitz</surname></persName><affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation></author><author><persName><forename type="first">A.</forename><surname>Keel</surname></persName><affiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</affiliation></author><author><persName><forename type="first">M.</forename><surname>Nienhusmeier</surname></persName><affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation></author><author><persName><forename type="first">R. P.</forename><surname>Maguire</surname></persName><affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</affiliation></author><author><persName><forename type="first">K. L.</forename><surname>Leenders</surname></persName><affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</affiliation></author><author><persName><forename type="first">H.‐P.</forename><surname>Ludin</surname></persName><affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation></author></analytic><monogr><title level="j">Human Brain Mapping</title><title level="j" type="abbrev">Hum. Brain Mapp.</title><idno type="pISSN">1065-9471</idno><idno type="eISSN">1097-0193</idno><idno type="DOI">10.1002/(ISSN)1097-0193</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-11"></date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="145">145</biblScope></imprint></monogr><idno type="istex">D7EED47BCE65FB85B857F750D4D6161B80A12437</idno><idno type="DOI">10.1002/1097-0193(200011)11:3<131::AID-HBM10>3.0.CO;2-M</idno><idno type="ArticleID">HBM10</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Somatosensory discrimination of cuboid objects was studied in a group of healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained with positron emission tomography (PET) and 15O labeled water [H215O]. A 6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET scan demonstrated that the patients may be grouped into those with normal and those with abnormally low FDOPA uptake in the caudate nucleus. The categorical group comparisons revealed that task‐induced rCBF increases were deficient in bilateral motor and sensory cortical areas in the Parkinson patients. Moreover, deficient rCBF increases were evident in the mesial and right dorsolateral prefrontal cortex for patients in a more advanced disease state, who showed low FDOPA uptake in the caudate nucleus. A principal component analysis (PCA), performed on the rCBF data, identified three patterns (principal components, PCs) that differentiated patients from normals. The first PC represented a right‐hemisphere dominant, bilateral group of brain areas known to be involved in tactile exploration. A second PC reflected a cortical‐subcortical pattern of functional interactions, comprising cortical areas important for working memory processes. The third group‐differentiating PC revealed a pattern of functional interactions involving bilateral temporo‐parieto‐occipital association cortices, which was consistent with a hypothesized supramodal network necessary for object discrimination. In an additional subgroup analysis, greater expression of the third PC pattern predicted greater caudate FDOPA uptake in patients. Our neuroimaging data revealed a disturbance of distinct patterns of brain functional interactions related to the sensorimotor deficit in Parkinson's disease and to deficits of cognitive information processing deficits in the more advanced stage of Parkinson's disease. Hum. Brain Mapping 11:131–145, 2000. © 2000 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>somatosensory discrimination</term></item><item><term>rCBF positron emission tomography (PET)</term></item><item><term>6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET</term></item><item><term>categorical comparisons</term></item><item><term>principal component analysis</term></item><item><term>tactile exploration</term></item><item><term>working memory</term></item><item><term>supramodal information transfer</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Original Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000-03-31">Received</change><change when="2000-07-11">Registration</change><change when="2000-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D7EED47BCE65FB85B857F750D4D6161B80A12437/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1097-0193</doi><issn type="print">1065-9471</issn><issn type="electronic">1097-0193</issn><idGroup><id type="product" value="HBM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="HUMAN BRAIN MAPPING">Human Brain Mapping</title><title type="short">Hum. Brain Mapp.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/1097-0193(200011)11:3<>1.0.CO;2-S</doi><numberingGroup><numbering type="journalVolume" number="11">11</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2000-11">November 2000</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="10" status="forIssue"><doi origin="wiley" registered="yes">10.1002/1097-0193(200011)11:3<131::AID-HBM10>3.0.CO;2-M</doi><idGroup><id type="unit" value="HBM10"></id></idGroup><countGroup><count type="pageTotal" number="15"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2000 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2000-03-31"></event><event type="manuscriptAccepted" date="2000-07-11"></event><event type="firstOnline" date="2000-09-20"></event><event type="publishedOnlineFinalForm" date="2000-09-20"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText mathml2tex" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-26"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">131</numbering><numbering type="pageLast">145</numbering></numberingGroup><correspondenceTo>Klinik für Neurologie, Kantonsspital St. Gallen, CH‐9007 St. Gallen, Switzerland</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:HBM.HBM10.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="85"></count><count type="wordTotal" number="10380"></count></countGroup><titleGroup><title type="main" xml:lang="en">Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title><title type="short" xml:lang="en">Object Discrimination in Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>B.</givenNames><familyName>Weder</familyName></personName><contactDetails><email>bruno.weder@kssg.ch</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>N. P.</givenNames><familyName>Azari</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>U.</givenNames><familyName>Knorr</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>R. J.</givenNames><familyName>Seitz</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>A.</givenNames><familyName>Keel</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>M.</givenNames><familyName>Nienhusmeier</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>R. P.</givenNames><familyName>Maguire</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af4"><personName><givenNames>K. L.</givenNames><familyName>Leenders</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>H.‐P.</givenNames><familyName>Ludin</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CH" type="organization"><unparsedAffiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="CH" type="organization"><unparsedAffiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CH" type="organization"><unparsedAffiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">somatosensory discrimination</keyword><keyword xml:id="kwd2">rCBF positron emission tomography (PET)</keyword><keyword xml:id="kwd3">6‐[<sup>18</sup>F]‐fluoro‐L‐dopa (FDOPA) PET</keyword><keyword xml:id="kwd4">categorical comparisons</keyword><keyword xml:id="kwd5">principal component analysis</keyword><keyword xml:id="kwd6">tactile exploration</keyword><keyword xml:id="kwd7">working memory</keyword><keyword xml:id="kwd8">supramodal information transfer</keyword></keywordGroup><fundingInfo><fundingAgency>Swiss National Foundation (Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung)</fundingAgency><fundingNumber>32‐37400.93</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Alexander von Humboldt Foundation</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Somatosensory discrimination of cuboid objects was studied in a group of healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained with positron emission tomography (PET) and <sup>15</sup>O labeled water [H<sub>2</sub><sup>15</sup>O]. A 6‐[<sup>18</sup>F]‐fluoro‐L‐dopa (FDOPA) PET scan demonstrated that the patients may be grouped into those with normal and those with abnormally low FDOPA uptake in the caudate nucleus. The categorical group comparisons revealed that task‐induced rCBF increases were deficient in bilateral motor and sensory cortical areas in the Parkinson patients. Moreover, deficient rCBF increases were evident in the mesial and right dorsolateral prefrontal cortex for patients in a more advanced disease state, who showed low FDOPA uptake in the caudate nucleus. A principal component analysis (PCA), performed on the rCBF data, identified three patterns (principal components, PCs) that differentiated patients from normals. The first PC represented a right‐hemisphere dominant, bilateral group of brain areas known to be involved in tactile exploration. A second PC reflected a cortical‐subcortical pattern of functional interactions, comprising cortical areas important for working memory processes. The third group‐differentiating PC revealed a pattern of functional interactions involving bilateral temporo‐parieto‐occipital association cortices, which was consistent with a hypothesized supramodal network necessary for object discrimination. In an additional subgroup analysis, greater expression of the third PC pattern predicted greater caudate FDOPA uptake in patients. Our neuroimaging data revealed a disturbance of distinct patterns of brain functional interactions related to the sensorimotor deficit in Parkinson's disease and to deficits of cognitive information processing deficits in the more advanced stage of Parkinson's disease. <i>Hum. Brain Mapping 11:131–145, 2000. </i>© 2000 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Object Discrimination in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Weder</namePart><affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><description>Correspondence: Klinik für Neurologie, Kantonsspital St. Gallen, CH‐9007 St. Gallen, Switzerland</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. P.</namePart><namePart type="family">Azari</namePart><affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Knorr</namePart><affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Seitz</namePart><affiliation>Neurology Department, Heinrich‐Heine‐University, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Keel</namePart><affiliation>Institute of Statistics, University of St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Nienhusmeier</namePart><affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. P.</namePart><namePart type="family">Maguire</namePart><affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. L.</namePart><namePart type="family">Leenders</namePart><affiliation>Paul Scherrer Institute (PSI), Villigen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐P.</namePart><namePart type="family">Ludin</namePart><affiliation>Neurology Department of Kantonsspital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2000-11</dateIssued><dateCaptured encoding="w3cdtf">2000-03-31</dateCaptured><dateValid encoding="w3cdtf">2000-07-11</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent><extent unit="references">85</extent><extent unit="words">10380</extent></physicalDescription><abstract lang="en">Somatosensory discrimination of cuboid objects was studied in a group of healthy volunteers and patients with Parkinson's disease using regional cerebral blood flow (rCBF) measurements obtained with positron emission tomography (PET) and 15O labeled water [H215O]. A 6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET scan demonstrated that the patients may be grouped into those with normal and those with abnormally low FDOPA uptake in the caudate nucleus. The categorical group comparisons revealed that task‐induced rCBF increases were deficient in bilateral motor and sensory cortical areas in the Parkinson patients. Moreover, deficient rCBF increases were evident in the mesial and right dorsolateral prefrontal cortex for patients in a more advanced disease state, who showed low FDOPA uptake in the caudate nucleus. A principal component analysis (PCA), performed on the rCBF data, identified three patterns (principal components, PCs) that differentiated patients from normals. The first PC represented a right‐hemisphere dominant, bilateral group of brain areas known to be involved in tactile exploration. A second PC reflected a cortical‐subcortical pattern of functional interactions, comprising cortical areas important for working memory processes. The third group‐differentiating PC revealed a pattern of functional interactions involving bilateral temporo‐parieto‐occipital association cortices, which was consistent with a hypothesized supramodal network necessary for object discrimination. In an additional subgroup analysis, greater expression of the third PC pattern predicted greater caudate FDOPA uptake in patients. Our neuroimaging data revealed a disturbance of distinct patterns of brain functional interactions related to the sensorimotor deficit in Parkinson's disease and to deficits of cognitive information processing deficits in the more advanced stage of Parkinson's disease. Hum. Brain Mapping 11:131–145, 2000. © 2000 Wiley‐Liss, Inc.</abstract><note type="funding">Swiss National Foundation (Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung) - No. 32‐37400.93; </note><note type="funding">Alexander von Humboldt Foundation</note><subject lang="en"><genre>Keywords</genre><topic>somatosensory discrimination</topic><topic>rCBF positron emission tomography (PET)</topic><topic>6‐[18F]‐fluoro‐L‐dopa (FDOPA) PET</topic><topic>categorical comparisons</topic><topic>principal component analysis</topic><topic>tactile exploration</topic><topic>working memory</topic><topic>supramodal information transfer</topic></subject><relatedItem type="host"><titleInfo><title>Human Brain Mapping</title></titleInfo><titleInfo type="abbreviated"><title>Hum. Brain Mapp.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Original Article</topic></subject><identifier type="ISSN">1065-9471</identifier><identifier type="eISSN">1097-0193</identifier><identifier type="DOI">10.1002/(ISSN)1097-0193</identifier><identifier type="PublisherID">HBM</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>131</start><end>145</end><total>15</total></extent></part></relatedItem><identifier type="istex">D7EED47BCE65FB85B857F750D4D6161B80A12437</identifier><identifier type="DOI">10.1002/1097-0193(200011)11:3<131::AID-HBM10>3.0.CO;2-M</identifier><identifier type="ArticleID">HBM10</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A55 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000A55 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:D7EED47BCE65FB85B857F750D4D6161B80A12437
|texte= Disturbed functional brain interactions underlying deficient tactile object discrimination in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |