Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease
Identifieur interne : 000919 ( Main/Corpus ); précédent : 000918; suivant : 000920Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease
Auteurs : Merle Ruberg ; François Rieger ; Albert Villageois ; Anne Marie Bonnet ; Yves AgidSource :
- Brain Research [ 0006-8993 ] ; 1985.
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Abstract
The molecular forms of acetylcholinesterase (AChE) and butyrylcholinesterasse (BChE) were studied in frontal cortex (grey and white matter), postmortem, and in cerebrospinal fluid (CSF) of demented patients with Parkinson's diesease compared to controls and non-demented parkinsonians. In the frontal cortex, AChE activity decreased significantly in both demented and non-demented parkinsonian subjects compared to controls; the 10S form of the enzyme was significantly lower in demented parkinsonians than in the non-demented subjects. The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. BChE activity decreased only in the non-demented parkinsonians; in the demented subjects, BChE activity was at control levels. Similar results were obtained with grey and white matter, although absolute levels of the two enzymes were different in the two types of tissue, suggesting that the enzymes were affected in the cholinergic neurones before transport to cortical nerve terminals. No decreases in AChE or BChE activity were observed in the CSF of the patients studied. On the contrary, AChE and BChE levels were significantly higher in demented parkinsonian patients compared to the non-demented subjects.
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DOI: 10.1016/0006-8993(86)91401-0
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In the frontal cortex, AChE activity decreased significantly in both demented and non-demented parkinsonian subjects compared to controls; the 10S form of the enzyme was significantly lower in demented parkinsonians than in the non-demented subjects. The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. BChE activity decreased only in the non-demented parkinsonians; in the demented subjects, BChE activity was at control levels. Similar results were obtained with grey and white matter, although absolute levels of the two enzymes were different in the two types of tissue, suggesting that the enzymes were affected in the cholinergic neurones before transport to cortical nerve terminals. No decreases in AChE or BChE activity were observed in the CSF of the patients studied. On the contrary, AChE and BChE levels were significantly higher in demented parkinsonian patients compared to the non-demented subjects.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Merle Ruberg</name><affiliations><json:string>INSERM U.289, Facultéde Médecine, Pitteé-Salpêtrière, 91, Boulevard de l'Hoˆpital, France</json:string></affiliations></json:item><json:item><name>François Rieger</name><affiliations><json:string>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</json:string></affiliations></json:item><json:item><name>Albert Villageois</name><affiliations><json:string>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</json:string></affiliations></json:item><json:item><name>Anne Marie Bonnet</name><affiliations><json:string>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</json:string></affiliations></json:item><json:item><name>Yves Agid</name><affiliations><json:string>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>acetylcholinesterase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>butyrylcholinesterase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cerebrospinal fluid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>human brain</value></json:item></subject><articleId><json:string>86914010</json:string></articleId><language><json:string>eng</json:string></language><abstract>The molecular forms of acetylcholinesterase (AChE) and butyrylcholinesterasse (BChE) were studied in frontal cortex (grey and white matter), postmortem, and in cerebrospinal fluid (CSF) of demented patients with Parkinson's diesease compared to controls and non-demented parkinsonians. In the frontal cortex, AChE activity decreased significantly in both demented and non-demented parkinsonian subjects compared to controls; the 10S form of the enzyme was significantly lower in demented parkinsonians than in the non-demented subjects. The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. BChE activity decreased only in the non-demented parkinsonians; in the demented subjects, BChE activity was at control levels. Similar results were obtained with grey and white matter, although absolute levels of the two enzymes were different in the two types of tissue, suggesting that the enzymes were affected in the cholinergic neurones before transport to cortical nerve terminals. No decreases in AChE or BChE activity were observed in the CSF of the patients studied. 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Ruberg, INSERM U.289, Facultéde Médecine, Pitié-Salpêtrière, 91, Boulevard de l'Hoˆpital, 75005 Paris, France.</p></note><affiliation>INSERM U.289, Facultéde Médecine, Pitteé-Salpêtrière, 91, Boulevard de l'Hoˆpital, France</affiliation></author><author><persName><forename type="first">François</forename><surname>Rieger</surname></persName><affiliation>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</affiliation></author><author><persName><forename type="first">Albert</forename><surname>Villageois</surname></persName><affiliation>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</affiliation></author><author><persName><forename type="first">Anne Marie</forename><surname>Bonnet</surname></persName><affiliation>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</affiliation></author><author><persName><forename type="first">Yves</forename><surname>Agid</surname></persName><affiliation>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</affiliation></author></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X1303-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985"></date><biblScope unit="volume">362</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="91">91</biblScope></imprint></monogr><idno type="istex">4B41EC21F26801F7DFB64511368D7E188E5DBF8D</idno><idno type="DOI">10.1016/0006-8993(86)91401-0</idno><idno type="PII">0006-8993(86)91401-0</idno><idno type="ArticleID">86914010</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1986</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The molecular forms of acetylcholinesterase (AChE) and butyrylcholinesterasse (BChE) were studied in frontal cortex (grey and white matter), postmortem, and in cerebrospinal fluid (CSF) of demented patients with Parkinson's diesease compared to controls and non-demented parkinsonians. In the frontal cortex, AChE activity decreased significantly in both demented and non-demented parkinsonian subjects compared to controls; the 10S form of the enzyme was significantly lower in demented parkinsonians than in the non-demented subjects. The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. BChE activity decreased only in the non-demented parkinsonians; in the demented subjects, BChE activity was at control levels. Similar results were obtained with grey and white matter, although absolute levels of the two enzymes were different in the two types of tissue, suggesting that the enzymes were affected in the cholinergic neurones before transport to cortical nerve terminals. No decreases in AChE or BChE activity were observed in the CSF of the patients studied. On the contrary, AChE and BChE levels were significantly higher in demented parkinsonian patients compared to the non-demented subjects.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>parkinsonism</term></item><item><term>dementia</term></item><item><term>acetylcholinesterase</term></item><item><term>butyrylcholinesterase</term></item><item><term>cerebrospinal fluid</term></item><item><term>human brain</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985-04-23">Registration</change><change when="1985">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>BRES</jid><aid>86914010</aid><ce:pii>0006-8993(86)91401-0</ce:pii><ce:doi>10.1016/0006-8993(86)91401-0</ce:doi><ce:copyright type="unknown" year="1986">Elsevier Science Publishers B.V. (Biomedical Division)</ce:copyright></item-info><head><ce:title>Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease</ce:title><ce:author-group><ce:author><ce:given-name>Merle</ce:given-name><ce:surname>Ruberg</ce:surname><ce:cross-ref refid="cor1"><ce:sup loc="post">*</ce:sup></ce:cross-ref><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>François</ce:given-name><ce:surname>Rieger</ce:surname><ce:cross-ref refid="aff2"><ce:sup loc="post">2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Albert</ce:given-name><ce:surname>Villageois</ce:surname><ce:cross-ref refid="aff2"><ce:sup loc="post">2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Anne Marie</ce:given-name><ce:surname>Bonnet</ce:surname><ce:cross-ref refid="aff3"><ce:sup loc="post">3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yves</ce:given-name><ce:surname>Agid</ce:surname><ce:cross-ref refid="aff3"><ce:sup loc="post">3</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>a</ce:label><ce:textfn>INSERM U.289, Facultéde Médecine, Pitteé-Salpêtrière, 91, Boulevard de l'Hoˆpital, France</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>b</ce:label><ce:textfn>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</ce:textfn></ce:affiliation><ce:affiliation id="aff3"><ce:label>c</ce:label><ce:textfn>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text><ce:italic>Correspondence</ce:italic>: M. Ruberg, INSERM U.289, Facultéde Médecine, Pitié-Salpêtrière, 91, Boulevard de l'Hoˆpital, 75005 Paris, France.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="23" month="4" year="1985"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">The molecular forms of acetylcholinesterase (AChE) and butyrylcholinesterasse (BChE) were studied in frontal cortex (grey and white matter), postmortem, and in cerebrospinal fluid (CSF) of demented patients with Parkinson's diesease compared to controls and non-demented parkinsonians. In the frontal cortex, AChE activity decreased significantly in both demented and non-demented parkinsonian subjects compared to controls; the 10S form of the enzyme was significantly lower in demented parkinsonians than in the non-demented subjects. The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. BChE activity decreased only in the non-demented parkinsonians; in the demented subjects, BChE activity was at control levels. Similar results were obtained with grey and white matter, although absolute levels of the two enzymes were different in the two types of tissue, suggesting that the enzymes were affected in the cholinergic neurones before transport to cortical nerve terminals. No decreases in AChE or BChE activity were observed in the CSF of the patients studied. 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Sci.</sb:maintitle></sb:title><sb:volume-nr>57</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>407</sb:first-page><sb:last-page>417</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Merle</namePart><namePart type="family">Ruberg</namePart><affiliation>INSERM U.289, Facultéde Médecine, Pitteé-Salpêtrière, 91, Boulevard de l'Hoˆpital, France</affiliation><description>Correspondence: M. Ruberg, INSERM U.289, Facultéde Médecine, Pitié-Salpêtrière, 91, Boulevard de l'Hoˆpital, 75005 Paris, France.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">François</namePart><namePart type="family">Rieger</namePart><affiliation>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Albert</namePart><namePart type="family">Villageois</namePart><affiliation>INSERM U.153, 17, rue du Fer-à-Moulin, 75005 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne Marie</namePart><namePart type="family">Bonnet</namePart><affiliation>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Agid</namePart><affiliation>Clinique de Neurologie et de Neuropsychologie, Hoˆpital de Salpêtriè, 47, Boulevard de l'Hoˆpital, 75013 Paris France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued><dateValid encoding="w3cdtf">1985-04-23</dateValid><copyrightDate encoding="w3cdtf">1986</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The molecular forms of acetylcholinesterase (AChE) and butyrylcholinesterasse (BChE) were studied in frontal cortex (grey and white matter), postmortem, and in cerebrospinal fluid (CSF) of demented patients with Parkinson's diesease compared to controls and non-demented parkinsonians. In the frontal cortex, AChE activity decreased significantly in both demented and non-demented parkinsonian subjects compared to controls; the 10S form of the enzyme was significantly lower in demented parkinsonians than in the non-demented subjects. The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. BChE activity decreased only in the non-demented parkinsonians; in the demented subjects, BChE activity was at control levels. Similar results were obtained with grey and white matter, although absolute levels of the two enzymes were different in the two types of tissue, suggesting that the enzymes were affected in the cholinergic neurones before transport to cortical nerve terminals. No decreases in AChE or BChE activity were observed in the CSF of the patients studied. On the contrary, AChE and BChE levels were significantly higher in demented parkinsonian patients compared to the non-demented subjects.</abstract><subject lang="en"><genre>Keywords</genre><topic>parkinsonism</topic><topic>dementia</topic><topic>acetylcholinesterase</topic><topic>butyrylcholinesterase</topic><topic>cerebrospinal fluid</topic><topic>human brain</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19860101</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X1303-0</identifier><part><detail type="volume"><number>362</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>204</end></extent><extent unit="pages"><start>83</start><end>91</end></extent></part></relatedItem><identifier type="istex">4B41EC21F26801F7DFB64511368D7E188E5DBF8D</identifier><identifier type="DOI">10.1016/0006-8993(86)91401-0</identifier><identifier type="PII">0006-8993(86)91401-0</identifier><identifier type="ArticleID">86914010</identifier><accessCondition type="use and reproduction" contentType="">© 1986Elsevier Science Publishers B.V. 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