Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions
Identifieur interne : 000602 ( Main/Corpus ); précédent : 000601; suivant : 000603Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions
Auteurs : Debra L. Schutte ; Ezra C. HolstonSource :
- Journal of Nursing Scholarship [ 1527-6546 ] ; 2006-12.
English descriptors
- KwdEn :
Abstract
Purpose: To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice. Design: An integrated review of the literature, including the organizing construct of the family systems genetic illness model. Findings: AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early‐onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late‐onset AD and PD. Conclusions: The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.
Url:
DOI: 10.1111/j.1547-5069.2006.00123.x
Links to Exploration step
ISTEX:9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title><author><name sortKey="Schutte, Debra L" sort="Schutte, Debra L" uniqKey="Schutte D" first="Debra L." last="Schutte">Debra L. Schutte</name><affiliation><mods:affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</mods:affiliation></affiliation></author><author><name sortKey="Holston, Ezra C" sort="Holston, Ezra C" uniqKey="Holston E" first="Ezra C." last="Holston">Ezra C. Holston</name><affiliation><mods:affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1111/j.1547-5069.2006.00123.x</idno><idno type="url">https://api.istex.fr/document/9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000602</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title><author><name sortKey="Schutte, Debra L" sort="Schutte, Debra L" uniqKey="Schutte D" first="Debra L." last="Schutte">Debra L. Schutte</name><affiliation><mods:affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</mods:affiliation></affiliation></author><author><name sortKey="Holston, Ezra C" sort="Holston, Ezra C" uniqKey="Holston E" first="Ezra C." last="Holston">Ezra C. Holston</name><affiliation><mods:affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Nursing Scholarship</title><idno type="ISSN">1527-6546</idno><idno type="eISSN">1547-5069</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2006-12">2006-12</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="334">334</biblScope></imprint><idno type="ISSN">1527-6546</idno></series><idno type="istex">9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA</idno><idno type="DOI">10.1111/j.1547-5069.2006.00123.x</idno><idno type="ArticleID">JNU123</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1527-6546</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Parkinson disease</term><term>dementia</term><term>genetics</term><term>gerontology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice. Design: An integrated review of the literature, including the organizing construct of the family systems genetic illness model. Findings: AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early‐onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late‐onset AD and PD. Conclusions: The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Debra L. Schutte</name><affiliations><json:string>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</json:string></affiliations></json:item><json:item><name>Ezra C. Holston</name><affiliations><json:string>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gerontology</value></json:item></subject><articleId><json:string>JNU123</json:string></articleId><language><json:string>eng</json:string></language><abstract>Purpose: To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice. Design: An integrated review of the literature, including the organizing construct of the family systems genetic illness model. Findings: AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early‐onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late‐onset AD and PD. Conclusions: The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.</abstract><qualityIndicators><score>7.232</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594.006 x 783.008 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1301</abstractCharCount><pdfWordCount>5106</pdfWordCount><pdfCharCount>34429</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>186</abstractWordCount></qualityIndicators><title>Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title><genre><json:string>article</json:string></genre><host><volume>38</volume><publisherId><json:string>JNU</json:string></publisherId><pages><total>7</total><last>334</last><first>328</first></pages><issn><json:string>1527-6546</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1547-5069</json:string></eissn><title>Journal of Nursing Scholarship</title><doi><json:string>10.1111/(ISSN)1547-5069</json:string></doi></host><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1111/j.1547-5069.2006.00123.x</json:string></doi><id>9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><availability><p>WILEY</p></availability><date>2006</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title><author><persName><forename type="first">Debra L.</forename><surname>Schutte</surname></persName><affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</affiliation></author><author><persName><forename type="first">Ezra C.</forename><surname>Holston</surname></persName><affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</affiliation></author></analytic><monogr><title level="j">Journal of Nursing Scholarship</title><idno type="pISSN">1527-6546</idno><idno type="eISSN">1547-5069</idno><idno type="DOI">10.1111/(ISSN)1547-5069</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2006-12"></date><biblScope unit="volume">38</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="328">328</biblScope><biblScope unit="page" to="334">334</biblScope></imprint></monogr><idno type="istex">9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA</idno><idno type="DOI">10.1111/j.1547-5069.2006.00123.x</idno><idno type="ArticleID">JNU123</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Purpose: To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice. Design: An integrated review of the literature, including the organizing construct of the family systems genetic illness model. Findings: AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early‐onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late‐onset AD and PD. Conclusions: The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>dementia</term></item><item><term>Alzheimer disease</term></item><item><term>Parkinson disease</term></item><item><term>genetics</term></item><item><term>gerontology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1547-5069</doi><issn type="print">1527-6546</issn><issn type="electronic">1547-5069</issn><idGroup><id type="product" value="JNU"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF NURSING SCHOLARSHIP">Journal of Nursing Scholarship</title></titleGroup></publicationMeta><publicationMeta level="part" position="12004"><doi origin="wiley">10.1111/jnu.2006.38.issue-4</doi><numberingGroup><numbering type="journalVolume" number="38">38</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2006-12">December 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1547-5069.2006.00123.x</doi><idGroup><id type="unit" value="JNU123"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">GENOMICS TO HEALTH</title></titleGroup><eventGroup><event type="firstOnline" date="2006-11-17"></event><event type="publishedOnlineFinalForm" date="2006-11-17"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="328">328</numbering><numbering type="pageLast" number="334">334</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:JNU.JNU123.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication July 11, 2006.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="58"></count><count type="linksCrossRef" number="78"></count></countGroup><titleGroup><title type="main">Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Debra L.</givenNames><familyName>Schutte</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Ezra C.</givenNames><familyName>Holston</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation><b>Debra L. Schutte</b>, RN, PhD, <i>Gamma</i>, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; <b>Ezra C. Holston</b>, RN, PhD, <i>Upsilon</i>, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: <email normalForm="debra-schutte@uiowa.edu">debra‐schutte@uiowa.edu</email></unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1"><i>dementia</i></keyword><keyword xml:id="k2"><i>Alzheimer disease</i></keyword><keyword xml:id="k3"><i>Parkinson disease</i></keyword><keyword xml:id="k4"><i>genetics</i></keyword><keyword xml:id="k5"><i>gerontology</i></keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i><b>Purpose:</b> To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice.</i> </p><p> <i><b>Design:</b> An integrated review of the literature, including the organizing construct of the family systems genetic illness model.</i> </p><p> <i><b>Findings:</b> AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early‐onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late‐onset AD and PD.</i> </p><p> <i><b>Conclusions:</b> The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.</i> </p><!-- Journal of Nursing Scholarship , 2006; 38:4, 328-334. ©2006 Sigma Theta Tau International .
</abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions</title></titleInfo><name type="personal"><namePart type="given">Debra L.</namePart><namePart type="family">Schutte</namePart><affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ezra C.</namePart><namePart type="family">Holston</namePart><affiliation>Debra L. Schutte, RN, PhD, Gamma, Assistant Professor, The University of Iowa College of Nursing, Iowa City, IA; Ezra C. Holston, RN, PhD, Upsilon, Assistant Professor, University of California, Los Angeles, School of Nursing, Los Angeles, CA. During the preparation of this manuscript, Dr. Schutte was supported by a John A. Hartford Foundation Building Academic Capacity Postdoctoral Fellowship. Dr. Holston was supported by the Clinical Genetics Postdoctoral Fellowship at the University of Iowa College of Nursing and was an Iowa Scholar in the Clinical Investigation Program at The University of Iowa College of Medicine. Correspondence to Dr. Schutte, The University of Iowa College of Nursing, Room 484NB, Iowa City, IA 52242. E‐mail: debra‐schutte@uiowa.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2006-12</dateIssued><edition>Accepted for publication July 11, 2006.</edition><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">58</extent></physicalDescription><abstract lang="en">Purpose: To (a) provide an overview of chronic dementing conditions; (b) discuss the etiologic and clinical characteristics of Alzheimer disease (AD) and Parkinson disease (PD) within the framework of the family systems genetic illness model; and (c) to explore opportunities to enhance outcomes through the integration of genomics information and technologies into nursing practice. Design: An integrated review of the literature, including the organizing construct of the family systems genetic illness model. Findings: AD and PD are both influenced by genetic and environmental factors; in a small percentage of families, gene mutations are the primary etiologic factor. Genetic testing is an option for some families experiencing early‐onset, familial disease. Presymptomatic and diagnostic genetic testing have limited clinical utility for the more common late‐onset AD and PD. Conclusions: The current abilities of healthcare professionals to effectively intervene in people with AD and PD are limited by an incomplete understanding of the biologic basis of these diseases. Advances in genomics research and technology are providing the information and tools necessary to understand the molecular basis of these devastating disorders toward the goal of more specific and effective interventions.</abstract><subject lang="en"><genre>Keywords</genre><topic>dementia</topic><topic>Alzheimer disease</topic><topic>Parkinson disease</topic><topic>genetics</topic><topic>gerontology</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Nursing Scholarship</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1527-6546</identifier><identifier type="eISSN">1547-5069</identifier><identifier type="DOI">10.1111/(ISSN)1547-5069</identifier><identifier type="PublisherID">JNU</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>38</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>328</start><end>334</end><total>7</total></extent></part></relatedItem><identifier type="istex">9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA</identifier><identifier type="DOI">10.1111/j.1547-5069.2006.00123.x</identifier><identifier type="ArticleID">JNU123</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000602 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000602 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:9E2F26D06A1BB162204E0D24EC6A9953A2E4EDDA
|texte= Chronic Dementing Conditions, Genomics, and New Opportunities for Nursing Interventions
}}
| This area was generated with Dilib version V0.6.23. |  |