Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.
Identifieur interne : 000770 ( PubMed/Curation ); précédent : 000769; suivant : 000771Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.
Auteurs : Carmen Noelker [France] ; Lydie Morel ; Thomas Lescot ; Anke Osterloh ; Daniel Alvarez-Fischer ; Minka Breloer ; Carmen Henze ; Candan Depboylu ; Delphine Skrzydelski ; Patrick P. Michel ; Richard C. Dodel ; Lixia Lu ; Etienne C. Hirsch ; Stéphane Hunot ; Andreas HartmannSource :
- Scientific reports [ 2045-2322 ] ; 2013.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects), Animals, Cell Death (genetics), Corpus Striatum (metabolism), Dopamine (metabolism), Homovanillic Acid (metabolism), Mice, Mice, Knockout, Microglia (metabolism), Parkinsonian Disorders (genetics), Parkinsonian Disorders (metabolism), Toll-Like Receptor 4 (genetics), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- genetics : Cell Death, Parkinsonian Disorders, Toll-Like Receptor 4.
- metabolism : Corpus Striatum, Dopamine, Homovanillic Acid, Microglia, Parkinsonian Disorders, Toll-Like Receptor 4.
- Animals, Mice, Mice, Knockout.
Abstract
In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression of a variety of immune-response genes, including inflammatory cytokines. It is therefore plausible to assume that TLRs are mediators in glial cells triggering the release of cytokines that ultimately kill DA neurons in the substantia nigra in Parkinson disease (PD). Accordingly, recent data indicate that TLR4 is up-regulated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in a mouse model of PD. Here, we wished to evaluate the role of TLR4 in the acute mouse MPTP model of PD: TLR4-deficient mice and wild-type littermates control mice were used for the acute administration way of MPTP or a corresponding volume of saline. We demonstrate that TLR4-deficient mice are less vulnerable to MPTP intoxication than wild-type mice and display a decreased number of Iba1+ and MHC II+ activated microglial cells after MPTP application, suggesting that the TLR4 pathway is involved in experimental PD.
DOI: 10.1038/srep01393
PubMed: 23462811
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000806
Links to Exploration step
pubmed:23462811Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.</title>
<author><name sortKey="Noelker, Carmen" sort="Noelker, Carmen" uniqKey="Noelker C" first="Carmen" last="Noelker">Carmen Noelker</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S975, Université Pierre et Marie Curie Paris 06 UMR_S975, CNRS UMR 7225, CR-ICM, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S975, Université Pierre et Marie Curie Paris 06 UMR_S975, CNRS UMR 7225, CR-ICM, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morel, Lydie" sort="Morel, Lydie" uniqKey="Morel L" first="Lydie" last="Morel">Lydie Morel</name>
</author>
<author><name sortKey="Lescot, Thomas" sort="Lescot, Thomas" uniqKey="Lescot T" first="Thomas" last="Lescot">Thomas Lescot</name>
</author>
<author><name sortKey="Osterloh, Anke" sort="Osterloh, Anke" uniqKey="Osterloh A" first="Anke" last="Osterloh">Anke Osterloh</name>
</author>
<author><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name>
</author>
<author><name sortKey="Breloer, Minka" sort="Breloer, Minka" uniqKey="Breloer M" first="Minka" last="Breloer">Minka Breloer</name>
</author>
<author><name sortKey="Henze, Carmen" sort="Henze, Carmen" uniqKey="Henze C" first="Carmen" last="Henze">Carmen Henze</name>
</author>
<author><name sortKey="Depboylu, Candan" sort="Depboylu, Candan" uniqKey="Depboylu C" first="Candan" last="Depboylu">Candan Depboylu</name>
</author>
<author><name sortKey="Skrzydelski, Delphine" sort="Skrzydelski, Delphine" uniqKey="Skrzydelski D" first="Delphine" last="Skrzydelski">Delphine Skrzydelski</name>
</author>
<author><name sortKey="Michel, Patrick P" sort="Michel, Patrick P" uniqKey="Michel P" first="Patrick P" last="Michel">Patrick P. Michel</name>
</author>
<author><name sortKey="Dodel, Richard C" sort="Dodel, Richard C" uniqKey="Dodel R" first="Richard C" last="Dodel">Richard C. Dodel</name>
</author>
<author><name sortKey="Lu, Lixia" sort="Lu, Lixia" uniqKey="Lu L" first="Lixia" last="Lu">Lixia Lu</name>
</author>
<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name>
</author>
<author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stéphane" last="Hunot">Stéphane Hunot</name>
</author>
<author><name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23462811</idno>
<idno type="pmid">23462811</idno>
<idno type="doi">10.1038/srep01393</idno>
<idno type="wicri:Area/PubMed/Corpus">000806</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000806</idno>
<idno type="wicri:Area/PubMed/Curation">000770</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000770</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.</title>
<author><name sortKey="Noelker, Carmen" sort="Noelker, Carmen" uniqKey="Noelker C" first="Carmen" last="Noelker">Carmen Noelker</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM UMR_S975, Université Pierre et Marie Curie Paris 06 UMR_S975, CNRS UMR 7225, CR-ICM, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S975, Université Pierre et Marie Curie Paris 06 UMR_S975, CNRS UMR 7225, CR-ICM, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Morel, Lydie" sort="Morel, Lydie" uniqKey="Morel L" first="Lydie" last="Morel">Lydie Morel</name>
</author>
<author><name sortKey="Lescot, Thomas" sort="Lescot, Thomas" uniqKey="Lescot T" first="Thomas" last="Lescot">Thomas Lescot</name>
</author>
<author><name sortKey="Osterloh, Anke" sort="Osterloh, Anke" uniqKey="Osterloh A" first="Anke" last="Osterloh">Anke Osterloh</name>
</author>
<author><name sortKey="Alvarez Fischer, Daniel" sort="Alvarez Fischer, Daniel" uniqKey="Alvarez Fischer D" first="Daniel" last="Alvarez-Fischer">Daniel Alvarez-Fischer</name>
</author>
<author><name sortKey="Breloer, Minka" sort="Breloer, Minka" uniqKey="Breloer M" first="Minka" last="Breloer">Minka Breloer</name>
</author>
<author><name sortKey="Henze, Carmen" sort="Henze, Carmen" uniqKey="Henze C" first="Carmen" last="Henze">Carmen Henze</name>
</author>
<author><name sortKey="Depboylu, Candan" sort="Depboylu, Candan" uniqKey="Depboylu C" first="Candan" last="Depboylu">Candan Depboylu</name>
</author>
<author><name sortKey="Skrzydelski, Delphine" sort="Skrzydelski, Delphine" uniqKey="Skrzydelski D" first="Delphine" last="Skrzydelski">Delphine Skrzydelski</name>
</author>
<author><name sortKey="Michel, Patrick P" sort="Michel, Patrick P" uniqKey="Michel P" first="Patrick P" last="Michel">Patrick P. Michel</name>
</author>
<author><name sortKey="Dodel, Richard C" sort="Dodel, Richard C" uniqKey="Dodel R" first="Richard C" last="Dodel">Richard C. Dodel</name>
</author>
<author><name sortKey="Lu, Lixia" sort="Lu, Lixia" uniqKey="Lu L" first="Lixia" last="Lu">Lixia Lu</name>
</author>
<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name>
</author>
<author><name sortKey="Hunot, Stephane" sort="Hunot, Stephane" uniqKey="Hunot S" first="Stéphane" last="Hunot">Stéphane Hunot</name>
</author>
<author><name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name>
</author>
</analytic>
<series><title level="j">Scientific reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects)</term>
<term>Animals</term>
<term>Cell Death (genetics)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Dopamine (metabolism)</term>
<term>Homovanillic Acid (metabolism)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Microglia (metabolism)</term>
<term>Parkinsonian Disorders (genetics)</term>
<term>Parkinsonian Disorders (metabolism)</term>
<term>Toll-Like Receptor 4 (genetics)</term>
<term>Toll-Like Receptor 4 (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Death</term>
<term>Parkinsonian Disorders</term>
<term>Toll-Like Receptor 4</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Dopamine</term>
<term>Homovanillic Acid</term>
<term>Microglia</term>
<term>Parkinsonian Disorders</term>
<term>Toll-Like Receptor 4</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mice</term>
<term>Mice, Knockout</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression of a variety of immune-response genes, including inflammatory cytokines. It is therefore plausible to assume that TLRs are mediators in glial cells triggering the release of cytokines that ultimately kill DA neurons in the substantia nigra in Parkinson disease (PD). Accordingly, recent data indicate that TLR4 is up-regulated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in a mouse model of PD. Here, we wished to evaluate the role of TLR4 in the acute mouse MPTP model of PD: TLR4-deficient mice and wild-type littermates control mice were used for the acute administration way of MPTP or a corresponding volume of saline. We demonstrate that TLR4-deficient mice are less vulnerable to MPTP intoxication than wild-type mice and display a decreased number of Iba1+ and MHC II+ activated microglial cells after MPTP application, suggesting that the TLR4 pathway is involved in experimental PD.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23462811</PMID>
<DateCreated><Year>2013</Year>
<Month>03</Month>
<Day>06</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>08</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>02</Month>
<Day>18</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>3</Volume>
<PubDate><Year>2013</Year>
</PubDate>
</JournalIssue>
<Title>Scientific reports</Title>
<ISOAbbreviation>Sci Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease.</ArticleTitle>
<Pagination><MedlinePgn>1393</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/srep01393</ELocationID>
<Abstract><AbstractText>In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression of a variety of immune-response genes, including inflammatory cytokines. It is therefore plausible to assume that TLRs are mediators in glial cells triggering the release of cytokines that ultimately kill DA neurons in the substantia nigra in Parkinson disease (PD). Accordingly, recent data indicate that TLR4 is up-regulated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in a mouse model of PD. Here, we wished to evaluate the role of TLR4 in the acute mouse MPTP model of PD: TLR4-deficient mice and wild-type littermates control mice were used for the acute administration way of MPTP or a corresponding volume of saline. We demonstrate that TLR4-deficient mice are less vulnerable to MPTP intoxication than wild-type mice and display a decreased number of Iba1+ and MHC II+ activated microglial cells after MPTP application, suggesting that the TLR4 pathway is involved in experimental PD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Noelker</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM UMR_S975, Université Pierre et Marie Curie Paris 06 UMR_S975, CNRS UMR 7225, CR-ICM, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morel</LastName>
<ForeName>Lydie</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lescot</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Osterloh</LastName>
<ForeName>Anke</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alvarez-Fischer</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Breloer</LastName>
<ForeName>Minka</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Henze</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Depboylu</LastName>
<ForeName>Candan</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Skrzydelski</LastName>
<ForeName>Delphine</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Michel</LastName>
<ForeName>Patrick P</ForeName>
<Initials>PP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Dodel</LastName>
<ForeName>Richard C</ForeName>
<Initials>RC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Lixia</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hirsch</LastName>
<ForeName>Etienne C</ForeName>
<Initials>EC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hunot</LastName>
<ForeName>Stéphane</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hartmann</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Sci Rep</MedlineTA>
<NlmUniqueID>101563288</NlmUniqueID>
<ISSNLinking>2045-2322</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9P21XSP91P</RegistryNumber>
<NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber>
<NameOfSubstance UI="D004298">Dopamine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>X77S6GMS36</RegistryNumber>
<NameOfSubstance UI="D006719">Homovanillic Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2001 Jan;15(1):155-163</RefSource>
<PMID Version="1">11149903</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S17-20</RefSource>
<PMID Version="1">22166424</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1988 Aug;38(8):1285-91</RefSource>
<PMID Version="1">3399080</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1998 Dec 11;282(5396):2085-8</RefSource>
<PMID Version="1">9851930</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Res. 1999 May 15;828(1-2):91-103</RefSource>
<PMID Version="1">10320728</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2006 Jan;12(1):9-13</RefSource>
<PMID Version="1">16337421</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2007 May;13(5):552-9</RefSource>
<PMID Version="1">17479101</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2007 Aug;102(4):1175-83</RefSource>
<PMID Version="1">17509088</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunopharmacol Immunotoxicol. 2008;30(4):729-40</RefSource>
<PMID Version="1">18686098</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2008 Nov;107(3):701-11</RefSource>
<PMID Version="1">18761710</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2009 Jan;119(1):182-92</RefSource>
<PMID Version="1">19104149</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2009 Feb 1;199(3):355-61</RefSource>
<PMID Version="1">19061424</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2009 Apr;8(4):382-97</RefSource>
<PMID Version="1">19296921</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Drug Discov. 2010 Apr;9(4):293-307</RefSource>
<PMID Version="1">20380038</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6632-7</RefSource>
<PMID Version="1">21467220</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2011 Jul 12;21(13):R488-93</RefSource>
<PMID Version="1">21741580</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Behav Immun. 2011 Aug;25(6):1143-52</RefSource>
<PMID Version="1">21376805</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2011 Jul;236(1-2):39-46</RefSource>
<PMID Version="1">21640391</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2011 Aug;179(2):954-63</RefSource>
<PMID Version="1">21801874</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroinflammation. 2011;8:137</RefSource>
<PMID Version="1">21989292</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 1988 Jul 28;334(6180):345-8</RefSource>
<PMID Version="1">2899295</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="N">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016923" MajorTopicYN="N">Cell Death</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006719" MajorTopicYN="N">Homovanillic Acid</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017628" MajorTopicYN="N">Microglia</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC3589722</OtherID>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>05</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2013</Year>
<Month>01</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>3</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>3</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>8</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23462811</ArticleId>
<ArticleId IdType="pii">srep01393</ArticleId>
<ArticleId IdType="doi">10.1038/srep01393</ArticleId>
<ArticleId IdType="pmc">PMC3589722</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000770 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000770 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:23462811 |texte= Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:23462811" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |