Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.
Identifieur interne : 000F92 ( PubMed/Curation ); précédent : 000F91; suivant : 000F93Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.
Auteurs : C. Levecque [France] ; A. Elbaz ; J. Clavel ; J S Vidal ; P. Amouyel ; A. Alpérovitch ; C. Tzourio ; M C Chartier-HarlinSource :
- Journal of neurology, neurosurgery, and psychiatry [ 0022-3050 ] ; 2004.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : tau Proteins.
- genetics : Parkinson Disease.
- pathology : Parkinson Disease.
- Aged, Case-Control Studies, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic.
Abstract
The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease.
PubMed: 14966169
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.</title><author><name sortKey="Levecque, C" sort="Levecque, C" uniqKey="Levecque C" first="C" last="Levecque">C. Levecque</name><affiliation wicri:level="1"><nlm:affiliation>INSERM Unit 508, Institut Pasteur de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 508, Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Elbaz, A" sort="Elbaz, A" uniqKey="Elbaz A" first="A" last="Elbaz">A. Elbaz</name></author><author><name sortKey="Clavel, J" sort="Clavel, J" uniqKey="Clavel J" first="J" last="Clavel">J. Clavel</name></author><author><name sortKey="Vidal, J S" sort="Vidal, J S" uniqKey="Vidal J" first="J S" last="Vidal">J S Vidal</name></author><author><name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P" last="Amouyel">P. Amouyel</name></author><author><name sortKey="Alperovitch, A" sort="Alperovitch, A" uniqKey="Alperovitch A" first="A" last="Alpérovitch">A. Alpérovitch</name></author><author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C" last="Tzourio">C. Tzourio</name></author><author><name sortKey="Chartier Harlin, M C" sort="Chartier Harlin, M C" uniqKey="Chartier Harlin M" first="M C" last="Chartier-Harlin">M C Chartier-Harlin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:14966169</idno><idno type="pmid">14966169</idno><idno type="wicri:Area/PubMed/Corpus">001033</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001033</idno><idno type="wicri:Area/PubMed/Curation">000F92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.</title><author><name sortKey="Levecque, C" sort="Levecque, C" uniqKey="Levecque C" first="C" last="Levecque">C. Levecque</name><affiliation wicri:level="1"><nlm:affiliation>INSERM Unit 508, Institut Pasteur de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 508, Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Elbaz, A" sort="Elbaz, A" uniqKey="Elbaz A" first="A" last="Elbaz">A. Elbaz</name></author><author><name sortKey="Clavel, J" sort="Clavel, J" uniqKey="Clavel J" first="J" last="Clavel">J. Clavel</name></author><author><name sortKey="Vidal, J S" sort="Vidal, J S" uniqKey="Vidal J" first="J S" last="Vidal">J S Vidal</name></author><author><name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P" last="Amouyel">P. Amouyel</name></author><author><name sortKey="Alperovitch, A" sort="Alperovitch, A" uniqKey="Alperovitch A" first="A" last="Alpérovitch">A. Alpérovitch</name></author><author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C" last="Tzourio">C. Tzourio</name></author><author><name sortKey="Chartier Harlin, M C" sort="Chartier Harlin, M C" uniqKey="Chartier Harlin M" first="M C" last="Chartier-Harlin">M C Chartier-Harlin</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (pathology)</term><term>Polymorphism, Genetic</term><term>tau Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Polymorphism, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14966169</PMID><DateCreated><Year>2004</Year><Month>02</Month><Day>17</Day></DateCreated><DateCompleted><Year>2004</Year><Month>03</Month><Day>23</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3050</ISSN><JournalIssue CitedMedium="Print"><Volume>75</Volume><Issue>3</Issue><PubDate><Year>2004</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>478-80</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To test these two genes for their association with Parkinson's disease in a large community based case-control study.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Cases (n = 208) were more often homozygotes for the Tau H1 haplotype than controls (n = 483; odds ratio (OR) = 1.71 (95% confidence interval, 1.20 to 2.43); p = 0.003), and the saitohin Q allele was in complete linkage disequilibrium with the H1 haplotype. This association was stronger among cases with Parkinson's disease onset below 65 years (< or =65 years: OR = 2.52 (1.49 to 4.25); p<0.001) than among those with older onset (>65 years: OR = 1.20 (0.73 to 1.98); p<0.47).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The data suggest that there is a functional polymorphism at this locus involved in Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Levecque</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM Unit 508, Institut Pasteur de Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elbaz</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Clavel</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Vidal</LastName><ForeName>J S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Amouyel</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Alpérovitch</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Chartier-Harlin</LastName><ForeName>M C</ForeName><Initials>MC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C458340">STH protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016875">tau Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006239" MajorTopicYN="N">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="Y">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016875" MajorTopicYN="N">tau Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1738939</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>2</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>3</Month><Day>24</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>2</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14966169</ArticleId><ArticleId IdType="pmc">PMC1738939</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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