MRI and cognitive impairment in Parkinson's disease
Identifieur interne : 000304 ( Main/Corpus ); précédent : 000303; suivant : 000305MRI and cognitive impairment in Parkinson's disease
Auteurs : Naroa Ibarretxe-Bilbao ; Eduardo Tolosa ; Carme Junque ; Maria-Jose MartiSource :
- Movement Disorders [ 0885-3185 ] ; 2009.
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Abstract
Patients with Parkinson's disease (PD) may present impairment in cognitive functions even at early stages of the disease. When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in PD is related to cortical structural changes and that specific cognitive dysfunctions can be attributed to atrophy in specific structures. We review the structural MRI studies carried out in PD using either a manual region of interest (ROI) approach or voxel‐based morphometry (VBM). ROI studies have shown that hippocampal volume is decreased in patients with PD with and without dementia; in addition, hippocampal atrophy correlated with deficits in verbal memory. VBM studies have demonstrated that dementia in PD involves structural changes in limbic areas and widespread cortical atrophy. Findings in nondemented patients with PD are less conclusive, possibly because cognitively heterogeneous groups of patients have been studied. Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22670
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When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in PD is related to cortical structural changes and that specific cognitive dysfunctions can be attributed to atrophy in specific structures. We review the structural MRI studies carried out in PD using either a manual region of interest (ROI) approach or voxel‐based morphometry (VBM). ROI studies have shown that hippocampal volume is decreased in patients with PD with and without dementia; in addition, hippocampal atrophy correlated with deficits in verbal memory. VBM studies have demonstrated that dementia in PD involves structural changes in limbic areas and widespread cortical atrophy. Findings in nondemented patients with PD are less conclusive, possibly because cognitively heterogeneous groups of patients have been studied. Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Naroa Ibarretxe‐Bilbao PhD</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</json:string><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Eduardo Tolosa MD</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</json:string><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Carme Junque PhD</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</json:string><json:string>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Maria‐Jose Marti MD</name><affiliations><json:string>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</json:string><json:string>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</json:string><json:string>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hallucinations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognitive functions</value></json:item></subject><articleId><json:string>MDS22670</json:string></articleId><language><json:string>eng</json:string></language><abstract>Patients with Parkinson's disease (PD) may present impairment in cognitive functions even at early stages of the disease. When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in PD is related to cortical structural changes and that specific cognitive dysfunctions can be attributed to atrophy in specific structures. We review the structural MRI studies carried out in PD using either a manual region of interest (ROI) approach or voxel‐based morphometry (VBM). ROI studies have shown that hippocampal volume is decreased in patients with PD with and without dementia; in addition, hippocampal atrophy correlated with deficits in verbal memory. VBM studies have demonstrated that dementia in PD involves structural changes in limbic areas and widespread cortical atrophy. Findings in nondemented patients with PD are less conclusive, possibly because cognitively heterogeneous groups of patients have been studied. Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. 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No. 2005SGR00855; No. UNI/2001/2003; No. UNI/2001/2004;</note><note>Ministerio de Educación y Ciencia - No. AP 2005‐019;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">MRI and cognitive impairment in Parkinson's disease</title><author><persName><forename type="first">Naroa</forename><surname>Ibarretxe‐Bilbao</surname></persName><roleName type="degree">PhD</roleName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Eduardo</forename><surname>Tolosa</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Villarroel 173, Barcelona, 08036, Spain</p></note><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Carme</forename><surname>Junque</surname></persName><roleName type="degree">PhD</roleName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Maria‐Jose</forename><surname>Marti</surname></persName><roleName type="degree">MD</roleName><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>dementia</term></item><item><term>hallucinations</term></item><item><term>MRI</term></item><item><term>cognitive functions</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-01-07">Received</change><change when="2009-05-10">Registration</change><change when="2009">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/F1483965523F12BF758E585A63C91965AA96FD4B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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Barcelona, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="ES" type="organization"><unparsedAffiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">dementia</keyword><keyword xml:id="kwd3">hallucinations</keyword><keyword xml:id="kwd4">MRI</keyword><keyword xml:id="kwd5">cognitive functions</keyword></keywordGroup><fundingInfo><fundingAgency>Generalitat de Catalunya</fundingAgency><fundingNumber>2005SGR00836</fundingNumber><fundingNumber>2005SGR00855</fundingNumber><fundingNumber>UNI/2001/2003</fundingNumber><fundingNumber>UNI/2001/2004</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Ministerio de Educación y Ciencia</fundingAgency><fundingNumber>AP 2005‐019</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Patients with Parkinson's disease (PD) may present impairment in cognitive functions even at early stages of the disease. When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in PD is related to cortical structural changes and that specific cognitive dysfunctions can be attributed to atrophy in specific structures. We review the structural MRI studies carried out in PD using either a manual region of interest (ROI) approach or voxel‐based morphometry (VBM). ROI studies have shown that hippocampal volume is decreased in patients with PD with and without dementia; in addition, hippocampal atrophy correlated with deficits in verbal memory. VBM studies have demonstrated that dementia in PD involves structural changes in limbic areas and widespread cortical atrophy. Findings in nondemented patients with PD are less conclusive, possibly because cognitively heterogeneous groups of patients have been studied. Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>MRI and cognitive impairment in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MRI and Cognitive Impairment in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>MRI and cognitive impairment in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Naroa</namePart><namePart type="family">Ibarretxe‐Bilbao</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eduardo</namePart><namePart type="family">Tolosa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><description>Correspondence: Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Villarroel 173, Barcelona, 08036, Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carme</namePart><namePart type="family">Junque</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria‐Jose</namePart><namePart type="family">Marti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><affiliation>Institute of Biomedical Research August Pi i Sunyer, Institut d'Investigacions Biomédiques August Pi i Sunyer, Barcelona, Spain</affiliation><affiliation>Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009</dateIssued><dateCaptured encoding="w3cdtf">2009-01-07</dateCaptured><dateValid encoding="w3cdtf">2009-05-10</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">59</extent><extent unit="words">3970</extent></physicalDescription><abstract lang="en">Patients with Parkinson's disease (PD) may present impairment in cognitive functions even at early stages of the disease. When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in PD is related to cortical structural changes and that specific cognitive dysfunctions can be attributed to atrophy in specific structures. We review the structural MRI studies carried out in PD using either a manual region of interest (ROI) approach or voxel‐based morphometry (VBM). ROI studies have shown that hippocampal volume is decreased in patients with PD with and without dementia; in addition, hippocampal atrophy correlated with deficits in verbal memory. VBM studies have demonstrated that dementia in PD involves structural changes in limbic areas and widespread cortical atrophy. Findings in nondemented patients with PD are less conclusive, possibly because cognitively heterogeneous groups of patients have been studied. Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Generalitat de Catalunya - No. 2005SGR00836; No. 2005SGR00855; No. UNI/2001/2003; No. UNI/2001/2004; </note><note type="funding">Ministerio de Educación y Ciencia - No. AP 2005‐019; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dementia</topic><topic>hallucinations</topic><topic>MRI</topic><topic>cognitive functions</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>S2</number></detail><extent unit="pages"><start>S748</start><end>S753</end><total>6</total></extent></part></relatedItem><identifier type="istex">F1483965523F12BF758E585A63C91965AA96FD4B</identifier><identifier type="DOI">10.1002/mds.22670</identifier><identifier type="ArticleID">MDS22670</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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