Environmental enrichment during adolescence regulates gene expression in the striatum of mice.
Identifieur interne : 000C36 ( PubMed/Curation ); précédent : 000C35; suivant : 000C37Environmental enrichment during adolescence regulates gene expression in the striatum of mice.
Auteurs : Nathalie Thiriet [France] ; Lahouari Amar ; Xavier Toussay ; Virginie Lardeux ; Bruce Ladenheim ; Kevin G. Becker ; Jean Lud Cadet ; Marcello Solinas ; Mohamed JaberSource :
- Brain research [ 0006-8993 ] ; 2008.
English descriptors
- KwdEn :
- Animals, Cell Differentiation (genetics), Cell Proliferation, Cluster Analysis, Corpus Striatum (cytology), Corpus Striatum (metabolism), Environment, Gene Expression Profiling (methods), Gene Expression Regulation, Developmental (genetics), Gene Expression Regulation, Developmental (physiology), Male, Mice, Mice, Inbred C57BL, Oligonucleotide Array Sequence Analysis (methods), RNA, Messenger (metabolism), Signal Transduction (genetics).
- MESH :
- chemical , metabolism : RNA, Messenger.
- cytology : Corpus Striatum.
- genetics : Cell Differentiation, Gene Expression Regulation, Developmental, Signal Transduction.
- metabolism : Corpus Striatum.
- methods : Gene Expression Profiling, Oligonucleotide Array Sequence Analysis.
- physiology : Gene Expression Regulation, Developmental.
- Animals, Cell Proliferation, Cluster Analysis, Environment, Male, Mice, Mice, Inbred C57BL.
Abstract
We have previously shown that environmental enrichment decreases the activating and rewarding effects of the psychostimulant cocaine and increases resistance to the neurotoxic effect of the Parkinson-inducing drug MPTP. These effects were accompanied by an increase in the striatal expression of the neurotrophin BDNF, an increase in the striatal levels of delta-Fos B and by a decrease in striatal levels of the dopamine transporter, the main molecular target for cocaine and MPTP. Here, we used cDNA arrays to investigate the effects of rearing mice in enriched environments from weaning to adulthood on the profile of expression of genes in the striatum focusing on genes involved in intracellular signalling and functioning. We found that mice reared in an enriched environment show several alterations in the levels of mRNA coding for proteins involved in cell proliferation, cell differentiation, signal transduction, transcription and translation, cell structure and metabolism. Several of these findings were further confirmed by real-time quantitative PCR and, in the case of protein kinase C lambda, also by western blot. These findings are the first description of alterations in striatal gene expression by an enriched environment. The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported.
DOI: 10.1016/j.brainres.2008.05.030
PubMed: 18585688
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Becker</name></author><author><name sortKey="Cadet, Jean Lud" sort="Cadet, Jean Lud" uniqKey="Cadet J" first="Jean Lud" last="Cadet">Jean Lud Cadet</name></author><author><name sortKey="Solinas, Marcello" sort="Solinas, Marcello" uniqKey="Solinas M" first="Marcello" last="Solinas">Marcello Solinas</name></author><author><name sortKey="Jaber, Mohamed" sort="Jaber, Mohamed" uniqKey="Jaber M" first="Mohamed" last="Jaber">Mohamed Jaber</name></author></analytic><series><title level="j">Brain research</title><idno type="ISSN">0006-8993</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Differentiation (genetics)</term><term>Cell Proliferation</term><term>Cluster Analysis</term><term>Corpus Striatum (cytology)</term><term>Corpus Striatum (metabolism)</term><term>Environment</term><term>Gene Expression Profiling (methods)</term><term>Gene Expression Regulation, Developmental (genetics)</term><term>Gene Expression Regulation, Developmental (physiology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Oligonucleotide Array Sequence Analysis (methods)</term><term>RNA, Messenger (metabolism)</term><term>Signal Transduction (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Differentiation</term><term>Gene Expression Regulation, Developmental</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gene Expression Profiling</term><term>Oligonucleotide Array Sequence Analysis</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gene Expression Regulation, Developmental</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Cluster Analysis</term><term>Environment</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have previously shown that environmental enrichment decreases the activating and rewarding effects of the psychostimulant cocaine and increases resistance to the neurotoxic effect of the Parkinson-inducing drug MPTP. These effects were accompanied by an increase in the striatal expression of the neurotrophin BDNF, an increase in the striatal levels of delta-Fos B and by a decrease in striatal levels of the dopamine transporter, the main molecular target for cocaine and MPTP. Here, we used cDNA arrays to investigate the effects of rearing mice in enriched environments from weaning to adulthood on the profile of expression of genes in the striatum focusing on genes involved in intracellular signalling and functioning. We found that mice reared in an enriched environment show several alterations in the levels of mRNA coding for proteins involved in cell proliferation, cell differentiation, signal transduction, transcription and translation, cell structure and metabolism. Several of these findings were further confirmed by real-time quantitative PCR and, in the case of protein kinase C lambda, also by western blot. These findings are the first description of alterations in striatal gene expression by an enriched environment. The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18585688</PMID><DateCreated><Year>2008</Year><Month>07</Month><Day>15</Day></DateCreated><DateCompleted><Year>2008</Year><Month>11</Month><Day>12</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-8993</ISSN><JournalIssue CitedMedium="Print"><Volume>1222</Volume><PubDate><Year>2008</Year><Month>Jul</Month><Day>30</Day></PubDate></JournalIssue><Title>Brain research</Title><ISOAbbreviation>Brain Res.</ISOAbbreviation></Journal><ArticleTitle>Environmental enrichment during adolescence regulates gene expression in the striatum of mice.</ArticleTitle><Pagination><MedlinePgn>31-41</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.brainres.2008.05.030</ELocationID><Abstract><AbstractText>We have previously shown that environmental enrichment decreases the activating and rewarding effects of the psychostimulant cocaine and increases resistance to the neurotoxic effect of the Parkinson-inducing drug MPTP. These effects were accompanied by an increase in the striatal expression of the neurotrophin BDNF, an increase in the striatal levels of delta-Fos B and by a decrease in striatal levels of the dopamine transporter, the main molecular target for cocaine and MPTP. Here, we used cDNA arrays to investigate the effects of rearing mice in enriched environments from weaning to adulthood on the profile of expression of genes in the striatum focusing on genes involved in intracellular signalling and functioning. We found that mice reared in an enriched environment show several alterations in the levels of mRNA coding for proteins involved in cell proliferation, cell differentiation, signal transduction, transcription and translation, cell structure and metabolism. Several of these findings were further confirmed by real-time quantitative PCR and, in the case of protein kinase C lambda, also by western blot. These findings are the first description of alterations in striatal gene expression by an enriched environment. The striatal gene expression regulation by environment that we report here may play a role in the resistance to the effects of drugs of abuse and dopaminergic neurotoxins previously reported.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thiriet</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institut de Biologie et Physiologie Cellulaires, University of Poitiers, 40 Avenue du Recteur Pineau, Poitiers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amar</LastName><ForeName>Lahouari</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Toussay</LastName><ForeName>Xavier</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Lardeux</LastName><ForeName>Virginie</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ladenheim</LastName><ForeName>Bruce</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Kevin G</ForeName><Initials>KG</Initials></Author><Author ValidYN="Y"><LastName>Cadet</LastName><ForeName>Jean Lud</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Solinas</LastName><ForeName>Marcello</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Jaber</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>Z01 AG000616-01</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>05</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Res</MedlineTA><NlmUniqueID>0045503</NlmUniqueID><ISSNLinking>0006-8993</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Learn Mem. 1996 Sep;66(2):93-6</RefSource><PMID Version="1">8946401</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Physiol Scand. 1989 Sep;137(1):1-13</RefSource><PMID Version="1">2678895</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1997 Apr 3;386(6624):493-5</RefSource><PMID Version="1">9087407</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 1999 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