Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease.
Identifieur interne : 001656 ( PubMed/Curation ); précédent : 001655; suivant : 001657Low affinity nerve growth factor receptor, adrenal transplant and Parkinson's disease.
Auteurs : O. Strada [France] ; E C Hirsch ; F. Javoy-Agid ; C. Duyckaerts ; J J Hauw ; Y. AgidSource :
- Journal of the neurological sciences [ 0022-510X ] ; 1993.
English descriptors
- KwdEn :
- Adrenal Medulla (metabolism), Adrenal Medulla (pathology), Adrenal Medulla (transplantation), Autopsy, Corpus Striatum (metabolism), Corpus Striatum (pathology), Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Parkinson Disease (therapy), Receptors, Nerve Growth Factor (analysis), Receptors, Nerve Growth Factor (metabolism), Transplantation, Autologous, Transplantation, Heterotopic.
- MESH :
- chemical , analysis : Receptors, Nerve Growth Factor.
- chemical , metabolism : Receptors, Nerve Growth Factor.
- chemical , therapeutic use : Levodopa.
- drug therapy : Parkinson Disease.
- metabolism : Adrenal Medulla, Corpus Striatum, Parkinson Disease.
- pathology : Adrenal Medulla, Corpus Striatum.
- therapy : Parkinson Disease.
- transplantation : Adrenal Medulla.
- Autopsy, Humans, Male, Middle Aged, Transplantation, Autologous, Transplantation, Heterotopic.
Abstract
Immunohistochemistry of low-affinity nerve growth factor receptor (LNGFR) was performed postmortem in the striatum and the adrenal gland of a parkinsonian patient with an adrenal to brain transplantation. Few LNGFR-positive fibers were observed in the necrotic graft. By contrast numerous immunostained fibers were detected in a restricted zone of the host striatum adjacent to the graft, corresponding to a selective zone of sprouting of tyrosine hydroxylase-positive fibers. This suggests that nerve growth factor or related growth factors may promote sprouting of catecholaminergic fibers in the host striatum.
PubMed: 8289077
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pubmed:8289077Le document en format XML
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<front><div type="abstract" xml:lang="en">Immunohistochemistry of low-affinity nerve growth factor receptor (LNGFR) was performed postmortem in the striatum and the adrenal gland of a parkinsonian patient with an adrenal to brain transplantation. Few LNGFR-positive fibers were observed in the necrotic graft. By contrast numerous immunostained fibers were detected in a restricted zone of the host striatum adjacent to the graft, corresponding to a selective zone of sprouting of tyrosine hydroxylase-positive fibers. This suggests that nerve growth factor or related growth factors may promote sprouting of catecholaminergic fibers in the host striatum.</div>
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<Abstract><AbstractText>Immunohistochemistry of low-affinity nerve growth factor receptor (LNGFR) was performed postmortem in the striatum and the adrenal gland of a parkinsonian patient with an adrenal to brain transplantation. Few LNGFR-positive fibers were observed in the necrotic graft. By contrast numerous immunostained fibers were detected in a restricted zone of the host striatum adjacent to the graft, corresponding to a selective zone of sprouting of tyrosine hydroxylase-positive fibers. This suggests that nerve growth factor or related growth factors may promote sprouting of catecholaminergic fibers in the host striatum.</AbstractText>
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