Non‐motor symptoms in Parkinson’s disease
Identifieur interne : 000818 ( Main/Corpus ); précédent : 000817; suivant : 000819Non‐motor symptoms in Parkinson’s disease
Auteurs : W. PoeweSource :
- European Journal of Neurology [ 1351-5101 ] ; 2008-04.
English descriptors
- KwdEn :
Abstract
Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.
Url:
DOI: 10.1111/j.1468-1331.2008.02056.x
Links to Exploration step
ISTEX:689BD88B651B71416308CDFC2199A8A3052FA007Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non‐motor symptoms in Parkinson’s disease</title><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W." last="Poewe">W. Poewe</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:689BD88B651B71416308CDFC2199A8A3052FA007</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1468-1331.2008.02056.x</idno><idno type="url">https://api.istex.fr/document/689BD88B651B71416308CDFC2199A8A3052FA007/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000818</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Non‐motor symptoms in Parkinson’s disease</title><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W." last="Poewe">W. Poewe</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-04">2008-04</date><biblScope unit="volume">15</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="14">14</biblScope><biblScope unit="page" to="20">20</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">689BD88B651B71416308CDFC2199A8A3052FA007</idno><idno type="DOI">10.1111/j.1468-1331.2008.02056.x</idno><idno type="ArticleID">ENE2056</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>autonomic dysfunction</term><term>dementia</term><term>depression</term><term>psychosis</term><term>sleep disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>W. Poewe</name><affiliations><json:string>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>autonomic dysfunction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>depression</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>psychosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sleep disorders</value></json:item></subject><articleId><json:string>ENE2056</json:string></articleId><language><json:string>eng</json:string></language><abstract>Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.</abstract><qualityIndicators><score>6.776</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1410</abstractCharCount><pdfWordCount>3924</pdfWordCount><pdfCharCount>26725</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>196</abstractWordCount></qualityIndicators><title>Non‐motor symptoms in Parkinson’s disease</title><genre><json:string>article</json:string></genre><host><volume>15</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>7</total><last>20</last><first>14</first></pages><issn><json:string>1351-5101</json:string></issn><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1468-1331.2008.02056.x</json:string></doi><id>689BD88B651B71416308CDFC2199A8A3052FA007</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/689BD88B651B71416308CDFC2199A8A3052FA007/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/689BD88B651B71416308CDFC2199A8A3052FA007/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/689BD88B651B71416308CDFC2199A8A3052FA007/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Non‐motor symptoms in Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Non‐motor symptoms in Parkinson’s disease</title><author><persName><forename type="first">W.</forename><surname>Poewe</surname></persName><affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-04"></date><biblScope unit="volume">15</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="14">14</biblScope><biblScope unit="page" to="20">20</biblScope></imprint></monogr><idno type="istex">689BD88B651B71416308CDFC2199A8A3052FA007</idno><idno type="DOI">10.1111/j.1468-1331.2008.02056.x</idno><idno type="ArticleID">ENE2056</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>autonomic dysfunction</term></item><item><term>dementia</term></item><item><term>depression</term></item><item><term>Parkinson’s disease</term></item><item><term>psychosis</term></item><item><term>sleep disorders</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/689BD88B651B71416308CDFC2199A8A3052FA007/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04000"><doi origin="wiley">10.1111/ene.2008.15.issue-s1</doi><titleGroup><title type="specialIssueTitle">The Scientific and Clinical Basis for Future Therapies in Parkinson’s Disease</title></titleGroup><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="supplement">s1</numbering></numberingGroup><coverDate startDate="2008-04">April 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2008.02056.x</doi><idGroup><id type="unit" value="ENE2056"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2008 The Author</copyright><eventGroup><event type="firstOnline" date="2008-03-17"></event><event type="publishedOnlineFinalForm" date="2008-03-17"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="14">14</numbering><numbering type="pageLast" number="20">20</numbering></numberingGroup><correspondenceTo>Prof. W. Poewe, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A‐6020 Innsbruck, Austria (tel.: +43 512 504 23850; fax: +43 512 504 23852; e‐mail: <email normalForm="werner.poewe@i-med.ac.at">werner.poewe@i‐med.ac.at</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2056.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 29 November 2007 Accepted 10 December 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Non‐motor symptoms in Parkinson’s disease</title><title type="shortAuthors">W. Poewe</title><title type="short">Non‐motor symptoms in Parkinson’s disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>W.</givenNames><familyName>Poewe</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="AT"><unparsedAffiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">autonomic dysfunction</keyword><keyword xml:id="k2">dementia</keyword><keyword xml:id="k3">depression</keyword><keyword xml:id="k4">Parkinson’s disease</keyword><keyword xml:id="k5">psychosis</keyword><keyword xml:id="k6">sleep disorders</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Non‐motor symptoms in Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Non‐motor symptoms in Parkinson’s disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Non‐motor symptoms in Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Poewe</namePart><affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-04</dateIssued><edition>Received 29 November 2007 Accepted 10 December 2007</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders. Sensory dysfunction with hyposmia or pain is almost universal, as are disturbances of sleep–wake cycle regulation. Autonomic dysfunction including orthostatic hypotension, urogenital dysfunction and constipation is also present to some degree in a majority of patients. Whilst overall non‐motor symptoms become increasingly prevalent with advancing disease, many of them can also antedate the first occurrence of motor signs – most notably depression, hyposmia or rapid eye movement sleep behaviour disorder (RBD). Although exact clinicopathological correlations for most of these non‐motor features are still poorly understood, the occurrence of constipation, RBD or hyposmia prior to the onset of clinically overt motor dysfunction would appear consistent with the ascending hypothesis of PD pathology proposed by Braak and colleagues. Screening these early non‐motor features might, therefore, be one approach towards early ‘preclinical’ diagnosis of PD. This review article provides an overview of the clinical spectrum of non‐motor symptoms in PD together with a brief review of treatment options.</abstract><subject lang="en"><genre>Keywords</genre><topic>autonomic dysfunction</topic><topic>dementia</topic><topic>depression</topic><topic>Parkinson’s disease</topic><topic>psychosis</topic><topic>sleep disorders</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2008</date><detail type="title"><title>The Scientific and Clinical Basis for Future Therapies in Parkinson’s Disease</title></detail><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>14</start><end>20</end><total>7</total></extent></part></relatedItem><identifier type="istex">689BD88B651B71416308CDFC2199A8A3052FA007</identifier><identifier type="DOI">10.1111/j.1468-1331.2008.02056.x</identifier><identifier type="ArticleID">ENE2056</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Author</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000818 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000818 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:689BD88B651B71416308CDFC2199A8A3052FA007
|texte= Non‐motor symptoms in Parkinson’s disease
}}
| This area was generated with Dilib version V0.6.23. |  |