Comparing exercise in Parkinson's disease—the Berlin BIG Study
Identifieur interne : 000815 ( Main/Corpus ); précédent : 000814; suivant : 000816Comparing exercise in Parkinson's disease—the Berlin BIG Study
Auteurs : Georg Ebersbach ; Almut Ebersbach ; Daniela Edler ; Olaf Kaufhold ; Matthias Kusch ; Andreas Kupsch ; Jörg WisselSource :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
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Abstract
Physiotherapy is widely used in Parkinson's disease (PD), but there are few controlled studies comparing active interventions. Recently, a technique named “LSVT®BIG” has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high‐amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one‐to‐one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow‐up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS‐motor score at final assessment (P < 0.001). Mean improvement of UPDRS in BIG was −5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed‐up‐and‐go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23212
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1902">1902</biblScope><biblScope unit="page" to="1908">1908</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E1386616813DEBA05880F997E555D6F7ECC0AC9A</idno><idno type="DOI">10.1002/mds.23212</idno><idno type="ArticleID">MDS23212</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>LSVT®BIG</term><term>Nordic walking</term><term>Parkinson's disease</term><term>exercise</term><term>physiotherapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Physiotherapy is widely used in Parkinson's disease (PD), but there are few controlled studies comparing active interventions. Recently, a technique named “LSVT®BIG” has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high‐amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one‐to‐one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow‐up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS‐motor score at final assessment (P < 0.001). Mean improvement of UPDRS in BIG was −5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed‐up‐and‐go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Georg Ebersbach MD</name><affiliations><json:string>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</json:string></affiliations></json:item><json:item><name>Almut Ebersbach MD</name><affiliations><json:string>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</json:string></affiliations></json:item><json:item><name>Daniela Edler MD</name><affiliations><json:string>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</json:string></affiliations></json:item><json:item><name>Olaf Kaufhold BSc</name><affiliations><json:string>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</json:string></affiliations></json:item><json:item><name>Matthias Kusch MD</name><affiliations><json:string>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</json:string></affiliations></json:item><json:item><name>Andreas Kupsch MD</name><affiliations><json:string>Department of Neurology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</json:string></affiliations></json:item><json:item><name>Jörg Wissel MD</name><affiliations><json:string>Neurologische Rehabilitationsklinik, Beelitz‐Heilstätten, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>LSVT®BIG</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Nordic walking</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>exercise</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>physiotherapy</value></json:item></subject><articleId><json:string>MDS23212</json:string></articleId><language><json:string>eng</json:string></language><abstract>Physiotherapy is widely used in Parkinson's disease (PD), but there are few controlled studies comparing active interventions. Recently, a technique named “LSVT®BIG” has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high‐amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one‐to‐one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow‐up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS‐motor score at final assessment (P > 0.001). Mean improvement of UPDRS in BIG was −5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed‐up‐and‐go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>6.435</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1432</abstractCharCount><pdfWordCount>3807</pdfWordCount><pdfCharCount>26155</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>219</abstractWordCount></qualityIndicators><title>Comparing exercise in Parkinson's disease—the Berlin BIG Study</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>1908</last><first>1902</first></pages><issn><json:string>0885-3185</json:string></issn><issue>12</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23212</json:string></doi><id>E1386616813DEBA05880F997E555D6F7ECC0AC9A</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/E1386616813DEBA05880F997E555D6F7ECC0AC9A/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/E1386616813DEBA05880F997E555D6F7ECC0AC9A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E1386616813DEBA05880F997E555D6F7ECC0AC9A/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Comparing exercise in Parkinson's disease—the Berlin BIG Study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Comparing exercise in Parkinson's disease—the Berlin BIG Study</title><author><persName><forename type="first">Georg</forename><surname>Ebersbach</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Fachkrankenhaus für Bewegungsstörungen / Parkinson, Paracelsusring 6a, 14547 Beelitz‐Heilstätten, Germany</p></note><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation></author><author><persName><forename type="first">Almut</forename><surname>Ebersbach</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation></author><author><persName><forename type="first">Daniela</forename><surname>Edler</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation></author><author><persName><forename type="first">Olaf</forename><surname>Kaufhold</surname></persName><roleName type="degree">BSc</roleName><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation></author><author><persName><forename type="first">Matthias</forename><surname>Kusch</surname></persName><roleName type="degree">MD</roleName><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation></author><author><persName><forename type="first">Andreas</forename><surname>Kupsch</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</affiliation></author><author><persName><forename type="first">Jörg</forename><surname>Wissel</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurologische Rehabilitationsklinik, Beelitz‐Heilstätten, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1902">1902</biblScope><biblScope unit="page" to="1908">1908</biblScope></imprint></monogr><idno type="istex">E1386616813DEBA05880F997E555D6F7ECC0AC9A</idno><idno type="DOI">10.1002/mds.23212</idno><idno type="ArticleID">MDS23212</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Physiotherapy is widely used in Parkinson's disease (PD), but there are few controlled studies comparing active interventions. Recently, a technique named “LSVT®BIG” has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high‐amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one‐to‐one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow‐up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS‐motor score at final assessment (P < 0.001). Mean improvement of UPDRS in BIG was −5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed‐up‐and‐go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>LSVT®BIG</term></item><item><term>Nordic walking</term></item><item><term>exercise</term></item><item><term>physiotherapy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-12-15">Received</change><change when="2010-03-30">Registration</change><change when="2010-09-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E1386616813DEBA05880F997E555D6F7ECC0AC9A/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Recently, a technique named “LSVT®BIG” has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high‐amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one‐to‐one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow‐up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS‐motor score at final assessment (<i>P</i> < 0.001). Mean improvement of UPDRS in BIG was −5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed‐up‐and‐go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparing exercise in Parkinson's disease—the Berlin BIG Study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Exercise in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparing exercise in Parkinson's disease—the Berlin BIG Study</title></titleInfo><name type="personal"><namePart type="given">Georg</namePart><namePart type="family">Ebersbach</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation><description>Correspondence: Fachkrankenhaus für Bewegungsstörungen / Parkinson, Paracelsusring 6a, 14547 Beelitz‐Heilstätten, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Almut</namePart><namePart type="family">Ebersbach</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniela</namePart><namePart type="family">Edler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Olaf</namePart><namePart type="family">Kaufhold</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias</namePart><namePart type="family">Kusch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Clinic, Beelitz‐Heilstätten, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Kupsch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Charité University Medicine Berlin, Campus Virchow, Berlin, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jörg</namePart><namePart type="family">Wissel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologische Rehabilitationsklinik, Beelitz‐Heilstätten, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-09-15</dateIssued><dateCaptured encoding="w3cdtf">2009-12-15</dateCaptured><dateValid encoding="w3cdtf">2010-03-30</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">41</extent><extent unit="words">4531</extent></physicalDescription><abstract lang="en">Physiotherapy is widely used in Parkinson's disease (PD), but there are few controlled studies comparing active interventions. Recently, a technique named “LSVT®BIG” has been introduced. LSVT®BIG is derived from the Lee Silverman Voice Treatment and focuses on intensive exercising of high‐amplitude movements. In the present comparative study, 60 patients with mild to moderate PD were randomly assigned to receive either one‐to‐one training (BIG), group training of Nordic Walking (WALK), or domestic nonsupervised exercises (HOME). Patients in training (BIG) and WALK received 16 hours of supervised training within 4 (BIG) or 8 (WALK) weeks. The primary efficacy measure was difference in change in Unified Parkinson's Disease Rating Scale (UPDRS) motor score from baseline to follow‐up at 16 weeks between groups. UPDRS scores were obtained by blinded video rating. ANCOVA showed significant group differences for UPDRS‐motor score at final assessment (P < 0.001). Mean improvement of UPDRS in BIG was −5.05 (SD 3.91) whereas there was a mild deterioration of 0.58 (SD 3.17) in WALK and of 1.68 (SD 5.95) in HOME. LSVT®BIG was also superior to WALK and HOME in timed‐up‐and‐go and timed 10 m walking. There were no significant group differences for quality of life (PDQ39). These results provide evidence that LSVT®BIG is an effective technique to improve motor performance in patients with PD. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>LSVT®BIG</topic><topic>Nordic walking</topic><topic>exercise</topic><topic>physiotherapy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1902</start><end>1908</end><total>7</total></extent></part></relatedItem><identifier type="istex">E1386616813DEBA05880F997E555D6F7ECC0AC9A</identifier><identifier type="DOI">10.1002/mds.23212</identifier><identifier type="ArticleID">MDS23212</identifier><accessCondition type="use and reproduction" contentType="copyright">Published 2010 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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