Comparison of a timed motor test battery to the Unified Parkinson's Disease Rating Scale‐III in Parkinson's disease
Identifieur interne : 000A02 ( Main/Corpus ); précédent : 000A01; suivant : 000A03Comparison of a timed motor test battery to the Unified Parkinson's Disease Rating Scale‐III in Parkinson's disease
Auteurs : Charlotte A. Haaxma ; Bastiaan R. Bloem ; George F. Borm ; Martin W. I. M. HorstinkSource :
- Movement Disorders [ 0885-3185 ] ; 2008-09-15.
English descriptors
Abstract
The most widely used scale currently available for the clinical evaluation of motor dysfunction in Parkinson's disease (PD)—the Unified Parkinson's Disease Rating Scale‐III (UPDRS‐III) —is time‐consuming, subjective, and has suboptimal sensitivity. A brief timed motor test (TMT) battery could possibly overcome these drawbacks. Two hundred eighty‐eight PD patients (disease duration 3.1 years; preceding dopaminergic treatment initiation) were assessed with the UPDRS‐III and nine TMTs based on aspects of (a) walking, (b) writing, (c) single and double‐handed pegboard performance, (d) finger tapping, and (e) rapid alternating forearm movements. We investigated validity, reliability, responsiveness, and feasibility. Completing the TMT battery took less than 5 minutes. The TMT correlated well with UPDRS‐III and disease duration. Two factors explained 61% of the TMT variance, the first represented mainly upper extremity function, the second mainly axial/lower extremity function. Cronbach's α was equal for the TMT and the UPDRS‐III (0.8). Test–retest reliability of the TMT sumscore was 0.93 to 0.89 for measurements separated by 3 up to 24 months, whereas UPDRS‐III correlations were 0.88 to 0.84. At group level, a trial using “change from baseline” as endpoint requires only 75% of the patients needed with the UPDRS‐III when applying the TMT battery, and 57% using the pegboard dexterity test. At patient level, TMT and UPDRS‐III were equally responsive. The TMT battery described here is valid, reliable, and feasible. Compared to the UPDRS‐III, it is more objective and more sensitive to change. Therefore, it could be a useful tool for both practical and scientific purposes. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22197
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A brief timed motor test (TMT) battery could possibly overcome these drawbacks. Two hundred eighty‐eight PD patients (disease duration 3.1 years; preceding dopaminergic treatment initiation) were assessed with the UPDRS‐III and nine TMTs based on aspects of (a) walking, (b) writing, (c) single and double‐handed pegboard performance, (d) finger tapping, and (e) rapid alternating forearm movements. We investigated validity, reliability, responsiveness, and feasibility. Completing the TMT battery took less than 5 minutes. The TMT correlated well with UPDRS‐III and disease duration. Two factors explained 61% of the TMT variance, the first represented mainly upper extremity function, the second mainly axial/lower extremity function. Cronbach's α was equal for the TMT and the UPDRS‐III (0.8). Test–retest reliability of the TMT sumscore was 0.93 to 0.89 for measurements separated by 3 up to 24 months, whereas UPDRS‐III correlations were 0.88 to 0.84. At group level, a trial using “change from baseline” as endpoint requires only 75% of the patients needed with the UPDRS‐III when applying the TMT battery, and 57% using the pegboard dexterity test. At patient level, TMT and UPDRS‐III were equally responsive. The TMT battery described here is valid, reliable, and feasible. Compared to the UPDRS‐III, it is more objective and more sensitive to change. Therefore, it could be a useful tool for both practical and scientific purposes. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Charlotte A. Haaxma MD</name><affiliations><json:string>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Bastiaan R. 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A brief timed motor test (TMT) battery could possibly overcome these drawbacks. Two hundred eighty‐eight PD patients (disease duration 3.1 years; preceding dopaminergic treatment initiation) were assessed with the UPDRS‐III and nine TMTs based on aspects of (a) walking, (b) writing, (c) single and double‐handed pegboard performance, (d) finger tapping, and (e) rapid alternating forearm movements. We investigated validity, reliability, responsiveness, and feasibility. Completing the TMT battery took less than 5 minutes. The TMT correlated well with UPDRS‐III and disease duration. Two factors explained 61% of the TMT variance, the first represented mainly upper extremity function, the second mainly axial/lower extremity function. Cronbach's α was equal for the TMT and the UPDRS‐III (0.8). Test–retest reliability of the TMT sumscore was 0.93 to 0.89 for measurements separated by 3 up to 24 months, whereas UPDRS‐III correlations were 0.88 to 0.84. At group level, a trial using “change from baseline” as endpoint requires only 75% of the patients needed with the UPDRS‐III when applying the TMT battery, and 57% using the pegboard dexterity test. At patient level, TMT and UPDRS‐III were equally responsive. The TMT battery described here is valid, reliable, and feasible. Compared to the UPDRS‐III, it is more objective and more sensitive to change. Therefore, it could be a useful tool for both practical and scientific purposes. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>UPDRS</term></item><item><term>timed motor tests</term></item><item><term>metric attributes</term></item><item><term>rating scales</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-12-12">Received</change><change when="2008-06-08">Registration</change><change when="2008-09-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/85770F5CB724E62689D2EC62237AB1C110FF6D80/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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A brief timed motor test (TMT) battery could possibly overcome these drawbacks. Two hundred eighty‐eight PD patients (disease duration 3.1 years; preceding dopaminergic treatment initiation) were assessed with the UPDRS‐III and nine TMTs based on aspects of (a) walking, (b) writing, (c) single and double‐handed pegboard performance, (d) finger tapping, and (e) rapid alternating forearm movements. We investigated validity, reliability, responsiveness, and feasibility. Completing the TMT battery took less than 5 minutes. The TMT correlated well with UPDRS‐III and disease duration. Two factors explained 61% of the TMT variance, the first represented mainly upper extremity function, the second mainly axial/lower extremity function. Cronbach's α was equal for the TMT and the UPDRS‐III (0.8). Test–retest reliability of the TMT sumscore was 0.93 to 0.89 for measurements separated by 3 up to 24 months, whereas UPDRS‐III correlations were 0.88 to 0.84. At group level, a trial using “change from baseline” as endpoint requires only 75% of the patients needed with the UPDRS‐III when applying the TMT battery, and 57% using the pegboard dexterity test. At patient level, TMT and UPDRS‐III were equally responsive. The TMT battery described here is valid, reliable, and feasible. Compared to the UPDRS‐III, it is more objective and more sensitive to change. Therefore, it could be a useful tool for both practical and scientific purposes. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn8"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparison of a timed motor test battery to the Unified Parkinson's Disease Rating Scale‐III in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Comparison of a Timed Motor Test Battery to UPDRS‐III</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparison of a timed motor test battery to the Unified Parkinson's Disease Rating Scale‐III in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Charlotte A.</namePart><namePart type="family">Haaxma</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bastiaan R.</namePart><namePart type="family">Bloem</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">George F.</namePart><namePart type="family">Borm</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin W.I.M.</namePart><namePart type="family">Horstink</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><description>Correspondence: Department of Neurology (935) and Parkinson Center Nijmegen (ParC), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-09-15</dateIssued><dateCaptured encoding="w3cdtf">2007-12-12</dateCaptured><dateValid encoding="w3cdtf">2008-06-08</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">59</extent><extent unit="words">6367</extent></physicalDescription><abstract lang="en">The most widely used scale currently available for the clinical evaluation of motor dysfunction in Parkinson's disease (PD)—the Unified Parkinson's Disease Rating Scale‐III (UPDRS‐III) —is time‐consuming, subjective, and has suboptimal sensitivity. A brief timed motor test (TMT) battery could possibly overcome these drawbacks. Two hundred eighty‐eight PD patients (disease duration 3.1 years; preceding dopaminergic treatment initiation) were assessed with the UPDRS‐III and nine TMTs based on aspects of (a) walking, (b) writing, (c) single and double‐handed pegboard performance, (d) finger tapping, and (e) rapid alternating forearm movements. We investigated validity, reliability, responsiveness, and feasibility. Completing the TMT battery took less than 5 minutes. The TMT correlated well with UPDRS‐III and disease duration. Two factors explained 61% of the TMT variance, the first represented mainly upper extremity function, the second mainly axial/lower extremity function. Cronbach's α was equal for the TMT and the UPDRS‐III (0.8). Test–retest reliability of the TMT sumscore was 0.93 to 0.89 for measurements separated by 3 up to 24 months, whereas UPDRS‐III correlations were 0.88 to 0.84. At group level, a trial using “change from baseline” as endpoint requires only 75% of the patients needed with the UPDRS‐III when applying the TMT battery, and 57% using the pegboard dexterity test. At patient level, TMT and UPDRS‐III were equally responsive. The TMT battery described here is valid, reliable, and feasible. Compared to the UPDRS‐III, it is more objective and more sensitive to change. Therefore, it could be a useful tool for both practical and scientific purposes. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Van Alkemade Fonds</note><note type="funding">ZonMw VIDI - No. 016.076.352; </note><note type="funding">Stichting De Regenboog</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>UPDRS</topic><topic>timed motor tests</topic><topic>metric attributes</topic><topic>rating scales</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1707</start><end>1717</end><total>11</total></extent></part></relatedItem><identifier type="istex">85770F5CB724E62689D2EC62237AB1C110FF6D80</identifier><identifier type="DOI">10.1002/mds.22197</identifier><identifier type="ArticleID">MDS22197</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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