Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.
Identifieur interne : 000A18 ( PubMed/Curation ); précédent : 000A17; suivant : 000A19Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.
Auteurs : Thibaud Lebouvier [France] ; Michel Neunlist ; Stanislas Bruley Des Varannes ; Emmanuel Coron ; Anne Drouard ; Jean-Michel N'Guyen ; Tanguy Chaumette ; Maddalena Tasselli ; Sébastien Paillusson ; Mathurin Flamand ; Jean-Paul Galmiche ; Philippe Damier ; Pascal DerkinderenSource :
- PloS one [ 1932-6203 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Biopsy, Colon (innervation), Colon (metabolism), Colon (pathology), Colonoscopy, Enteric Nervous System (metabolism), Enteric Nervous System (pathology), Female, Humans, Lewy Bodies (metabolism), Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (pathology).
- MESH :
- diagnosis : Parkinson Disease.
- innervation : Colon.
- metabolism : Colon, Enteric Nervous System, Lewy Bodies, Parkinson Disease.
- pathology : Colon, Enteric Nervous System, Parkinson Disease.
- Adult, Aged, Biopsy, Colonoscopy, Female, Humans, Male, Middle Aged.
Abstract
The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.
DOI: 10.1371/journal.pone.0012728
PubMed: 20856865
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pubmed:20856865Le document en format XML
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<term>Aged</term>
<term>Biopsy</term>
<term>Colon (innervation)</term>
<term>Colon (metabolism)</term>
<term>Colon (pathology)</term>
<term>Colonoscopy</term>
<term>Enteric Nervous System (metabolism)</term>
<term>Enteric Nervous System (pathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Lewy Bodies (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Colon</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colon</term>
<term>Enteric Nervous System</term>
<term>Lewy Bodies</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term>
<term>Enteric Nervous System</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Biopsy</term>
<term>Colonoscopy</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.</div>
</front>
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<DateCreated><Year>2010</Year>
<Month>09</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>02</Month>
<Day>18</Day>
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<DateRevised><Year>2016</Year>
<Month>12</Month>
<Day>15</Day>
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<Day>14</Day>
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<Title>PloS one</Title>
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<ArticleTitle>Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.</AbstractText>
<AbstractText Label="METHODOLOGY/PRINCIPAL FINDINGS" NlmCategory="RESULTS">A total of 10 control and 29 PD patients divided into 3 groups according to disease duration were included. PD and GI symptoms were assessed using the Unified Parkinson's Disease Rating Scale part III and the Rome III questionnaire, respectively. Four biopsies were taken from the ascending and descending colon during the course of a total colonoscopy. Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein, neurofilaments NF 220 kDa (NF) and tyrosine hydroxylase (TH). The density of LN, labeled by anti-phosphorylated alpha-synuclein antibodies, was evaluated using a quantitative rating score. Lewy pathology was apparent in the colonic biopsies from 21 patients and in none of the controls. A decreased number of NF-immunoreactive neurons per ganglion was observed in the SMP of PD patients compared to controls. The amount of LN in the ENS was inversely correlated with neuronal count and positively correlated with levodopa-unresponsive features and constipation.</AbstractText>
<AbstractText Label="CONCLUSION/SIGNIFICANCE" NlmCategory="CONCLUSIONS">Analysis of the ENS by routine colonoscopy biopsies is a useful tool for pre-mortem neuropathological diagnosis of PD, and also provides insight into the progression of motor and non-motor symptoms.</AbstractText>
</Abstract>
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<Author ValidYN="Y"><LastName>Bruley des Varannes</LastName>
<ForeName>Stanislas</ForeName>
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<Author ValidYN="Y"><LastName>Coron</LastName>
<ForeName>Emmanuel</ForeName>
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<PMID Version="1">18982334</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol. 2000 Apr;247 Suppl 2:II3-10</RefSource>
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