ParkinsonFranceV1, PubMed, Curation, bibRecord, 000761

Pathogenesis of Parkinson's disease.

Identifieur interne : 000761 ( PubMed/Curation ); précédent : 000760; suivant : 000762

Pathogenesis of Parkinson's disease.

Auteurs : Etienne C. Hirsch [France] ; Peter Jenner ; Serge Przedborski

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.

RBID : pubmed:22927094

English descriptors

KwdEn :
- Calcium (metabolism), Cell Death (physiology), Humans, Mitochondrial Diseases (complications), Nerve Degeneration (pathology), Neurons (metabolism), Neurons (pathology), Parkinson Disease (etiology), Parkinson Disease (pathology).
MESH :
- chemical , metabolism : Calcium.
- complications : Mitochondrial Diseases.
- etiology : Parkinson Disease.
- metabolism : Neurons.
- pathology : Nerve Degeneration, Neurons, Parkinson Disease.
- physiology : Cell Death.
- Humans.

Abstract

Parkinson's disease is a common adult-onset neurodegenerative disorder whose pathogenesis remains essentially unknown. Currently, it is believed that the neurodegenerative process in Parkinson's disease is a combination of both cell-autonomous and non-cell-autonomous mechanisms. Proposed cell-autonomous mechanisms include alterations in mitochondrial bioenergetics, dysregulation of calcium homeostasis, and impaired turnover of mitochondria. As for the proposed non-cell-autonomous mechanisms, they involve prion-like behavior of misfolded proteins and neuroinflammation. This suggests that cell death in Parkinson's disease is caused by a multifactorial cascade of pathogenic events and argues that effective neuroprotective therapy for Parkinson's disease may have to rely on multiple drug interventions.

DOI: 10.1002/mds.25032
PubMed: 22927094

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Le document en format XML

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<author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name>
<affiliation wicri:level="1"><nlm:affiliation>Université Pierre et Marie Curie-Paris 06, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Pierre et Marie Curie-Paris 06, Centre de Recherche de l'Institut du Cerveau et de la Moëlle Épinière, Hôpital de la Salpêtrière, Paris</wicri:regionArea>
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<author><name sortKey="Przedborski, Serge" sort="Przedborski, Serge" uniqKey="Przedborski S" first="Serge" last="Przedborski">Serge Przedborski</name>
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<term>Nerve Degeneration (pathology)</term>
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<term>Neurons (pathology)</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease is a common adult-onset neurodegenerative disorder whose pathogenesis remains essentially unknown. Currently, it is believed that the neurodegenerative process in Parkinson's disease is a combination of both cell-autonomous and non-cell-autonomous mechanisms. Proposed cell-autonomous mechanisms include alterations in mitochondrial bioenergetics, dysregulation of calcium homeostasis, and impaired turnover of mitochondria. As for the proposed non-cell-autonomous mechanisms, they involve prion-like behavior of misfolded proteins and neuroinflammation. This suggests that cell death in Parkinson's disease is caused by a multifactorial cascade of pathogenic events and argues that effective neuroprotective therapy for Parkinson's disease may have to rely on multiple drug interventions.</div>
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<CopyrightInformation>Copyright © 2013 Movement Disorders Society.</CopyrightInformation>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Pathogenesis of Parkinson's disease.

Pathogenesis of Parkinson's disease.

Source :

English descriptors

Abstract

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