Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: five year follow-up.
Identifieur interne : 000B81 ( PubMed/Curation ); précédent : 000B80; suivant : 000B82Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: five year follow-up.
Auteurs : Hélène Gervais-Bernard [France] ; Jing Xie-Brustolin ; Patrick Mertens ; Gustavo Polo ; Hélène Klinger ; Dario Adamec ; Emmanuel Broussolle ; Stéphane ThoboisSource :
- Journal of neurology [ 1432-1459 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (administration & dosage), Blinking (drug effects), Blinking (physiology), Deep Brain Stimulation (methods), Depressive Disorder (etiology), Disease Progression, Dose-Response Relationship, Drug, Drug Resistance, Dysarthria (etiology), Female, Follow-Up Studies, Functional Laterality (physiology), Humans, Male, Middle Aged, Outcome Assessment (Health Care) (methods), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (physiology), Time, Time Factors, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- anatomy & histology : Subthalamic Nucleus.
- drug effects : Blinking.
- etiology : Depressive Disorder, Dysarthria.
- methods : Deep Brain Stimulation, Outcome Assessment (Health Care).
- physiology : Blinking, Functional Laterality, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Aged, Disease Progression, Dose-Response Relationship, Drug, Drug Resistance, Female, Follow-Up Studies, Humans, Male, Middle Aged, Time, Time Factors, Treatment Outcome.
Abstract
To assess the long-term efficacy and safety of bilateral subthalamic nucleus (STN) stimulation in patients with advanced Parkinson's disease (PD).
DOI: 10.1007/s00415-009-0076-2
PubMed: 19242649
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pubmed:19242649Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Claude Bernard Lyon I, Université de Lyon, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Claude Bernard Lyon I, Université de Lyon, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon</wicri:regionArea>
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<author><name sortKey="Xie Brustolin, Jing" sort="Xie Brustolin, Jing" uniqKey="Xie Brustolin J" first="Jing" last="Xie-Brustolin">Jing Xie-Brustolin</name>
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<author><name sortKey="Adamec, Dario" sort="Adamec, Dario" uniqKey="Adamec D" first="Dario" last="Adamec">Dario Adamec</name>
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<series><title level="j">Journal of neurology</title>
<idno type="eISSN">1432-1459</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antiparkinson Agents (administration & dosage)</term>
<term>Blinking (drug effects)</term>
<term>Blinking (physiology)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Depressive Disorder (etiology)</term>
<term>Disease Progression</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Resistance</term>
<term>Dysarthria (etiology)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Functional Laterality (physiology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Outcome Assessment (Health Care) (methods)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Subthalamic Nucleus (anatomy & histology)</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Time</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blinking</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depressive Disorder</term>
<term>Dysarthria</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
<term>Outcome Assessment (Health Care)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term>
<term>Functional Laterality</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Disease Progression</term>
<term>Dose-Response Relationship, Drug</term>
<term>Drug Resistance</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Time</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">To assess the long-term efficacy and safety of bilateral subthalamic nucleus (STN) stimulation in patients with advanced Parkinson's disease (PD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19242649</PMID>
<DateCreated><Year>2009</Year>
<Month>03</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>07</Month>
<Day>14</Day>
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<Month>03</Month>
<Day>16</Day>
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<JournalIssue CitedMedium="Internet"><Volume>256</Volume>
<Issue>2</Issue>
<PubDate><Year>2009</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Journal of neurology</Title>
<ISOAbbreviation>J. Neurol.</ISOAbbreviation>
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<ArticleTitle>Bilateral subthalamic nucleus stimulation in advanced Parkinson's disease: five year follow-up.</ArticleTitle>
<Pagination><MedlinePgn>225-33</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00415-009-0076-2</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the long-term efficacy and safety of bilateral subthalamic nucleus (STN) stimulation in patients with advanced Parkinson's disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">42 consecutive patients with idiopathic PD treated with bilateral STN stimulation were enrolled. Parkinsonian status, medication intake and neuropsychological evaluation were assessed preoperatively and at 1 and 5 years postoperatively in on and off medication/on and off stimulation conditions.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">23 patients could be followed-up 5 years after surgery. In the remaining cases, 5 died, 1 could not be assessed because of device removal for infection, 1 decided not to be stimulated, and 11 were lost of follow-up (one because of a liver carcinoma and the others because they refused the formal four conditions of assessment). STN stimulation reduced the UPDRS motor score by 55 % compared to baseline in the off-medication conditions. Tremor, rigidity, bradykinesia, postural stability, and gait improved by 74 %, 66 %, 59 %, 17 % and 37 %, respectively. UPDRS part II scores were reduced by 38 %. The dopaminergic treatment daily dose was reduced by 54.4 % after surgery. Axial dopa-unresponsive signs worsened in some patients. Among the 42 initial patients we observed the following: 2 brain hemorrhages, 3 infections of the device, 2 phlebitis and 1 pulmonary embolism. In addition, 2 patients needed a repositioning of the electrode. Among the 23 patients followed at 5 years, long lasting side effects consisted in dysarthria (56 %), depression (39 %), eyelid opening apraxia (30.4 %) and apathy (4.3 %).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data confirm that bilateral STN stimulation is beneficial in the long-term for PD patients but does not prevent disease progression and the occurence of axial levodopa unresponsive signs in some patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gervais-Bernard</LastName>
<ForeName>Hélène</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Claude Bernard Lyon I, Université de Lyon, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Xie-Brustolin</LastName>
<ForeName>Jing</ForeName>
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<Author ValidYN="Y"><LastName>Mertens</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
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<Author ValidYN="Y"><LastName>Polo</LastName>
<ForeName>Gustavo</ForeName>
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</Author>
<Author ValidYN="Y"><LastName>Klinger</LastName>
<ForeName>Hélène</ForeName>
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<Author ValidYN="Y"><LastName>Adamec</LastName>
<ForeName>Dario</ForeName>
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<Author ValidYN="Y"><LastName>Broussolle</LastName>
<ForeName>Emmanuel</ForeName>
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<Author ValidYN="Y"><LastName>Thobois</LastName>
<ForeName>Stéphane</ForeName>
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<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D013995" MajorTopicYN="N">Time</DescriptorName>
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