Subthalamic nucleus stimulation affects subjective emotional experience in Parkinson's disease patients.
Identifieur interne : 000B41 ( PubMed/Curation ); précédent : 000B40; suivant : 000B42Subthalamic nucleus stimulation affects subjective emotional experience in Parkinson's disease patients.
Auteurs : Siobhan Vicente [France] ; Isabelle Biseul ; Julie Péron ; Pierre Philippot ; Sophie Drapier ; Dominique Drapier ; Paul Sauleau ; Claire Haegelen ; Marc VérinSource :
- Neuropsychologia [ 1873-3514 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- methods : Deep Brain Stimulation, Photic Stimulation.
- physiology : Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Emotions, Facial Expression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Statistics, Nonparametric.
Abstract
A number of studies have reported impaired facial emotion recognition following subthalamic nucleus (STN) stimulation in Parkinson's disease (PD), and have related these changes to a limbic dysfunction induced by STN stimulation. The present study examined the effect of STN stimulation in PD patients on a specific component of emotion, namely the subjective experience of emotion. Thirteen post-operative PD patients, 13 pre-operative PD patients matched on clinical and neuropsychological characteristics, and 16 controls matched on age and education, were administered a validated battery of film excerpts known to primarily induce specific emotional feelings (anger, happiness, sadness, fear, disgust, and neutral), and self-rated the intensity of their emotional feelings on a discrete emotions questionnaire. The post-operative group showed a significant lower level of differentiation between the target feeling (i.e., the more likely to be reported) and non-target feelings for the film excerpts intended to induce "sadness" and "fear" respectively, as compared with the pre-operative and healthy control groups. Moreover, the post-operative group reported significantly less intense feelings of fear, anxiety and disgust for the excerpt intended to induce "fear" as compared with the pre-operative and the control groups, while no significant difference was observed between the pre-operative and control groups. Finally, the post-operative group reported significantly less intense feelings of sadness and anxiety during the excerpt intended to induce "sadness" as compared to the control group, although the differences between the pre- and post-operative groups and between the pre-operative and the control groups did not reach significance. Our study suggests that STN stimulation affects the subjective experience of emotion, thus providing a preliminary account of the modulation induced by STN stimulation of a distributed neuronal network underlying the subjective experience of emotion, although the exact contribution of the STN within such network remains to be specified.
DOI: 10.1016/j.neuropsychologia.2009.03.003
PubMed: 19428425
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uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name></author><author><name sortKey="Philippot, Pierre" sort="Philippot, Pierre" uniqKey="Philippot P" first="Pierre" last="Philippot">Pierre Philippot</name></author><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></author></titleStmt><publicationStmt><idno 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France. siobhan.vicente@univ-poitiers.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche Universitaire 425 Comportement et Noyaux Gris Centraux, Université de Rennes 1, Service de Neurologie, CHU de Rennes</wicri:regionArea></affiliation></author><author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name></author><author><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name></author><author><name sortKey="Philippot, Pierre" sort="Philippot, Pierre" uniqKey="Philippot P" first="Pierre" last="Philippot">Pierre Philippot</name></author><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></author></analytic><series><title level="j">Neuropsychologia</title><idno type="eISSN">1873-3514</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep Brain Stimulation (methods)</term><term>Emotions</term><term>Facial Expression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Photic Stimulation (methods)</term><term>Statistics, Nonparametric</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Photic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Emotions</term><term>Facial Expression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A number of studies have reported impaired facial emotion recognition following subthalamic nucleus (STN) stimulation in Parkinson's disease (PD), and have related these changes to a limbic dysfunction induced by STN stimulation. The present study examined the effect of STN stimulation in PD patients on a specific component of emotion, namely the subjective experience of emotion. Thirteen post-operative PD patients, 13 pre-operative PD patients matched on clinical and neuropsychological characteristics, and 16 controls matched on age and education, were administered a validated battery of film excerpts known to primarily induce specific emotional feelings (anger, happiness, sadness, fear, disgust, and neutral), and self-rated the intensity of their emotional feelings on a discrete emotions questionnaire. The post-operative group showed a significant lower level of differentiation between the target feeling (i.e., the more likely to be reported) and non-target feelings for the film excerpts intended to induce "sadness" and "fear" respectively, as compared with the pre-operative and healthy control groups. Moreover, the post-operative group reported significantly less intense feelings of fear, anxiety and disgust for the excerpt intended to induce "fear" as compared with the pre-operative and the control groups, while no significant difference was observed between the pre-operative and control groups. Finally, the post-operative group reported significantly less intense feelings of sadness and anxiety during the excerpt intended to induce "sadness" as compared to the control group, although the differences between the pre- and post-operative groups and between the pre-operative and the control groups did not reach significance. Our study suggests that STN stimulation affects the subjective experience of emotion, thus providing a preliminary account of the modulation induced by STN stimulation of a distributed neuronal network underlying the subjective experience of emotion, although the exact contribution of the STN within such network remains to be specified.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19428425</PMID><DateCreated><Year>2009</Year><Month>05</Month><Day>11</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3514</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>8-9</Issue><PubDate><Year>2009</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Neuropsychologia</Title><ISOAbbreviation>Neuropsychologia</ISOAbbreviation></Journal><ArticleTitle>Subthalamic nucleus stimulation affects subjective emotional experience in Parkinson's disease patients.</ArticleTitle><Pagination><MedlinePgn>1928-37</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuropsychologia.2009.03.003</ELocationID><Abstract><AbstractText>A number of studies have reported impaired facial emotion recognition following subthalamic nucleus (STN) stimulation in Parkinson's disease (PD), and have related these changes to a limbic dysfunction induced by STN stimulation. The present study examined the effect of STN stimulation in PD patients on a specific component of emotion, namely the subjective experience of emotion. Thirteen post-operative PD patients, 13 pre-operative PD patients matched on clinical and neuropsychological characteristics, and 16 controls matched on age and education, were administered a validated battery of film excerpts known to primarily induce specific emotional feelings (anger, happiness, sadness, fear, disgust, and neutral), and self-rated the intensity of their emotional feelings on a discrete emotions questionnaire. The post-operative group showed a significant lower level of differentiation between the target feeling (i.e., the more likely to be reported) and non-target feelings for the film excerpts intended to induce "sadness" and "fear" respectively, as compared with the pre-operative and healthy control groups. Moreover, the post-operative group reported significantly less intense feelings of fear, anxiety and disgust for the excerpt intended to induce "fear" as compared with the pre-operative and the control groups, while no significant difference was observed between the pre-operative and control groups. Finally, the post-operative group reported significantly less intense feelings of sadness and anxiety during the excerpt intended to induce "sadness" as compared to the control group, although the differences between the pre- and post-operative groups and between the pre-operative and the control groups did not reach significance. Our study suggests that STN stimulation affects the subjective experience of emotion, thus providing a preliminary account of the modulation induced by STN stimulation of a distributed neuronal network underlying the subjective experience of emotion, although the exact contribution of the STN within such network remains to be specified.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vicente</LastName><ForeName>Siobhan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Unité de Recherche Universitaire 425 Comportement et Noyaux Gris Centraux, Université de Rennes 1, Service de Neurologie, CHU de Rennes, France. siobhan.vicente@univ-poitiers.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biseul</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Péron</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Philippot</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Drapier</LastName><ForeName>Sophie</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Drapier</LastName><ForeName>Dominique</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Sauleau</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Haegelen</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Vérin</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuropsychologia</MedlineTA><NlmUniqueID>0020713</NlmUniqueID><ISSNLinking>0028-3932</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D046690" MajorTopicYN="N">Deep Brain Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004644" MajorTopicYN="Y">Emotions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005149" MajorTopicYN="N">Facial Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010775" MajorTopicYN="N">Photic Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2008</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2009</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>03</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>5</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>5</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>8</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19428425</ArticleId><ArticleId IdType="pii">S0028-3932(09)00112-2</ArticleId><ArticleId IdType="doi">10.1016/j.neuropsychologia.2009.03.003</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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