Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases
Identifieur interne : 000876 ( Main/Corpus ); précédent : 000875; suivant : 000877Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases
Auteurs : Anna G Mez ; Isidre FerrerSource :
- Journal of Neuroscience Research [ 0360-4012 ] ; 2009-03.
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Abstract
Lipoxidative damage of aldolase A, enolase 1, and glyceraldehyde dehydrogenase (GAPDH) was found in the frontal cortex in a percentage of aged controls by bidimensional gel electrophoresis, Western blot test, in‐gel digestion, and mass spectrometry. Aldolase A and enolase 1 were altered in 12 of 19 cases, whereas oxidation of GAPDH was found in 6 of 19 controls. The three enzymes were oxidized in the frontal cortex in the majority of cases of incidental Parkinson's disease (iPD), PD, and dementia with Lewy bodies (DLB). Differences were statistically significant (χ2 test) for GAPDH in PD and DLB. Densitometric studies have shown that the ratio of oxidized protein per spot is higher in iPD, PD, and DLB compared with controls. These findings show oxidation of three enzymes linked with glycolysis and energy metabolism in the adult human brain as well as increased oxidation of aldolase A, enolase 1, and GAPDH in the frontal cortex in Lewy body diseases. Modifications of these enzymes may result in decreased activity and may partly account for impaired metabolism and function of the frontal lobe in PD. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/jnr.21904
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Aldolase A and enolase 1 were altered in 12 of 19 cases, whereas oxidation of GAPDH was found in 6 of 19 controls. The three enzymes were oxidized in the frontal cortex in the majority of cases of incidental Parkinson's disease (iPD), PD, and dementia with Lewy bodies (DLB). Differences were statistically significant (χ2 test) for GAPDH in PD and DLB. Densitometric studies have shown that the ratio of oxidized protein per spot is higher in iPD, PD, and DLB compared with controls. These findings show oxidation of three enzymes linked with glycolysis and energy metabolism in the adult human brain as well as increased oxidation of aldolase A, enolase 1, and GAPDH in the frontal cortex in Lewy body diseases. Modifications of these enzymes may result in decreased activity and may partly account for impaired metabolism and function of the frontal lobe in PD. © 2008 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Anna Gómez</name><affiliations><json:string>Institut Neuropatologia, Servei Anatomia Patològica, Idibell‐Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain</json:string></affiliations></json:item><json:item><name>Isidre Ferrer</name><affiliations><json:string>Institut Neuropatologia, Servei Anatomia Patològica, Idibell‐Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lewy body disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia with Lewy bodies</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>incidental Lewy body disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>aldolase A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>enolase 1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>glyceraldehyde dehydrogenase</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>oxidative damage</value></json:item></subject><articleId><json:string>JNR21904</json:string></articleId><language><json:string>eng</json:string></language><abstract>Lipoxidative damage of aldolase A, enolase 1, and glyceraldehyde dehydrogenase (GAPDH) was found in the frontal cortex in a percentage of aged controls by bidimensional gel electrophoresis, Western blot test, in‐gel digestion, and mass spectrometry. 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Aldolase A and enolase 1 were altered in 12 of 19 cases, whereas oxidation of GAPDH was found in 6 of 19 controls. The three enzymes were oxidized in the frontal cortex in the majority of cases of incidental Parkinson's disease (iPD), PD, and dementia with Lewy bodies (DLB). Differences were statistically significant (χ<sup>2</sup> test) for GAPDH in PD and DLB. Densitometric studies have shown that the ratio of oxidized protein per spot is higher in iPD, PD, and DLB compared with controls. These findings show oxidation of three enzymes linked with glycolysis and energy metabolism in the adult human brain as well as increased oxidation of aldolase A, enolase 1, and GAPDH in the frontal cortex in Lewy body diseases. Modifications of these enzymes may result in decreased activity and may partly account for impaired metabolism and function of the frontal lobe in PD. © 2008 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Oxidation in Frontal Cortex in Lewy Body Diseases</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases</title></titleInfo><name type="personal"><namePart type="given">Anna</namePart><namePart type="family">Gómez</namePart><affiliation>Institut Neuropatologia, Servei Anatomia Patològica, Idibell‐Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Isidre</namePart><namePart type="family">Ferrer</namePart><affiliation>Institut Neuropatologia, Servei Anatomia Patològica, Idibell‐Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain</affiliation><description>Correspondence: Institut Neuropatologia, Servei Anatomia Patològica, Idibell‐Hospital Universitari de Bellvitge, carrer Feixa Llarga sn 08907, Hospitalet de Llobregat, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-03</dateIssued><dateCaptured encoding="w3cdtf">2008-06-04</dateCaptured><dateValid encoding="w3cdtf">2008-08-19</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">7</extent><extent unit="tables">3</extent><extent unit="references">59</extent><extent unit="words">8003</extent></physicalDescription><abstract lang="en">Lipoxidative damage of aldolase A, enolase 1, and glyceraldehyde dehydrogenase (GAPDH) was found in the frontal cortex in a percentage of aged controls by bidimensional gel electrophoresis, Western blot test, in‐gel digestion, and mass spectrometry. Aldolase A and enolase 1 were altered in 12 of 19 cases, whereas oxidation of GAPDH was found in 6 of 19 controls. The three enzymes were oxidized in the frontal cortex in the majority of cases of incidental Parkinson's disease (iPD), PD, and dementia with Lewy bodies (DLB). Differences were statistically significant (χ2 test) for GAPDH in PD and DLB. Densitometric studies have shown that the ratio of oxidized protein per spot is higher in iPD, PD, and DLB compared with controls. These findings show oxidation of three enzymes linked with glycolysis and energy metabolism in the adult human brain as well as increased oxidation of aldolase A, enolase 1, and GAPDH in the frontal cortex in Lewy body diseases. Modifications of these enzymes may result in decreased activity and may partly account for impaired metabolism and function of the frontal lobe in PD. © 2008 Wiley‐Liss, Inc.</abstract><note type="funding">Spanish Ministry of Health - No. PI05/1570; </note><note type="funding">Instituto de Salud Carlos III</note><note type="funding">European Commission under the Sixth Framework Programme</note><note type="funding">BrainNet Europe II - No. LSHM‐CT‐2004‐503039; </note><note type="funding">INDABIP</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson disease</topic><topic>Lewy body disease</topic><topic>dementia with Lewy bodies</topic><topic>incidental Lewy body disease</topic><topic>aldolase A</topic><topic>enolase 1</topic><topic>glyceraldehyde dehydrogenase</topic><topic>oxidative damage</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neuroscience Research</title></titleInfo><titleInfo type="abbreviated"><title>J. Neurosci. 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