Survival of Parkinson's disease patients in a large prospective cohort of male health professionals
Identifieur interne : 000A36 ( Main/Corpus ); précédent : 000A35; suivant : 000A37Survival of Parkinson's disease patients in a large prospective cohort of male health professionals
Auteurs : Honglei Chen ; Shumin M. Zhang ; Michael A. Schwarzschild ; Miguel A. Hernán ; Alberto AscherioSource :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
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Abstract
Parkinson's disease (PD) patients have higher mortality than individuals without PD. However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P < 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20881
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However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P < 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Honglei Chen MD, PhD</name><affiliations><json:string>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA</json:string><json:string>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Shumin M. Zhang MD, ScD</name><affiliations><json:string>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</json:string><json:string>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>Michael A. 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However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P > 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P > 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. 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No. CA55075; No. NS048468;</note><note>Kinetic Foundation</note><note>Intramural Research Program at the National Institute of Environmental Health Sciences, NIH</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Survival of Parkinson's disease patients in a large prospective cohort of male health professionals</title><author><persName><forename type="first">Honglei</forename><surname>Chen</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Epidemiology Branch, National Institute of Environmental Health Sciences, Mail drop A3‐05, Building Rall 101 Room # A362, 111 WT Alexander Dr., Research Triangle Park, NC 27709</p></note><affiliation>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA</affiliation><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Shumin M.</forename><surname>Zhang</surname></persName><roleName type="degree">MD, ScD</roleName><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Michael A.</forename><surname>Schwarzschild</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Miguel A.</forename><surname>Hernán</surname></persName><roleName type="degree">MD, DrPH</roleName><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation></author><author><persName><forename type="first">Alberto</forename><surname>Ascherio</surname></persName><roleName type="degree">MD, DrPH</roleName><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. 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However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (<i>P</i> < 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; <i>P</i> < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; <i>P</i> = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Survival of Parkinson's disease patients in a large prospective cohort of male health professionals</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Parkinson's Disease Survival</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Survival of Parkinson's disease patients in a large prospective cohort of male health professionals</title></titleInfo><name type="personal"><namePart type="given">Honglei</namePart><namePart type="family">Chen</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA</affiliation><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><description>Correspondence: Epidemiology Branch, National Institute of Environmental Health Sciences, Mail drop A3‐05, Building Rall 101 Room # A362, 111 WT Alexander Dr., Research Triangle Park, NC 27709</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shumin M.</namePart><namePart type="family">Zhang</namePart><namePart type="termsOfAddress">MD, ScD</namePart><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael A.</namePart><namePart type="family">Schwarzschild</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miguel A.</namePart><namePart type="family">Hernán</namePart><namePart type="termsOfAddress">MD, DrPH</namePart><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Ascherio</namePart><namePart type="termsOfAddress">MD, DrPH</namePart><affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</affiliation><affiliation>Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-07</dateIssued><dateCaptured encoding="w3cdtf">2005-04-06</dateCaptured><dateValid encoding="w3cdtf">2005-11-09</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">28</extent><extent unit="words">4110</extent></physicalDescription><abstract lang="en">Parkinson's disease (PD) patients have higher mortality than individuals without PD. However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow‐up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3–2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age‐adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P < 0.0001 for trend). As expected, cigarette smoking was strongly and positively associated with total mortality among men free of PD (comparing >30 pack‐years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals. © 2006 Movement Disorder Society</abstract><note type="funding">National Institutes of Health (NIH), Bethesda, MD - No. NS35624; No. CA55075; No. NS048468; </note><note type="funding">Kinetic Foundation</note><note type="funding">Intramural Research Program at the National Institute of Environmental Health Sciences, NIH</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>morality</topic><topic>survival</topic><topic>smoking</topic><topic>disease duration</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>1002</start><end>1007</end><total>6</total></extent></part></relatedItem><identifier type="istex">111017AF10D36762A15A4C8D7E1FDB288A72D2EB</identifier><identifier type="DOI">10.1002/mds.20881</identifier><identifier type="ArticleID">MDS20881</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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