Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.
Identifieur interne : 000A18 ( PubMed/Curation ); précédent : 000A17; suivant : 000A19Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.
Auteurs : Thibaud Lebouvier [France] ; Michel Neunlist ; Stanislas Bruley Des Varannes ; Emmanuel Coron ; Anne Drouard ; Jean-Michel N'Guyen ; Tanguy Chaumette ; Maddalena Tasselli ; Sébastien Paillusson ; Mathurin Flamand ; Jean-Paul Galmiche ; Philippe Damier ; Pascal DerkinderenSource :
- PloS one [ 1932-6203 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Biopsy, Colon (innervation), Colon (metabolism), Colon (pathology), Colonoscopy, Enteric Nervous System (metabolism), Enteric Nervous System (pathology), Female, Humans, Lewy Bodies (metabolism), Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (pathology).
- MESH :
- diagnosis : Parkinson Disease.
- innervation : Colon.
- metabolism : Colon, Enteric Nervous System, Lewy Bodies, Parkinson Disease.
- pathology : Colon, Enteric Nervous System, Parkinson Disease.
- Adult, Aged, Biopsy, Colonoscopy, Female, Humans, Male, Middle Aged.
Abstract
The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.
DOI: 10.1371/journal.pone.0012728
PubMed: 20856865
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A58
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pubmed:20856865Le document en format XML
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Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name></author><author><name sortKey="Drouard, Anne" sort="Drouard, Anne" uniqKey="Drouard A" first="Anne" last="Drouard">Anne Drouard</name></author><author><name sortKey="N Guyen, Jean Michel" sort="N Guyen, Jean Michel" uniqKey="N Guyen J" first="Jean-Michel" last="N'Guyen">Jean-Michel N'Guyen</name></author><author><name sortKey="Chaumette, Tanguy" sort="Chaumette, Tanguy" uniqKey="Chaumette T" first="Tanguy" last="Chaumette">Tanguy Chaumette</name></author><author><name sortKey="Tasselli, Maddalena" sort="Tasselli, Maddalena" uniqKey="Tasselli M" first="Maddalena" last="Tasselli">Maddalena Tasselli</name></author><author><name sortKey="Paillusson, Sebastien" sort="Paillusson, Sebastien" uniqKey="Paillusson S" first="Sébastien" last="Paillusson">Sébastien Paillusson</name></author><author><name sortKey="Flamand, Mathurin" sort="Flamand, Mathurin" uniqKey="Flamand M" first="Mathurin" last="Flamand">Mathurin Flamand</name></author><author><name sortKey="Galmiche, Jean Paul" sort="Galmiche, Jean Paul" uniqKey="Galmiche J" first="Jean-Paul" last="Galmiche">Jean-Paul Galmiche</name></author><author><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20856865</idno><idno type="pmid">20856865</idno><idno type="doi">10.1371/journal.pone.0012728</idno><idno type="wicri:Area/PubMed/Corpus">000A58</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A58</idno><idno type="wicri:Area/PubMed/Curation">000A18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.</title><author><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name><affiliation wicri:level="1"><nlm:affiliation>UMR 913, Inserm, Nantes, France. thibaud.lebouvier@univ-nantes.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR 913, Inserm, Nantes</wicri:regionArea></affiliation></author><author><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name></author><author><name sortKey="Bruley Des Varannes, Stanislas" sort="Bruley Des Varannes, Stanislas" uniqKey="Bruley Des Varannes S" first="Stanislas" last="Bruley Des Varannes">Stanislas Bruley Des Varannes</name></author><author><name sortKey="Coron, Emmanuel" sort="Coron, Emmanuel" uniqKey="Coron E" first="Emmanuel" last="Coron">Emmanuel Coron</name></author><author><name sortKey="Drouard, Anne" sort="Drouard, Anne" uniqKey="Drouard A" first="Anne" last="Drouard">Anne Drouard</name></author><author><name sortKey="N Guyen, Jean Michel" sort="N Guyen, Jean Michel" uniqKey="N Guyen J" first="Jean-Michel" last="N'Guyen">Jean-Michel N'Guyen</name></author><author><name sortKey="Chaumette, Tanguy" sort="Chaumette, Tanguy" uniqKey="Chaumette T" first="Tanguy" last="Chaumette">Tanguy Chaumette</name></author><author><name sortKey="Tasselli, Maddalena" sort="Tasselli, Maddalena" uniqKey="Tasselli M" first="Maddalena" last="Tasselli">Maddalena Tasselli</name></author><author><name sortKey="Paillusson, Sebastien" sort="Paillusson, Sebastien" uniqKey="Paillusson S" first="Sébastien" last="Paillusson">Sébastien Paillusson</name></author><author><name sortKey="Flamand, Mathurin" sort="Flamand, Mathurin" uniqKey="Flamand M" first="Mathurin" last="Flamand">Mathurin Flamand</name></author><author><name sortKey="Galmiche, Jean Paul" sort="Galmiche, Jean Paul" uniqKey="Galmiche J" first="Jean-Paul" last="Galmiche">Jean-Paul Galmiche</name></author><author><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Colon (innervation)</term><term>Colon (metabolism)</term><term>Colon (pathology)</term><term>Colonoscopy</term><term>Enteric Nervous System (metabolism)</term><term>Enteric Nervous System (pathology)</term><term>Female</term><term>Humans</term><term>Lewy Bodies (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Colon</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colon</term><term>Enteric Nervous System</term><term>Lewy Bodies</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term><term>Enteric Nervous System</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Colonoscopy</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20856865</PMID><DateCreated><Year>2010</Year><Month>09</Month><Day>21</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>15</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>9</Issue><PubDate><Year>2010</Year><Month>Sep</Month><Day>14</Day></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.</ArticleTitle><Pagination><MedlinePgn>e12728</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0012728</ELocationID><ELocationID EIdType="pii" ValidYN="Y">e12728</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients. The aims of the present research were to use routine colonoscopy biopsies (1) to analyze, in depth, enteric pathology throughout the colonic submucosal plexus (SMP), and (2) to correlate the pathological burden with neurological and gastrointestinal (GI) symptoms.</AbstractText><AbstractText Label="METHODOLOGY/PRINCIPAL FINDINGS" NlmCategory="RESULTS">A total of 10 control and 29 PD patients divided into 3 groups according to disease duration were included. PD and GI symptoms were assessed using the Unified Parkinson's Disease Rating Scale part III and the Rome III questionnaire, respectively. Four biopsies were taken from the ascending and descending colon during the course of a total colonoscopy. Immunohistochemical analysis was performed using antibodies against phosphorylated alpha-synuclein, neurofilaments NF 220 kDa (NF) and tyrosine hydroxylase (TH). The density of LN, labeled by anti-phosphorylated alpha-synuclein antibodies, was evaluated using a quantitative rating score. Lewy pathology was apparent in the colonic biopsies from 21 patients and in none of the controls. A decreased number of NF-immunoreactive neurons per ganglion was observed in the SMP of PD patients compared to controls. The amount of LN in the ENS was inversely correlated with neuronal count and positively correlated with levodopa-unresponsive features and constipation.</AbstractText><AbstractText Label="CONCLUSION/SIGNIFICANCE" NlmCategory="CONCLUSIONS">Analysis of the ENS by routine colonoscopy biopsies is a useful tool for pre-mortem neuropathological diagnosis of PD, and also provides insight into the progression of motor and non-motor symptoms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lebouvier</LastName><ForeName>Thibaud</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>UMR 913, Inserm, Nantes, France. thibaud.lebouvier@univ-nantes.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neunlist</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bruley des Varannes</LastName><ForeName>Stanislas</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Coron</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Drouard</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>N'Guyen</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Chaumette</LastName><ForeName>Tanguy</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tasselli</LastName><ForeName>Maddalena</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Paillusson</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Flamand</LastName><ForeName>Mathurin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Galmiche</LastName><ForeName>Jean-Paul</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Damier</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Derkinderen</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00491062</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>09</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2009 Jun 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MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003113" MajorTopicYN="N">Colonoscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017615" MajorTopicYN="N">Enteric Nervous System</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016631" MajorTopicYN="N">Lewy Bodies</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC2939055</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>08</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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|area= ParkinsonFranceV1
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:20856865
|texte= Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:20856865" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |