Are medium and long latency reflexes a screening tool for early Parkinson's disease?
Identifieur interne : 000A09 ( Main/Corpus ); précédent : 000A08; suivant : 000A10Are medium and long latency reflexes a screening tool for early Parkinson's disease?
Auteurs : B. R. Bloem ; D. J. Beckley ; J. G. Van Dijk ; A. H. Zwinderman ; R. A. C. RoosSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1992.
Abstract
We have studied whether assessment of medium latency (ML) and long latency (LL) reflex amplitudes may serve as a marker for early Parkinson's disease. Twenty-three patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1 to 4) and 24 controls received 20 4° toe-up rotations of a platform upon which they were standing. All antiparkinsonian medication was withheld for at least 12 h before the study. ML reflexes in the stretched gastrocnemius muscle and LL reflexes in the shortened tibialis anterior muscle were recorded from both legs. ML responses were significantly enhanced in patients compared to controls. In contrast to previous studies which studied patients who continued their usual treatment, we observed that LL responses were significantly reduced in patients compared to controls. For the purpose of individual analysis, we subsequently determined the optimal specificity and sensitivity using various criteria for abnormality. The presence of either enhanced ML responses or reduced LL responses (or both) in at least one leg yielded a maximum sensitivity of 65.2% with a specificity of 75.0% (positive likelihood ratio 2.6; negative likelihood ratio 0.5). Abnormal reflexes were almost exclusively present in patients with advanced and long-standing Parkinson's disease. These results show abnormalities of ML and LL responses in advanced Parkinson's disease, but render it unlikely that these abnormalities are a suitable screening tool for early stages of the disease. The fact that LL responses were reduced in patients taken off antiparkinsonian medication raises the possibility that this reflex is under supraspinal dopaminergic control.
Url:
DOI: 10.1016/0022-510X(92)90262-J
Links to Exploration step
ISTEX:8A93578E643CF29B25A91B1D01A5CB5DA4A963EBLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title><author><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Beckley, D J" sort="Beckley, D J" uniqKey="Beckley D" first="D. J." last="Beckley">D. J. Beckley</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, UC Davis, Davis, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Van Dijk, J G" sort="Van Dijk, J G" uniqKey="Van Dijk J" first="J. G." last="Van Dijk">J. G. Van Dijk</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name><affiliation><mods:affiliation>Department of Medical Statistics, State University Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8A93578E643CF29B25A91B1D01A5CB5DA4A963EB</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0022-510X(92)90262-J</idno><idno type="url">https://api.istex.fr/document/8A93578E643CF29B25A91B1D01A5CB5DA4A963EB/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title><author><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Beckley, D J" sort="Beckley, D J" uniqKey="Beckley D" first="D. J." last="Beckley">D. J. Beckley</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, UC Davis, Davis, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Van Dijk, J G" sort="Van Dijk, J G" uniqKey="Van Dijk J" first="J. G." last="Van Dijk">J. G. Van Dijk</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name><affiliation><mods:affiliation>Department of Medical Statistics, State University Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">113</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="38">38</biblScope><biblScope unit="page" to="42">42</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">8A93578E643CF29B25A91B1D01A5CB5DA4A963EB</idno><idno type="DOI">10.1016/0022-510X(92)90262-J</idno><idno type="PII">0022-510X(92)90262-J</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have studied whether assessment of medium latency (ML) and long latency (LL) reflex amplitudes may serve as a marker for early Parkinson's disease. Twenty-three patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1 to 4) and 24 controls received 20 4° toe-up rotations of a platform upon which they were standing. All antiparkinsonian medication was withheld for at least 12 h before the study. ML reflexes in the stretched gastrocnemius muscle and LL reflexes in the shortened tibialis anterior muscle were recorded from both legs. ML responses were significantly enhanced in patients compared to controls. In contrast to previous studies which studied patients who continued their usual treatment, we observed that LL responses were significantly reduced in patients compared to controls. For the purpose of individual analysis, we subsequently determined the optimal specificity and sensitivity using various criteria for abnormality. The presence of either enhanced ML responses or reduced LL responses (or both) in at least one leg yielded a maximum sensitivity of 65.2% with a specificity of 75.0% (positive likelihood ratio 2.6; negative likelihood ratio 0.5). Abnormal reflexes were almost exclusively present in patients with advanced and long-standing Parkinson's disease. These results show abnormalities of ML and LL responses in advanced Parkinson's disease, but render it unlikely that these abnormalities are a suitable screening tool for early stages of the disease. The fact that LL responses were reduced in patients taken off antiparkinsonian medication raises the possibility that this reflex is under supraspinal dopaminergic control.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>B.R. Bloem</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>D.J. Beckley</name><affiliations><json:string>Department of Neurology, School of Medicine, UC Davis, Davis, CA, USA</json:string></affiliations></json:item><json:item><name>J.G. van Dijk</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>A.H. Zwinderman</name><affiliations><json:string>Department of Medical Statistics, State University Leiden, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>R.A.C. Roos</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Medium latency reflex</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Long latency reflex</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Early detection</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We have studied whether assessment of medium latency (ML) and long latency (LL) reflex amplitudes may serve as a marker for early Parkinson's disease. Twenty-three patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1 to 4) and 24 controls received 20 4° toe-up rotations of a platform upon which they were standing. All antiparkinsonian medication was withheld for at least 12 h before the study. ML reflexes in the stretched gastrocnemius muscle and LL reflexes in the shortened tibialis anterior muscle were recorded from both legs. ML responses were significantly enhanced in patients compared to controls. In contrast to previous studies which studied patients who continued their usual treatment, we observed that LL responses were significantly reduced in patients compared to controls. For the purpose of individual analysis, we subsequently determined the optimal specificity and sensitivity using various criteria for abnormality. The presence of either enhanced ML responses or reduced LL responses (or both) in at least one leg yielded a maximum sensitivity of 65.2% with a specificity of 75.0% (positive likelihood ratio 2.6; negative likelihood ratio 0.5). Abnormal reflexes were almost exclusively present in patients with advanced and long-standing Parkinson's disease. These results show abnormalities of ML and LL responses in advanced Parkinson's disease, but render it unlikely that these abnormalities are a suitable screening tool for early stages of the disease. The fact that LL responses were reduced in patients taken off antiparkinsonian medication raises the possibility that this reflex is under supraspinal dopaminergic control.</abstract><qualityIndicators><score>6.606</score><pdfVersion>1.2</pdfVersion><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1673</abstractCharCount><pdfWordCount>3630</pdfWordCount><pdfCharCount>20515</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>248</abstractWordCount></qualityIndicators><title>Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title><pii><json:string>0022-510X(92)90262-J</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>113</volume><pii><json:string>S0022-510X(00)X0314-0</json:string></pii><pages><last>42</last><first>38</first></pages><issn><json:string>0022-510X</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Journal of the Neurological Sciences</title><publicationDate>1992</publicationDate></host><categories><wos><json:string>CLINICAL NEUROLOGY</json:string><json:string>NEUROIMAGING</json:string><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><doi><json:string>10.1016/0022-510X(92)90262-J</json:string></doi><id>8A93578E643CF29B25A91B1D01A5CB5DA4A963EB</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/8A93578E643CF29B25A91B1D01A5CB5DA4A963EB/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/8A93578E643CF29B25A91B1D01A5CB5DA4A963EB/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/8A93578E643CF29B25A91B1D01A5CB5DA4A963EB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8A93578E643CF29B25A91B1D01A5CB5DA4A963EB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1992</date></publicationStmt><notesStmt><note type="content">Section title: Research article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title><author><persName><forename type="first">B.R.</forename><surname>Bloem</surname></persName><note type="correspondence"><p>Correspondence to: Bastiaan R. Bloem, Dept of Neurology and Clinical Neurophysiology, University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Tel.: (71) 263920; Fax: (71) 154537.</p></note><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</affiliation></author><author><persName><forename type="first">D.J.</forename><surname>Beckley</surname></persName><affiliation>Department of Neurology, School of Medicine, UC Davis, Davis, CA, USA</affiliation></author><author><persName><forename type="first">J.G.</forename><surname>van Dijk</surname></persName><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</affiliation></author><author><persName><forename type="first">A.H.</forename><surname>Zwinderman</surname></persName><affiliation>Department of Medical Statistics, State University Leiden, Leiden, The Netherlands</affiliation></author><author><persName><forename type="first">R.A.C.</forename><surname>Roos</surname></persName><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</affiliation></author></analytic><monogr><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="pISSN">0022-510X</idno><idno type="PII">S0022-510X(00)X0314-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">113</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="38">38</biblScope><biblScope unit="page" to="42">42</biblScope></imprint></monogr><idno type="istex">8A93578E643CF29B25A91B1D01A5CB5DA4A963EB</idno><idno type="DOI">10.1016/0022-510X(92)90262-J</idno><idno type="PII">0022-510X(92)90262-J</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We have studied whether assessment of medium latency (ML) and long latency (LL) reflex amplitudes may serve as a marker for early Parkinson's disease. Twenty-three patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1 to 4) and 24 controls received 20 4° toe-up rotations of a platform upon which they were standing. All antiparkinsonian medication was withheld for at least 12 h before the study. ML reflexes in the stretched gastrocnemius muscle and LL reflexes in the shortened tibialis anterior muscle were recorded from both legs. ML responses were significantly enhanced in patients compared to controls. In contrast to previous studies which studied patients who continued their usual treatment, we observed that LL responses were significantly reduced in patients compared to controls. For the purpose of individual analysis, we subsequently determined the optimal specificity and sensitivity using various criteria for abnormality. The presence of either enhanced ML responses or reduced LL responses (or both) in at least one leg yielded a maximum sensitivity of 65.2% with a specificity of 75.0% (positive likelihood ratio 2.6; negative likelihood ratio 0.5). Abnormal reflexes were almost exclusively present in patients with advanced and long-standing Parkinson's disease. These results show abnormalities of ML and LL responses in advanced Parkinson's disease, but render it unlikely that these abnormalities are a suitable screening tool for early stages of the disease. The fact that LL responses were reduced in patients taken off antiparkinsonian medication raises the possibility that this reflex is under supraspinal dopaminergic control.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>Medium latency reflex</term></item><item><term>Long latency reflex</term></item><item><term>Early detection</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992-07-06">Registration</change><change when="1992-06-26">Modified</change><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNS</jid><aid>9290262J</aid><ce:pii>0022-510X(92)90262-J</ce:pii><ce:doi>10.1016/0022-510X(92)90262-J</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Research article</ce:textfn></ce:dochead><ce:title>Are medium and long latency reflexes a screening tool for early Parkinson's disease?</ce:title><ce:author-group><ce:author><ce:given-name>B.R.</ce:given-name><ce:surname>Bloem</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>D.J.</ce:given-name><ce:surname>Beckley</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.G.</ce:given-name><ce:surname>van Dijk</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.H.</ce:given-name><ce:surname>Zwinderman</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>R.A.C.</ce:given-name><ce:surname>Roos</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Neurology, School of Medicine, UC Davis, Davis, CA, USA</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Department of Medical Statistics, State University Leiden, Leiden, The Netherlands</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Correspondence to: Bastiaan R. Bloem, Dept of Neurology and Clinical Neurophysiology, University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Tel.: (71) 263920; Fax: (71) 154537.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="25" month="2" year="1992"></ce:date-received><ce:date-revised day="26" month="6" year="1992"></ce:date-revised><ce:date-accepted day="6" month="7" year="1992"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>We have studied whether assessment of medium latency (ML) and long latency (LL) reflex amplitudes may serve as a marker for early Parkinson's disease. Twenty-three patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1 to 4) and 24 controls received 20 4° toe-up rotations of a platform upon which they were standing. All antiparkinsonian medication was withheld for at least 12 h before the study. ML reflexes in the stretched gastrocnemius muscle and LL reflexes in the shortened tibialis anterior muscle were recorded from both legs. ML responses were significantly enhanced in patients compared to controls. In contrast to previous studies which studied patients who continued their usual treatment, we observed that LL responses were significantly reduced in patients compared to controls. For the purpose of individual analysis, we subsequently determined the optimal specificity and sensitivity using various criteria for abnormality. The presence of either enhanced ML responses or reduced LL responses (or both) in at least one leg yielded a maximum sensitivity of 65.2% with a specificity of 75.0% (positive likelihood ratio 2.6; negative likelihood ratio 0.5). Abnormal reflexes were almost exclusively present in patients with advanced and long-standing Parkinson's disease. These results show abnormalities of ML and LL responses in advanced Parkinson's disease, but render it unlikely that these abnormalities are a suitable screening tool for early stages of the disease. The fact that LL responses were reduced in patients taken off antiparkinsonian medication raises the possibility that this reflex is under supraspinal dopaminergic control.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Medium latency reflex</ce:text></ce:keyword><ce:keyword><ce:text>Long latency reflex</ce:text></ce:keyword><ce:keyword><ce:text>Early detection</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Are medium and long latency reflexes a screening tool for early Parkinson's disease?</title></titleInfo><name type="personal"><namePart type="given">B.R.</namePart><namePart type="family">Bloem</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</affiliation><description>Correspondence to: Bastiaan R. Bloem, Dept of Neurology and Clinical Neurophysiology, University Hospital, P.O. Box 9600, 2300 RC Leiden, The Netherlands. Tel.: (71) 263920; Fax: (71) 154537.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.J.</namePart><namePart type="family">Beckley</namePart><affiliation>Department of Neurology, School of Medicine, UC Davis, Davis, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.G.</namePart><namePart type="family">van Dijk</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.H.</namePart><namePart type="family">Zwinderman</namePart><affiliation>Department of Medical Statistics, State University Leiden, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.A.C.</namePart><namePart type="family">Roos</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital Leiden, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><dateValid encoding="w3cdtf">1992-07-06</dateValid><dateModified encoding="w3cdtf">1992-06-26</dateModified><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We have studied whether assessment of medium latency (ML) and long latency (LL) reflex amplitudes may serve as a marker for early Parkinson's disease. Twenty-three patients with idiopathic Parkinson's disease (Hoehn and Yahr stage 1 to 4) and 24 controls received 20 4° toe-up rotations of a platform upon which they were standing. All antiparkinsonian medication was withheld for at least 12 h before the study. ML reflexes in the stretched gastrocnemius muscle and LL reflexes in the shortened tibialis anterior muscle were recorded from both legs. ML responses were significantly enhanced in patients compared to controls. In contrast to previous studies which studied patients who continued their usual treatment, we observed that LL responses were significantly reduced in patients compared to controls. For the purpose of individual analysis, we subsequently determined the optimal specificity and sensitivity using various criteria for abnormality. The presence of either enhanced ML responses or reduced LL responses (or both) in at least one leg yielded a maximum sensitivity of 65.2% with a specificity of 75.0% (positive likelihood ratio 2.6; negative likelihood ratio 0.5). Abnormal reflexes were almost exclusively present in patients with advanced and long-standing Parkinson's disease. These results show abnormalities of ML and LL responses in advanced Parkinson's disease, but render it unlikely that these abnormalities are a suitable screening tool for early stages of the disease. The fact that LL responses were reduced in patients taken off antiparkinsonian medication raises the possibility that this reflex is under supraspinal dopaminergic control.</abstract><note type="content">Section title: Research article</note><subject><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Medium latency reflex</topic><topic>Long latency reflex</topic><topic>Early detection</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title></titleInfo><titleInfo type="abbreviated"><title>JNS</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199211</dateIssued></originInfo><identifier type="ISSN">0022-510X</identifier><identifier type="PII">S0022-510X(00)X0314-0</identifier><part><date>199211</date><detail type="volume"><number>113</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>124</end></extent><extent unit="pages"><start>38</start><end>42</end></extent></part></relatedItem><identifier type="istex">8A93578E643CF29B25A91B1D01A5CB5DA4A963EB</identifier><identifier type="DOI">10.1016/0022-510X(92)90262-J</identifier><identifier type="PII">0022-510X(92)90262-J</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/8A93578E643CF29B25A91B1D01A5CB5DA4A963EB/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROIMAGING</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000A09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:8A93578E643CF29B25A91B1D01A5CB5DA4A963EB
|texte= Are medium and long latency reflexes a screening tool for early Parkinson's disease?
}}
| This area was generated with Dilib version V0.6.23. |  |