Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild
Identifieur interne : 000249 ( Main/Corpus ); précédent : 000248; suivant : 000250Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild
Auteurs : Bernd Müller ; Jan Petter Larsen ; Tore Wentzel-Larsen ; Geir Olve Skeie ; Ole-Bj Rn TysnesSource :
- Movement Disorders [ 0885-3185 ] ; 2011-01.
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- KwdEn :
Abstract
Although nonmotor symptoms are increasingly recognized as key features in Parkinson's disease (PD), the occurrence and severity of autonomic and sensory symptoms in patients with very early and untreated PD are poorly documented. Two hundred seven patients with newly diagnosed, untreated PD and 175 controls from the population‐based Norwegian ParkWest study were included. Postural blood pressure and olfactory function were measured and eight autonomic and sensory symptoms assessed using interview‐based rating scales. Autonomic and sensory symptoms were more frequent in patients compared with controls (mean number of symptoms 2.9 vs. 1.1; P < 0.001) and in the postural instability and gait difficulty motor‐subtype vs. tremor dominant subtype (mean 3.3 vs. 2.5; P = 0.008). In the patient group, reduced olfaction (59%), urinary problems (47%), increased saliva or drooling (42%), constipation (39%), and sensory complaints (34%) were the most frequent symptoms. Daily activities were not affected by these symptoms in 58% of the patients, and the influence on daily activities was rated as “mild” or less for all of these symptoms in 90%. A higher Hoehn and Yahr stage was associated with a higher number of autonomic and sensory symptoms and with the occurrence of gastrointestinal symptoms. Autonomic and sensory symptoms are common in patients with untreated, early PD although the severity of these symptoms is mild, with little or no influence on daily activities. The high prevalence of increased saliva or drooling close to the time of diagnosis is noteworthy and not described earlier. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23387
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Two hundred seven patients with newly diagnosed, untreated PD and 175 controls from the population‐based Norwegian ParkWest study were included. Postural blood pressure and olfactory function were measured and eight autonomic and sensory symptoms assessed using interview‐based rating scales. Autonomic and sensory symptoms were more frequent in patients compared with controls (mean number of symptoms 2.9 vs. 1.1; P < 0.001) and in the postural instability and gait difficulty motor‐subtype vs. tremor dominant subtype (mean 3.3 vs. 2.5; P = 0.008). In the patient group, reduced olfaction (59%), urinary problems (47%), increased saliva or drooling (42%), constipation (39%), and sensory complaints (34%) were the most frequent symptoms. Daily activities were not affected by these symptoms in 58% of the patients, and the influence on daily activities was rated as “mild” or less for all of these symptoms in 90%. A higher Hoehn and Yahr stage was associated with a higher number of autonomic and sensory symptoms and with the occurrence of gastrointestinal symptoms. Autonomic and sensory symptoms are common in patients with untreated, early PD although the severity of these symptoms is mild, with little or no influence on daily activities. The high prevalence of increased saliva or drooling close to the time of diagnosis is noteworthy and not described earlier. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Bernd Müller MD</name><affiliations><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string><json:string>Institute for clinical medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Jan Petter Larsen PhD</name><affiliations><json:string>Institute for clinical medicine, University of Bergen, Bergen, Norway</json:string><json:string>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</json:string><json:string>The Norwegian Centre for Movement Disorders, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Tore Wentzel‐Larsen MSc</name><affiliations><json:string>Centre for clinical research, Haukeland University Hospital, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Geir Olve Skeie PhD</name><affiliations><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string><json:string>Institute for clinical medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item><json:item><name>Ole‐Bjørn Tysnes PhD</name><affiliations><json:string>Department of Neurology, Haukeland University Hospital, Bergen, Norway</json:string><json:string>Institute for clinical medicine, University of Bergen, Bergen, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>autonomic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>sensory</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drooling</value></json:item></subject><articleId><json:string>MDS23387</json:string></articleId><language><json:string>eng</json:string></language><abstract>Although nonmotor symptoms are increasingly recognized as key features in Parkinson's disease (PD), the occurrence and severity of autonomic and sensory symptoms in patients with very early and untreated PD are poorly documented. Two hundred seven patients with newly diagnosed, untreated PD and 175 controls from the population‐based Norwegian ParkWest study were included. Postural blood pressure and olfactory function were measured and eight autonomic and sensory symptoms assessed using interview‐based rating scales. Autonomic and sensory symptoms were more frequent in patients compared with controls (mean number of symptoms 2.9 vs. 1.1; P > 0.001) and in the postural instability and gait difficulty motor‐subtype vs. tremor dominant subtype (mean 3.3 vs. 2.5; P = 0.008). In the patient group, reduced olfaction (59%), urinary problems (47%), increased saliva or drooling (42%), constipation (39%), and sensory complaints (34%) were the most frequent symptoms. Daily activities were not affected by these symptoms in 58% of the patients, and the influence on daily activities was rated as “mild” or less for all of these symptoms in 90%. A higher Hoehn and Yahr stage was associated with a higher number of autonomic and sensory symptoms and with the occurrence of gastrointestinal symptoms. Autonomic and sensory symptoms are common in patients with untreated, early PD although the severity of these symptoms is mild, with little or no influence on daily activities. The high prevalence of increased saliva or drooling close to the time of diagnosis is noteworthy and not described earlier. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.806</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1635</abstractCharCount><pdfWordCount>4818</pdfWordCount><pdfCharCount>31237</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>249</abstractWordCount></qualityIndicators><title>Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild</title><corporate><json:item><name>for The Parkwest Study Group</name></json:item></corporate><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>72</last><first>65</first></pages><issn><json:string>0885-3185</json:string></issn><issue>1</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23387</json:string></doi><id>10B4210CA3FC63C5094C1FBA02C4BF9F2DDFFA4D</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/10B4210CA3FC63C5094C1FBA02C4BF9F2DDFFA4D/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/10B4210CA3FC63C5094C1FBA02C4BF9F2DDFFA4D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/10B4210CA3FC63C5094C1FBA02C4BF9F2DDFFA4D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Members of the “Parkwest Study Group” are listed as an Appendix.</note><note type="content">*Potential conflict of interest: The authors have no potential conflicts of interest to report</note><note>Western Norway Regional Health Authority - No. 911218;</note><note>Research Council of Norway - No. 177966;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild</title><author><orgName>for The Parkwest Study Group</orgName></author><author><persName><forename type="first">Bernd</forename><surname>Müller</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway</p></note><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation></author><author><persName><forename type="first">Jan Petter</forename><surname>Larsen</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Tore</forename><surname>Wentzel‐Larsen</surname></persName><roleName type="degree">MSc</roleName><affiliation>Centre for clinical research, Haukeland University Hospital, Bergen, Norway</affiliation></author><author><persName><forename type="first">Geir Olve</forename><surname>Skeie</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation></author><author><persName><forename type="first">Ole‐Bjørn</forename><surname>Tysnes</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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A higher Hoehn and Yahr stage was associated with a higher number of autonomic and sensory symptoms and with the occurrence of gastrointestinal symptoms. Autonomic and sensory symptoms are common in patients with untreated, early PD although the severity of these symptoms is mild, with little or no influence on daily activities. 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xml:id="kwd3">sensory</keyword><keyword xml:id="kwd4">epidemiology</keyword><keyword xml:id="kwd5">drooling</keyword></keywordGroup><fundingInfo><fundingAgency>Western Norway Regional Health Authority</fundingAgency><fundingNumber>911218</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber>177966</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Although nonmotor symptoms are increasingly recognized as key features in Parkinson's disease (PD), the occurrence and severity of autonomic and sensory symptoms in patients with very early and untreated PD are poorly documented. Two hundred seven patients with newly diagnosed, untreated PD and 175 controls from the population‐based Norwegian ParkWest study were included. Postural blood pressure and olfactory function were measured and eight autonomic and sensory symptoms assessed using interview‐based rating scales. Autonomic and sensory symptoms were more frequent in patients compared with controls (mean number of symptoms 2.9 vs. 1.1; <i>P</i> < 0.001) and in the postural instability and gait difficulty motor‐subtype vs. tremor dominant subtype (mean 3.3 vs. 2.5; <i>P</i> = 0.008). In the patient group, reduced olfaction (59%), urinary problems (47%), increased saliva or drooling (42%), constipation (39%), and sensory complaints (34%) were the most frequent symptoms. Daily activities were not affected by these symptoms in 58% of the patients, and the influence on daily activities was rated as “mild” or less for all of these symptoms in 90%. A higher Hoehn and Yahr stage was associated with a higher number of autonomic and sensory symptoms and with the occurrence of gastrointestinal symptoms. Autonomic and sensory symptoms are common in patients with untreated, early PD although the severity of these symptoms is mild, with little or no influence on daily activities. The high prevalence of increased saliva or drooling close to the time of diagnosis is noteworthy and not described earlier. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn3"><p>Members of the “Parkwest Study Group” are listed as an Appendix.</p></note><note xml:id="fn4"><p>Potential conflict of interest: The authors have no potential conflicts of interest to report</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Autonomic and Sensory Symptoms in de novo PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild</title></titleInfo><name type="personal"><namePart type="given">Bernd</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation><description>Correspondence: Department of Neurology, Haukeland University Hospital, 5021 Bergen, Norway</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan Petter</namePart><namePart type="family">Larsen</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation><affiliation>Department of Neurology, Stavanger University Hospital, Stavanger, Norway</affiliation><affiliation>The Norwegian Centre for Movement Disorders, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tore</namePart><namePart type="family">Wentzel‐Larsen</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Centre for clinical research, Haukeland University Hospital, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geir Olve</namePart><namePart type="family">Skeie</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ole‐Bjørn</namePart><namePart type="family">Tysnes</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Haukeland University Hospital, Bergen, Norway</affiliation><affiliation>Institute for clinical medicine, University of Bergen, Bergen, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>for The Parkwest Study Group</namePart><description>Department of Neurology, Haukeland University Hospital, Bergen, NorwayInstitute for clinical medicine, University of Bergen, Bergen, NorwayDepartment of Neurology, Stavanger University Hospital, Stavanger, NorwayThe Norwegian Centre for Movement Disorders, Stavanger, NorwayCentre for clinical research, Haukeland University Hospital, Bergen, Norway</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-01</dateIssued><dateCaptured encoding="w3cdtf">2010-01-28</dateCaptured><dateValid encoding="w3cdtf">2010-07-13</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">39</extent><extent unit="words">5816</extent></physicalDescription><abstract lang="en">Although nonmotor symptoms are increasingly recognized as key features in Parkinson's disease (PD), the occurrence and severity of autonomic and sensory symptoms in patients with very early and untreated PD are poorly documented. Two hundred seven patients with newly diagnosed, untreated PD and 175 controls from the population‐based Norwegian ParkWest study were included. Postural blood pressure and olfactory function were measured and eight autonomic and sensory symptoms assessed using interview‐based rating scales. Autonomic and sensory symptoms were more frequent in patients compared with controls (mean number of symptoms 2.9 vs. 1.1; P < 0.001) and in the postural instability and gait difficulty motor‐subtype vs. tremor dominant subtype (mean 3.3 vs. 2.5; P = 0.008). In the patient group, reduced olfaction (59%), urinary problems (47%), increased saliva or drooling (42%), constipation (39%), and sensory complaints (34%) were the most frequent symptoms. Daily activities were not affected by these symptoms in 58% of the patients, and the influence on daily activities was rated as “mild” or less for all of these symptoms in 90%. A higher Hoehn and Yahr stage was associated with a higher number of autonomic and sensory symptoms and with the occurrence of gastrointestinal symptoms. Autonomic and sensory symptoms are common in patients with untreated, early PD although the severity of these symptoms is mild, with little or no influence on daily activities. The high prevalence of increased saliva or drooling close to the time of diagnosis is noteworthy and not described earlier. © 2010 Movement Disorder Society</abstract><note type="content">*Members of the “Parkwest Study Group” are listed as an Appendix.</note><note type="content">*Potential conflict of interest: The authors have no potential conflicts of interest to report</note><note type="funding">Western Norway Regional Health Authority - No. 911218; </note><note type="funding">Research Council of Norway - No. 177966; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>autonomic</topic><topic>sensory</topic><topic>epidemiology</topic><topic>drooling</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>65</start><end>72</end><total>8</total></extent></part></relatedItem><identifier type="istex">10B4210CA3FC63C5094C1FBA02C4BF9F2DDFFA4D</identifier><identifier type="DOI">10.1002/mds.23387</identifier><identifier type="ArticleID">MDS23387</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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