Visual thresholds to low‐contrast pattern displacement, color contrast, and luminance contrast stimuli in Parkinson's disease
Identifieur interne : 000471 ( Main/Corpus ); précédent : 000470; suivant : 000472Visual thresholds to low‐contrast pattern displacement, color contrast, and luminance contrast stimuli in Parkinson's disease
Auteurs : Haug ; Claudia Trenkwalder ; Geoffrey B. Arden ; Wolfgang H. Oertel ; Walter PaulusSource :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
Abstract
We used the computerized Moorfield Vision System to demonstrate specific increases in various perceptual visual thresholds in idiopathic Parkinson's syndrome. Fifteen patients were compared to 13 age‐matched normals. Motion detection was impaired maximally (2p < 0.01 and better in two‐tailed t test) at luminance contrasts of 3–7%. Stimulus was an achromatic vertical 4 cycles/°sine wave grating subtending 3° × 2°, centered 5° in the nasal field and oscillating at 5 Hz. In addition, stationary color and luminance contrast thresholds were tested with flashed display of 5° × 6° random letters, which were presented for 200 ms (color) and 50 ms (achromatic). Color discrimination was impaired in the tritan axis only (2p < 0.05 in two‐tailed t test). All achromatic stimuli–luminance increments, decrements, and phase reversing stimuli–were equally well seen by patients and controls. We conclude that the dopaminergic deficit of retinal amacrine cells in Parkinson patients can be monitored by combined low‐contrast and motion (displacement) stimuli. Future studies will determine if moving colored targets are more effective in discriminating patients from controls than are the achromatic gratings used in this work.
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DOI: 10.1002/mds.870090510
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ISTEX:6F618AE73923A2C52E1B70BC1696463B48FC421ALe document en format XML
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Fifteen patients were compared to 13 age‐matched normals. Motion detection was impaired maximally (2p < 0.01 and better in two‐tailed t test) at luminance contrasts of 3–7%. Stimulus was an achromatic vertical 4 cycles/°sine wave grating subtending 3° × 2°, centered 5° in the nasal field and oscillating at 5 Hz. In addition, stationary color and luminance contrast thresholds were tested with flashed display of 5° × 6° random letters, which were presented for 200 ms (color) and 50 ms (achromatic). Color discrimination was impaired in the tritan axis only (2p < 0.05 in two‐tailed t test). All achromatic stimuli–luminance increments, decrements, and phase reversing stimuli–were equally well seen by patients and controls. We conclude that the dopaminergic deficit of retinal amacrine cells in Parkinson patients can be monitored by combined low‐contrast and motion (displacement) stimuli. 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Fifteen patients were compared to 13 age‐matched normals. Motion detection was impaired maximally (2p < 0.01 and better in two‐tailed <i>t</i> test) at luminance contrasts of 3–7%. Stimulus was an achromatic vertical 4 cycles/°sine wave grating subtending 3° × 2°, centered 5° in the nasal field and oscillating at 5 Hz. In addition, stationary color and luminance contrast thresholds were tested with flashed display of 5° × 6° random letters, which were presented for 200 ms (color) and 50 ms (achromatic). Color discrimination was impaired in the tritan axis only (2p < 0.05 in two‐tailed <i>t</i> test). All achromatic stimuli–luminance increments, decrements, and phase reversing stimuli–were equally well seen by patients and controls. We conclude that the dopaminergic deficit of retinal amacrine cells in Parkinson patients can be monitored by combined low‐contrast and motion (displacement) stimuli. Future studies will determine if moving colored targets are more effective in discriminating patients from controls than are the achromatic gratings used in this work.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Visual thresholds to low‐contrast pattern displacement, color contrast, and luminance contrast stimuli in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>VISUAL THRESHOLDS IN PARKINSON'S DISEASE</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Visual thresholds to low‐contrast pattern displacement, color contrast, and luminance contrast stimuli in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Haug</namePart><affiliation>Department of Clinical Neurophysiology, Georg August University, Göttingen, Germany</affiliation><description>Correspondence: Department of Neurology and Clinical Neurophysiology, Georg August University, Robert‐Koch‐St. 40, D‐37075 Göttingen, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Claudia</namePart><namePart type="family">Trenkwalder</namePart><affiliation>Max Planck Institute for Psychiatry, Clinical Institute of Neurology, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geoffrey B.</namePart><namePart type="family">Arden</namePart><affiliation>Institute of Ophthalmology, Moorfields Eye Hospital, London, U.K.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang H.</namePart><namePart type="family">Oertel</namePart><affiliation>Department of Neurology, Ludwig Maximilians University, Munich, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Walter</namePart><namePart type="family">Paulus</namePart><affiliation>Department of Clinical Neurophysiology, Georg August University, Göttingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">41</extent></physicalDescription><abstract lang="en">We used the computerized Moorfield Vision System to demonstrate specific increases in various perceptual visual thresholds in idiopathic Parkinson's syndrome. Fifteen patients were compared to 13 age‐matched normals. Motion detection was impaired maximally (2p < 0.01 and better in two‐tailed t test) at luminance contrasts of 3–7%. Stimulus was an achromatic vertical 4 cycles/°sine wave grating subtending 3° × 2°, centered 5° in the nasal field and oscillating at 5 Hz. In addition, stationary color and luminance contrast thresholds were tested with flashed display of 5° × 6° random letters, which were presented for 200 ms (color) and 50 ms (achromatic). Color discrimination was impaired in the tritan axis only (2p < 0.05 in two‐tailed t test). All achromatic stimuli–luminance increments, decrements, and phase reversing stimuli–were equally well seen by patients and controls. We conclude that the dopaminergic deficit of retinal amacrine cells in Parkinson patients can be monitored by combined low‐contrast and motion (displacement) stimuli. Future studies will determine if moving colored targets are more effective in discriminating patients from controls than are the achromatic gratings used in this work.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Visual thresholds</topic><topic>Displacement stimuli</topic><topic>Color contrast</topic><topic>Luminance contrast</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>563</start><end>570</end><total>8</total></extent></part></relatedItem><identifier type="istex">6F618AE73923A2C52E1B70BC1696463B48FC421A</identifier><identifier type="DOI">10.1002/mds.870090510</identifier><identifier type="ArticleID">MDS870090510</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1994 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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