Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat
Identifieur interne : 000212 ( France/Analysis ); précédent : 000211; suivant : 000213Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat
Auteurs : V. Ben [France] ; B. Bruguerolle [France]Source :
- Life Sciences [ 0024-3205 ] ; 2000.
Abstract
The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.
Url:
DOI: 10.1016/S0024-3205(00)00751-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 000810
- to stream Main, to step Curation: 000706
- to stream Main, to step Exploration: 001B37
- to stream France, to step Extraction: 000212
Links to Exploration step
ISTEX:AB8F7D8B3267253813F1B7834234B6C786D6545FLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</title><author><name sortKey="Ben, V" sort="Ben, V" uniqKey="Ben V" first="V." last="Ben">V. Ben</name></author><author><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B." last="Bruguerolle">B. Bruguerolle</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AB8F7D8B3267253813F1B7834234B6C786D6545F</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0024-3205(00)00751-7</idno><idno type="url">https://api.istex.fr/document/AB8F7D8B3267253813F1B7834234B6C786D6545F/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000810</idno><idno type="wicri:Area/Main/Curation">000706</idno><idno type="wicri:Area/Main/Exploration">001B37</idno><idno type="wicri:Area/France/Extraction">000212</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat</title><author><name sortKey="Ben, V" sort="Ben, V" uniqKey="Ben V" first="V." last="Ben">V. Ben</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B." last="Bruguerolle">B. Bruguerolle</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille, 27 Bd J. Moulin, F 13385 Marseille Cedex 5</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="1549">1549</biblScope><biblScope unit="page" to="1558">1558</biblScope></imprint><idno type="ISSN">0024-3205</idno></series><idno type="istex">AB8F7D8B3267253813F1B7834234B6C786D6545F</idno><idno type="DOI">10.1016/S0024-3205(00)00751-7</idno><idno type="PII">S0024-3205(00)00751-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a possible perturbation of the circadian rythmicity. H, T and A were measured by radiotelemetry after surgical implantation of the transmitters (Data Sciences). After a recovery period, the study was divided into a control period (C) for baseline measurements of T, H and A daily rhythms. Then, the stereotaxic 6-OHDA striatal lesion was done to a group of 4 rats while the control rats were injected into striata with saline; a second period of four registration weeks was observed {D 1–7 (W1), D 8–14 (W2), D 15–21 (W3), D 22–28 (W4)}. Finally, at the end of this period the seven rats were decapited in order to determine their striatal dopamine (DA) content. Our data document that the circadian rhythms of H,T and A were differently affected according to time. Thus, a temporary loss of circadian periodicity was observed particularly for heart rate. 6-OHDA-induced modifications of H, T and A circadian rhythm characteristics were also observed: a significant decrease of the mesor was observed for the three rhythms as well as a phase advance. Concerning the amplitude of these rhythms, only H was significantly decreased. These perturbations were observed during the four weeks following the intervention, never reaching the initial control levels. Such observed perturbations would supply a basis for the future study of the chronopharmacology of antiparkinsonian drugs.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Ben, V" sort="Ben, V" uniqKey="Ben V" first="V." last="Ben">V. Ben</name></region><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B." last="Bruguerolle">B. Bruguerolle</name><name sortKey="Bruguerolle, B" sort="Bruguerolle, B" uniqKey="Bruguerolle B" first="B." last="Bruguerolle">B. Bruguerolle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000212 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000212 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:AB8F7D8B3267253813F1B7834234B6C786D6545F
|texte= Effects of bilateral striatal 6-OHDA lesions on circadian rhythms in the rat
}}
| This area was generated with Dilib version V0.6.23. |  |