Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients
Identifieur interne : 000321 ( France/Analysis ); précédent : 000320; suivant : 000322Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients
Auteurs : L. Pique [France] ; S. Jegou ; X. Bertagna [France] ; F. Javoy-Agid ; D. Seurin [France] ; M. F. Proeschel [France] ; F. Girard [France] ; Yves Agid [France] ; H. Vaudry ; J. P. Luton [France]Source :
- Neuroscience Letters [ 0304-3940 ] ; 1984.
English descriptors
Abstract
The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.
Url:
DOI: 10.1016/S0304-3940(85)80069-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 001F38
- to stream Main, to step Curation: 001C44
- to stream Main, to step Exploration: 002A08
- to stream France, to step Extraction: 000321
Links to Exploration step
ISTEX:E38C574F3DB3EAC392E36B0802A6E0FA2DA25472Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients</title><author><name sortKey="Pique, L" sort="Pique, L" uniqKey="Pique L" first="L." last="Pique">L. Pique</name></author><author><name sortKey="Jegou, S" sort="Jegou, S" uniqKey="Jegou S" first="S." last="Jegou">S. Jegou</name></author><author><name sortKey="Bertagna, X" sort="Bertagna, X" uniqKey="Bertagna X" first="X." last="Bertagna">X. Bertagna</name></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name></author><author><name sortKey="Seurin, D" sort="Seurin, D" uniqKey="Seurin D" first="D." last="Seurin">D. Seurin</name></author><author><name sortKey="Proeschel, M F" sort="Proeschel, M F" uniqKey="Proeschel M" first="M. F." last="Proeschel">M. F. Proeschel</name></author><author><name sortKey="Girard, F" sort="Girard, F" uniqKey="Girard F" first="F." last="Girard">F. Girard</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Vaudry, H" sort="Vaudry, H" uniqKey="Vaudry H" first="H." last="Vaudry">H. Vaudry</name></author><author><name sortKey="Luton, J P" sort="Luton, J P" uniqKey="Luton J" first="J. P." last="Luton">J. P. Luton</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E38C574F3DB3EAC392E36B0802A6E0FA2DA25472</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1016/S0304-3940(85)80069-0</idno><idno type="url">https://api.istex.fr/document/E38C574F3DB3EAC392E36B0802A6E0FA2DA25472/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001F38</idno><idno type="wicri:Area/Main/Curation">001C44</idno><idno type="wicri:Area/Main/Exploration">002A08</idno><idno type="wicri:Area/France/Extraction">000321</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients</title><author><name sortKey="Pique, L" sort="Pique, L" uniqKey="Pique L" first="L." last="Pique">L. Pique</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author><author><name sortKey="Jegou, S" sort="Jegou, S" uniqKey="Jegou S" first="S." last="Jegou">S. Jegou</name><affiliation><wicri:noCountry code="subField">Rouen (France)</wicri:noCountry></affiliation></author><author><name sortKey="Bertagna, X" sort="Bertagna, X" uniqKey="Bertagna X" first="X." last="Bertagna">X. Bertagna</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation><wicri:noCountry code="subField">Paris (France)</wicri:noCountry></affiliation></author><author><name sortKey="Seurin, D" sort="Seurin, D" uniqKey="Seurin D" first="D." last="Seurin">D. Seurin</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author><author><name sortKey="Proeschel, M F" sort="Proeschel, M F" uniqKey="Proeschel M" first="M. F." last="Proeschel">M. F. Proeschel</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author><author><name sortKey="Girard, F" sort="Girard, F" uniqKey="Girard F" first="F." last="Girard">F. Girard</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation><wicri:noCountry code="subField">Paris (France)</wicri:noCountry><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author><author><name sortKey="Vaudry, H" sort="Vaudry, H" uniqKey="Vaudry H" first="H." last="Vaudry">H. Vaudry</name><affiliation><wicri:noCountry code="subField">Rouen (France)</wicri:noCountry></affiliation></author><author><name sortKey="Luton, J P" sort="Luton, J P" uniqKey="Luton J" first="J. P." last="Luton">J. P. Luton</name><affiliation wicri:level="0"><country wicri:rule="zip">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience Letters</title><title level="j" type="abbrev">NSL</title><idno type="ISSN">0304-3940</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">54</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="141">141</biblScope><biblScope unit="page" to="146">146</biblScope></imprint><idno type="ISSN">0304-3940</idno></series><idno type="istex">E38C574F3DB3EAC392E36B0802A6E0FA2DA25472</idno><idno type="DOI">10.1016/S0304-3940(85)80069-0</idno><idno type="PII">S0304-3940(85)80069-0</idno><idno type="ArticleID">80069</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson</term><term>gel filtration</term><term>hypothalamus</term><term>pro-opiomelanocortin</term><term>radioimmunoassay</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The concentrations of γ3-melanotropin-, α-melanotropin-, corticotropin-, γ-lipotropin- and β-endorphin-immunoreactivities were determined simultaneously, before and after gel exclusion chromatography, in whole hypothalamic extracts of normal subjects and Parkinson patients. All five immunoreactivities were present and were all significantly correlated to each other. Shorter peptides (α-melanotropin, γ3-melanotropin, β-endorphin and a lipotropin37–58-like peptide) were the dominant products. Whereas the dopamine content was significantly reduced in Parkinson patients, there was no significant difference for any peptide between normal subjects and Parkinson patients, either in tissue concentrations or in chromatographic patterns.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><noCountry><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><name sortKey="Jegou, S" sort="Jegou, S" uniqKey="Jegou S" first="S." last="Jegou">S. Jegou</name><name sortKey="Vaudry, H" sort="Vaudry, H" uniqKey="Vaudry H" first="H." last="Vaudry">H. Vaudry</name></noCountry><country name="France"><noRegion><name sortKey="Pique, L" sort="Pique, L" uniqKey="Pique L" first="L." last="Pique">L. Pique</name></noRegion><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Bertagna, X" sort="Bertagna, X" uniqKey="Bertagna X" first="X." last="Bertagna">X. Bertagna</name><name sortKey="Girard, F" sort="Girard, F" uniqKey="Girard F" first="F." last="Girard">F. Girard</name><name sortKey="Luton, J P" sort="Luton, J P" uniqKey="Luton J" first="J. P." last="Luton">J. P. Luton</name><name sortKey="Proeschel, M F" sort="Proeschel, M F" uniqKey="Proeschel M" first="M. F." last="Proeschel">M. F. Proeschel</name><name sortKey="Seurin, D" sort="Seurin, D" uniqKey="Seurin D" first="D." last="Seurin">D. Seurin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000321 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000321 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:E38C574F3DB3EAC392E36B0802A6E0FA2DA25472
|texte= Pro-opiomelanocortin peptides in the human hypothalamus: Comparative study between normal subjects and parkinson patients
}}
| This area was generated with Dilib version V0.6.23. |  |