Sequences of memory-guided saccades in Parkinson's disease.
Identifieur interne : 001642 ( PubMed/Curation ); précédent : 001641; suivant : 001643Sequences of memory-guided saccades in Parkinson's disease.
Auteurs : A I Vermersch [France] ; S. Rivaud ; M. Vidailhet ; A M Bonnet ; B. Gaymard ; Y. Agid ; C. Pierrot-DeseillignySource :
- Annals of neurology [ 0364-5134 ] ; 1994.
English descriptors
- KwdEn :
- MESH :
- physiology : Memory, Reaction Time, Saccades.
- physiopathology : Parkinson Disease.
- Electrooculography, Humans, Middle Aged, Photic Stimulation.
Abstract
Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., "on") and without (i.e., "off") levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the "off" state, but significantly improved during the "on" period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.
DOI: 10.1002/ana.410350419
PubMed: 8154878
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pubmed:8154878Le document en format XML
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<front><div type="abstract" xml:lang="en">Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., "on") and without (i.e., "off") levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the "off" state, but significantly improved during the "on" period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.</div>
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