Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson's disease--A [(11)C]-raclopride PET study.
Identifieur interne : 001035 ( PubMed/Curation ); précédent : 001034; suivant : 001036Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson's disease--A [(11)C]-raclopride PET study.
Auteurs : S. Thobois [France] ; V. Fraix ; M. Savasta ; N. Costes ; P. Pollak ; P. Mertens ; A. Koudsie ; D. Le Bars ; A L Benabid ; E. BroussolleSource :
- Journal of neurology [ 0340-5354 ] ; 2003.
English descriptors
- KwdEn :
- Adult, Aged, Carbon Radioisotopes, Dopamine (secretion), Dopamine Antagonists, Electric Stimulation Therapy, Female, Humans, Male, Middle Aged, Parkinson Disease (diagnostic imaging), Parkinson Disease (therapy), Raclopride, Receptors, Dopamine D2 (physiology), Subthalamic Nucleus (physiology), Tomography, Emission-Computed.
- MESH :
- chemical , physiology : Receptors, Dopamine D2.
- chemical , secretion : Dopamine.
- chemical : Carbon Radioisotopes, Dopamine Antagonists, Raclopride.
- diagnostic imaging : Parkinson Disease.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Adult, Aged, Electric Stimulation Therapy, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed.
Abstract
Subthalamic nucleus (STN) stimulation mechanism of action remains a matter for debate. In animals, an increased striatal dopamine (DA) release due to STN stimulation has been reported.
DOI: 10.1007/s00415-003-0188-z
PubMed: 14586606
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Savasta</name></author><author><name sortKey="Costes, N" sort="Costes, N" uniqKey="Costes N" first="N" last="Costes">N. Costes</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author><author><name sortKey="Mertens, P" sort="Mertens, P" uniqKey="Mertens P" first="P" last="Mertens">P. Mertens</name></author><author><name sortKey="Koudsie, A" sort="Koudsie, A" uniqKey="Koudsie A" first="A" last="Koudsie">A. Koudsie</name></author><author><name sortKey="Le Bars, D" sort="Le Bars, D" uniqKey="Le Bars D" first="D" last="Le Bars">D. Le Bars</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E" last="Broussolle">E. 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Chazot) and INSERM U 534, Hôpital Neurologique Pierre Wertheimer, 59 Bd Pinel, 69003 Lyon, France. stephane.thobois@chu-lyon.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Dept. of Neurology D (Pr. G. Chazot) and INSERM U 534, Hôpital Neurologique Pierre Wertheimer, 59 Bd Pinel, 69003 Lyon</wicri:regionArea></affiliation></author><author><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V" last="Fraix">V. Fraix</name></author><author><name sortKey="Savasta, M" sort="Savasta, M" uniqKey="Savasta M" first="M" last="Savasta">M. Savasta</name></author><author><name sortKey="Costes, N" sort="Costes, N" uniqKey="Costes N" first="N" last="Costes">N. Costes</name></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name></author><author><name sortKey="Mertens, P" sort="Mertens, P" uniqKey="Mertens P" first="P" last="Mertens">P. Mertens</name></author><author><name sortKey="Koudsie, A" sort="Koudsie, A" uniqKey="Koudsie A" first="A" last="Koudsie">A. Koudsie</name></author><author><name sortKey="Le Bars, D" sort="Le Bars, D" uniqKey="Le Bars D" first="D" last="Le Bars">D. Le Bars</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E" last="Broussolle">E. Broussolle</name></author></analytic><series><title level="j">Journal of neurology</title><idno type="ISSN">0340-5354</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Carbon Radioisotopes</term><term>Dopamine (secretion)</term><term>Dopamine Antagonists</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (therapy)</term><term>Raclopride</term><term>Receptors, Dopamine D2 (physiology)</term><term>Subthalamic Nucleus (physiology)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carbon Radioisotopes</term><term>Dopamine Antagonists</term><term>Raclopride</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Electric Stimulation Therapy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus (STN) stimulation mechanism of action remains a matter for debate. In animals, an increased striatal dopamine (DA) release due to STN stimulation has been reported.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14586606</PMID><DateCreated><Year>2003</Year><Month>10</Month><Day>30</Day></DateCreated><DateCompleted><Year>2003</Year><Month>12</Month><Day>12</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-5354</ISSN><JournalIssue CitedMedium="Print"><Volume>250</Volume><Issue>10</Issue><PubDate><Year>2003</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of neurology</Title><ISOAbbreviation>J. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson's disease--A [(11)C]-raclopride PET study.</ArticleTitle><Pagination><MedlinePgn>1219-23</MedlinePgn></Pagination><Abstract><AbstractText Label="CONTEXT" NlmCategory="BACKGROUND">Subthalamic nucleus (STN) stimulation mechanism of action remains a matter for debate. In animals, an increased striatal dopamine (DA) release due to STN stimulation has been reported.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine in Parkinson's disease (PD) patients using positron emission tomography (PET) and [11C]-Raclopride, whether STN stimulation induces a striatal DA release.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Nine PD patients with bilateral STN stimulation were enrolled and underwent two [11C]-Raclopride PET scans. The scans were randomly performed in off and on stimulation conditions. Striatal [11C]-Raclopride binding potential (BP) was calculated using regions of interest and statistical parametric mapping.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For PD patients, the mean [(11C]-Raclopride BP (+/- SD) were, in Off stimulation condition: 1.7 +/- 0.3 for the right caudate nucleus, 1.8 +/- 0.4 for the left caudate nucleus, 2.6 +/- 0.5 for the right putamenand 2.6 +/- 0.5 for the left putamen. In On stimulation condition: 1.7 +/- 0.4 for the right caudate nucleus, 1.9 +/- 0.5 for the left caudate nucleus, 2.8 +/- 0.7 for the right putamen and 2.7 +/- 0.8 for the left putamen. No significant difference of BP related to the stimulation was noted.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">STN stimulation does not produce significant variations of striatal DA release as assessed by PET and [11C]-Raclopride.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thobois</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dept. of Neurology D (Pr. G. Chazot) and INSERM U 534, Hôpital Neurologique Pierre Wertheimer, 59 Bd Pinel, 69003 Lyon, France. stephane.thobois@chu-lyon.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraix</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Savasta</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Costes</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Pollak</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Mertens</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Koudsie</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Le Bars</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Benabid</LastName><ForeName>A L</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Broussolle</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Neurol</MedlineTA><NlmUniqueID>0423161</NlmUniqueID><ISSNLinking>0340-5354</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002250">Carbon Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018492">Dopamine Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017448">Receptors, Dopamine D2</NameOfSubstance></Chemical><Chemical><RegistryNumber>430K3SOZ7G</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020891" MajorTopicYN="Y">Raclopride</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017448" MajorTopicYN="N">Receptors, Dopamine D2</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName 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PubStatus="entrez"><Year>2003</Year><Month>10</Month><Day>31</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14586606</ArticleId><ArticleId IdType="doi">10.1007/s00415-003-0188-z</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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