Neurostimulation for Parkinson's disease with early motor complications.
Identifieur interne : 000737 ( PubMed/Curation ); précédent : 000736; suivant : 000738Neurostimulation for Parkinson's disease with early motor complications.
Auteurs : W M M. Schuepbach [France] ; J. Rau ; K. Knudsen ; J. Volkmann ; P. Krack ; L. Timmermann ; T D H Lbig ; H. Hesekamp ; S M Navarro ; N. Meier ; D. Falk ; M. Mehdorn ; S. Paschen ; M. Maarouf ; M T Barbe ; G R Fink ; A. Kupsch ; D. Gruber ; G-H Schneider ; E. Seigneuret ; A. Kistner ; P. Chaynes ; F. Ory-Magne ; C. Brefel Courbon ; J. Vesper ; A. Schnitzler ; L. Wojtecki ; J-L Houeto ; B. Bataille ; D. Maltête ; P. Damier ; S. Raoul ; F. Sixel-Doering ; D. Hellwig ; A. Gharabaghi ; R. Krüger ; M O Pinsker ; F. Amtage ; J-M Régis ; T. Witjas ; S. Thobois ; P. Mertens ; M. Kloss ; A. Hartmann ; W H Oertel ; B. Post ; H. Speelman ; Y. Agid ; C. Schade-Brittinger ; G. DeuschlSource :
- The New England journal of medicine [ 1533-4406 ] ; 2013.
English descriptors
- KwdEn :
- Activities of Daily Living, Adult, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Combined Modality Therapy, Dopamine Agonists (adverse effects), Dopamine Agonists (therapeutic use), Dyskinesias (etiology), Electric Stimulation Therapy (adverse effects), Female, Humans, Implantable Neurostimulators (adverse effects), Intention to Treat Analysis, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Quality of Life, Subthalamic Nucleus, Surveys and Questionnaires, Treatment Outcome.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agonists.
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agonists.
- adverse effects : Electric Stimulation Therapy, Implantable Neurostimulators.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesias.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Activities of Daily Living, Adult, Combined Modality Therapy, Female, Humans, Intention to Treat Analysis, Male, Middle Aged, Quality of Life, Subthalamic Nucleus, Surveys and Questionnaires, Treatment Outcome.
Abstract
Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease.
DOI: 10.1056/NEJMoa1205158
PubMed: 23406026
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pubmed:23406026Le document en format XML
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Schuepbach</name><affiliation wicri:level="1"><nlm:affiliation>Assistance Publique–Hôpitaux de Paris, Centre d'Investigation Clinique (CIC) 9503, Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 and INSERM, Centre Hospitalier Universitaire (CHU) Pitié–Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique–Hôpitaux de Paris, Centre d'Investigation Clinique (CIC) 9503, Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 and INSERM, Centre Hospitalier Universitaire (CHU) Pitié–Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Rau, J" sort="Rau, J" uniqKey="Rau J" first="J" last="Rau">J. Rau</name></author><author><name sortKey="Knudsen, K" sort="Knudsen, K" uniqKey="Knudsen K" first="K" last="Knudsen">K. Knudsen</name></author><author><name sortKey="Volkmann, J" sort="Volkmann, J" uniqKey="Volkmann J" first="J" last="Volkmann">J. Volkmann</name></author><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name></author><author><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L" last="Timmermann">L. Timmermann</name></author><author><name sortKey="H Lbig, T D" sort="H Lbig, T D" uniqKey="H Lbig T" first="T D" last="H Lbig">T D H Lbig</name></author><author><name sortKey="Hesekamp, H" sort="Hesekamp, H" uniqKey="Hesekamp H" first="H" last="Hesekamp">H. Hesekamp</name></author><author><name sortKey="Navarro, S M" sort="Navarro, S M" uniqKey="Navarro S" first="S M" last="Navarro">S M Navarro</name></author><author><name sortKey="Meier, N" sort="Meier, N" uniqKey="Meier N" first="N" last="Meier">N. Meier</name></author><author><name sortKey="Falk, D" sort="Falk, D" uniqKey="Falk D" first="D" last="Falk">D. 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Schuepbach</name><affiliation wicri:level="1"><nlm:affiliation>Assistance Publique–Hôpitaux de Paris, Centre d'Investigation Clinique (CIC) 9503, Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 and INSERM, Centre Hospitalier Universitaire (CHU) Pitié–Salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique–Hôpitaux de Paris, Centre d'Investigation Clinique (CIC) 9503, Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 and INSERM, Centre Hospitalier Universitaire (CHU) Pitié–Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Rau, J" sort="Rau, J" uniqKey="Rau J" first="J" last="Rau">J. Rau</name></author><author><name sortKey="Knudsen, K" sort="Knudsen, K" uniqKey="Knudsen K" first="K" last="Knudsen">K. Knudsen</name></author><author><name sortKey="Volkmann, J" sort="Volkmann, J" uniqKey="Volkmann J" first="J" last="Volkmann">J. Volkmann</name></author><author><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name></author><author><name sortKey="Timmermann, L" sort="Timmermann, L" uniqKey="Timmermann L" first="L" last="Timmermann">L. Timmermann</name></author><author><name sortKey="H Lbig, T D" sort="H Lbig, T D" uniqKey="H Lbig T" first="T D" last="H Lbig">T D H Lbig</name></author><author><name sortKey="Hesekamp, H" sort="Hesekamp, H" uniqKey="Hesekamp H" first="H" last="Hesekamp">H. Hesekamp</name></author><author><name sortKey="Navarro, S M" sort="Navarro, S M" uniqKey="Navarro S" first="S M" last="Navarro">S M Navarro</name></author><author><name sortKey="Meier, N" sort="Meier, N" uniqKey="Meier N" first="N" last="Meier">N. Meier</name></author><author><name sortKey="Falk, D" sort="Falk, D" uniqKey="Falk D" first="D" last="Falk">D. Falk</name></author><author><name sortKey="Mehdorn, M" sort="Mehdorn, M" uniqKey="Mehdorn M" first="M" last="Mehdorn">M. Mehdorn</name></author><author><name sortKey="Paschen, S" sort="Paschen, S" uniqKey="Paschen S" first="S" last="Paschen">S. Paschen</name></author><author><name sortKey="Maarouf, M" sort="Maarouf, M" uniqKey="Maarouf M" first="M" last="Maarouf">M. Maarouf</name></author><author><name sortKey="Barbe, M T" sort="Barbe, M T" uniqKey="Barbe M" first="M T" last="Barbe">M T Barbe</name></author><author><name sortKey="Fink, G R" sort="Fink, G R" uniqKey="Fink G" first="G R" last="Fink">G R Fink</name></author><author><name sortKey="Kupsch, A" sort="Kupsch, A" uniqKey="Kupsch A" first="A" last="Kupsch">A. Kupsch</name></author><author><name sortKey="Gruber, D" sort="Gruber, D" uniqKey="Gruber D" first="D" last="Gruber">D. Gruber</name></author><author><name sortKey="Schneider, G H" sort="Schneider, G H" uniqKey="Schneider G" first="G-H" last="Schneider">G-H Schneider</name></author><author><name sortKey="Seigneuret, E" sort="Seigneuret, E" uniqKey="Seigneuret E" first="E" last="Seigneuret">E. Seigneuret</name></author><author><name sortKey="Kistner, A" sort="Kistner, A" uniqKey="Kistner A" first="A" last="Kistner">A. Kistner</name></author><author><name sortKey="Chaynes, P" sort="Chaynes, P" uniqKey="Chaynes P" first="P" last="Chaynes">P. Chaynes</name></author><author><name sortKey="Ory Magne, F" sort="Ory Magne, F" uniqKey="Ory Magne F" first="F" last="Ory-Magne">F. Ory-Magne</name></author><author><name sortKey="Brefel Courbon, C" sort="Brefel Courbon, C" uniqKey="Brefel Courbon C" first="C" last="Brefel Courbon">C. Brefel Courbon</name></author><author><name sortKey="Vesper, J" sort="Vesper, J" uniqKey="Vesper J" first="J" last="Vesper">J. Vesper</name></author><author><name sortKey="Schnitzler, A" sort="Schnitzler, A" uniqKey="Schnitzler A" first="A" last="Schnitzler">A. Schnitzler</name></author><author><name sortKey="Wojtecki, L" sort="Wojtecki, L" uniqKey="Wojtecki L" first="L" last="Wojtecki">L. Wojtecki</name></author><author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J-L" last="Houeto">J-L Houeto</name></author><author><name sortKey="Bataille, B" sort="Bataille, B" uniqKey="Bataille B" first="B" last="Bataille">B. Bataille</name></author><author><name sortKey="Maltete, D" sort="Maltete, D" uniqKey="Maltete D" first="D" last="Maltête">D. Maltête</name></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name></author><author><name sortKey="Raoul, S" sort="Raoul, S" uniqKey="Raoul S" first="S" last="Raoul">S. Raoul</name></author><author><name sortKey="Sixel Doering, F" sort="Sixel Doering, F" uniqKey="Sixel Doering F" first="F" last="Sixel-Doering">F. Sixel-Doering</name></author><author><name sortKey="Hellwig, D" sort="Hellwig, D" uniqKey="Hellwig D" first="D" last="Hellwig">D. Hellwig</name></author><author><name sortKey="Gharabaghi, A" sort="Gharabaghi, A" uniqKey="Gharabaghi A" first="A" last="Gharabaghi">A. Gharabaghi</name></author><author><name sortKey="Kruger, R" sort="Kruger, R" uniqKey="Kruger R" first="R" last="Krüger">R. Krüger</name></author><author><name sortKey="Pinsker, M O" sort="Pinsker, M O" uniqKey="Pinsker M" first="M O" last="Pinsker">M O Pinsker</name></author><author><name sortKey="Amtage, F" sort="Amtage, F" uniqKey="Amtage F" first="F" last="Amtage">F. Amtage</name></author><author><name sortKey="Regis, J M" sort="Regis, J M" uniqKey="Regis J" first="J-M" last="Régis">J-M Régis</name></author><author><name sortKey="Witjas, T" sort="Witjas, T" uniqKey="Witjas T" first="T" last="Witjas">T. Witjas</name></author><author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S" last="Thobois">S. Thobois</name></author><author><name sortKey="Mertens, P" sort="Mertens, P" uniqKey="Mertens P" first="P" last="Mertens">P. Mertens</name></author><author><name sortKey="Kloss, M" sort="Kloss, M" uniqKey="Kloss M" first="M" last="Kloss">M. Kloss</name></author><author><name sortKey="Hartmann, A" sort="Hartmann, A" uniqKey="Hartmann A" first="A" last="Hartmann">A. Hartmann</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author><author><name sortKey="Post, B" sort="Post, B" uniqKey="Post B" first="B" last="Post">B. Post</name></author><author><name sortKey="Speelman, H" sort="Speelman, H" uniqKey="Speelman H" first="H" last="Speelman">H. Speelman</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Y. Agid</name></author><author><name sortKey="Schade Brittinger, C" sort="Schade Brittinger, C" uniqKey="Schade Brittinger C" first="C" last="Schade-Brittinger">C. Schade-Brittinger</name></author><author><name sortKey="Deuschl, G" sort="Deuschl, G" uniqKey="Deuschl G" first="G" last="Deuschl">G. Deuschl</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Combined Modality Therapy</term><term>Dopamine Agonists (adverse effects)</term><term>Dopamine Agonists (therapeutic use)</term><term>Dyskinesias (etiology)</term><term>Electric Stimulation Therapy (adverse effects)</term><term>Female</term><term>Humans</term><term>Implantable Neurostimulators (adverse effects)</term><term>Intention to Treat Analysis</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Quality of Life</term><term>Subthalamic Nucleus</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Implantable Neurostimulators</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Combined Modality Therapy</term><term>Female</term><term>Humans</term><term>Intention to Treat Analysis</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Subthalamic Nucleus</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23406026</PMID><DateCreated><Year>2013</Year><Month>02</Month><Day>14</Day></DateCreated><DateCompleted><Year>2013</Year><Month>02</Month><Day>26</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>368</Volume><Issue>7</Issue><PubDate><Year>2013</Year><Month>Feb</Month><Day>14</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation></Journal><ArticleTitle>Neurostimulation for Parkinson's disease with early motor complications.</ArticleTitle><Pagination><MedlinePgn>610-22</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1056/NEJMoa1205158</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Subthalamic stimulation reduces motor disability and improves quality of life in patients with advanced Parkinson's disease who have severe levodopa-induced motor complications. We hypothesized that neurostimulation would be beneficial at an earlier stage of Parkinson's disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this 2-year trial, we randomly assigned 251 patients with Parkinson's disease and early motor complications (mean age, 52 years; mean duration of disease, 7.5 years) to undergo neurostimulation plus medical therapy or medical therapy alone. The primary end point was quality of life, as assessed with the use of the Parkinson's Disease Questionnaire (PDQ-39) summary index (with scores ranging from 0 to 100 and higher scores indicating worse function). Major secondary outcomes included parkinsonian motor disability, activities of daily living, levodopa-induced motor complications (as assessed with the use of the Unified Parkinson's Disease Rating Scale, parts III, II, and IV, respectively), and time with good mobility and no dyskinesia.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">For the primary outcome of quality of life, the mean score for the neurostimulation group improved by 7.8 points, and that for the medical-therapy group worsened by 0.2 points (between-group difference in mean change from baseline to 2 years, 8.0 points; P=0.002). Neurostimulation was superior to medical therapy with respect to motor disability (P<0.001), activities of daily living (P<0.001), levodopa-induced motor complications (P<0.001), and time with good mobility and no dyskinesia (P=0.01). Serious adverse events occurred in 54.8% of the patients in the neurostimulation group and in 44.1% of those in the medical-therapy group. Serious adverse events related to surgical implantation or the neurostimulation device occurred in 17.7% of patients. An expert panel confirmed that medical therapy was consistent with practice guidelines for 96.8% of the patients in the neurostimulation group and for 94.5% of those in the medical-therapy group.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Subthalamic stimulation was superior to medical therapy in patients with Parkinson's disease and early motor complications. (Funded by the German Ministry of Research and others; EARLYSTIM ClinicalTrials.gov number, NCT00354133.).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schuepbach</LastName><ForeName>W M M</ForeName><Initials>WM</Initials><AffiliationInfo><Affiliation>Assistance Publique–Hôpitaux de Paris, Centre d'Investigation Clinique (CIC) 9503, Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 and INSERM, Centre Hospitalier Universitaire (CHU) Pitié–Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rau</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Knudsen</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Volkmann</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author 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RefType="CommentIn"><RefSource>Fortschr Neurol Psychiatr. 2013 Aug;81(8):424</RefSource><PMID Version="1">24133683</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2013 May 23;368(21):2038</RefSource><PMID Version="1">23697520</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000203" MajorTopicYN="N">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018491" MajorTopicYN="N">Dopamine 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