The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
Identifieur interne : 000323 ( Main/Corpus ); précédent : 000322; suivant : 000324The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status
Auteurs : Sook K. Song ; Ji E. Lee ; Hae-Jeong Park ; Young H. Sohn ; Jong Doo Lee ; Phil Hyu LeeSource :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
English descriptors
Abstract
Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23477
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ISTEX:79DFEAE14D58531B3E43D438CFA4FC21CD3292F7Le document en format XML
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Lee</name><affiliation><mods:affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Hae Eong" sort="Park, Hae Eong" uniqKey="Park H" first="Hae-Jeong" last="Park">Hae-Jeong Park</name><affiliation><mods:affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><affiliation><mods:affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Jong Doo" sort="Lee, Jong Doo" uniqKey="Lee J" first="Jong Doo" last="Lee">Jong Doo Lee</name><affiliation><mods:affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><affiliation><mods:affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23477</idno><idno type="url">https://api.istex.fr/document/79DFEAE14D58531B3E43D438CFA4FC21CD3292F7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000323</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title><author><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K." last="Song">Sook K. Song</name><affiliation><mods:affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E." last="Lee">Ji E. Lee</name><affiliation><mods:affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Park, Hae Eong" sort="Park, Hae Eong" uniqKey="Park H" first="Hae-Jeong" last="Park">Hae-Jeong Park</name><affiliation><mods:affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><affiliation><mods:affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Jong Doo" sort="Lee, Jong Doo" uniqKey="Lee J" first="Jong Doo" last="Lee">Jong Doo Lee</name><affiliation><mods:affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><affiliation><mods:affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="296">296</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</idno><idno type="DOI">10.1002/mds.23477</idno><idno type="ArticleID">MDS23477</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cortical atrophy</term><term>dementia</term><term>mild cognitive impairment</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sook K. Song MD</name><affiliations><json:string>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</json:string></affiliations></json:item><json:item><name>Ji E. Lee MD</name><affiliations><json:string>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Hae‐Jeong Park PhD</name><affiliations><json:string>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Young H. Sohn MD, PhD</name><affiliations><json:string>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Jong Doo Lee MD, PhD</name><affiliations><json:string>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Phil Hyu Lee MD, PhD</name><affiliations><json:string>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mild cognitive impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cortical atrophy</value></json:item></subject><articleId><json:string>MDS23477</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (>5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>7.496</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1624</abstractCharCount><pdfWordCount>4556</pdfWordCount><pdfCharCount>28944</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>245</abstractWordCount></qualityIndicators><title>The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>296</last><first>289</first></pages><issn><json:string>0885-3185</json:string></issn><issue>2</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23477</json:string></doi><id>79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/79DFEAE14D58531B3E43D438CFA4FC21CD3292F7/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/79DFEAE14D58531B3E43D438CFA4FC21CD3292F7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/79DFEAE14D58531B3E43D438CFA4FC21CD3292F7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Relevant conflict of interest/financial disclosure: This report was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084227). Full financial disclosures and author roles can be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title><author><persName><forename type="first">Sook K.</forename><surname>Song</surname></persName><roleName type="degree">MD</roleName><note type="biography">Sook K. Song and Ji E. Lee contributed equally to this work.</note><affiliation>Sook K. Song and Ji E. Lee contributed equally to this work.</affiliation><affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</affiliation></author><author><persName><forename type="first">Ji E.</forename><surname>Lee</surname></persName><roleName type="degree">MD</roleName><note type="biography">Sook K. Song and Ji E. Lee contributed equally to this work.</note><affiliation>Sook K. Song and Ji E. Lee contributed equally to this work.</affiliation><affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</affiliation></author><author><persName><forename type="first">Hae‐Jeong</forename><surname>Park</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</affiliation></author><author><persName><forename type="first">Young H.</forename><surname>Sohn</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</affiliation></author><author><persName><forename type="first">Jong Doo</forename><surname>Lee</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</affiliation></author><author><persName><forename type="first">Phil Hyu</forename><surname>Lee</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun‐gu, Seoul 120‐752, South Korea</p></note><affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01"></date><biblScope unit="volume">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="289">289</biblScope><biblScope unit="page" to="296">296</biblScope></imprint></monogr><idno type="istex">79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</idno><idno type="DOI">10.1002/mds.23477</idno><idno type="ArticleID">MDS23477</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>mild cognitive impairment</term></item><item><term>dementia</term></item><item><term>cortical atrophy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-06-11">Received</change><change when="2010-09-20">Registration</change><change when="2011-02-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/79DFEAE14D58531B3E43D438CFA4FC21CD3292F7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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href="file:MDS.MDS23477.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="27"></count><count type="wordTotal" number="5891"></count></countGroup><titleGroup><title type="main" xml:lang="en">The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status<link href="#fn1"></link></title><title type="short" xml:lang="en">Pattern of Cortical Atrophy in Patients with PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" noteRef="#fn2"><personName><givenNames>Sook K.</givenNames><familyName>Song</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" noteRef="#fn2"><personName><givenNames>Ji E.</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Hae‐Jeong</givenNames><familyName>Park</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Young H.</givenNames><familyName>Sohn</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jong Doo</givenNames><familyName>Lee</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Phil Hyu</givenNames><familyName>Lee</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>phisland@chol.net</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="KR" type="organization"><unparsedAffiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="KR" type="organization"><unparsedAffiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="KR" type="organization"><unparsedAffiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">mild cognitive impairment</keyword><keyword xml:id="kwd3">dementia</keyword><keyword xml:id="kwd4">cortical atrophy</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23477:MDS_23477_sm_suppinfofig1"></mediaResource><caption>Supporting Information Figure 1.</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23477:MDS_23477_sm_suppinfotab1"></mediaResource><caption>Supplementary Table 1. Neuropsychological data in patients with PD‐IC, PD‐MCI and PDD.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Background:</b> Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. <b>Methods:</b> To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. <b>Results:</b> The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). <b>Conclusions:</b> These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Relevant conflict of interest/financial disclosure:</b> This report was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084227). Full financial disclosures and author roles can be found in the online version of this article.</p></note><note xml:id="fn2"><p>Sook K. Song and Ji E. Lee contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pattern of Cortical Atrophy in Patients with PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status</title></titleInfo><name type="personal"><namePart type="given">Sook K.</namePart><namePart type="family">Song</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</affiliation><description>Sook K. Song and Ji E. Lee contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ji E.</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</affiliation><description>Sook K. Song and Ji E. Lee contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hae‐Jeong</namePart><namePart type="family">Park</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Young H.</namePart><namePart type="family">Sohn</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jong Doo</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Diagnostic Radiology, Nuclear Medicine and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Phil Hyu</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Jeju University College of Medicine, Jeju, Korea</affiliation><description>Correspondence: Department of Neurology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun‐gu, Seoul 120‐752, South Korea</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-02-01</dateIssued><dateCaptured encoding="w3cdtf">2010-06-11</dateCaptured><dateValid encoding="w3cdtf">2010-09-20</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">27</extent><extent unit="words">5891</extent></physicalDescription><abstract lang="en">Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (<5 year) showed greater GM atrophy in the posterior cingulate area than did those with longer disease duration (≥5 year). Conclusions: These data suggest that cortical atrophy in PD exhibits a greater extent with increasing levels of cognitive impairment, and different anatomical substrates would correspond to each cognitive status. © 2011 Movement Disorder Society</abstract><note type="content">*Relevant conflict of interest/financial disclosure: This report was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A084227). Full financial disclosures and author roles can be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>mild cognitive impairment</topic><topic>dementia</topic><topic>cortical atrophy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Information Figure 1. - Supplementary Table 1. Neuropsychological data in patients with PD‐IC, PD‐MCI and PDD. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>289</start><end>296</end><total>8</total></extent></part></relatedItem><identifier type="istex">79DFEAE14D58531B3E43D438CFA4FC21CD3292F7</identifier><identifier type="DOI">10.1002/mds.23477</identifier><identifier type="ArticleID">MDS23477</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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