Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study
Identifieur interne : 000999 ( Main/Corpus ); précédent : 000998; suivant : 000A00Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study
Auteurs : C. Rossi ; D. Frosini ; D. Volterrani ; P. De Feo ; E. Unti ; V. Nicoletti ; L. Kiferle ; U. Bonuccelli ; R. CeravoloSource :
- European Journal of Neurology [ 1351-5101 ] ; 2010-04.
English descriptors
- KwdEn :
Abstract
Introduction: In idiopathic Parkinson’s disease (PD), two different clinical phenotypes are usually distinguished: a tremor dominant variant (TD) and an akinetic‐rigid type (ART). TD patients are characterized by a slower disease progression and a minor cognitive impairment. Striatal density of DAT, as quantified by FP‐CIT SPECT, has been reported to correlate with rigidity and akinesia but not with tremor. Objective: To evaluate FP‐CIT uptake in TD and ART phenotypes. Methods: We retrospectively evaluated from our database the pre‐synaptic nigro‐striatal function of 24 patients with TD‐PD and 38 patients with ART‐PD who underwent a FP‐CIT SPECT within 1 year from disease onset. Results: Disease duration, age at the time of SPECT scan and disease severity as measured with Unified Parkinson’s Disease Rating scale part III (UPDRS III) were not statistically different between the two groups. Putamen contralateral to the most clinically affected side showed a lower FP‐CIT uptake in ART patients compared to TD patients. No statistically significant differences emerged when considering bilateral caudate and ipsilateral putaminal uptake, as well as asymmetry indices and caudate/putamen ratios. FP‐CIT contralateral putaminal uptake correlated with the severity of rigidity and hypokinesia but not with tremor. Conclusions: These data suggest that other neurotransmitter systems apart from the nigro‐striatal dopaminergic system are involved in the generation of Parkinsonian tremor, and they are consistent with previous evidence of a lack of correlation between tremor severity and FP‐CIT uptake. Putaminal relative sparing in TD patients could partially explain the slower disease progression reported in this PD phenotype.
Url:
DOI: 10.1111/j.1468-1331.2009.02898.x
Links to Exploration step
ISTEX:1E9E738496BD61BBE08D8388FD6B88149D4C1966Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title><author><name sortKey="Rossi, C" sort="Rossi, C" uniqKey="Rossi C" first="C." last="Rossi">C. Rossi</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Frosini, D" sort="Frosini, D" uniqKey="Frosini D" first="D." last="Frosini">D. Frosini</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Volterrani, D" sort="Volterrani, D" uniqKey="Volterrani D" first="D." last="Volterrani">D. Volterrani</name><affiliation><mods:affiliation>Nuclear Medicine Unit, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="De Feo, P" sort="De Feo, P" uniqKey="De Feo P" first="P." last="De Feo">P. De Feo</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Unti, E" sort="Unti, E" uniqKey="Unti E" first="E." last="Unti">E. Unti</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, V" sort="Nicoletti, V" uniqKey="Nicoletti V" first="V." last="Nicoletti">V. Nicoletti</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Kiferle, L" sort="Kiferle, L" uniqKey="Kiferle L" first="L." last="Kiferle">L. Kiferle</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, U" sort="Bonuccelli, U" uniqKey="Bonuccelli U" first="U." last="Bonuccelli">U. Bonuccelli</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, R" sort="Ceravolo, R" uniqKey="Ceravolo R" first="R." last="Ceravolo">R. Ceravolo</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1E9E738496BD61BBE08D8388FD6B88149D4C1966</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1468-1331.2009.02898.x</idno><idno type="url">https://api.istex.fr/document/1E9E738496BD61BBE08D8388FD6B88149D4C1966/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000999</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title><author><name sortKey="Rossi, C" sort="Rossi, C" uniqKey="Rossi C" first="C." last="Rossi">C. Rossi</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Frosini, D" sort="Frosini, D" uniqKey="Frosini D" first="D." last="Frosini">D. Frosini</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Volterrani, D" sort="Volterrani, D" uniqKey="Volterrani D" first="D." last="Volterrani">D. Volterrani</name><affiliation><mods:affiliation>Nuclear Medicine Unit, University of Pisa, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="De Feo, P" sort="De Feo, P" uniqKey="De Feo P" first="P." last="De Feo">P. De Feo</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Unti, E" sort="Unti, E" uniqKey="Unti E" first="E." last="Unti">E. Unti</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, V" sort="Nicoletti, V" uniqKey="Nicoletti V" first="V." last="Nicoletti">V. Nicoletti</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Kiferle, L" sort="Kiferle, L" uniqKey="Kiferle L" first="L." last="Kiferle">L. Kiferle</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Bonuccelli, U" sort="Bonuccelli, U" uniqKey="Bonuccelli U" first="U." last="Bonuccelli">U. Bonuccelli</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author><author><name sortKey="Ceravolo, R" sort="Ceravolo, R" uniqKey="Ceravolo R" first="R." last="Ceravolo">R. Ceravolo</name><affiliation><mods:affiliation>Department of Neuroscience</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-04">2010-04</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="626">626</biblScope><biblScope unit="page" to="630">630</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">1E9E738496BD61BBE08D8388FD6B88149D4C1966</idno><idno type="DOI">10.1111/j.1468-1331.2009.02898.x</idno><idno type="ArticleID">ENE2898</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FP‐CIT SPECT</term><term>Parkinson disease</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction: In idiopathic Parkinson’s disease (PD), two different clinical phenotypes are usually distinguished: a tremor dominant variant (TD) and an akinetic‐rigid type (ART). TD patients are characterized by a slower disease progression and a minor cognitive impairment. Striatal density of DAT, as quantified by FP‐CIT SPECT, has been reported to correlate with rigidity and akinesia but not with tremor. Objective: To evaluate FP‐CIT uptake in TD and ART phenotypes. Methods: We retrospectively evaluated from our database the pre‐synaptic nigro‐striatal function of 24 patients with TD‐PD and 38 patients with ART‐PD who underwent a FP‐CIT SPECT within 1 year from disease onset. Results: Disease duration, age at the time of SPECT scan and disease severity as measured with Unified Parkinson’s Disease Rating scale part III (UPDRS III) were not statistically different between the two groups. Putamen contralateral to the most clinically affected side showed a lower FP‐CIT uptake in ART patients compared to TD patients. No statistically significant differences emerged when considering bilateral caudate and ipsilateral putaminal uptake, as well as asymmetry indices and caudate/putamen ratios. FP‐CIT contralateral putaminal uptake correlated with the severity of rigidity and hypokinesia but not with tremor. Conclusions: These data suggest that other neurotransmitter systems apart from the nigro‐striatal dopaminergic system are involved in the generation of Parkinsonian tremor, and they are consistent with previous evidence of a lack of correlation between tremor severity and FP‐CIT uptake. Putaminal relative sparing in TD patients could partially explain the slower disease progression reported in this PD phenotype.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>C. Rossi</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>D. Frosini</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>D. Volterrani</name><affiliations><json:string>Nuclear Medicine Unit, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>P. De Feo</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>E. Unti</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>V. Nicoletti</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>L. Kiferle</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>U. Bonuccelli</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item><json:item><name>R. Ceravolo</name><affiliations><json:string>Department of Neuroscience</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>FP‐CIT SPECT</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tremor</value></json:item></subject><articleId><json:string>ENE2898</json:string></articleId><language><json:string>eng</json:string></language><abstract>Introduction: In idiopathic Parkinson’s disease (PD), two different clinical phenotypes are usually distinguished: a tremor dominant variant (TD) and an akinetic‐rigid type (ART). TD patients are characterized by a slower disease progression and a minor cognitive impairment. Striatal density of DAT, as quantified by FP‐CIT SPECT, has been reported to correlate with rigidity and akinesia but not with tremor. Objective: To evaluate FP‐CIT uptake in TD and ART phenotypes. Methods: We retrospectively evaluated from our database the pre‐synaptic nigro‐striatal function of 24 patients with TD‐PD and 38 patients with ART‐PD who underwent a FP‐CIT SPECT within 1 year from disease onset. Results: Disease duration, age at the time of SPECT scan and disease severity as measured with Unified Parkinson’s Disease Rating scale part III (UPDRS III) were not statistically different between the two groups. Putamen contralateral to the most clinically affected side showed a lower FP‐CIT uptake in ART patients compared to TD patients. No statistically significant differences emerged when considering bilateral caudate and ipsilateral putaminal uptake, as well as asymmetry indices and caudate/putamen ratios. FP‐CIT contralateral putaminal uptake correlated with the severity of rigidity and hypokinesia but not with tremor. Conclusions: These data suggest that other neurotransmitter systems apart from the nigro‐striatal dopaminergic system are involved in the generation of Parkinsonian tremor, and they are consistent with previous evidence of a lack of correlation between tremor severity and FP‐CIT uptake. Putaminal relative sparing in TD patients could partially explain the slower disease progression reported in this PD phenotype.</abstract><qualityIndicators><score>6.15</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1742</abstractCharCount><pdfWordCount>3174</pdfWordCount><pdfCharCount>20164</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>248</abstractWordCount></qualityIndicators><title>Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title><genre><json:string>article</json:string></genre><host><volume>17</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>5</total><last>630</last><first>626</first></pages><issn><json:string>1351-5101</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1111/j.1468-1331.2009.02898.x</json:string></doi><id>1E9E738496BD61BBE08D8388FD6B88149D4C1966</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1E9E738496BD61BBE08D8388FD6B88149D4C1966/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1E9E738496BD61BBE08D8388FD6B88149D4C1966/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1E9E738496BD61BBE08D8388FD6B88149D4C1966/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title><author><persName><forename type="first">C.</forename><surname>Rossi</surname></persName><note type="biography">These authors contributed equally to this work.</note><affiliation>These authors contributed equally to this work.</affiliation><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">D.</forename><surname>Frosini</surname></persName><note type="biography">These authors contributed equally to this work.</note><affiliation>These authors contributed equally to this work.</affiliation><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">D.</forename><surname>Volterrani</surname></persName><affiliation>Nuclear Medicine Unit, University of Pisa, Pisa, Italy</affiliation></author><author><persName><forename type="first">P.</forename><surname>De Feo</surname></persName><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">E.</forename><surname>Unti</surname></persName><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">V.</forename><surname>Nicoletti</surname></persName><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">L.</forename><surname>Kiferle</surname></persName><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">U.</forename><surname>Bonuccelli</surname></persName><affiliation>Department of Neuroscience</affiliation></author><author><persName><forename type="first">R.</forename><surname>Ceravolo</surname></persName><affiliation>Department of Neuroscience</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-04"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="626">626</biblScope><biblScope unit="page" to="630">630</biblScope></imprint></monogr><idno type="istex">1E9E738496BD61BBE08D8388FD6B88149D4C1966</idno><idno type="DOI">10.1111/j.1468-1331.2009.02898.x</idno><idno type="ArticleID">ENE2898</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Introduction: In idiopathic Parkinson’s disease (PD), two different clinical phenotypes are usually distinguished: a tremor dominant variant (TD) and an akinetic‐rigid type (ART). TD patients are characterized by a slower disease progression and a minor cognitive impairment. Striatal density of DAT, as quantified by FP‐CIT SPECT, has been reported to correlate with rigidity and akinesia but not with tremor. Objective: To evaluate FP‐CIT uptake in TD and ART phenotypes. Methods: We retrospectively evaluated from our database the pre‐synaptic nigro‐striatal function of 24 patients with TD‐PD and 38 patients with ART‐PD who underwent a FP‐CIT SPECT within 1 year from disease onset. Results: Disease duration, age at the time of SPECT scan and disease severity as measured with Unified Parkinson’s Disease Rating scale part III (UPDRS III) were not statistically different between the two groups. Putamen contralateral to the most clinically affected side showed a lower FP‐CIT uptake in ART patients compared to TD patients. No statistically significant differences emerged when considering bilateral caudate and ipsilateral putaminal uptake, as well as asymmetry indices and caudate/putamen ratios. FP‐CIT contralateral putaminal uptake correlated with the severity of rigidity and hypokinesia but not with tremor. Conclusions: These data suggest that other neurotransmitter systems apart from the nigro‐striatal dopaminergic system are involved in the generation of Parkinsonian tremor, and they are consistent with previous evidence of a lack of correlation between tremor severity and FP‐CIT uptake. Putaminal relative sparing in TD patients could partially explain the slower disease progression reported in this PD phenotype.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>FP‐CIT SPECT</term></item><item><term>Parkinson disease</term></item><item><term>tremor</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/1E9E738496BD61BBE08D8388FD6B88149D4C1966/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04004"><doi origin="wiley">10.1111/ene.2010.17.issue-4</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2010-04">April 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="21" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2009.02898.x</doi><idGroup><id type="unit" value="ENE2898"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2009 The Author(s). Journal compilation © 2009 EFNS</copyright><eventGroup><event type="firstOnline" date="2009-12-29"></event><event type="publishedOnlineFinalForm" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="626">626</numbering><numbering type="pageLast" number="630">630</numbering></numberingGroup><correspondenceTo>Dr. R. Ceravolo, Department of Neurosciences, Section of Neurology, University of Pisa, via Roma 67, 56126 Pisa, Italy (tel.: +39 050 992051; fax: +39 050 550 563; e‐mail: <email>r.ceravolo@med.unipi.it</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2898.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 11 August 2009 Accepted 21 October 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title><title type="shortAuthors">C. Rossi <i>et al.</i></title><title type="short">SPECT in clinical variants of Parkinson disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>C.</givenNames><familyName>Rossi</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>D.</givenNames><familyName>Frosini</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>D.</givenNames><familyName>Volterrani</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>P.</givenNames><familyName>De Feo</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>E.</givenNames><familyName>Unti</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>V.</givenNames><familyName>Nicoletti</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>L.</givenNames><familyName>Kiferle</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1"><personName><givenNames>U.</givenNames><familyName>Bonuccelli</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>R.</givenNames><familyName>Ceravolo</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Neuroscience</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="IT"><unparsedAffiliation>Nuclear Medicine Unit, University of Pisa, Pisa, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">FP‐CIT SPECT</keyword><keyword xml:id="k2">Parkinson disease</keyword><keyword xml:id="k3">tremor</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Introduction: </b> In idiopathic Parkinson’s disease (PD), two different clinical phenotypes are usually distinguished: a tremor dominant variant (TD) and an akinetic‐rigid type (ART). TD patients are characterized by a slower disease progression and a minor cognitive impairment. Striatal density of DAT, as quantified by FP‐CIT SPECT, has been reported to correlate with rigidity and akinesia but not with tremor.</p><p><b>Objective: </b> To evaluate FP‐CIT uptake in TD and ART phenotypes.</p><p><b>Methods: </b> We retrospectively evaluated from our database the pre‐synaptic nigro‐striatal function of 24 patients with TD‐PD and 38 patients with ART‐PD who underwent a FP‐CIT SPECT within 1 year from disease onset.</p><p><b>Results: </b> Disease duration, age at the time of SPECT scan and disease severity as measured with Unified Parkinson’s Disease Rating scale part III (UPDRS III) were not statistically different between the two groups. Putamen contralateral to the most clinically affected side showed a lower FP‐CIT uptake in ART patients compared to TD patients. No statistically significant differences emerged when considering bilateral caudate and ipsilateral putaminal uptake, as well as asymmetry indices and caudate/putamen ratios. FP‐CIT contralateral putaminal uptake correlated with the severity of rigidity and hypokinesia but not with tremor.</p><p><b>Conclusions: </b> These data suggest that other neurotransmitter systems apart from the nigro‐striatal dopaminergic system are involved in the generation of Parkinsonian tremor, and they are consistent with previous evidence of a lack of correlation between tremor severity and FP‐CIT uptake. Putaminal relative sparing in TD patients could partially explain the slower disease progression reported in this PD phenotype.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p> These authors contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title></titleInfo><titleInfo type="abbreviated"><title>SPECT in clinical variants of Parkinson disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study</title></titleInfo><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Rossi</namePart><affiliation>Department of Neuroscience</affiliation><description>These authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Frosini</namePart><affiliation>Department of Neuroscience</affiliation><description>These authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Volterrani</namePart><affiliation>Nuclear Medicine Unit, University of Pisa, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">De Feo</namePart><affiliation>Department of Neuroscience</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Unti</namePart><affiliation>Department of Neuroscience</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Nicoletti</namePart><affiliation>Department of Neuroscience</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Kiferle</namePart><affiliation>Department of Neuroscience</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Bonuccelli</namePart><affiliation>Department of Neuroscience</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Ceravolo</namePart><affiliation>Department of Neuroscience</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-04</dateIssued><edition>Received 11 August 2009 Accepted 21 October 2009</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Introduction: In idiopathic Parkinson’s disease (PD), two different clinical phenotypes are usually distinguished: a tremor dominant variant (TD) and an akinetic‐rigid type (ART). TD patients are characterized by a slower disease progression and a minor cognitive impairment. Striatal density of DAT, as quantified by FP‐CIT SPECT, has been reported to correlate with rigidity and akinesia but not with tremor. Objective: To evaluate FP‐CIT uptake in TD and ART phenotypes. Methods: We retrospectively evaluated from our database the pre‐synaptic nigro‐striatal function of 24 patients with TD‐PD and 38 patients with ART‐PD who underwent a FP‐CIT SPECT within 1 year from disease onset. Results: Disease duration, age at the time of SPECT scan and disease severity as measured with Unified Parkinson’s Disease Rating scale part III (UPDRS III) were not statistically different between the two groups. Putamen contralateral to the most clinically affected side showed a lower FP‐CIT uptake in ART patients compared to TD patients. No statistically significant differences emerged when considering bilateral caudate and ipsilateral putaminal uptake, as well as asymmetry indices and caudate/putamen ratios. FP‐CIT contralateral putaminal uptake correlated with the severity of rigidity and hypokinesia but not with tremor. Conclusions: These data suggest that other neurotransmitter systems apart from the nigro‐striatal dopaminergic system are involved in the generation of Parkinsonian tremor, and they are consistent with previous evidence of a lack of correlation between tremor severity and FP‐CIT uptake. Putaminal relative sparing in TD patients could partially explain the slower disease progression reported in this PD phenotype.</abstract><subject lang="en"><genre>Keywords</genre><topic>FP‐CIT SPECT</topic><topic>Parkinson disease</topic><topic>tremor</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>626</start><end>630</end><total>5</total></extent></part></relatedItem><identifier type="istex">1E9E738496BD61BBE08D8388FD6B88149D4C1966</identifier><identifier type="DOI">10.1111/j.1468-1331.2009.02898.x</identifier><identifier type="ArticleID">ENE2898</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 The Author(s). Journal compilation © 2009 EFNS</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000999 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000999 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:1E9E738496BD61BBE08D8388FD6B88149D4C1966
|texte= Differences in nigro‐striatal impairment in clinical variants of early Parkinson’s disease: evidence from a FP‐CIT SPECT study
}}
| This area was generated with Dilib version V0.6.23. |  |