Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's disease.
Identifieur interne : 000D47 ( PubMed/Curation ); précédent : 000D46; suivant : 000D48Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's disease.
Auteurs : D. Devos [France] ; P. Krystkowiak ; F. Clement ; K. Dujardin ; O. Cottencin ; N. Waucquier ; K. Ajebbar ; B. Thielemans ; M. Kroumova ; A. Duhamel ; A. Destée ; R. Bordet ; L. DefebvreSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2007.
English descriptors
- KwdEn :
- Aged, Central Nervous System Stimulants (therapeutic use), Dose-Response Relationship, Drug, Fatigue, Female, Gait Disorders, Neurologic (drug therapy), Gait Disorders, Neurologic (etiology), Humans, Male, Methylphenidate (therapeutic use), Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Severity of Illness Index, Single-Blind Method, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Central Nervous System Stimulants, Methylphenidate.
- complications : Parkinson Disease.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- Aged, Dose-Response Relationship, Drug, Fatigue, Female, Humans, Male, Middle Aged, Severity of Illness Index, Single-Blind Method, Treatment Outcome.
Abstract
Therapeutic management of gait disorders in patients with advanced Parkinson's disease (PD) can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for limb-related parkinsonian signs than for gait disorders. Gait disorders could also be partly related to norepinephrine system impairment, and the pharmacological modulation of both dopamine and norepinephrine pathways could potentially improve the symptomatology.
DOI: 10.1136/jnnp.2006.100016
PubMed: 17098845
Links toward previous steps (curation, corpus...)
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pubmed:17098845Le document en format XML
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<front><div type="abstract" xml:lang="en">Therapeutic management of gait disorders in patients with advanced Parkinson's disease (PD) can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for limb-related parkinsonian signs than for gait disorders. Gait disorders could also be partly related to norepinephrine system impairment, and the pharmacological modulation of both dopamine and norepinephrine pathways could potentially improve the symptomatology.</div>
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<Month>04</Month>
<Day>16</Day>
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<Month>04</Month>
<Day>19</Day>
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<DateRevised><Year>2014</Year>
<Month>09</Month>
<Day>07</Day>
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<JournalIssue CitedMedium="Internet"><Volume>78</Volume>
<Issue>5</Issue>
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<Month>May</Month>
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<Title>Journal of neurology, neurosurgery, and psychiatry</Title>
<ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation>
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<ArticleTitle>Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>470-5</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Therapeutic management of gait disorders in patients with advanced Parkinson's disease (PD) can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for limb-related parkinsonian signs than for gait disorders. Gait disorders could also be partly related to norepinephrine system impairment, and the pharmacological modulation of both dopamine and norepinephrine pathways could potentially improve the symptomatology.</AbstractText>
<AbstractText Label="AIM" NlmCategory="OBJECTIVE">To assess the clinical value of chronic, high doses of methylphenidate (MPD) in patients with PD having gait disorders, despite their use of optimal dopaminergic doses and STN stimulation parameters.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Efficacy was blindly assessed on video for 17 patients in the absence of L-dopa and again after acute administration of the drug, both before and after a 3-month course of MPD, using a Stand-Walk-Sit (SWS) Test, the Tinetti Scale, the Unified Parkinson's Disease Rating Scale (UPDRS) part III score and the Dyskinesia Rating Scale.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">An improvement was observed in the number of steps and time in the SWS Test, the number of freezing episodes, the Tinetti Scale score and the UPDRS part III score in the absence of L-dopa after 3 months of taking MPD. The L-dopa-induced improvement in these various scores was also stronger after the 3-month course of MPD than before. The Epworth Sleepiness Scale score fell dramatically in all patients. No significant induction of adverse effects was found.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Chronic, high doses of MPD improved gait and motor symptoms in the absence of L-dopa and increased the intensity of response of these symptoms to L-dopa in a population with advanced PD.</AbstractText>
</Abstract>
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