Monoamine oxidase inhibitors, cognitive functions and neurodegenerative diseases.
Identifieur interne : 001652 ( PubMed/Curation ); précédent : 001651; suivant : 001653Monoamine oxidase inhibitors, cognitive functions and neurodegenerative diseases.
Auteurs : J C Delumeau [France] ; D. Bentué-Ferrer ; J M Gandon ; R. Amrein ; S. Belliard ; H. AllainSource :
- Journal of neural transmission. Supplementum [ 0303-6995 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Monoamine Oxidase.
- drug effects : Cognition.
- drug therapy : Alzheimer Disease, Parkinson Disease.
- metabolism : Brain.
- psychology : Alzheimer Disease, Parkinson Disease.
- chemical , therapeutic use : Monoamine Oxidase Inhibitors.
- Animals, Humans.
Abstract
Recent data obtained in animals and in humans suggest that both MAO-A and MAO-B inhibitors present cognitive enhancing properties of possible interest in the treatment of cognitive disorders. In addition, the rational for using selegiline as a neuroprotector in Parkinson's disease may also be applicable in Alzheimer's disease in which a dramatic increase in the MAO-B activity has been reported. It seems then worthwhile to investigate the neuroprotective effect of MAOIs in humans and to assess, furthermore, the real therapeutical benefit of their cognitive enhancing properties.
PubMed: 7931235
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