Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease
Identifieur interne : 000955 ( Main/Corpus ); précédent : 000954; suivant : 000956Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease
Auteurs : R. Nandhagopal ; Andre R. Troiano ; Edwin Mak ; Michael Schulzer ; Mary Catherine Bushnell ; Alexander Jon StoesslSource :
- Pain Medicine [ 1526-2375 ] ; 2010-06.
English descriptors
Abstract
Background. Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective. The aim of this study is to assess thermal experience and emotional content, as well as side‐to‐side sensory differences in PD “off” and “on” dopaminergic therapy following thermal cutaneous stimulation. Design. Cross‐sectional design. Setting. University teaching hospital. Methods. Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results. There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions. These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.
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DOI: 10.1111/j.1526-4637.2010.00866.x
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ISTEX:94DA14434C90D78B3209493A33007C3309D30262Le document en format XML
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Troiano</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Bushnell, Mary Catherine" sort="Bushnell, Mary Catherine" uniqKey="Bushnell M" first="Mary Catherine" last="Bushnell">Mary Catherine Bushnell</name><affiliation><mods:affiliation>Faculty of Medicine, Department of Anesthesia, McGill University, Montreal, Quebec, Canada</mods:affiliation></affiliation></author><author><name sortKey="Stoessl, Alexander Jon" sort="Stoessl, Alexander Jon" uniqKey="Stoessl A" first="Alexander Jon" last="Stoessl">Alexander Jon Stoessl</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:94DA14434C90D78B3209493A33007C3309D30262</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1526-4637.2010.00866.x</idno><idno type="url">https://api.istex.fr/document/94DA14434C90D78B3209493A33007C3309D30262/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000955</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title><author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Troiano, Andre R" sort="Troiano, Andre R" uniqKey="Troiano A" first="Andre R." last="Troiano">Andre R. Troiano</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author><author><name sortKey="Bushnell, Mary Catherine" sort="Bushnell, Mary Catherine" uniqKey="Bushnell M" first="Mary Catherine" last="Bushnell">Mary Catherine Bushnell</name><affiliation><mods:affiliation>Faculty of Medicine, Department of Anesthesia, McGill University, Montreal, Quebec, Canada</mods:affiliation></affiliation></author><author><name sortKey="Stoessl, Alexander Jon" sort="Stoessl, Alexander Jon" uniqKey="Stoessl A" first="Alexander Jon" last="Stoessl">Alexander Jon Stoessl</name><affiliation><mods:affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Pain Medicine</title><idno type="ISSN">1526-2375</idno><idno type="eISSN">1526-4637</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-06">2010-06</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="834">834</biblScope><biblScope unit="page" to="840">840</biblScope></imprint><idno type="ISSN">1526-2375</idno></series><idno type="istex">94DA14434C90D78B3209493A33007C3309D30262</idno><idno type="DOI">10.1111/j.1526-4637.2010.00866.x</idno><idno type="ArticleID">PME866</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1526-2375</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Heat Pain</term><term>Medication Status</term><term>Parkinson's Disease</term><term>Unpleasantness</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective. The aim of this study is to assess thermal experience and emotional content, as well as side‐to‐side sensory differences in PD “off” and “on” dopaminergic therapy following thermal cutaneous stimulation. Design. Cross‐sectional design. Setting. University teaching hospital. Methods. Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results. There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions. These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>R. Nandhagopal DM</name><affiliations><json:string>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</json:string></affiliations></json:item><json:item><name>Andre R. Troiano MD</name><affiliations><json:string>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</json:string></affiliations></json:item><json:item><name>Edwin Mak BSc</name><affiliations><json:string>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</json:string></affiliations></json:item><json:item><name>Michael Schulzer MD, PhD</name><affiliations><json:string>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</json:string></affiliations></json:item><json:item><name>Mary Catherine Bushnell PhD</name><affiliations><json:string>Faculty of Medicine, Department of Anesthesia, McGill University, Montreal, Quebec, Canada</json:string></affiliations></json:item><json:item><name>Alexander Jon Stoessl MD, FRCPC</name><affiliations><json:string>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's Disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Heat Pain</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Unpleasantness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Medication Status</value></json:item></subject><articleId><json:string>PME866</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background. Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective. The aim of this study is to assess thermal experience and emotional content, as well as side‐to‐side sensory differences in PD “off” and “on” dopaminergic therapy following thermal cutaneous stimulation. Design. Cross‐sectional design. Setting. University teaching hospital. Methods. Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results. There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions. These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.</abstract><qualityIndicators><score>5.692</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 796 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1175</abstractCharCount><pdfWordCount>3568</pdfWordCount><pdfCharCount>22824</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>177</abstractWordCount></qualityIndicators><title>Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title><genre><json:string>article</json:string></genre><host><volume>11</volume><publisherId><json:string>PME</json:string></publisherId><pages><total>7</total><last>840</last><first>834</first></pages><issn><json:string>1526-2375</json:string></issn><issue>6</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1526-4637</json:string></eissn><title>Pain Medicine</title><doi><json:string>10.1111/(ISSN)1526-4637</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1111/j.1526-4637.2010.00866.x</json:string></doi><id>94DA14434C90D78B3209493A33007C3309D30262</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/94DA14434C90D78B3209493A33007C3309D30262/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/94DA14434C90D78B3209493A33007C3309D30262/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/94DA14434C90D78B3209493A33007C3309D30262/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title><author><persName><forename type="first">R.</forename><surname>Nandhagopal</surname></persName><roleName type="degree">DM</roleName><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation></author><author><persName><forename type="first">Andre R.</forename><surname>Troiano</surname></persName><roleName type="degree">MD</roleName><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation></author><author><persName><forename type="first">Edwin</forename><surname>Mak</surname></persName><roleName type="degree">BSc</roleName><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation></author><author><persName><forename type="first">Michael</forename><surname>Schulzer</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation></author><author><persName><forename type="first">Mary Catherine</forename><surname>Bushnell</surname></persName><roleName type="degree">PhD</roleName><affiliation>Faculty of Medicine, Department of Anesthesia, McGill University, Montreal, Quebec, Canada</affiliation></author><author><persName><forename type="first">Alexander Jon</forename><surname>Stoessl</surname></persName><roleName type="degree">MD, FRCPC</roleName><note type="correspondence"><p>Correspondence: Alexander Jon Stoessl, CM, MD, FRCPC, Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC V6T2B5, Canada. Tel: 604‐822‐7979; Fax: +1‐604‐822‐7866; E‐mail:</p></note><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation></author></analytic><monogr><title level="j">Pain Medicine</title><idno type="pISSN">1526-2375</idno><idno type="eISSN">1526-4637</idno><idno type="DOI">10.1111/(ISSN)1526-4637</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-06"></date><biblScope unit="volume">11</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="834">834</biblScope><biblScope unit="page" to="840">840</biblScope></imprint></monogr><idno type="istex">94DA14434C90D78B3209493A33007C3309D30262</idno><idno type="DOI">10.1111/j.1526-4637.2010.00866.x</idno><idno type="ArticleID">PME866</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background. Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective. The aim of this study is to assess thermal experience and emotional content, as well as side‐to‐side sensory differences in PD “off” and “on” dopaminergic therapy following thermal cutaneous stimulation. Design. Cross‐sectional design. Setting. University teaching hospital. Methods. Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results. There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions. These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's Disease</term></item><item><term>Heat Pain</term></item><item><term>Unpleasantness</term></item><item><term>Medication Status</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/94DA14434C90D78B3209493A33007C3309D30262/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1526-4637</doi><issn type="print">1526-2375</issn><issn type="electronic">1526-4637</issn><idGroup><id type="product" value="PME"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="PAIN MEDICINE">Pain Medicine</title></titleGroup></publicationMeta><publicationMeta level="part" position="06006"><doi origin="wiley">10.1111/pme.2010.11.issue-6</doi><numberingGroup><numbering type="journalVolume" number="11">11</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2010-06">June 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1111/j.1526-4637.2010.00866.x</doi><idGroup><id type="unit" value="PME866"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL RESEARCH ARTICLES</title></titleGroup><copyright>Wiley Periodicals, Inc.</copyright><eventGroup><event type="firstOnline" date="2010-06-02"></event><event type="publishedOnlineFinalForm" date="2010-06-02"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-06-03"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="834">834</numbering><numbering type="pageLast" number="840">840</numbering></numberingGroup><correspondenceTo>Alexander Jon Stoessl, CM, MD, FRCPC, Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC V6T2B5, Canada. Tel: 604‐822‐7979; Fax: +1‐604‐822‐7866; E‐mail: <email>jstoessl@interchange.ubc.ca</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PME.PME866.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="4"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="31"></count><count type="wordTotal" number="4136"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title><title type="shortAuthors">Nandhagopal et al.</title><title type="short">Thermal Response and Parkinson's Disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>R.</givenNames><familyName>Nandhagopal</familyName><degrees>DM</degrees></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Andre R.</givenNames><familyName>Troiano</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Edwin</givenNames><familyName>Mak</familyName><degrees>BSc</degrees></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Michael</givenNames><familyName>Schulzer</familyName><degrees>MD, PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>Mary Catherine</givenNames><familyName>Bushnell</familyName><degrees>PhD</degrees></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Alexander Jon</givenNames><familyName>Stoessl</familyName><degrees>MD, FRCPC</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="CA"><unparsedAffiliation>Faculty of Medicine, Department of Anesthesia, McGill University, Montreal, Quebec, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Parkinson's Disease</keyword><keyword xml:id="k2">Heat Pain</keyword><keyword xml:id="k3">Unpleasantness</keyword><keyword xml:id="k4">Medication Status</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Background. </b> Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied.</p><p><b>Objective. </b> The aim of this study is to assess thermal experience and emotional content, as well as side‐to‐side sensory differences in PD “off” and “on” dopaminergic therapy following thermal cutaneous stimulation.</p><p><b>Design. </b> Cross‐sectional design.</p><p><b>Setting. </b> University teaching hospital.</p><p><b>Methods. </b> Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls.</p><p><b>Results. </b> There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state.</p><p><b>Conclusions. </b> These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title></titleInfo><titleInfo type="abbreviated"><title>Thermal Response and Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Nandhagopal</namePart><namePart type="termsOfAddress">DM</namePart><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andre R.</namePart><namePart type="family">Troiano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edwin</namePart><namePart type="family">Mak</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Schulzer</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary Catherine</namePart><namePart type="family">Bushnell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Faculty of Medicine, Department of Anesthesia, McGill University, Montreal, Quebec, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexander Jon</namePart><namePart type="family">Stoessl</namePart><namePart type="termsOfAddress">MD, FRCPC</namePart><affiliation>Pacific Parkinson's Research Centre, 2221 Wesbrook Mall, Vancouver, British Columbia;</affiliation><description>Correspondence: Alexander Jon Stoessl, CM, MD, FRCPC, Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Purdy Pavilion, 2221 Wesbrook Mall, Vancouver, BC V6T2B5, Canada. Tel: 604‐822‐7979; Fax: +1‐604‐822‐7866; E‐mail: </description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2010-06</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">31</extent><extent unit="words">4136</extent></physicalDescription><abstract lang="en">Background. Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective. The aim of this study is to assess thermal experience and emotional content, as well as side‐to‐side sensory differences in PD “off” and “on” dopaminergic therapy following thermal cutaneous stimulation. Design. Cross‐sectional design. Setting. University teaching hospital. Methods. Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results. There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions. These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's Disease</topic><topic>Heat Pain</topic><topic>Unpleasantness</topic><topic>Medication Status</topic></subject><relatedItem type="host"><titleInfo><title>Pain Medicine</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1526-2375</identifier><identifier type="eISSN">1526-4637</identifier><identifier type="DOI">10.1111/(ISSN)1526-4637</identifier><identifier type="PublisherID">PME</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>834</start><end>840</end><total>7</total></extent></part></relatedItem><identifier type="istex">94DA14434C90D78B3209493A33007C3309D30262</identifier><identifier type="DOI">10.1111/j.1526-4637.2010.00866.x</identifier><identifier type="ArticleID">PME866</identifier><accessCondition type="use and reproduction" contentType="copyright">Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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