The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
Identifieur interne : 000486 ( Main/Corpus ); précédent : 000485; suivant : 000487The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
Auteurs : Magdalena Eriksson Domellöf ; Eva Elgh ; Lars ForsgrenSource :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
English descriptors
Abstract
Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23814
Links to Exploration step
ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title><author><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name><affiliation><mods:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name><affiliation><mods:affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name><affiliation><mods:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23814</idno><idno type="url">https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000486</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title><author><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name><affiliation><mods:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name><affiliation><mods:affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name><affiliation><mods:affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2183">2183</biblScope><biblScope unit="page" to="2189">2189</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno><idno type="DOI">10.1002/mds.23814</idno><idno type="ArticleID">MDS23814</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>newly diagnosed</term><term>population based</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Magdalena Eriksson Domellöf MSc</name><affiliations><json:string>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</json:string><json:string>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</json:string></affiliations></json:item><json:item><name>Eva Elgh PhD</name><affiliations><json:string>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</json:string></affiliations></json:item><json:item><name>Lars Forsgren MD, PhD</name><affiliations><json:string>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>population based</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>newly diagnosed</value></json:item></subject><articleId><json:string>MDS23814</json:string></articleId><language><json:string>eng</json:string></language><abstract>Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.769</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1860</abstractCharCount><pdfWordCount>4269</pdfWordCount><pdfCharCount>29466</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>254</abstractWordCount></qualityIndicators><title>The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>2189</last><first>2183</first></pages><issn><json:string>0885-3185</json:string></issn><issue>12</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23814</json:string></doi><id>774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Funding agencies: This study was supported by grants from the Swedish Medical Research Council, the Parkinson Foundation in Sweden, the Swedish Association of Persons with Neurological Disabilities, Umeå University, Västerbotten County Council (ALF), the King Gustaf V and Queen Victoria Freemason Foundation, the Swedish Brain Foundation, and the Lions Clubs Sweden's Foundation for Research in Age‐Related Diseases.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Lars Forsgren serves on scientific advisory boards for Pfizer and UCB and receives research support from the Parkinson Foundation, King Gustaf V and Queen Victoria Freemason Foundation, the Kempe Foundation, Västerbotten County Council, Umeå University, and the Swedish Medical Research Council.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title><author><persName><forename type="first">Magdalena Eriksson</forename><surname>Domellöf</surname></persName><roleName type="degree">MSc</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Umeå University, SE‐90185 Umeå, Sweden</p></note><affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</affiliation><affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</affiliation></author><author><persName><forename type="first">Eva</forename><surname>Elgh</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</affiliation></author><author><persName><forename type="first">Lars</forename><surname>Forsgren</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2183">2183</biblScope><biblScope unit="page" to="2189">2189</biblScope></imprint></monogr><idno type="istex">774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno><idno type="DOI">10.1002/mds.23814</idno><idno type="ArticleID">MDS23814</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>cognition</term></item><item><term>population based</term></item><item><term>newly diagnosed</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-01-13">Received</change><change when="2011-05-08">Registration</change><change when="2011-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/mds.v26.12</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2011-10">October 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="120" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23814</doi><idGroup><id type="unit" value="MDS23814"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2011 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2011-01-13"></event><event type="manuscriptRevised" date="2011-04-29"></event><event type="manuscriptAccepted" date="2011-05-08"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-04"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-06-09"></event><event type="publishedOnlineFinalForm" date="2011-10-21"></event><event type="firstOnline" date="2011-06-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2183</numbering><numbering type="pageLast">2189</numbering></numberingGroup><correspondenceTo>Department of Neurology, Umeå University, SE‐90185 Umeå, Sweden</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23814.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="7638"></count></countGroup><titleGroup><title type="main" xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease<link href="#fn8"></link><link href="#fn9"></link><link href="#fn10"></link></title><title type="short" xml:lang="en">Cognition and Motor Dysfunction in New PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Magdalena Eriksson</givenNames><familyName>Domellöf</familyName><degrees>MSc</degrees></personName><contactDetails><email>magdalena.domellof@neuro.umu.se</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Eva</givenNames><familyName>Elgh</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Lars</givenNames><familyName>Forsgren</familyName><degrees>MD, PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="SE" type="organization"><unparsedAffiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="SE" type="organization"><unparsedAffiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">cognition</keyword><keyword xml:id="kwd3">population based</keyword><keyword xml:id="kwd4">newly diagnosed</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn8"><p><b>Funding agencies:</b> This study was supported by grants from the Swedish Medical Research Council, the Parkinson Foundation in Sweden, the Swedish Association of Persons with Neurological Disabilities, Umeå University, Västerbotten County Council (ALF), the King Gustaf V and Queen Victoria Freemason Foundation, the Swedish <i>Brain</i> Foundation, and the Lions Clubs Sweden's Foundation for Research in Age‐Related Diseases.</p></note><note xml:id="fn9"><p><b>Relevant conflicts of interest/financial disclosures:</b> Lars Forsgren serves on scientific advisory boards for Pfizer and UCB and receives research support from the Parkinson Foundation, King Gustaf V and Queen Victoria Freemason Foundation, the Kempe Foundation, Västerbotten County Council, Umeå University, and the Swedish Medical Research Council.</p></note><note xml:id="fn10"><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cognition and Motor Dysfunction in New PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Magdalena Eriksson</namePart><namePart type="family">Domellöf</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</affiliation><affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</affiliation><description>Correspondence: Department of Neurology, Umeå University, SE‐90185 Umeå, Sweden</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eva</namePart><namePart type="family">Elgh</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Forsgren</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><dateCaptured encoding="w3cdtf">2011-01-13</dateCaptured><dateValid encoding="w3cdtf">2011-05-08</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">35</extent><extent unit="words">7638</extent></physicalDescription><abstract lang="en">Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: This study was supported by grants from the Swedish Medical Research Council, the Parkinson Foundation in Sweden, the Swedish Association of Persons with Neurological Disabilities, Umeå University, Västerbotten County Council (ALF), the King Gustaf V and Queen Victoria Freemason Foundation, the Swedish Brain Foundation, and the Lions Clubs Sweden's Foundation for Research in Age‐Related Diseases.</note><note type="content">*Relevant conflicts of interest/financial disclosures: Lars Forsgren serves on scientific advisory boards for Pfizer and UCB and receives research support from the Parkinson Foundation, King Gustaf V and Queen Victoria Freemason Foundation, the Kempe Foundation, Västerbotten County Council, Umeå University, and the Swedish Medical Research Council.</note><note type="content">*Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>cognition</topic><topic>population based</topic><topic>newly diagnosed</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>2183</start><end>2189</end><total>7</total></extent></part></relatedItem><identifier type="istex">774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</identifier><identifier type="DOI">10.1002/mds.23814</identifier><identifier type="ArticleID">MDS23814</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000486 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000486 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9
|texte= The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |