Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
Identifieur interne : 000640 ( Main/Corpus ); précédent : 000639; suivant : 000641Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered
Auteurs : Heiko Braak ; Jürgen R. Bohl ; Christian M. Müller ; Udo Rüb ; Rob A. I. De Vos ; Kelly Del TrediciSource :
- Movement Disorders [ 0885-3185 ] ; 2006-12.
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- KwdEn :
Abstract
The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid‐ and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross‐sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age‐ and gender‐matched controls. Here, the staging hypothesis is critically reconsidered and discussed. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21065
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ISTEX:D0F3B49CC3CA1E54780D86FD5BD8C87D7368E124Le document en format XML
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A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid‐ and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross‐sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age‐ and gender‐matched controls. Here, the staging hypothesis is critically reconsidered and discussed. © 2006 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Heiko Braak MD</name><affiliations><json:string>Institute for Clinical Neuroanatomy, J.W. Goethe University, Frankfurt/Main, BRD</json:string></affiliations></json:item><json:item><name>Jürgen R. Bohl MD</name><affiliations><json:string>Department of Neuropathology, Johannes Gutenberg University, Mainz, BRD</json:string></affiliations></json:item><json:item><name>Christian M. Müller PhD</name><affiliations><json:string>Institute for Clinical Neuroanatomy, J.W. 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This cross‐sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age‐ and gender‐matched controls. Here, the staging hypothesis is critically reconsidered and discussed. © 2006 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>aging</term></item><item><term>α‐synuclein</term></item><item><term>Lewy bodies/neurites</term></item><item><term>pathoarchitectonics</term></item><item><term>sporadic Parkinson's disease</term></item><item><term>staging</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005-05-15">Received</change><change when="2005-10-21">Registration</change><change when="2006-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/D0F3B49CC3CA1E54780D86FD5BD8C87D7368E124/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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Goethe University, Frankfurt/Main, BRD</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neuropathology, Johannes Gutenberg University, Mainz, BRD</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NL" type="organization"><unparsedAffiliation>Laboratorium Pathologie Oost Nederland, Enschede, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">aging</keyword><keyword xml:id="kwd2">α‐synuclein</keyword><keyword xml:id="kwd3">Lewy bodies/neurites</keyword><keyword xml:id="kwd4">pathoarchitectonics</keyword><keyword xml:id="kwd5">sporadic Parkinson's disease</keyword><keyword xml:id="kwd6">staging</keyword></keywordGroup><fundingInfo><fundingAgency>Deutsche Forschungsgemeinschaft (DFG)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid‐ and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross‐sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age‐ and gender‐matched controls. Here, the staging hypothesis is critically reconsidered and discussed. © 2006 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Stanley Fahn Lecture 2005</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered</title></titleInfo><name type="personal"><namePart type="given">Heiko</namePart><namePart type="family">Braak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute for Clinical Neuroanatomy, J.W. Goethe University, Frankfurt/Main, BRD</affiliation><description>Correspondence: Institute for Clinical Neuroanatomy, J.W. Goethe University, Theodor Stern Kai 7, 60590 Frankfurt/Main, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jürgen R.</namePart><namePart type="family">Bohl</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuropathology, Johannes Gutenberg University, Mainz, BRD</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian M.</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute for Clinical Neuroanatomy, J.W. Goethe University, Frankfurt/Main, BRD</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Udo</namePart><namePart type="family">Rüb</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute for Clinical Neuroanatomy, J.W. Goethe University, Frankfurt/Main, BRD</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rob A.I.</namePart><namePart type="family">de Vos</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratorium Pathologie Oost Nederland, Enschede, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kelly</namePart><namePart type="family">Del Tredici</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Institute for Clinical Neuroanatomy, J.W. Goethe University, Frankfurt/Main, BRD</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-12</dateIssued><dateCaptured encoding="w3cdtf">2005-05-15</dateCaptured><dateValid encoding="w3cdtf">2005-10-21</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">110</extent><extent unit="words">6640</extent></physicalDescription><abstract lang="en">The synucleinopathy known as sporadic Parkinson's disease (PD) is a multisystem disorder that severely damages predisposed nerve cell types in circumscribed regions of the human nervous system. A recent staging procedure for the inclusion body pathology associated with PD proposes that, in the brain, the pathological process (formation of proteinaceous intraneuronal Lewy bodies and Lewy neurites) begins at two sites and continues in a topographically predictable sequence in six stages, during which components of the olfactory, autonomic, limbic, and somatomotor systems become progressively involved. In stages 1 to 2, the Lewy body pathology is confined to the medulla oblongata/pontine tegmentum and anterior olfactory structures. In stages 3 to 4, the substantia nigra and other nuclei of the basal mid‐ and forebrain become the focus of initially subtle and, then, severe changes. During this phase, the illness probably becomes clinically manifest. In the final stages 5 to 6, the lesions appear in the neocortex. This cross‐sectional study originally was performed on 168 autopsy cases using material from 69 incidental cases and 41 clinically diagnosed PD patients as well as 58 age‐ and gender‐matched controls. Here, the staging hypothesis is critically reconsidered and discussed. © 2006 Movement Disorder Society</abstract><note type="funding">Deutsche Forschungsgemeinschaft (DFG)</note><subject lang="en"><genre>Keywords</genre><topic>aging</topic><topic>α‐synuclein</topic><topic>Lewy bodies/neurites</topic><topic>pathoarchitectonics</topic><topic>sporadic Parkinson's disease</topic><topic>staging</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Review</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>2042</start><end>2051</end><total>10</total></extent></part></relatedItem><identifier type="istex">D0F3B49CC3CA1E54780D86FD5BD8C87D7368E124</identifier><identifier type="DOI">10.1002/mds.21065</identifier><identifier type="ArticleID">MDS21065</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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