Point of view: Dementia in Parkinson's disease
Identifieur interne : 000947 ( Main/Corpus ); précédent : 000946; suivant : 000948Point of view: Dementia in Parkinson's disease
Auteurs : Abraham N. LiebermanSource :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1997.
Abstract
The prevalence of dementia in Parkinson's disease (PD) was analyzed in eight reports from peer-reviewed journals. Each report examined at least 100 patients, the period covered being 1966 to 1996. Among 1907 patients, 513,27%, were demented. The prevalence of dementia was similar in prospective and retrospective reports, and in clinic- and community-based reports. Demented patients were older than non-demented patients: 70.3 yr versus 64.3 yr. Disease duration was similar in demented and non-demented patients: 7.7 yr versus 7.9 yr. The incidence of dementia in PD was calculated from two prospective community-based reports and one retrospective clinic-based report. For the age range 55 to 64 yr, the incidence is 2.7 patients per 100 patients per year (2.7% per year). For the age range 70 to 79 yr, the incidence increased to 13.7%. For the age range 80 + yr, the incidence is 9.3%. The pathology of PD dementia was analyzed in 15 reports, each report examined at least 10 patients. Among 412 demented patients, 28%, had a pathology characterized primarily by Lewy bodies (Lbs) and 40% of the patients with Lbs (10% of all demented PD patients), had subcortical changes, only 60% of the patients with Lbs (17% of all demented PD patients), had subcortical and cortical Lbs. Among the 412 demented patients, 72%, the pathology consisted of subcortical Lbs and cortical AD changes: plaques and neurofibrillary tangles (nfts). Some of these patients also had cortical Lbs. It is postulated there are two types of PD dementia, and by inference two types of PD. One type, which may include familial PD, is characterized by cortical Lbs. The second, related to AD, or frontotemporal dementia (FTD), is characterized by cortical senile plaques and nfts. As 90% of demented PD patients have cortical changes, it is argued that PD dementia should be referred to as a cortical not a subcortical dementia.
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DOI: 10.1016/S1353-8020(97)00017-5
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Lieberman</name></author></analytic><monogr></monogr><series><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="ISSN">1353-8020</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="151">151</biblScope><biblScope unit="page" to="158">158</biblScope></imprint><idno type="ISSN">1353-8020</idno></series><idno type="istex">B4BC812BEC91CE876DCD4D99E8C136F626A4F663</idno><idno type="DOI">10.1016/S1353-8020(97)00017-5</idno><idno type="PII">S1353-8020(97)00017-5</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1353-8020</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The prevalence of dementia in Parkinson's disease (PD) was analyzed in eight reports from peer-reviewed journals. Each report examined at least 100 patients, the period covered being 1966 to 1996. Among 1907 patients, 513,27%, were demented. The prevalence of dementia was similar in prospective and retrospective reports, and in clinic- and community-based reports. Demented patients were older than non-demented patients: 70.3 yr versus 64.3 yr. Disease duration was similar in demented and non-demented patients: 7.7 yr versus 7.9 yr. The incidence of dementia in PD was calculated from two prospective community-based reports and one retrospective clinic-based report. For the age range 55 to 64 yr, the incidence is 2.7 patients per 100 patients per year (2.7% per year). For the age range 70 to 79 yr, the incidence increased to 13.7%. For the age range 80 + yr, the incidence is 9.3%. The pathology of PD dementia was analyzed in 15 reports, each report examined at least 10 patients. Among 412 demented patients, 28%, had a pathology characterized primarily by Lewy bodies (Lbs) and 40% of the patients with Lbs (10% of all demented PD patients), had subcortical changes, only 60% of the patients with Lbs (17% of all demented PD patients), had subcortical and cortical Lbs. Among the 412 demented patients, 72%, the pathology consisted of subcortical Lbs and cortical AD changes: plaques and neurofibrillary tangles (nfts). Some of these patients also had cortical Lbs. It is postulated there are two types of PD dementia, and by inference two types of PD. One type, which may include familial PD, is characterized by cortical Lbs. The second, related to AD, or frontotemporal dementia (FTD), is characterized by cortical senile plaques and nfts. As 90% of demented PD patients have cortical changes, it is argued that PD dementia should be referred to as a cortical not a subcortical dementia.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Abraham N. Lieberman</name></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Diffuse</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lewy body disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimers disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Subcortical dementia</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The prevalence of dementia in Parkinson's disease (PD) was analyzed in eight reports from peer-reviewed journals. Each report examined at least 100 patients, the period covered being 1966 to 1996. Among 1907 patients, 513,27%, were demented. The prevalence of dementia was similar in prospective and retrospective reports, and in clinic- and community-based reports. Demented patients were older than non-demented patients: 70.3 yr versus 64.3 yr. Disease duration was similar in demented and non-demented patients: 7.7 yr versus 7.9 yr. The incidence of dementia in PD was calculated from two prospective community-based reports and one retrospective clinic-based report. For the age range 55 to 64 yr, the incidence is 2.7 patients per 100 patients per year (2.7% per year). For the age range 70 to 79 yr, the incidence increased to 13.7%. For the age range 80 + yr, the incidence is 9.3%. The pathology of PD dementia was analyzed in 15 reports, each report examined at least 10 patients. Among 412 demented patients, 28%, had a pathology characterized primarily by Lewy bodies (Lbs) and 40% of the patients with Lbs (10% of all demented PD patients), had subcortical changes, only 60% of the patients with Lbs (17% of all demented PD patients), had subcortical and cortical Lbs. Among the 412 demented patients, 72%, the pathology consisted of subcortical Lbs and cortical AD changes: plaques and neurofibrillary tangles (nfts). Some of these patients also had cortical Lbs. It is postulated there are two types of PD dementia, and by inference two types of PD. One type, which may include familial PD, is characterized by cortical Lbs. The second, related to AD, or frontotemporal dementia (FTD), is characterized by cortical senile plaques and nfts. 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Each report examined at least 100 patients, the period covered being 1966 to 1996. Among 1907 patients, 513,27%, were demented. The prevalence of dementia was similar in prospective and retrospective reports, and in clinic- and community-based reports. Demented patients were older than non-demented patients: 70.3 yr versus 64.3 yr. Disease duration was similar in demented and non-demented patients: 7.7 yr versus 7.9 yr. The incidence of dementia in PD was calculated from two prospective community-based reports and one retrospective clinic-based report. For the age range 55 to 64 yr, the incidence is 2.7 patients per 100 patients per year (2.7% per year). For the age range 70 to 79 yr, the incidence increased to 13.7%. For the age range 80 + yr, the incidence is 9.3%. The pathology of PD dementia was analyzed in 15 reports, each report examined at least 10 patients. Among 412 demented patients, 28%, had a pathology characterized primarily by Lewy bodies (Lbs) and 40% of the patients with Lbs (10% of all demented PD patients), had subcortical changes, only 60% of the patients with Lbs (17% of all demented PD patients), had subcortical and cortical Lbs. Among the 412 demented patients, 72%, the pathology consisted of subcortical Lbs and cortical AD changes: plaques and neurofibrillary tangles (nfts). Some of these patients also had cortical Lbs. It is postulated there are two types of PD dementia, and by inference two types of PD. One type, which may include familial PD, is characterized by cortical Lbs. The second, related to AD, or frontotemporal dementia (FTD), is characterized by cortical senile plaques and nfts. As 90% of demented PD patients have cortical changes, it is argued that PD dementia should be referred to as a cortical not a subcortical dementia.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Dementia</term></item><item><term>Diffuse</term></item><item><term>Lewy body disease</term></item><item><term>Alzheimers disease</term></item><item><term>Subcortical dementia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-04-20">Registration</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PRD</jid><aid>97000175</aid><ce:pii>S1353-8020(97)00017-5</ce:pii><ce:doi>10.1016/S1353-8020(97)00017-5</ce:doi><ce:copyright type="unknown" year="1997"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Paper</ce:textfn></ce:dochead><ce:title>Point of view: Dementia in Parkinson's disease</ce:title><ce:author-group><ce:author><ce:given-name>Abraham N.</ce:given-name><ce:surname>Lieberman</ce:surname><ce:ranking><ce:sup>∗</ce:sup></ce:ranking></ce:author></ce:author-group><ce:date-accepted day="20" month="4" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The prevalence of dementia in Parkinson's disease (PD) was analyzed in eight reports from peer-reviewed journals. Each report examined at least 100 patients, the period covered being 1966 to 1996. Among 1907 patients, 513,27%, were demented. The prevalence of dementia was similar in prospective and retrospective reports, and in clinic- and community-based reports. Demented patients were older than non-demented patients: 70.3 yr versus 64.3 yr. Disease duration was similar in demented and non-demented patients: 7.7 yr versus 7.9 yr.</ce:simple-para><ce:simple-para>The incidence of dementia in PD was calculated from two prospective community-based reports and one retrospective clinic-based report. For the age range 55 to 64 yr, the incidence is 2.7 patients per 100 patients per year (2.7% per year). For the age range 70 to 79 yr, the incidence increased to 13.7%. For the age range 80 + yr, the incidence is 9.3%.</ce:simple-para><ce:simple-para>The pathology of PD dementia was analyzed in 15 reports, each report examined at least 10 patients. Among 412 demented patients, 28%, had a pathology characterized primarily by Lewy bodies (Lbs) and 40% of the patients with Lbs (10% of all demented PD patients), had subcortical changes, only 60% of the patients with Lbs (17% of all demented PD patients), had subcortical and cortical Lbs. Among the 412 demented patients, 72%, the pathology consisted of subcortical Lbs and cortical AD changes: plaques and neurofibrillary tangles (nfts). Some of these patients also had cortical Lbs.</ce:simple-para><ce:simple-para>It is postulated there are two types of PD dementia, and by inference two types of PD. One type, which may include familial PD, is characterized by cortical Lbs. The second, related to AD, or frontotemporal dementia (FTD), is characterized by cortical senile plaques and nfts. As 90% of demented PD patients have cortical changes, it is argued that PD dementia should be referred to as a cortical not a subcortical dementia.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Dementia</ce:text></ce:keyword><ce:keyword><ce:text>Diffuse</ce:text></ce:keyword><ce:keyword><ce:text>Lewy body disease</ce:text></ce:keyword><ce:keyword><ce:text>Alzheimers disease</ce:text></ce:keyword><ce:keyword><ce:text>Subcortical dementia</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Point of view: Dementia in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Point of view: Dementia in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Abraham N.</namePart><namePart type="family">Lieberman</namePart><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateValid encoding="w3cdtf">1997-04-20</dateValid><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The prevalence of dementia in Parkinson's disease (PD) was analyzed in eight reports from peer-reviewed journals. Each report examined at least 100 patients, the period covered being 1966 to 1996. Among 1907 patients, 513,27%, were demented. The prevalence of dementia was similar in prospective and retrospective reports, and in clinic- and community-based reports. Demented patients were older than non-demented patients: 70.3 yr versus 64.3 yr. Disease duration was similar in demented and non-demented patients: 7.7 yr versus 7.9 yr. The incidence of dementia in PD was calculated from two prospective community-based reports and one retrospective clinic-based report. For the age range 55 to 64 yr, the incidence is 2.7 patients per 100 patients per year (2.7% per year). For the age range 70 to 79 yr, the incidence increased to 13.7%. For the age range 80 + yr, the incidence is 9.3%. The pathology of PD dementia was analyzed in 15 reports, each report examined at least 10 patients. Among 412 demented patients, 28%, had a pathology characterized primarily by Lewy bodies (Lbs) and 40% of the patients with Lbs (10% of all demented PD patients), had subcortical changes, only 60% of the patients with Lbs (17% of all demented PD patients), had subcortical and cortical Lbs. Among the 412 demented patients, 72%, the pathology consisted of subcortical Lbs and cortical AD changes: plaques and neurofibrillary tangles (nfts). Some of these patients also had cortical Lbs. It is postulated there are two types of PD dementia, and by inference two types of PD. One type, which may include familial PD, is characterized by cortical Lbs. The second, related to AD, or frontotemporal dementia (FTD), is characterized by cortical senile plaques and nfts. As 90% of demented PD patients have cortical changes, it is argued that PD dementia should be referred to as a cortical not a subcortical dementia.</abstract><note type="content">Section title: Paper</note><subject><genre>Keywords</genre><topic>Dementia</topic><topic>Diffuse</topic><topic>Lewy body disease</topic><topic>Alzheimers disease</topic><topic>Subcortical dementia</topic></subject><relatedItem type="host"><titleInfo><title>Parkinsonism and Related Disorders</title></titleInfo><titleInfo type="abbreviated"><title>PRD</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199711</dateIssued></originInfo><identifier type="ISSN">1353-8020</identifier><identifier type="PII">S1353-8020(00)X0009-0</identifier><part><date>199711</date><detail type="volume"><number>3</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>125</start><end>173</end></extent><extent unit="pages"><start>151</start><end>158</end></extent></part></relatedItem><identifier type="istex">B4BC812BEC91CE876DCD4D99E8C136F626A4F663</identifier><identifier type="DOI">10.1016/S1353-8020(97)00017-5</identifier><identifier type="PII">S1353-8020(97)00017-5</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/B4BC812BEC91CE876DCD4D99E8C136F626A4F663/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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