Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images.
Identifieur interne : 000D22 ( PubMed/Curation ); précédent : 000D21; suivant : 000D23Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images.
Auteurs : Aurélie Kas [France] ; Pierre Payoux ; Marie-Odile Habert ; Zoulikha Malek ; Yann Cointepas ; Georges El Fakhri ; Philippe Chaumet-Riffaud ; Emmanuel Itti ; Philippe RemySource :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine [ 0161-5505 ] ; 2007.
English descriptors
- KwdEn :
- Aged, Brain (diagnostic imaging), Brain (metabolism), Data Interpretation, Statistical, Dopamine Plasma Membrane Transport Proteins (metabolism), Essential Tremor (diagnostic imaging), Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease (diagnostic imaging), Pilot Projects, Radionuclide Imaging, Radiopharmaceuticals, Tropanes.
- MESH :
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- diagnostic imaging : Brain, Essential Tremor, Parkinson Disease.
- metabolism : Brain.
- Aged, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Pilot Projects, Radionuclide Imaging, Radiopharmaceuticals, Tropanes.
Abstract
(123)I-FP-CIT ((123)I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane) is a SPECT dopamine transporter (DAT) tracer that probes dopaminergic cell loss in Parkinson's disease (PD). Quantification of (123)I-FP-CIT images is performed at equilibrium using a ratio (BR) of specific (striatal) to nonspecific (occipital) uptake with values obtained from regions of interest drawn manually over these structures. Statistical parametric mapping (SPM) is a fully automated voxel-based statistical approach that has great potential in the context of DAT imaging. However, the accuracy of the spatial normalization provided by SPM has not been validated for (123)I-FP-CIT images. Our first aim was to create an (123)I-FP-CIT template that does not require the acquisition of patient-specific MRI and to validate the spatial normalization procedure. Next, we hypothesized that this customized template could be used by different SPECT centers without affecting the outcomes of imaging analyses.
DOI: 10.2967/jnumed.106.038646
PubMed: 17704252
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sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name></author><author><name sortKey="Malek, Zoulikha" sort="Malek, Zoulikha" uniqKey="Malek Z" first="Zoulikha" last="Malek">Zoulikha Malek</name></author><author><name sortKey="Cointepas, Yann" sort="Cointepas, Yann" uniqKey="Cointepas Y" first="Yann" last="Cointepas">Yann Cointepas</name></author><author><name sortKey="El Fakhri, Georges" sort="El Fakhri, Georges" uniqKey="El Fakhri G" first="Georges" last="El Fakhri">Georges El Fakhri</name></author><author><name sortKey="Chaumet Riffaud, Philippe" sort="Chaumet Riffaud, Philippe" uniqKey="Chaumet Riffaud P" first="Philippe" last="Chaumet-Riffaud">Philippe Chaumet-Riffaud</name></author><author><name sortKey="Itti, Emmanuel" sort="Itti, Emmanuel" uniqKey="Itti E" first="Emmanuel" last="Itti">Emmanuel Itti</name></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17704252</idno><idno type="pmid">17704252</idno><idno type="doi">10.2967/jnumed.106.038646</idno><idno type="wicri:Area/PubMed/Corpus">000D62</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D62</idno><idno type="wicri:Area/PubMed/Curation">000D22</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images.</title><author><name sortKey="Kas, Aurelie" sort="Kas, Aurelie" uniqKey="Kas A" first="Aurélie" last="Kas">Aurélie Kas</name><affiliation wicri:level="1"><nlm:affiliation>URA Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique 2210, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, 91401 Orsay, France. aurelie.kas@psl.aphp.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URA Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique 2210, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, 91401 Orsay</wicri:regionArea></affiliation></author><author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name></author><author><name sortKey="Habert, Marie Odile" sort="Habert, Marie Odile" uniqKey="Habert M" first="Marie-Odile" last="Habert">Marie-Odile Habert</name></author><author><name sortKey="Malek, Zoulikha" sort="Malek, Zoulikha" uniqKey="Malek Z" first="Zoulikha" last="Malek">Zoulikha Malek</name></author><author><name sortKey="Cointepas, Yann" sort="Cointepas, Yann" uniqKey="Cointepas Y" first="Yann" last="Cointepas">Yann Cointepas</name></author><author><name sortKey="El Fakhri, Georges" sort="El Fakhri, Georges" uniqKey="El Fakhri G" first="Georges" last="El Fakhri">Georges El Fakhri</name></author><author><name sortKey="Chaumet Riffaud, Philippe" sort="Chaumet Riffaud, Philippe" uniqKey="Chaumet Riffaud P" first="Philippe" last="Chaumet-Riffaud">Philippe Chaumet-Riffaud</name></author><author><name sortKey="Itti, Emmanuel" sort="Itti, Emmanuel" uniqKey="Itti E" first="Emmanuel" last="Itti">Emmanuel Itti</name></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author></analytic><series><title level="j">Journal of nuclear medicine : official publication, Society of Nuclear Medicine</title><idno type="ISSN">0161-5505</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (diagnostic imaging)</term><term>Brain (metabolism)</term><term>Data Interpretation, Statistical</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Essential Tremor (diagnostic imaging)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnostic imaging)</term><term>Pilot Projects</term><term>Radionuclide Imaging</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Data Interpretation, Statistical</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Radionuclide Imaging</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">(123)I-FP-CIT ((123)I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane) is a SPECT dopamine transporter (DAT) tracer that probes dopaminergic cell loss in Parkinson's disease (PD). Quantification of (123)I-FP-CIT images is performed at equilibrium using a ratio (BR) of specific (striatal) to nonspecific (occipital) uptake with values obtained from regions of interest drawn manually over these structures. Statistical parametric mapping (SPM) is a fully automated voxel-based statistical approach that has great potential in the context of DAT imaging. However, the accuracy of the spatial normalization provided by SPM has not been validated for (123)I-FP-CIT images. Our first aim was to create an (123)I-FP-CIT template that does not require the acquisition of patient-specific MRI and to validate the spatial normalization procedure. Next, we hypothesized that this customized template could be used by different SPECT centers without affecting the outcomes of imaging analyses.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17704252</PMID><DateCreated><Year>2007</Year><Month>09</Month><Day>05</Day></DateCreated><DateCompleted><Year>2007</Year><Month>11</Month><Day>27</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0161-5505</ISSN><JournalIssue CitedMedium="Print"><Volume>48</Volume><Issue>9</Issue><PubDate><Year>2007</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images.</ArticleTitle><Pagination><MedlinePgn>1459-67</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">(123)I-FP-CIT ((123)I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane) is a SPECT dopamine transporter (DAT) tracer that probes dopaminergic cell loss in Parkinson's disease (PD). Quantification of (123)I-FP-CIT images is performed at equilibrium using a ratio (BR) of specific (striatal) to nonspecific (occipital) uptake with values obtained from regions of interest drawn manually over these structures. Statistical parametric mapping (SPM) is a fully automated voxel-based statistical approach that has great potential in the context of DAT imaging. However, the accuracy of the spatial normalization provided by SPM has not been validated for (123)I-FP-CIT images. Our first aim was to create an (123)I-FP-CIT template that does not require the acquisition of patient-specific MRI and to validate the spatial normalization procedure. Next, we hypothesized that this customized template could be used by different SPECT centers without affecting the outcomes of imaging analyses.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The spatial normalization to the customized template created with SPM (template A1) was validated using (123)I-FP-CIT images obtained from 6 subjects with essential tremor (ET) with normal DAT status and 6 PD patients. Variability in BR values due to the normalization was evaluated using striatal volume of interest (VOI). To determine whether different SPECT centers could use a unique (123)I-FP-CIT template, we generated 3 other (123)I-FP-CIT templates using different subjects and image-processing schemes. The interchangeability of these templates was assessed using (a) putamen BR values analyzed with the intraclass correlation coefficient (ICC) and the Bland-Altman graphical analysis, and (b) SPM analysis comparing the results of group comparisons-that is, ET versus PD, obtained after normalization to each of the 4 templates.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no significant difference between pre- and post-normalization striatal BR values in our study. The mean variability calculated with putamen VOI values after normalization to each template was <10%, with the lowest ICC of 98%. Intergroup analyses performed with VOI and SPM approaches provided similar results independently of the template used.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">SPM normalization was accurate even in subjects with low striatal (123)I-FP-CIT uptake, making it a promising approach for automatic analysis of (123)I-FP-CIT images using a single customized template at different centers.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kas</LastName><ForeName>Aurélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>URA Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique 2210, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, 91401 Orsay, France. aurelie.kas@psl.aphp.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Payoux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Habert</LastName><ForeName>Marie-Odile</ForeName><Initials>MO</Initials></Author><Author ValidYN="Y"><LastName>Malek</LastName><ForeName>Zoulikha</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Cointepas</LastName><ForeName>Yann</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>El Fakhri</LastName><ForeName>Georges</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Chaumet-Riffaud</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Itti</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D023361">Validation Studies</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>08</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050483">Dopamine Plasma Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014326">Tropanes</NameOfSubstance></Chemical><Chemical><RegistryNumber>155797-99-2</RegistryNumber><NameOfSubstance UI="C087552">2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003627" MajorTopicYN="N">Data Interpretation, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050483" MajorTopicYN="N">Dopamine Plasma Membrane Transport Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020329" MajorTopicYN="N">Essential Tremor</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010865" MajorTopicYN="N">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011877" MajorTopicYN="N">Radionuclide Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019275" MajorTopicYN="Y">Radiopharmaceuticals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014326" MajorTopicYN="Y">Tropanes</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>12</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>21</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17704252</ArticleId><ArticleId IdType="pii">jnumed.106.038646</ArticleId><ArticleId IdType="doi">10.2967/jnumed.106.038646</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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