Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease
Identifieur interne : 000101 ( France/Analysis ); précédent : 000100; suivant : 000102Microsubthalamotomy: An immediate predictor of long‐term subthalamic stimulation efficacy in Parkinson disease
Auteurs : David Maltête [France] ; Stéphane Derrey [France] ; Nathalie Chastan [France] ; Bertrand Debono [France] ; Emmanuel Gérardin [France] ; Pierre Fréger [France] ; Bruno Mihout [France] ; Jean François Menard [France] ; Didier Hannequin [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
English descriptors
Abstract
A microsubthalamotomy (mSTN) effect is commonly described after implantation that improves Parkinson's motor disability and is considered to be an obvious sign of good placement of the definitive electrode within the subthalamic nucleus (STN). There has been no formal study, however, demonstrating whether this mSTN effect can predict the long‐term efficacy of STN stimulation in Parkinson Disease. The mSTN effect was defined by the percentage improvement of unified parkinson's disease rating scale (UPDRS III) baseline score assessed the third day morning following STN implantation, after at least a 12 hour withdrawal of dopaminergic treatment and before the programmable pulse generator was switched on. It was assessed in 30 consecutive patients with PD submitted for STN stimulation. Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22054
Affiliations:
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Multiple stepwise regression analysis showed that mSTN effect (P = 0.005) and global mean intensity of stimulation (P = 0.004) were accurate independent predictors of the 6‐month postoperative UPDRS III motor score improvement in the off‐drug/on‐stimulation condition. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Rouen</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name></noRegion><name sortKey="Chastan, Nathalie" sort="Chastan, Nathalie" uniqKey="Chastan N" first="Nathalie" last="Chastan">Nathalie Chastan</name><name sortKey="Debono, Bertrand" sort="Debono, Bertrand" uniqKey="Debono B" first="Bertrand" last="Debono">Bertrand Debono</name><name sortKey="Derrey, Stephane" sort="Derrey, Stephane" uniqKey="Derrey S" first="Stéphane" last="Derrey">Stéphane Derrey</name><name sortKey="Freger, Pierre" sort="Freger, Pierre" uniqKey="Freger P" first="Pierre" last="Fréger">Pierre Fréger</name><name sortKey="Gerardin, Emmanuel" sort="Gerardin, Emmanuel" uniqKey="Gerardin E" first="Emmanuel" last="Gérardin">Emmanuel Gérardin</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Maltete, David" sort="Maltete, David" uniqKey="Maltete D" first="David" last="Maltête">David Maltête</name><name sortKey="Menard, Jean Francois" sort="Menard, Jean Francois" uniqKey="Menard J" first="Jean François" last="Menard">Jean François Menard</name><name sortKey="Mihout, Bruno" sort="Mihout, Bruno" uniqKey="Mihout B" first="Bruno" last="Mihout">Bruno Mihout</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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