The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease
Identifieur interne : 000260 ( Main/Corpus ); précédent : 000259; suivant : 000261The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease
Auteurs : A. Röhl ; H. Friedrich ; G. Ulm ; P. ViereggeSource :
- European Journal of Neurology [ 1351-5101 ] ; 1994-09.
English descriptors
Abstract
Clinical outcome and relevance of genetic and epidemiological factors were evaluated in 161 patients with idiopathic Parkinson's disease (PD) with regard to onset symptoms [tremor (T) vs non‐tremor (NT)], to clinical classification into tremor‐dominant (TD), alkineto‐rigid (AR), and equivalent (EQ) subtypes, and to disease onset before the 45th year of age (EO) and after age 69 (LO). Patients were investigated by questionnaire‐based personal interview and clinical examination. Allegedly symptomatic first‐degree relatives were examined personally or had sufficient medical documentation to allow neurological diagnosis. Disease course was more favorable in T than in NT, in TD than in AR or EQ, and in EO compared with LO. Among EO and LO patients, clinical subtypes TD, AR and EQ were not differently distributed. Frequency of first‐degree relatives with PD or essential tremor and any epidemiological variable tested were not elicited differently between TD, AR and EQ patients, with the exception that TD reported more frequent premorbid travelling. EO patients reported higher frequencies of premorbid head trauma and rural living than LO patients. The more favorable disease prognosis of patients with predominant tremor at presentation and of patients with early disease onset is corroborated. Clinical subgroups do not differ in genetic and epidemiological factors.
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DOI: 10.1111/j.1468-1331.1994.tb00052.x
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ISTEX:0D261649DE70FE78C47D14739F62CFD2F4F18422Le document en format XML
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Röhl</name><affiliation><mods:affiliation>Departments of Neurology, Kassel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Friedrich, H" sort="Friedrich, H" uniqKey="Friedrich H" first="H." last="Friedrich">H. Friedrich</name><affiliation><mods:affiliation>Statistics and Medical Documentation, Medical University of Lübeck, Kassel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ulm, G" sort="Ulm, G" uniqKey="Ulm G" first="G." last="Ulm">G. Ulm</name><affiliation><mods:affiliation>Paracelsus Elena Klinik, Kassel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. 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Patients were investigated by questionnaire‐based personal interview and clinical examination. Allegedly symptomatic first‐degree relatives were examined personally or had sufficient medical documentation to allow neurological diagnosis. Disease course was more favorable in T than in NT, in TD than in AR or EQ, and in EO compared with LO. Among EO and LO patients, clinical subtypes TD, AR and EQ were not differently distributed. Frequency of first‐degree relatives with PD or essential tremor and any epidemiological variable tested were not elicited differently between TD, AR and EQ patients, with the exception that TD reported more frequent premorbid travelling. EO patients reported higher frequencies of premorbid head trauma and rural living than LO patients. The more favorable disease prognosis of patients with predominant tremor at presentation and of patients with early disease onset is corroborated. Clinical subgroups do not differ in genetic and epidemiological factors.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>A. Röhl</name><affiliations><json:string>Departments of Neurology, Kassel, Germany</json:string></affiliations></json:item><json:item><name>H.‐J. Friedrich</name><affiliations><json:string>Statistics and Medical Documentation, Medical University of Lübeck, Kassel, Germany</json:string></affiliations></json:item><json:item><name>G. Ulm</name><affiliations><json:string>Paracelsus Elena Klinik, Kassel, Germany</json:string></affiliations></json:item><json:item><name>P. 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Patients were investigated by questionnaire‐based personal interview and clinical examination. Allegedly symptomatic first‐degree relatives were examined personally or had sufficient medical documentation to allow neurological diagnosis. Disease course was more favorable in T than in NT, in TD than in AR or EQ, and in EO compared with LO. Among EO and LO patients, clinical subtypes TD, AR and EQ were not differently distributed. Frequency of first‐degree relatives with PD or essential tremor and any epidemiological variable tested were not elicited differently between TD, AR and EQ patients, with the exception that TD reported more frequent premorbid travelling. EO patients reported higher frequencies of premorbid head trauma and rural living than LO patients. The more favorable disease prognosis of patients with predominant tremor at presentation and of patients with early disease onset is corroborated. 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Vieregge, Department of Neurology, Medical University of Lübeck, Ratzeburger Allee 160, D‐23538 Lübeck, Germany</p></note><affiliation>Departments of Neurology, Kassel, Germany</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-09"></date><biblScope unit="volume">1</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="65">65</biblScope><biblScope unit="page" to="72">72</biblScope></imprint></monogr><idno type="istex">0D261649DE70FE78C47D14739F62CFD2F4F18422</idno><idno type="DOI">10.1111/j.1468-1331.1994.tb00052.x</idno><idno type="ArticleID">ENE52</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Clinical outcome and relevance of genetic and epidemiological factors were evaluated in 161 patients with idiopathic Parkinson's disease (PD) with regard to onset symptoms [tremor (T) vs non‐tremor (NT)], to clinical classification into tremor‐dominant (TD), alkineto‐rigid (AR), and equivalent (EQ) subtypes, and to disease onset before the 45th year of age (EO) and after age 69 (LO). 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Vieregge, Department of Neurology, Medical University of Lübeck, Ratzeburger Allee 160, D‐23538 Lübeck, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE52.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 2 February 1994; accepted 7 June 1994; as revised 7 June 1994</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="50"></count><count type="linksCrossRef" number="5"></count></countGroup><titleGroup><title type="main">The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>A.</givenNames><familyName>Röhl</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>H.‐J.</givenNames><familyName>Friedrich</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>G.</givenNames><familyName>Ulm</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1" corresponding="yes"><personName><givenNames>P.</givenNames><familyName>Vieregge</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Departments of Neurology, Kassel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Statistics and Medical Documentation, Medical University of Lübeck, Kassel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="DE"><unparsedAffiliation>Paracelsus Elena Klinik, Kassel, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Clinical subtypes</keyword><keyword xml:id="k2">Diagnosis</keyword><keyword xml:id="k3">Early onset</keyword><keyword xml:id="k4">Epidemiology</keyword><keyword xml:id="k5">Genetics</keyword><keyword xml:id="k6">Parkinson's disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Clinical outcome and relevance of genetic and epidemiological factors were evaluated in 161 patients with idiopathic Parkinson's disease (PD) with regard to onset symptoms [tremor (T) vs non‐tremor (NT)], to clinical classification into tremor‐dominant (TD), alkineto‐rigid (AR), and equivalent (EQ) subtypes, and to disease onset before the 45th year of age (EO) and after age 69 (LO). 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Clinical subgroups do not differ in genetic and epidemiological factors.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Röhl</namePart><affiliation>Departments of Neurology, Kassel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐J.</namePart><namePart type="family">Friedrich</namePart><affiliation>Statistics and Medical Documentation, Medical University of Lübeck, Kassel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Ulm</namePart><affiliation>Paracelsus Elena Klinik, Kassel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Vieregge</namePart><affiliation>Departments of Neurology, Kassel, Germany</affiliation><description>Correspondence: P. Vieregge, Department of Neurology, Medical University of Lübeck, Ratzeburger Allee 160, D‐23538 Lübeck, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1994-09</dateIssued><edition>Received 2 February 1994; accepted 7 June 1994; as revised 7 June 1994</edition><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">50</extent></physicalDescription><abstract lang="en">Clinical outcome and relevance of genetic and epidemiological factors were evaluated in 161 patients with idiopathic Parkinson's disease (PD) with regard to onset symptoms [tremor (T) vs non‐tremor (NT)], to clinical classification into tremor‐dominant (TD), alkineto‐rigid (AR), and equivalent (EQ) subtypes, and to disease onset before the 45th year of age (EO) and after age 69 (LO). Patients were investigated by questionnaire‐based personal interview and clinical examination. Allegedly symptomatic first‐degree relatives were examined personally or had sufficient medical documentation to allow neurological diagnosis. Disease course was more favorable in T than in NT, in TD than in AR or EQ, and in EO compared with LO. Among EO and LO patients, clinical subtypes TD, AR and EQ were not differently distributed. Frequency of first‐degree relatives with PD or essential tremor and any epidemiological variable tested were not elicited differently between TD, AR and EQ patients, with the exception that TD reported more frequent premorbid travelling. EO patients reported higher frequencies of premorbid head trauma and rural living than LO patients. The more favorable disease prognosis of patients with predominant tremor at presentation and of patients with early disease onset is corroborated. Clinical subgroups do not differ in genetic and epidemiological factors.</abstract><subject lang="en"><genre>Keywords</genre><topic>Clinical subtypes</topic><topic>Diagnosis</topic><topic>Early onset</topic><topic>Epidemiology</topic><topic>Genetics</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>65</start><end>72</end><total>8</total></extent></part></relatedItem><identifier type="istex">0D261649DE70FE78C47D14739F62CFD2F4F18422</identifier><identifier type="DOI">10.1111/j.1468-1331.1994.tb00052.x</identifier><identifier type="ArticleID">ENE52</identifier><accessCondition type="use and reproduction" contentType="copyright">1994 Lippincott Williams & Wilkins</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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