White matter connectivity of human hypothalamus.
Identifieur interne : 000967 ( PubMed/Curation ); précédent : 000966; suivant : 000968White matter connectivity of human hypothalamus.
Auteurs : Jean-Jacques Lemaire [France] ; Andrew J. Frew ; David Mcarthur ; Alessandra A. Gorgulho ; Jeffry R. Alger ; Noriko Salomon ; Clive Chen ; Eric J. Behnke ; Antonio A F. De SallesSource :
- Brain research [ 1872-6240 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- pathology : Essential Tremor, Parkinson Disease.
- ultrastructure : Axons, Brain, Hypothalamus, Nerve Fibers, Neural Pathways.
- Aged, Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged.
Abstract
The macroscopic extrinsic white matter connectivity and the internal structure of the hypothalamus are still incompletely defined in humans. We investigated whether in-vivo diffusion tensor imaging tractography provides evidence of systematization according to hypothalamic compartmentalization. Six defined hypothalamic macroscopic compartments, preoptic, supraoptic, anteroventral, anterodorsal, lateral and posterior, were probed, within the right and left hemispheres of 14 subjects. Important new insights into the macroscopic structure of hypothalamus and white matter connections were found; the preoptic, anteroventral, lateral and posterior compartments are strongly connected to the cortex. The anteroventral connects particularly to the prefrontal cortex while the preoptic compartment connects mainly to the deep anterior brain. The anterodorsal connects mainly to the medial thalamus and the midline gray matter. There is a rightward frontal trend of hemispheric connectivity for the preoptic, anteroventral and lateral compartments. These findings may aid new neuromodulation applications and understanding in brain connectomics.
DOI: 10.1016/j.brainres.2010.11.072
PubMed: 21122799
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Frew</name></author><author><name sortKey="Mcarthur, David" sort="Mcarthur, David" uniqKey="Mcarthur D" first="David" last="Mcarthur">David Mcarthur</name></author><author><name sortKey="Gorgulho, Alessandra A" sort="Gorgulho, Alessandra A" uniqKey="Gorgulho A" first="Alessandra A" last="Gorgulho">Alessandra A. Gorgulho</name></author><author><name sortKey="Alger, Jeffry R" sort="Alger, Jeffry R" uniqKey="Alger J" first="Jeffry R" last="Alger">Jeffry R. Alger</name></author><author><name sortKey="Salomon, Noriko" sort="Salomon, Noriko" uniqKey="Salomon N" first="Noriko" last="Salomon">Noriko Salomon</name></author><author><name sortKey="Chen, Clive" sort="Chen, Clive" uniqKey="Chen C" first="Clive" last="Chen">Clive Chen</name></author><author><name sortKey="Behnke, Eric J" sort="Behnke, Eric J" uniqKey="Behnke E" first="Eric J" last="Behnke">Eric J. Behnke</name></author><author><name sortKey="De Salles, Antonio A F" sort="De Salles, Antonio A F" uniqKey="De Salles A" first="Antonio A F" last="De Salles">Antonio A F. 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Frew</name></author><author><name sortKey="Mcarthur, David" sort="Mcarthur, David" uniqKey="Mcarthur D" first="David" last="Mcarthur">David Mcarthur</name></author><author><name sortKey="Gorgulho, Alessandra A" sort="Gorgulho, Alessandra A" uniqKey="Gorgulho A" first="Alessandra A" last="Gorgulho">Alessandra A. Gorgulho</name></author><author><name sortKey="Alger, Jeffry R" sort="Alger, Jeffry R" uniqKey="Alger J" first="Jeffry R" last="Alger">Jeffry R. Alger</name></author><author><name sortKey="Salomon, Noriko" sort="Salomon, Noriko" uniqKey="Salomon N" first="Noriko" last="Salomon">Noriko Salomon</name></author><author><name sortKey="Chen, Clive" sort="Chen, Clive" uniqKey="Chen C" first="Clive" last="Chen">Clive Chen</name></author><author><name sortKey="Behnke, Eric J" sort="Behnke, Eric J" uniqKey="Behnke E" first="Eric J" last="Behnke">Eric J. Behnke</name></author><author><name sortKey="De Salles, Antonio A F" sort="De Salles, Antonio A F" uniqKey="De Salles A" first="Antonio A F" last="De Salles">Antonio A F. De Salles</name></author></analytic><series><title level="j">Brain research</title><idno type="eISSN">1872-6240</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Axons (ultrastructure)</term><term>Brain (ultrastructure)</term><term>Diffusion Tensor Imaging</term><term>Essential Tremor (pathology)</term><term>Female</term><term>Humans</term><term>Hypothalamus (ultrastructure)</term><term>Male</term><term>Middle Aged</term><term>Nerve Fibers (ultrastructure)</term><term>Neural Pathways (ultrastructure)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Axons</term><term>Brain</term><term>Hypothalamus</term><term>Nerve Fibers</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diffusion Tensor Imaging</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The macroscopic extrinsic white matter connectivity and the internal structure of the hypothalamus are still incompletely defined in humans. We investigated whether in-vivo diffusion tensor imaging tractography provides evidence of systematization according to hypothalamic compartmentalization. Six defined hypothalamic macroscopic compartments, preoptic, supraoptic, anteroventral, anterodorsal, lateral and posterior, were probed, within the right and left hemispheres of 14 subjects. Important new insights into the macroscopic structure of hypothalamus and white matter connections were found; the preoptic, anteroventral, lateral and posterior compartments are strongly connected to the cortex. The anteroventral connects particularly to the prefrontal cortex while the preoptic compartment connects mainly to the deep anterior brain. The anterodorsal connects mainly to the medial thalamus and the midline gray matter. There is a rightward frontal trend of hemispheric connectivity for the preoptic, anteroventral and lateral compartments. These findings may aid new neuromodulation applications and understanding in brain connectomics.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21122799</PMID><DateCreated><Year>2011</Year><Month>01</Month><Day>17</Day></DateCreated><DateCompleted><Year>2011</Year><Month>06</Month><Day>14</Day></DateCompleted><DateRevised><Year>2011</Year><Month>01</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-6240</ISSN><JournalIssue CitedMedium="Internet"><Volume>1371</Volume><PubDate><Year>2011</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Brain research</Title><ISOAbbreviation>Brain Res.</ISOAbbreviation></Journal><ArticleTitle>White matter connectivity of human hypothalamus.</ArticleTitle><Pagination><MedlinePgn>43-64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.brainres.2010.11.072</ELocationID><Abstract><AbstractText>The macroscopic extrinsic white matter connectivity and the internal structure of the hypothalamus are still incompletely defined in humans. We investigated whether in-vivo diffusion tensor imaging tractography provides evidence of systematization according to hypothalamic compartmentalization. Six defined hypothalamic macroscopic compartments, preoptic, supraoptic, anteroventral, anterodorsal, lateral and posterior, were probed, within the right and left hemispheres of 14 subjects. Important new insights into the macroscopic structure of hypothalamus and white matter connections were found; the preoptic, anteroventral, lateral and posterior compartments are strongly connected to the cortex. The anteroventral connects particularly to the prefrontal cortex while the preoptic compartment connects mainly to the deep anterior brain. The anterodorsal connects mainly to the medial thalamus and the midline gray matter. There is a rightward frontal trend of hemispheric connectivity for the preoptic, anteroventral and lateral compartments. These findings may aid new neuromodulation applications and understanding in brain connectomics.</AbstractText><CopyrightInformation>Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lemaire</LastName><ForeName>Jean-Jacques</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Univ Clermont 1, UFR Médecine, EA3295, Equipe de Recherche en signal et Imagerie Médicale, Clermont-Ferrand, F-63001, France. jjlemaire@chu-clermontferrand.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frew</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>McArthur</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Gorgulho</LastName><ForeName>Alessandra A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Alger</LastName><ForeName>Jeffry R</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Salomon</LastName><ForeName>Noriko</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Clive</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Behnke</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials></Author><Author ValidYN="Y"><LastName>De Salles</LastName><ForeName>Antonio A F</ForeName><Initials>AA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>11</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Res</MedlineTA><NlmUniqueID>0045503</NlmUniqueID><ISSNLinking>0006-8993</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001369" MajorTopicYN="N">Axons</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056324" MajorTopicYN="N">Diffusion Tensor Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020329" MajorTopicYN="N">Essential Tremor</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007031" MajorTopicYN="N">Hypothalamus</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009412" MajorTopicYN="N">Nerve Fibers</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009434" MajorTopicYN="N">Neural Pathways</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>11</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21122799</ArticleId><ArticleId IdType="pii">S0006-8993(10)02585-0</ArticleId><ArticleId IdType="doi">10.1016/j.brainres.2010.11.072</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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