Deep brain stimulation effect on freezing of gait
Identifieur interne : 000831 ( Main/Corpus ); précédent : 000830; suivant : 000832Deep brain stimulation effect on freezing of gait
Auteurs : Murielle U. Ferraye ; Bettina Debû ; Pierre PollakSource :
- Movement Disorders [ 0885-3185 ] ; 2008.
English descriptors
Abstract
The majority of patients with Parkinson's disease suffer from freezing of gait (FOG), which responds more or less to levodopa. Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa‐responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa‐resistant FOG. In the few cases of levodopa‐induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off‐ and on‐levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21975
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ISTEX:715529C6080CF0315467069436DC7AE98A850632Le document en format XML
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Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa‐responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa‐resistant FOG. In the few cases of levodopa‐induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off‐ and on‐levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Murielle U. Ferraye MSc</name><affiliations><json:string>INSERM, U836, Grenoble Institute of Neuroscience, Grenoble, France</json:string><json:string>Université Joseph Fourier, Grenoble, France</json:string></affiliations></json:item><json:item><name>Bettina Debû PhD</name><affiliations><json:string>INSERM, U836, Grenoble Institute of Neuroscience, Grenoble, France</json:string><json:string>Université Joseph Fourier, Grenoble, France</json:string></affiliations></json:item><json:item><name>Pierre Pollak MD</name><affiliations><json:string>INSERM, U836, Grenoble Institute of Neuroscience, Grenoble, France</json:string><json:string>Université Joseph Fourier, Grenoble, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>freezing of gait</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item></subject><articleId><json:string>MDS21975</json:string></articleId><language><json:string>eng</json:string></language><abstract>The majority of patients with Parkinson's disease suffer from freezing of gait (FOG), which responds more or less to levodopa. 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Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off‐ and on‐levodopa gait impairments. 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Thalamic stimulation, mainly used in the treatment of tremor dominant Parkinson's disease is ineffective in FOG. GPi stimulation moderately improves FOG, but this effect may abate in the long term. STN stimulation was reported to improve levodopa‐responsive FOG. In some patients, the benefit from levodopa is greater than that from STN stimulation, and levodopa and STN stimulation can have additive effects. On the contrary, STN stimulation is ineffective on levodopa‐resistant FOG. In the few cases of levodopa‐induced FOG, STN stimulation can indirectly be effective, thanks to a great decrease or arrest of levodopa. Stimulation of the pedunculopontine nucleus has recently been performed in small groups of patients suffering from both off‐ and on‐levodopa gait impairments. The first results appear encouraging, but they need to be confirmed by controlled studies in larger series of patients. © 2008 Movement Disorder Society</abstract><note type="content">*No potential conflict of interest.</note><note type="funding">Michael J. Fox Foundation</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson disease</topic><topic>freezing of gait</topic><topic>deep brain stimulation</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. 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