Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.
Identifieur interne : 000323 ( France/Analysis ); précédent : 000322; suivant : 000324Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.
Auteurs : D. Rougemont ; J C Baron ; P. Collard ; P. Bustany ; D. Comar ; Yves Agid [France]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 1984-08.
Abstract
Using the 18f-fluoro-2-deoxy-d-glucose technique and positron emission tomography (PET), the local cerebral glucose utilisation (1CMRGlc) was measured in four non-demented patients with early-onset, bilateral Parkinson's disease characterised by the predominance of akinesia. The study was done twice, first in the untreated condition, and then after levodopa had been resumed. Despite a marked clinical improvement, we found no alteration in 1CMRGlc between the first and second studies in any of the brain structure analysed. Compared to control values, 1CMRGlc in the basal ganglia was moderately increased in both studies. These essentially negative findings agree with most previous human or animal studies, and indicate that the functional alterations in the central dopaminergic systems of patients with Parkinson's disease have metabolic correlates that are too small to be demonstrated by current PET devices.
Url:
DOI: 10.1136/jnnp.47.8.824
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 002F26
- to stream Main, to step Curation: 002B38
- to stream Main, to step Exploration: 002A25
- to stream France, to step Extraction: 000323
Links to Exploration step
ISTEX:FE2651B6A8FC3F9DB825797A1E648439C8C6F544Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.</title>
<author><name sortKey="Rougemont, D" sort="Rougemont, D" uniqKey="Rougemont D" first="D" last="Rougemont">D. Rougemont</name>
</author>
<author><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name>
</author>
<author><name sortKey="Collard, P" sort="Collard, P" uniqKey="Collard P" first="P" last="Collard">P. Collard</name>
</author>
<author><name sortKey="Bustany, P" sort="Bustany, P" uniqKey="Bustany P" first="P" last="Bustany">P. Bustany</name>
</author>
<author><name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D" last="Comar">D. Comar</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FE2651B6A8FC3F9DB825797A1E648439C8C6F544</idno>
<date when="1984-08-01" year="1984">1984-08-01</date>
<idno type="doi">10.1136/jnnp.47.8.824</idno>
<idno type="url">https://api.istex.fr/document/FE2651B6A8FC3F9DB825797A1E648439C8C6F544/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002F26</idno>
<idno type="wicri:Area/Main/Curation">002B38</idno>
<idno type="wicri:Area/Main/Exploration">002A25</idno>
<idno type="wicri:Area/France/Extraction">000323</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease.</title>
<author><name sortKey="Rougemont, D" sort="Rougemont, D" uniqKey="Rougemont D" first="D" last="Rougemont">D. Rougemont</name>
</author>
<author><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name>
</author>
<author><name sortKey="Collard, P" sort="Collard, P" uniqKey="Collard P" first="P" last="Collard">P. Collard</name>
</author>
<author><name sortKey="Bustany, P" sort="Bustany, P" uniqKey="Bustany P" first="P" last="Bustany">P. Bustany</name>
</author>
<author><name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D" last="Comar">D. Comar</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title>
<title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><publisher>BMJ Publishing Group Ltd</publisher>
<date type="published" when="1984-08">1984-08</date>
<biblScope unit="volume">47</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="824">824</biblScope>
</imprint>
<idno type="ISSN">0022-3050</idno>
</series>
<idno type="istex">FE2651B6A8FC3F9DB825797A1E648439C8C6F544</idno>
<idno type="DOI">10.1136/jnnp.47.8.824</idno>
<idno type="href">jnnp-47-824.pdf</idno>
<idno type="PMID">6332176</idno>
<idno type="local">jnnp;47/8/824</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-3050</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Using the 18f-fluoro-2-deoxy-d-glucose technique and positron emission tomography (PET), the local cerebral glucose utilisation (1CMRGlc) was measured in four non-demented patients with early-onset, bilateral Parkinson's disease characterised by the predominance of akinesia. The study was done twice, first in the untreated condition, and then after levodopa had been resumed. Despite a marked clinical improvement, we found no alteration in 1CMRGlc between the first and second studies in any of the brain structure analysed. Compared to control values, 1CMRGlc in the basal ganglia was moderately increased in both studies. These essentially negative findings agree with most previous human or animal studies, and indicate that the functional alterations in the central dopaminergic systems of patients with Parkinson's disease have metabolic correlates that are too small to be demonstrated by current PET devices.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
<orgName><li>Hôpital de la Salpêtrière</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name>
<name sortKey="Bustany, P" sort="Bustany, P" uniqKey="Bustany P" first="P" last="Bustany">P. Bustany</name>
<name sortKey="Collard, P" sort="Collard, P" uniqKey="Collard P" first="P" last="Collard">P. Collard</name>
<name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D" last="Comar">D. Comar</name>
<name sortKey="Rougemont, D" sort="Rougemont, D" uniqKey="Rougemont D" first="D" last="Rougemont">D. Rougemont</name>
</noCountry>
<country name="France"><region name="Île-de-France"><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000323 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000323 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= France |étape= Analysis |type= RBID |clé= ISTEX:FE2651B6A8FC3F9DB825797A1E648439C8C6F544 |texte= Local cerebral glucose utilisation in treated and untreated patients with Parkinson's disease. }}
This area was generated with Dilib version V0.6.23. |