Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease
Identifieur interne : 000605 ( Main/Corpus ); précédent : 000604; suivant : 000606Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease
Auteurs : Magdalena Sabaté ; Isidro González ; Felix Ruperez ; Manuel RodríguezSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1995.
Abstract
Pulmonary dysfunction was investigated in fifty-eight Parkinson's patients. Clinical disability was assessed by the Unified Parkinson's Disease Rating Scale. Pulmonary dysfunction was studied by spirometry with flow-volume loops, body plethysmography with lung volumes computation and maximal inspiratory and expiratory static mouth pressures. Forced vital capacity (FVC), forced expiratory volume in 1 min (FEV1), FEV1 FVC% and arterial PO2 and PCO2 were significantly below normal values. Residual volume (RV) and total rows were above normal values. Thirty-six had upper airway obstruction as judged by inspiratory flow peaks (PIF) <31/s and FEV1 PEF% (expiratory flow peak) > 8.51/min and MEF50 MIF50 > 1. Eighteen patients had a central (FEV1 < 80% and FEV1 FVC% < 80% of normal values) or peripheral (maximal expiratory flow between 75% and 25% of FVC and maximal expiratory flow after expiration of 50% below 70% of normal values) obstructive pattern. Sixteen patients had a restrictive dysfunction as judged by a total lung capacity < 85% or FVC < 80% with FEV1 FVC% > 80%. Sixteen patients had air trapping (RV > 120% and RV TLC > 40%) and seven patients had lung insufflation (TLC > 120%). Rigidity, Rx signs of cervical arthrosis and limitations for passive movement of neck were higher in patients with central or peripheral airway obstruction. Bradykinesia and Rx signs of dorsal arthrosis was higher in patients with upper airway obstruction. Restrictive dysfunction was not related to tremor, rigidity or bradykinesia. The present data support the hypothesis that Parkinson patients present a high risk for pneumologic disturbances. These pulmonary dysfunctions are induced by the simultaneous action of a group of factors including the degree of bradykinesia or rigidity and the musculoskeletal limitations of vertebral column probably induced by chronic anomalous posture.
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DOI: 10.1016/0022-510X(96)00003-2
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease</title><author><name sortKey="Sabate, Magdalena" sort="Sabate, Magdalena" uniqKey="Sabate M" first="Magdalena" last="Sabaté">Magdalena Sabaté</name><affiliation><mods:affiliation>Service of Physical Medicine and Rehabilitation, Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tererife, Canary Islands, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez, Isidro" sort="Gonzalez, Isidro" uniqKey="Gonzalez I" first="Isidro" last="González">Isidro González</name><affiliation><mods:affiliation>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</mods:affiliation></affiliation></author><author><name sortKey="Ruperez, Felix" sort="Ruperez, Felix" uniqKey="Ruperez F" first="Felix" last="Ruperez">Felix Ruperez</name><affiliation><mods:affiliation>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez, Manuel" sort="Rodriguez, Manuel" uniqKey="Rodriguez M" first="Manuel" last="Rodríguez">Manuel Rodríguez</name><affiliation><mods:affiliation>Corresponding autor. Fax: 34-22-603529; Phone; 34-22-603492.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physiology, Faculty of Medicine, University of La Laguna, 38320, Tenerife, Canary Islands, Spain</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:075D15621FCD7BFB759007B44D01A890BC9A6ABB</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/0022-510X(96)00003-2</idno><idno type="url">https://api.istex.fr/document/075D15621FCD7BFB759007B44D01A890BC9A6ABB/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000605</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease</title><author><name sortKey="Sabate, Magdalena" sort="Sabate, Magdalena" uniqKey="Sabate M" first="Magdalena" last="Sabaté">Magdalena Sabaté</name><affiliation><mods:affiliation>Service of Physical Medicine and Rehabilitation, Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tererife, Canary Islands, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gonzalez, Isidro" sort="Gonzalez, Isidro" uniqKey="Gonzalez I" first="Isidro" last="González">Isidro González</name><affiliation><mods:affiliation>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</mods:affiliation></affiliation></author><author><name sortKey="Ruperez, Felix" sort="Ruperez, Felix" uniqKey="Ruperez F" first="Felix" last="Ruperez">Felix Ruperez</name><affiliation><mods:affiliation>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez, Manuel" sort="Rodriguez, Manuel" uniqKey="Rodriguez M" first="Manuel" last="Rodríguez">Manuel Rodríguez</name><affiliation><mods:affiliation>Corresponding autor. Fax: 34-22-603529; Phone; 34-22-603492.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Physiology, Faculty of Medicine, University of La Laguna, 38320, Tenerife, Canary Islands, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">138</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="114">114</biblScope><biblScope unit="page" to="119">119</biblScope></imprint><idno type="ISSN">0022-510X</idno></series><idno type="istex">075D15621FCD7BFB759007B44D01A890BC9A6ABB</idno><idno type="DOI">10.1016/0022-510X(96)00003-2</idno><idno type="PII">0022-510X(96)00003-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pulmonary dysfunction was investigated in fifty-eight Parkinson's patients. Clinical disability was assessed by the Unified Parkinson's Disease Rating Scale. Pulmonary dysfunction was studied by spirometry with flow-volume loops, body plethysmography with lung volumes computation and maximal inspiratory and expiratory static mouth pressures. Forced vital capacity (FVC), forced expiratory volume in 1 min (FEV1), FEV1 FVC% and arterial PO2 and PCO2 were significantly below normal values. Residual volume (RV) and total rows were above normal values. Thirty-six had upper airway obstruction as judged by inspiratory flow peaks (PIF) <31/s and FEV1 PEF% (expiratory flow peak) > 8.51/min and MEF50 MIF50 > 1. Eighteen patients had a central (FEV1 < 80% and FEV1 FVC% < 80% of normal values) or peripheral (maximal expiratory flow between 75% and 25% of FVC and maximal expiratory flow after expiration of 50% below 70% of normal values) obstructive pattern. Sixteen patients had a restrictive dysfunction as judged by a total lung capacity < 85% or FVC < 80% with FEV1 FVC% > 80%. Sixteen patients had air trapping (RV > 120% and RV TLC > 40%) and seven patients had lung insufflation (TLC > 120%). Rigidity, Rx signs of cervical arthrosis and limitations for passive movement of neck were higher in patients with central or peripheral airway obstruction. Bradykinesia and Rx signs of dorsal arthrosis was higher in patients with upper airway obstruction. Restrictive dysfunction was not related to tremor, rigidity or bradykinesia. The present data support the hypothesis that Parkinson patients present a high risk for pneumologic disturbances. These pulmonary dysfunctions are induced by the simultaneous action of a group of factors including the degree of bradykinesia or rigidity and the musculoskeletal limitations of vertebral column probably induced by chronic anomalous posture.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Magdalena Sabaté</name><affiliations><json:string>Service of Physical Medicine and Rehabilitation, Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tererife, Canary Islands, Spain</json:string></affiliations></json:item><json:item><name>Isidro González</name><affiliations><json:string>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</json:string></affiliations></json:item><json:item><name>Felix Ruperez</name><affiliations><json:string>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</json:string></affiliations></json:item><json:item><name>Manuel Rodríguez</name><affiliations><json:string>Corresponding autor. Fax: 34-22-603529; Phone; 34-22-603492.</json:string><json:string>Department of Physiology, Faculty of Medicine, University of La Laguna, 38320, Tenerife, Canary Islands, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clinical section</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Pulmonary dysfunction was investigated in fifty-eight Parkinson's patients. Clinical disability was assessed by the Unified Parkinson's Disease Rating Scale. Pulmonary dysfunction was studied by spirometry with flow-volume loops, body plethysmography with lung volumes computation and maximal inspiratory and expiratory static mouth pressures. Forced vital capacity (FVC), forced expiratory volume in 1 min (FEV1), FEV1 FVC% and arterial PO2 and PCO2 were significantly below normal values. Residual volume (RV) and total rows were above normal values. Thirty-six had upper airway obstruction as judged by inspiratory flow peaks (PIF) >31/s and FEV1 PEF% (expiratory flow peak) > 8.51/min and MEF50 MIF50 > 1. Eighteen patients had a central (FEV1 > 80% and FEV1 FVC% > 80% of normal values) or peripheral (maximal expiratory flow between 75% and 25% of FVC and maximal expiratory flow after expiration of 50% below 70% of normal values) obstructive pattern. Sixteen patients had a restrictive dysfunction as judged by a total lung capacity > 85% or FVC > 80% with FEV1 FVC% > 80%. Sixteen patients had air trapping (RV > 120% and RV TLC > 40%) and seven patients had lung insufflation (TLC > 120%). Rigidity, Rx signs of cervical arthrosis and limitations for passive movement of neck were higher in patients with central or peripheral airway obstruction. Bradykinesia and Rx signs of dorsal arthrosis was higher in patients with upper airway obstruction. Restrictive dysfunction was not related to tremor, rigidity or bradykinesia. The present data support the hypothesis that Parkinson patients present a high risk for pneumologic disturbances. These pulmonary dysfunctions are induced by the simultaneous action of a group of factors including the degree of bradykinesia or rigidity and the musculoskeletal limitations of vertebral column probably induced by chronic anomalous posture.</abstract><qualityIndicators><score>6.835</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>1889</abstractCharCount><pdfWordCount>3835</pdfWordCount><pdfCharCount>25090</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>287</abstractWordCount></qualityIndicators><title>Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease</title><pii><json:string>0022-510X(96)00003-2</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>60</volume><pages><last>741</last><first>740</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Sem. 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Fax: 34-22-603529; Phone; 34-22-603492.</affiliation><affiliation>Department of Physiology, Faculty of Medicine, University of La Laguna, 38320, Tenerife, Canary Islands, Spain</affiliation></author></analytic><monogr><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="pISSN">0022-510X</idno><idno type="PII">S0022-510X(00)X0001-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">138</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="114">114</biblScope><biblScope unit="page" to="119">119</biblScope></imprint></monogr><idno type="istex">075D15621FCD7BFB759007B44D01A890BC9A6ABB</idno><idno type="DOI">10.1016/0022-510X(96)00003-2</idno><idno type="PII">0022-510X(96)00003-2</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Pulmonary dysfunction was investigated in fifty-eight Parkinson's patients. Clinical disability was assessed by the Unified Parkinson's Disease Rating Scale. Pulmonary dysfunction was studied by spirometry with flow-volume loops, body plethysmography with lung volumes computation and maximal inspiratory and expiratory static mouth pressures. Forced vital capacity (FVC), forced expiratory volume in 1 min (FEV1), FEV1 FVC% and arterial PO2 and PCO2 were significantly below normal values. Residual volume (RV) and total rows were above normal values. Thirty-six had upper airway obstruction as judged by inspiratory flow peaks (PIF) <31/s and FEV1 PEF% (expiratory flow peak) > 8.51/min and MEF50 MIF50 > 1. Eighteen patients had a central (FEV1 < 80% and FEV1 FVC% < 80% of normal values) or peripheral (maximal expiratory flow between 75% and 25% of FVC and maximal expiratory flow after expiration of 50% below 70% of normal values) obstructive pattern. Sixteen patients had a restrictive dysfunction as judged by a total lung capacity < 85% or FVC < 80% with FEV1 FVC% > 80%. Sixteen patients had air trapping (RV > 120% and RV TLC > 40%) and seven patients had lung insufflation (TLC > 120%). Rigidity, Rx signs of cervical arthrosis and limitations for passive movement of neck were higher in patients with central or peripheral airway obstruction. Bradykinesia and Rx signs of dorsal arthrosis was higher in patients with upper airway obstruction. Restrictive dysfunction was not related to tremor, rigidity or bradykinesia. The present data support the hypothesis that Parkinson patients present a high risk for pneumologic disturbances. These pulmonary dysfunctions are induced by the simultaneous action of a group of factors including the degree of bradykinesia or rigidity and the musculoskeletal limitations of vertebral column probably induced by chronic anomalous posture.</p></abstract><textClass><keywords scheme="keyword"><list><head>Article category</head><item><term>Clinical section</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995-12-16">Registration</change><change when="1995-12-07">Modified</change><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNS</jid><aid>96000032</aid><ce:pii>0022-510X(96)00003-2</ce:pii><ce:doi>10.1016/0022-510X(96)00003-2</ce:doi><ce:copyright type="unknown" year="1996"></ce:copyright><ce:doctopics><ce:doctopic><ce:text>Clinical section</ce:text></ce:doctopic></ce:doctopics></item-info><head><ce:dochead><ce:textfn>Research article</ce:textfn></ce:dochead><ce:title>Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease</ce:title><ce:author-group><ce:author><ce:given-name>Magdalena</ce:given-name><ce:surname>Sabaté</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Isidro</ce:given-name><ce:surname>González</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Felix</ce:given-name><ce:surname>Ruperez</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Manuel</ce:given-name><ce:surname>Rodríguez</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Physiology, Faculty of Medicine, University of La Laguna, 38320, Tenerife, Canary Islands, Spain</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Service of Physical Medicine and Rehabilitation, Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tererife, Canary Islands, Spain</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding autor. Fax: 34-22-603529; Phone; 34-22-603492.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="13" month="2" year="1995"></ce:date-received><ce:date-revised day="7" month="12" year="1995"></ce:date-revised><ce:date-accepted day="16" month="12" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Pulmonary dysfunction was investigated in fifty-eight Parkinson's patients. Clinical disability was assessed by the Unified Parkinson's Disease Rating Scale. Pulmonary dysfunction was studied by spirometry with flow-volume loops, body plethysmography with lung volumes computation and maximal inspiratory and expiratory static mouth pressures. Forced vital capacity (FVC), forced expiratory volume in 1 min (FEV1), <math altimg="si1.gif"><fr shape="sol"><nu><rm>FEV</rm>1</nu><de><rm>FVC</rm>%</de></fr></math> and arterial PO2 and PCO2 were significantly below normal values. Residual volume (RV) and total rows were above normal values. Thirty-six had upper airway obstruction as judged by inspiratory flow peaks (PIF) <31/s and <math altimg="si2.gif"><fr shape="sol"><nu><rm>FEV</rm>1</nu><de><rm>PEF</rm>%</de></fr></math> (expiratory flow peak) > 8.51/min and <math altimg="si3.gif"><fr shape="sol"><nu><rm>MEF</rm>50</nu><de><rm>MIF</rm>50</de></fr></math> > 1. Eighteen patients had a central (FEV1 < 80% and <math altimg="si4.gif"><fr shape="sol"><nu><rm>FEV</rm>1</nu><de><rm>FVC</rm>%</de></fr></math> < 80% of normal values) or peripheral (maximal expiratory flow between 75% and 25% of FVC and maximal expiratory flow after expiration of 50% below 70% of normal values) obstructive pattern. Sixteen patients had a restrictive dysfunction as judged by a total lung capacity < 85% or FVC < 80% with <math altimg="si5.gif"><fr shape="sol"><nu><rm>FEV</rm>1</nu><de><rm>FVC</rm>%</de></fr></math> > 80%. Sixteen patients had air trapping (RV > 120% and <math altimg="si6.gif"><fr shape="sol"><nu><rm>RV</rm></nu><de><rm>TLC</rm></de></fr></math> > 40%) and seven patients had lung insufflation (TLC > 120%). Rigidity, Rx signs of cervical arthrosis and limitations for passive movement of neck were higher in patients with central or peripheral airway obstruction. Bradykinesia and Rx signs of dorsal arthrosis was higher in patients with upper airway obstruction. Restrictive dysfunction was not related to tremor, rigidity or bradykinesia. The present data support the hypothesis that Parkinson patients present a high risk for pneumologic disturbances. These pulmonary dysfunctions are induced by the simultaneous action of a group of factors including the degree of bradykinesia or rigidity and the musculoskeletal limitations of vertebral column probably induced by chronic anomalous posture.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Obstructive and restrictive pulmonary dysfunctions in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Magdalena</namePart><namePart type="family">Sabaté</namePart><affiliation>Service of Physical Medicine and Rehabilitation, Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tererife, Canary Islands, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Isidro</namePart><namePart type="family">González</namePart><affiliation>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Felix</namePart><namePart type="family">Ruperez</namePart><affiliation>Respiratory Division of the Department of Medicine at the University Hospital of the Canary Islands, Tenerife, 38320, Tenerife, Canary Islands, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Manuel</namePart><namePart type="family">Rodríguez</namePart><affiliation>Corresponding autor. Fax: 34-22-603529; Phone; 34-22-603492.</affiliation><affiliation>Department of Physiology, Faculty of Medicine, University of La Laguna, 38320, Tenerife, Canary Islands, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><dateValid encoding="w3cdtf">1995-12-16</dateValid><dateModified encoding="w3cdtf">1995-12-07</dateModified><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Pulmonary dysfunction was investigated in fifty-eight Parkinson's patients. Clinical disability was assessed by the Unified Parkinson's Disease Rating Scale. Pulmonary dysfunction was studied by spirometry with flow-volume loops, body plethysmography with lung volumes computation and maximal inspiratory and expiratory static mouth pressures. Forced vital capacity (FVC), forced expiratory volume in 1 min (FEV1), FEV1 FVC% and arterial PO2 and PCO2 were significantly below normal values. Residual volume (RV) and total rows were above normal values. Thirty-six had upper airway obstruction as judged by inspiratory flow peaks (PIF) <31/s and FEV1 PEF% (expiratory flow peak) > 8.51/min and MEF50 MIF50 > 1. Eighteen patients had a central (FEV1 < 80% and FEV1 FVC% < 80% of normal values) or peripheral (maximal expiratory flow between 75% and 25% of FVC and maximal expiratory flow after expiration of 50% below 70% of normal values) obstructive pattern. Sixteen patients had a restrictive dysfunction as judged by a total lung capacity < 85% or FVC < 80% with FEV1 FVC% > 80%. Sixteen patients had air trapping (RV > 120% and RV TLC > 40%) and seven patients had lung insufflation (TLC > 120%). Rigidity, Rx signs of cervical arthrosis and limitations for passive movement of neck were higher in patients with central or peripheral airway obstruction. Bradykinesia and Rx signs of dorsal arthrosis was higher in patients with upper airway obstruction. Restrictive dysfunction was not related to tremor, rigidity or bradykinesia. The present data support the hypothesis that Parkinson patients present a high risk for pneumologic disturbances. These pulmonary dysfunctions are induced by the simultaneous action of a group of factors including the degree of bradykinesia or rigidity and the musculoskeletal limitations of vertebral column probably induced by chronic anomalous posture.</abstract><note type="content">Section title: Research article</note><subject><genre>Article category</genre><topic>Clinical section</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title></titleInfo><titleInfo type="abbreviated"><title>JNS</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199606</dateIssued></originInfo><identifier type="ISSN">0022-510X</identifier><identifier type="PII">S0022-510X(00)X0001-9</identifier><part><date>199606</date><detail type="volume"><number>138</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>174</end></extent><extent unit="pages"><start>114</start><end>119</end></extent></part></relatedItem><identifier type="istex">075D15621FCD7BFB759007B44D01A890BC9A6ABB</identifier><identifier type="DOI">10.1016/0022-510X(96)00003-2</identifier><identifier type="PII">0022-510X(96)00003-2</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/075D15621FCD7BFB759007B44D01A890BC9A6ABB/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROIMAGING</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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