(99mTc)-HM-PAO SPECT and cognitive impairment in Parkinson's disease: a comparison with dementia of the Alzheimer type.
Identifieur interne : 001743 ( PubMed/Curation ); précédent : 001742; suivant : 001744(99mTc)-HM-PAO SPECT and cognitive impairment in Parkinson's disease: a comparison with dementia of the Alzheimer type.
Auteurs : U. Spampinato [France] ; M O Habert ; J L Mas ; M C Bourdel ; M. Ziegler ; J. De Recondo ; S. Askienazy ; P. RondotSource :
- Journal of neurology, neurosurgery, and psychiatry [ 0022-3050 ] ; 1991.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (diagnosis), Alzheimer Disease (diagnostic imaging), Alzheimer Disease (physiopathology), Brain (blood supply), Brain (diagnostic imaging), Cerebral Cortex (blood supply), Dementia (diagnosis), Dementia (diagnostic imaging), Dementia (physiopathology), Diagnosis, Differential, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (diagnosis), Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Regional Blood Flow (physiology), Tomography, Emission-Computed, Single-Photon.
- MESH :
- blood supply : Brain, Cerebral Cortex.
- diagnosis : Alzheimer Disease, Dementia, Parkinson Disease.
- diagnostic imaging : Alzheimer Disease, Brain, Dementia, Parkinson Disease.
- physiology : Regional Blood Flow.
- physiopathology : Alzheimer Disease, Dementia, Parkinson Disease.
- Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon.
Abstract
Regional cerebral perfusion was evaluated by single photon emission tomography (SPECT) using (99mTc)-HM-PAO as a tracer, in thirty Parkinsonian patients with (n = 15) or without (n = 15) dementia, nineteen patients with dementia of the Alzheimer type (DAT) and thirteen control subjects. HM-PAO uptake was measured in the frontal, parietal, temporal and occipital cortex and tracer perfusion was expressed as cortical/cerebellar activity ratios. Regional HM-PAO ratios in nondemented Parkinsonian patients did not differ from controls, whereas in demented patients with Parkinson's disease (DPD) a significant reduction was found in the parietal, temporal and occipital cortex. Tracer uptake ratios were significantly reduced in all regions in the DAT group. Thus DPD and DAT shared a common pattern of marked posterior hypoperfusion, although the perfusion defect was greater and more extensive in the DAT patients.
PubMed: 1955897
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Spampinato</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Sainte Anne, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Sainte Anne, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Habert, M O" sort="Habert, M O" uniqKey="Habert M" first="M O" last="Habert">M O Habert</name></author><author><name sortKey="Mas, J L" sort="Mas, J L" uniqKey="Mas J" first="J L" last="Mas">J L Mas</name></author><author><name sortKey="Bourdel, M C" sort="Bourdel, M C" uniqKey="Bourdel M" first="M C" last="Bourdel">M C Bourdel</name></author><author><name sortKey="Ziegler, M" sort="Ziegler, M" uniqKey="Ziegler M" first="M" last="Ziegler">M. Ziegler</name></author><author><name sortKey="De Recondo, J" sort="De Recondo, J" uniqKey="De Recondo J" first="J" last="De Recondo">J. De Recondo</name></author><author><name sortKey="Askienazy, S" sort="Askienazy, S" uniqKey="Askienazy S" first="S" last="Askienazy">S. Askienazy</name></author><author><name sortKey="Rondot, P" sort="Rondot, P" uniqKey="Rondot P" first="P" last="Rondot">P. Rondot</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1955897</idno><idno type="pmid">1955897</idno><idno type="wicri:Area/PubMed/Corpus">001784</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001784</idno><idno type="wicri:Area/PubMed/Curation">001743</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001743</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">(99mTc)-HM-PAO SPECT and cognitive impairment in Parkinson's disease: a comparison with dementia of the Alzheimer type.</title><author><name sortKey="Spampinato, U" sort="Spampinato, U" uniqKey="Spampinato U" first="U" last="Spampinato">U. Spampinato</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Sainte Anne, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Sainte Anne, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Habert, M O" sort="Habert, M O" uniqKey="Habert M" first="M O" last="Habert">M O Habert</name></author><author><name sortKey="Mas, J L" sort="Mas, J L" uniqKey="Mas J" first="J L" last="Mas">J L Mas</name></author><author><name sortKey="Bourdel, M C" sort="Bourdel, M C" uniqKey="Bourdel M" first="M C" last="Bourdel">M C Bourdel</name></author><author><name sortKey="Ziegler, M" sort="Ziegler, M" uniqKey="Ziegler M" first="M" last="Ziegler">M. Ziegler</name></author><author><name sortKey="De Recondo, J" sort="De Recondo, J" uniqKey="De Recondo J" first="J" last="De Recondo">J. De Recondo</name></author><author><name sortKey="Askienazy, S" sort="Askienazy, S" uniqKey="Askienazy S" first="S" last="Askienazy">S. Askienazy</name></author><author><name sortKey="Rondot, P" sort="Rondot, P" uniqKey="Rondot P" first="P" last="Rondot">P. Rondot</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer Disease (diagnostic imaging)</term><term>Alzheimer Disease (physiopathology)</term><term>Brain (blood supply)</term><term>Brain (diagnostic imaging)</term><term>Cerebral Cortex (blood supply)</term><term>Dementia (diagnosis)</term><term>Dementia (diagnostic imaging)</term><term>Dementia (physiopathology)</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Regional Blood Flow (physiology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Regional cerebral perfusion was evaluated by single photon emission tomography (SPECT) using (99mTc)-HM-PAO as a tracer, in thirty Parkinsonian patients with (n = 15) or without (n = 15) dementia, nineteen patients with dementia of the Alzheimer type (DAT) and thirteen control subjects. HM-PAO uptake was measured in the frontal, parietal, temporal and occipital cortex and tracer perfusion was expressed as cortical/cerebellar activity ratios. Regional HM-PAO ratios in nondemented Parkinsonian patients did not differ from controls, whereas in demented patients with Parkinson's disease (DPD) a significant reduction was found in the parietal, temporal and occipital cortex. Tracer uptake ratios were significantly reduced in all regions in the DAT group. Thus DPD and DAT shared a common pattern of marked posterior hypoperfusion, although the perfusion defect was greater and more extensive in the DAT patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1955897</PMID><DateCreated><Year>1991</Year><Month>12</Month><Day>31</Day></DateCreated><DateCompleted><Year>1991</Year><Month>12</Month><Day>31</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3050</ISSN><JournalIssue CitedMedium="Print"><Volume>54</Volume><Issue>9</Issue><PubDate><Year>1991</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>(99mTc)-HM-PAO SPECT and cognitive impairment in Parkinson's disease: a comparison with dementia of the Alzheimer type.</ArticleTitle><Pagination><MedlinePgn>787-92</MedlinePgn></Pagination><Abstract><AbstractText>Regional cerebral perfusion was evaluated by single photon emission tomography (SPECT) using (99mTc)-HM-PAO as a tracer, in thirty Parkinsonian patients with (n = 15) or without (n = 15) dementia, nineteen patients with dementia of the Alzheimer type (DAT) and thirteen control subjects. HM-PAO uptake was measured in the frontal, parietal, temporal and occipital cortex and tracer perfusion was expressed as cortical/cerebellar activity ratios. Regional HM-PAO ratios in nondemented Parkinsonian patients did not differ from controls, whereas in demented patients with Parkinson's disease (DPD) a significant reduction was found in the parietal, temporal and occipital cortex. Tracer uptake ratios were significantly reduced in all regions in the DAT group. Thus DPD and DAT shared a common pattern of marked posterior hypoperfusion, although the perfusion defect was greater and more extensive in the DAT patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Spampinato</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Sainte Anne, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Habert</LastName><ForeName>M O</ForeName><Initials>MO</Initials></Author><Author ValidYN="Y"><LastName>Mas</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Bourdel</LastName><ForeName>M C</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Ziegler</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>de Recondo</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Askienazy</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Rondot</LastName><ForeName>P</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1967 Oct;17(10):952-60</RefSource><PMID Version="1">6069607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1990 Jan;40(1):1-8</RefSource><PMID Version="1">2153271</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nerv Ment Dis. 1972 Jun;154(6):445-52</RefSource><PMID 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Version="1">1431975</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002540" MajorTopicYN="N">Cerebral Cortex</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="N">blood supply</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003704" MajorTopicYN="N">Dementia</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012039" MajorTopicYN="N">Regional Blood Flow</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015899" MajorTopicYN="Y">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1014518</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate 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