Familial associations of Alzheimer disease and essential tremor with Parkinson disease
Identifieur interne : 000211 ( Main/Corpus ); précédent : 000210; suivant : 000212Familial associations of Alzheimer disease and essential tremor with Parkinson disease
Auteurs : S. Costello ; Y. Bordelon ; J. Bronstein ; B. RitzSource :
- European Journal of Neurology [ 1351-5101 ] ; 2010-06.
English descriptors
Abstract
Background: We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Conclusion: Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.
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DOI: 10.1111/j.1468-1331.2010.02974.x
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ISTEX:AA7D93FCEBE7E8B94879BE20EE7D755690071F77Le document en format XML
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Bronstein</name><affiliation><mods:affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Ritz, B" sort="Ritz, B" uniqKey="Ritz B" first="B." last="Ritz">B. Ritz</name><affiliation><mods:affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AA7D93FCEBE7E8B94879BE20EE7D755690071F77</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1468-1331.2010.02974.x</idno><idno type="url">https://api.istex.fr/document/AA7D93FCEBE7E8B94879BE20EE7D755690071F77/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000211</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Familial associations of Alzheimer disease and essential tremor with Parkinson disease</title><author><name sortKey="Costello, S" sort="Costello, S" uniqKey="Costello S" first="S." last="Costello">S. Costello</name><affiliation><mods:affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Bordelon, Y" sort="Bordelon, Y" uniqKey="Bordelon Y" first="Y." last="Bordelon">Y. Bordelon</name><affiliation><mods:affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Bronstein, J" sort="Bronstein, J" uniqKey="Bronstein J" first="J." last="Bronstein">J. Bronstein</name><affiliation><mods:affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Ritz, B" sort="Ritz, B" uniqKey="Ritz B" first="B." last="Ritz">B. Ritz</name><affiliation><mods:affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-06">2010-06</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="871">871</biblScope><biblScope unit="page" to="878">878</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">AA7D93FCEBE7E8B94879BE20EE7D755690071F77</idno><idno type="DOI">10.1111/j.1468-1331.2010.02974.x</idno><idno type="ArticleID">ENE2974</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Parkinson disease</term><term>epidemiology</term><term>familial aggregation</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Conclusion: Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>S. Costello</name><affiliations><json:string>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</json:string></affiliations></json:item><json:item><name>Y. Bordelon</name><affiliations><json:string>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</json:string></affiliations></json:item><json:item><name>J. Bronstein</name><affiliations><json:string>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</json:string></affiliations></json:item><json:item><name>B. Ritz</name><affiliations><json:string>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>familial aggregation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tremor</value></json:item></subject><articleId><json:string>ENE2974</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background: We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. 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Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Conclusion: Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Alzheimer disease</term></item><item><term>epidemiology</term></item><item><term>familial aggregation</term></item><item><term>Parkinson disease</term></item><item><term>tremor</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/AA7D93FCEBE7E8B94879BE20EE7D755690071F77/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="06006"><doi origin="wiley">10.1111/ene.2010.17.issue-6</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2010-06">June 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="18" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2010.02974.x</doi><idGroup><id type="unit" value="ENE2974"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2010 The Author(s). Journal compilation © 2010 EFNS</copyright><eventGroup><event type="firstOnline" date="2010-03-17"></event><event type="publishedOnlineFinalForm" date="2010-05-13"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-05-17"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-17"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="871">871</numbering><numbering type="pageLast" number="878">878</numbering></numberingGroup><correspondenceTo>S. Costello, University of California, Berkeley, School of Public Health, Environmental Health Science, 50 University Hall #7360, Berkeley, CA 94720, USA (tel.: +1 510 643 4613; fax: +1 510 642 5815; e‐mail: <email>sadie@berkeley.edu</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2974.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 14 October 2009 Accepted 22 December 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Familial associations of Alzheimer disease and essential tremor with Parkinson disease</title><title type="shortAuthors">S. Costello <i>et al.</i></title><title type="short">Familial Associations: Parkinson’s, Alzheimer’s, Tremor</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>S.</givenNames><familyName>Costello</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Y.</givenNames><familyName>Bordelon</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#aff-1-1"><personName><givenNames>J.</givenNames><familyName>Bronstein</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#aff-1-1"><personName><givenNames>B.</givenNames><familyName>Ritz</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="US"><unparsedAffiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Alzheimer disease</keyword><keyword xml:id="k2">epidemiology</keyword><keyword xml:id="k3">familial aggregation</keyword><keyword xml:id="k4">Parkinson disease</keyword><keyword xml:id="k5">tremor</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls.</p><p><b>Methods: </b> We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties.</p><p><b>Results: </b> Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses.</p><p><b>Conclusion: </b> Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Familial associations of Alzheimer disease and essential tremor with Parkinson disease</title></titleInfo><titleInfo type="abbreviated"><title>Familial Associations: Parkinson’s, Alzheimer’s, Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Familial associations of Alzheimer disease and essential tremor with Parkinson disease</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Costello</namePart><affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Bordelon</namePart><affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Bronstein</namePart><affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ritz</namePart><affiliation>University of California, Los Angeles, Schools of Public Health and Medicine Los Angeles, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-06</dateIssued><edition>Received 14 October 2009 Accepted 22 December 2009</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Background: We constructed a cohort of first‐degree relatives of participants in a population‐based case–control study of Parkinson disease (PD) and compared the occurrence of Alzheimer disease (AD) and essential tremor (ET) in relatives of PD cases and controls. Methods: We relied on proband interviews to assess family history in 372 probands with incident PD confirmed by a movement disorder specialist and 404 controls from three rural California counties. Results: Overall, for the 2980 first‐degree relatives of PD cases, the risk of AD was not increased compared with the 2981 relatives of controls. But relatives of younger onset PD cases (≤60 years of age) were three times more likely to have received an AD diagnosis [hazard ratios (HR): 2.86; 95%CI: 1.44, 5.71]. Our data also suggest that some relatives of PD probands might be at a slightly increased risk of receiving an ET diagnosis, especially relatives of tremor dominant cases (HR: 1.69; 95%CI 0.99, 2.88), younger onset cases (HR: 2.03; 95%CI 0.93, 4.44), and male relatives (HR: 2.31; 95%CI 1.13, 4.73). In addition, fathers of cases were almost 15 years younger than fathers of controls when diagnosed with ET. Results were stable in sensitivity analyses. Conclusion: Our study suggests a familial susceptibility to AD amongst first‐degree relatives of younger onset PD cases.</abstract><subject lang="en"><genre>Keywords</genre><topic>Alzheimer disease</topic><topic>epidemiology</topic><topic>familial aggregation</topic><topic>Parkinson disease</topic><topic>tremor</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>871</start><end>878</end><total>8</total></extent></part></relatedItem><identifier type="istex">AA7D93FCEBE7E8B94879BE20EE7D755690071F77</identifier><identifier type="DOI">10.1111/j.1468-1331.2010.02974.x</identifier><identifier type="ArticleID">ENE2974</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Author(s). 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