[Intracerebral grafts in Parkinson disease. Current experiences and perspectives].
Identifieur interne : 001389 ( PubMed/Curation ); précédent : 001388; suivant : 001390[Intracerebral grafts in Parkinson disease. Current experiences and perspectives].
Auteurs : M. LevivierSource :
- Bulletin et memoires de l'Academie royale de medecine de Belgique [ 0377-8231 ] ; 1999.
English descriptors
- KwdEn :
- Brain Tissue Transplantation (methods), Brain Tissue Transplantation (trends), Ethics, Medical, Fetal Tissue Transplantation (methods), Fetal Tissue Transplantation (trends), Genetic Engineering, Humans, Neurons (transplantation), Parkinson Disease (surgery), Putamen (surgery), Transplantation, Heterologous.
- MESH :
- methods : Brain Tissue Transplantation, Fetal Tissue Transplantation.
- surgery : Parkinson Disease, Putamen.
- transplantation : Neurons.
- trends : Brain Tissue Transplantation, Fetal Tissue Transplantation.
- Ethics, Medical, Genetic Engineering, Humans, Transplantation, Heterologous.
Abstract
Six patients with advanced Parkinson's disease have been grafted with human fetal neuronal cells. This clinical work is based on the technique originally described by the groups of Lund, Sweden and Créteil, France, with which we closely collaborate. A first group of 3 patients was grafted between 1995 and 1996, with neuronal tissue obtained from same-day abortions. We have observed bilateral improvement of motor functions after unilateral transplantation into the putamen. One patient had a second graft, into the heterolateral putamen, one year after the first one. Another group of 3 patients was operated between 1997 and 1998, and received grafts of hibernated tissue, in order to facilitate the technical organization of the transplantation procedure. Altogether, these clinical results are encouraging, but the technical and ethical limitations related with the use of human fetal tissue prompted us to develop alternative solutions, such as the use of xenografts and the transplantation of genetically modified cells.
PubMed: 10535160
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Current experiences and perspectives].</title><author><name sortKey="Levivier, M" sort="Levivier, M" uniqKey="Levivier M" first="M" last="Levivier">M. Levivier</name></author></analytic><series><title level="j">Bulletin et memoires de l'Academie royale de medecine de Belgique</title><idno type="ISSN">0377-8231</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Tissue Transplantation (methods)</term><term>Brain Tissue Transplantation (trends)</term><term>Ethics, Medical</term><term>Fetal Tissue Transplantation (methods)</term><term>Fetal Tissue Transplantation (trends)</term><term>Genetic Engineering</term><term>Humans</term><term>Neurons (transplantation)</term><term>Parkinson Disease (surgery)</term><term>Putamen (surgery)</term><term>Transplantation, Heterologous</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Fetal Tissue Transplantation</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Fetal Tissue Transplantation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Ethics, Medical</term><term>Genetic Engineering</term><term>Humans</term><term>Transplantation, Heterologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Six patients with advanced Parkinson's disease have been grafted with human fetal neuronal cells. This clinical work is based on the technique originally described by the groups of Lund, Sweden and Créteil, France, with which we closely collaborate. A first group of 3 patients was grafted between 1995 and 1996, with neuronal tissue obtained from same-day abortions. We have observed bilateral improvement of motor functions after unilateral transplantation into the putamen. One patient had a second graft, into the heterolateral putamen, one year after the first one. Another group of 3 patients was operated between 1997 and 1998, and received grafts of hibernated tissue, in order to facilitate the technical organization of the transplantation procedure. Altogether, these clinical results are encouraging, but the technical and ethical limitations related with the use of human fetal tissue prompted us to develop alternative solutions, such as the use of xenografts and the transplantation of genetically modified cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10535160</PMID><DateCreated><Year>1999</Year><Month>11</Month><Day>16</Day></DateCreated><DateCompleted><Year>1999</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0377-8231</ISSN><JournalIssue CitedMedium="Print"><Volume>154</Volume><Issue>1</Issue><PubDate><Year>1999</Year></PubDate></JournalIssue><Title>Bulletin et memoires de l'Academie royale de medecine de Belgique</Title><ISOAbbreviation>Bull. Mem. Acad. R. Med. Belg.</ISOAbbreviation></Journal><ArticleTitle>[Intracerebral grafts in Parkinson disease. Current experiences and perspectives].</ArticleTitle><Pagination><MedlinePgn>99-106; discussion 106-9</MedlinePgn></Pagination><Abstract><AbstractText>Six patients with advanced Parkinson's disease have been grafted with human fetal neuronal cells. This clinical work is based on the technique originally described by the groups of Lund, Sweden and Créteil, France, with which we closely collaborate. A first group of 3 patients was grafted between 1995 and 1996, with neuronal tissue obtained from same-day abortions. We have observed bilateral improvement of motor functions after unilateral transplantation into the putamen. One patient had a second graft, into the heterolateral putamen, one year after the first one. Another group of 3 patients was operated between 1997 and 1998, and received grafts of hibernated tissue, in order to facilitate the technical organization of the transplantation procedure. Altogether, these clinical results are encouraging, but the technical and ethical limitations related with the use of human fetal tissue prompted us to develop alternative solutions, such as the use of xenografts and the transplantation of genetically modified cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Levivier</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Greffes intracérébrales dans la maladie de Parkinson. 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