Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy
Identifieur interne : 000857 ( Main/Corpus ); précédent : 000856; suivant : 000858Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy
Auteurs : Martin Köllensperger ; Klaus Seppi ; Claudia Liener ; Sylvia Boesch ; Dirk Heute ; Katherina J. Mair ; Joerg Mueller ; Martin Sawires ; Christoph Scherfler ; Michael F. Schocke ; Eveline Donnemilier ; Irene Virgolini ; Gregor K. Wenning ; Werner PoeweSource :
- Movement Disorders [ 0885-3185 ] ; 2007-09-15.
English descriptors
Abstract
Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21614
Links to Exploration step
ISTEX:A102EE0D4B9850C17E566F570FC6BA81BF454B28Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title><author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Liener, Claudia" sort="Liener, Claudia" uniqKey="Liener C" first="Claudia" last="Liener">Claudia Liener</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Heute, Dirk" sort="Heute, Dirk" uniqKey="Heute D" first="Dirk" last="Heute">Dirk Heute</name><affiliation><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J." last="Mair">Katherina J. Mair</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Mueller, Joerg" sort="Mueller, Joerg" uniqKey="Mueller J" first="Joerg" last="Mueller">Joerg Mueller</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Schocke, Michael F" sort="Schocke, Michael F" uniqKey="Schocke M" first="Michael F." last="Schocke">Michael F. Schocke</name><affiliation><mods:affiliation>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Donnemilier, Eveline" sort="Donnemilier, Eveline" uniqKey="Donnemilier E" first="Eveline" last="Donnemilier">Eveline Donnemilier</name><affiliation><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Virgolini, Irene" sort="Virgolini, Irene" uniqKey="Virgolini I" first="Irene" last="Virgolini">Irene Virgolini</name><affiliation><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A102EE0D4B9850C17E566F570FC6BA81BF454B28</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21614</idno><idno type="url">https://api.istex.fr/document/A102EE0D4B9850C17E566F570FC6BA81BF454B28/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000857</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title><author><name sortKey="Kollensperger, Martin" sort="Kollensperger, Martin" uniqKey="Kollensperger M" first="Martin" last="Köllensperger">Martin Köllensperger</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Liener, Claudia" sort="Liener, Claudia" uniqKey="Liener C" first="Claudia" last="Liener">Claudia Liener</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Boesch, Sylvia" sort="Boesch, Sylvia" uniqKey="Boesch S" first="Sylvia" last="Boesch">Sylvia Boesch</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Heute, Dirk" sort="Heute, Dirk" uniqKey="Heute D" first="Dirk" last="Heute">Dirk Heute</name><affiliation><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J." last="Mair">Katherina J. Mair</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Mueller, Joerg" sort="Mueller, Joerg" uniqKey="Mueller J" first="Joerg" last="Mueller">Joerg Mueller</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Schocke, Michael F" sort="Schocke, Michael F" uniqKey="Schocke M" first="Michael F." last="Schocke">Michael F. Schocke</name><affiliation><mods:affiliation>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Donnemilier, Eveline" sort="Donnemilier, Eveline" uniqKey="Donnemilier E" first="Eveline" last="Donnemilier">Eveline Donnemilier</name><affiliation><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Virgolini, Irene" sort="Virgolini, Irene" uniqKey="Virgolini I" first="Irene" last="Virgolini">Irene Virgolini</name><affiliation><mods:affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation><mods:affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-09-15">2007-09-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1771">1771</biblScope><biblScope unit="page" to="1776">1776</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A102EE0D4B9850C17E566F570FC6BA81BF454B28</idno><idno type="DOI">10.1002/mds.21614</idno><idno type="ArticleID">MDS21614</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MIBG scintigraphy</term><term>Parkinson's disease</term><term>diffusion weighted imaging</term><term>multiple system atrophy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Martin Köllensperger MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Klaus Seppi MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Claudia Liener MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Sylvia Boesch MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Dirk Heute MD</name><affiliations><json:string>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Katherina J. Mair MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Joerg Mueller MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Martin Sawires MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Christoph Scherfler MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Michael F. Schocke MD</name><affiliations><json:string>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Eveline DonnemilIer MD</name><affiliations><json:string>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Irene Virgolini MD</name><affiliations><json:string>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Gregor K. Wenning MD, PhD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Werner Poewe MD</name><affiliations><json:string>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>MIBG scintigraphy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diffusion weighted imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item></subject><articleId><json:string>MDS21614</json:string></articleId><language><json:string>eng</json:string></language><abstract>Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society</abstract><qualityIndicators><score>6.263</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1385</abstractCharCount><pdfWordCount>3791</pdfWordCount><pdfCharCount>24530</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>206</abstractWordCount></qualityIndicators><title>Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title><genre><json:string>article</json:string></genre><host><volume>22</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>6</total><last>1776</last><first>1771</first></pages><issn><json:string>0885-3185</json:string></issn><issue>12</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mds.21614</json:string></doi><id>A102EE0D4B9850C17E566F570FC6BA81BF454B28</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A102EE0D4B9850C17E566F570FC6BA81BF454B28/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A102EE0D4B9850C17E566F570FC6BA81BF454B28/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A102EE0D4B9850C17E566F570FC6BA81BF454B28/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2007</date></publicationStmt><notesStmt><note>“Jubiläumsfonds der Österreichischen Nationalbank” - No. 10982;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title><author><persName><forename type="first">Martin</forename><surname>Köllensperger</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Klaus</forename><surname>Seppi</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Claudia</forename><surname>Liener</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Sylvia</forename><surname>Boesch</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Dirk</forename><surname>Heute</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Katherina J.</forename><surname>Mair</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Joerg</forename><surname>Mueller</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Martin</forename><surname>Sawires</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Christoph</forename><surname>Scherfler</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Michael F.</forename><surname>Schocke</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Eveline</forename><surname>DonnemilIer</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Irene</forename><surname>Virgolini</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Gregor K.</forename><surname>Wenning</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Professor of Clinical Neurobiology, Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</p></note><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Werner</forename><surname>Poewe</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-09-15"></date><biblScope unit="volume">22</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1771">1771</biblScope><biblScope unit="page" to="1776">1776</biblScope></imprint></monogr><idno type="istex">A102EE0D4B9850C17E566F570FC6BA81BF454B28</idno><idno type="DOI">10.1002/mds.21614</idno><idno type="ArticleID">MDS21614</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>MIBG scintigraphy</term></item><item><term>diffusion weighted imaging</term></item><item><term>Parkinson's disease</term></item><item><term>multiple system atrophy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-02-08">Received</change><change when="2007-05-08">Registration</change><change when="2007-09-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A102EE0D4B9850C17E566F570FC6BA81BF454B28/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/mds.v22:12</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2007-09-15">15 September 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="120" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21614</doi><idGroup><id type="unit" value="MDS21614"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2007 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2007-02-08"></event><event type="manuscriptRevised" date="2007-04-10"></event><event type="manuscriptAccepted" date="2007-05-08"></event><event type="publishedOnlineEarlyUnpaginated" date="2007-06-19"></event><event type="firstOnline" date="2007-06-19"></event><event type="publishedOnlineFinalForm" date="2007-09-21"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">1771</numbering><numbering type="pageLast">1776</numbering></numberingGroup><correspondenceTo>Professor of Clinical Neurobiology, Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21614.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="40"></count><count type="wordTotal" number="4332"></count></countGroup><titleGroup><title type="main" xml:lang="en">Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title><title type="short" xml:lang="en">DW‐MRI and Heart MIBG Scintigraphy</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Martin</givenNames><familyName>Köllensperger</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Klaus</givenNames><familyName>Seppi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Claudia</givenNames><familyName>Liener</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sylvia</givenNames><familyName>Boesch</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Dirk</givenNames><familyName>Heute</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Katherina J.</givenNames><familyName>Mair</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Joerg</givenNames><familyName>Mueller</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Martin</givenNames><familyName>Sawires</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Christoph</givenNames><familyName>Scherfler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Michael F.</givenNames><familyName>Schocke</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Eveline</givenNames><familyName>DonnemilIer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Irene</givenNames><familyName>Virgolini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Gregor K.</givenNames><familyName>Wenning</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email normalForm="gregor.wenning@i-med.ac.at">gregor.wenning@i‐med.ac.at</email></contactDetails></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Werner</givenNames><familyName>Poewe</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="AT" type="organization"><unparsedAffiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="AT" type="organization"><unparsedAffiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="AT" type="organization"><unparsedAffiliation>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">MIBG scintigraphy</keyword><keyword xml:id="kwd2">diffusion weighted imaging</keyword><keyword xml:id="kwd3">Parkinson's disease</keyword><keyword xml:id="kwd4">multiple system atrophy</keyword></keywordGroup><fundingInfo><fundingAgency>“Jubiläumsfonds der Österreichischen Nationalbank”</fundingAgency><fundingNumber>10982</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and <i>meta</i>‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DW‐MRI and Heart MIBG Scintigraphy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy</title></titleInfo><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Köllensperger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Klaus</namePart><namePart type="family">Seppi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudia</namePart><namePart type="family">Liener</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvia</namePart><namePart type="family">Boesch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dirk</namePart><namePart type="family">Heute</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katherina J.</namePart><namePart type="family">Mair</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joerg</namePart><namePart type="family">Mueller</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Sawires</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Scherfler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael F.</namePart><namePart type="family">Schocke</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Radiology I, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eveline</namePart><namePart type="family">DonnemilIer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Irene</namePart><namePart type="family">Virgolini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Nuclear Medicine, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gregor K.</namePart><namePart type="family">Wenning</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><description>Correspondence: Professor of Clinical Neurobiology, Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Werner</namePart><namePart type="family">Poewe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Department of Neurology, Innsbruck Medical University, Anichstraβe 35, A‐6020 Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-09-15</dateIssued><dateCaptured encoding="w3cdtf">2007-02-08</dateCaptured><dateValid encoding="w3cdtf">2007-05-08</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent><extent unit="references">40</extent><extent unit="words">4332</extent></physicalDescription><abstract lang="en">Both diffusion weighted magnetic resonance imaging (DWI) of the basal ganglia and meta‐iodobenzylguanidin (MIBG) scintigraphy of the heart have been reported useful in the differential diagnosis of patients with Parkinson's disease (PD) vs. the parkinson variant of multiple system atrophy (MSA‐P). Their diagnostic value, however, has never been directly compared in patients with parkinsonism and autonomic dysfunction. We have studied 9 patients with PD and 9 patients with MSA‐P matched for age and disease severity. Regional trace of the diffusion tensor values were determined in the putamina. Cardiac MIBG uptake was quantified by comparing regions of interest over heart and mediastinum Heart/Mediastinum (H/M) ratio. Furthermore, all patients underwent tilt testing. PD patients showed significantly lower H/M ratios than normal controls; however, there was considerable overlap between the two patient groups. We did not detect any significant differences of blood pressure response to passive tilt between the two patient groups. Sensitivity of MIBG scintigraphy versus DWI for the differentiation of MSA‐P from PD was 55.6% vs. 100%, specificity 88.8% vs. 100%, and area under the curve 0.802 vs. 1.000. Our data suggest that DWI is superior to both tilt table testing and MIBG scintigraphy in the differential diagnosis of PD versus MSA‐P. © 2007 Movement Disorder Society</abstract><note type="funding">“Jubiläumsfonds der Österreichischen Nationalbank” - No. 10982; </note><subject lang="en"><genre>Keywords</genre><topic>MIBG scintigraphy</topic><topic>diffusion weighted imaging</topic><topic>Parkinson's disease</topic><topic>multiple system atrophy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1771</start><end>1776</end><total>6</total></extent></part></relatedItem><identifier type="istex">A102EE0D4B9850C17E566F570FC6BA81BF454B28</identifier><identifier type="DOI">10.1002/mds.21614</identifier><identifier type="ArticleID">MDS21614</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000857 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000857 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:A102EE0D4B9850C17E566F570FC6BA81BF454B28
|texte= Diffusion weighted imaging best discriminates PD from MSA‐P: A comparison with tilt table testing and heart MIBG scintigraphy
}}
| This area was generated with Dilib version V0.6.23. |  |