Normal frontal perfusion in patients with frozen gait.
Identifieur interne : 001423 ( PubMed/Curation ); précédent : 001422; suivant : 001424Normal frontal perfusion in patients with frozen gait.
Auteurs : N. Fabre [France] ; C. Brefel ; U. Sabatini ; P. Celsis ; J L Montastruc ; F. Chollet ; O. RascolSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Blood Flow Velocity (physiology), Brain Mapping, Dominance, Cerebral (physiology), Female, Frontal Lobe (blood supply), Frontal Lobe (diagnostic imaging), Gait (physiology), Humans, Male, Muscle Rigidity (diagnostic imaging), Muscle Rigidity (physiopathology), Neurologic Examination, Neurons (physiology), Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Regional Blood Flow (physiology), Supranuclear Palsy, Progressive (diagnostic imaging), Supranuclear Palsy, Progressive (physiopathology), Tomography, Emission-Computed, Single-Photon, Xenon Radioisotopes.
- MESH :
- chemical : Xenon Radioisotopes.
- blood supply : Frontal Lobe.
- diagnostic imaging : Frontal Lobe, Muscle Rigidity, Parkinson Disease, Supranuclear Palsy, Progressive.
- physiology : Blood Flow Velocity, Dominance, Cerebral, Gait, Neurons, Regional Blood Flow.
- physiopathology : Muscle Rigidity, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Aged, 80 and over, Brain Mapping, Female, Humans, Male, Neurologic Examination, Tomography, Emission-Computed, Single-Photon.
Abstract
We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of "isolated gait ignition failure" (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe "off" freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.
DOI: 10.1002/mds.870130412
PubMed: 9686774
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Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. 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Fabre</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Health and Medical Research, INSERM U 455, Department of Neurology, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute of Health and Medical Research, INSERM U 455, Department of Neurology, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Brefel, C" sort="Brefel, C" uniqKey="Brefel C" first="C" last="Brefel">C. Brefel</name></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Blood Flow Velocity (physiology)</term><term>Brain Mapping</term><term>Dominance, Cerebral (physiology)</term><term>Female</term><term>Frontal Lobe (blood supply)</term><term>Frontal Lobe (diagnostic imaging)</term><term>Gait (physiology)</term><term>Humans</term><term>Male</term><term>Muscle Rigidity (diagnostic imaging)</term><term>Muscle Rigidity (physiopathology)</term><term>Neurologic Examination</term><term>Neurons (physiology)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Regional Blood Flow (physiology)</term><term>Supranuclear Palsy, Progressive (diagnostic imaging)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Xenon Radioisotopes</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Xenon Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Frontal Lobe</term><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Flow Velocity</term><term>Dominance, Cerebral</term><term>Gait</term><term>Neurons</term><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle Rigidity</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Neurologic Examination</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of "isolated gait ignition failure" (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe "off" freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9686774</PMID><DateCreated><Year>1998</Year><Month>10</Month><Day>28</Day></DateCreated><DateCompleted><Year>1998</Year><Month>10</Month><Day>28</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>4</Issue><PubDate><Year>1998</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Normal frontal perfusion in patients with frozen gait.</ArticleTitle><Pagination><MedlinePgn>677-83</MedlinePgn></Pagination><Abstract><AbstractText>We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait: 10 patients with the syndrome of "isolated gait ignition failure" (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe "off" freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fabre</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>National Institute of Health and Medical Research, INSERM U 455, Department of Neurology, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brefel</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Sabatini</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Celsis</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Montastruc</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Chollet</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>O</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014980">Xenon Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001783" MajorTopicYN="N">Blood Flow Velocity</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001931" MajorTopicYN="N">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004292" MajorTopicYN="N">Dominance, Cerebral</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005625" MajorTopicYN="N">Frontal Lobe</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005684" MajorTopicYN="N">Gait</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009127" MajorTopicYN="N">Muscle Rigidity</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009460" MajorTopicYN="N">Neurologic Examination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012039" MajorTopicYN="N">Regional Blood Flow</DescriptorName><QualifierName UI="Q000502" 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